Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies

Abstract Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hema...
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Autor*in:	Wang, Hao [verfasserIn] Kaur, Gurbakhash Sankin, Alexander I. Chen, Fuxiang Guan, Fangxia Zang, Xingxing

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Hematologic malignancies Immune checkpoints CAR-T Immunotherapy CTLA-4 PD-1 New targets

Anmerkung:	© The Author(s). 2019

Übergeordnetes Werk:	Enthalten in: Journal of hematology & oncology - London : Biomed Central, 2008, 12(2019), 1 vom: 11. Juni
Übergeordnetes Werk:	volume:12 ; year:2019 ; number:1 ; day:11 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s13045-019-0746-1

Katalog-ID:	SPR029624371

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allfields	10.1186/s13045-019-0746-1 doi (DE-627)SPR029624371 (SPR)s13045-019-0746-1-e DE-627 ger DE-627 rakwb eng Wang, Hao verfasserin aut Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Abstract Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the preclinical and clinical advances of CTLA-4 and PD-L1/PD-1-based ICB and CD19-specific CAR-T cell therapy in hematologic malignancies. We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies. Hematologic malignancies (dpeaa)DE-He213 Immune checkpoints (dpeaa)DE-He213 CAR-T (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 CTLA-4 (dpeaa)DE-He213 PD-1 (dpeaa)DE-He213 New targets (dpeaa)DE-He213 Kaur, Gurbakhash aut Sankin, Alexander I. aut Chen, Fuxiang aut Guan, Fangxia aut Zang, Xingxing aut Enthalten in Journal of hematology & oncology London : Biomed Central, 2008 12(2019), 1 vom: 11. Juni (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:12 year:2019 number:1 day:11 month:06 https://dx.doi.org/10.1186/s13045-019-0746-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1 11 06
spelling	10.1186/s13045-019-0746-1 doi (DE-627)SPR029624371 (SPR)s13045-019-0746-1-e DE-627 ger DE-627 rakwb eng Wang, Hao verfasserin aut Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Abstract Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the preclinical and clinical advances of CTLA-4 and PD-L1/PD-1-based ICB and CD19-specific CAR-T cell therapy in hematologic malignancies. We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies. Hematologic malignancies (dpeaa)DE-He213 Immune checkpoints (dpeaa)DE-He213 CAR-T (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 CTLA-4 (dpeaa)DE-He213 PD-1 (dpeaa)DE-He213 New targets (dpeaa)DE-He213 Kaur, Gurbakhash aut Sankin, Alexander I. aut Chen, Fuxiang aut Guan, Fangxia aut Zang, Xingxing aut Enthalten in Journal of hematology & oncology London : Biomed Central, 2008 12(2019), 1 vom: 11. Juni (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:12 year:2019 number:1 day:11 month:06 https://dx.doi.org/10.1186/s13045-019-0746-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1 11 06
allfields_unstemmed	10.1186/s13045-019-0746-1 doi (DE-627)SPR029624371 (SPR)s13045-019-0746-1-e DE-627 ger DE-627 rakwb eng Wang, Hao verfasserin aut Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Abstract Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the preclinical and clinical advances of CTLA-4 and PD-L1/PD-1-based ICB and CD19-specific CAR-T cell therapy in hematologic malignancies. We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies. Hematologic malignancies (dpeaa)DE-He213 Immune checkpoints (dpeaa)DE-He213 CAR-T (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 CTLA-4 (dpeaa)DE-He213 PD-1 (dpeaa)DE-He213 New targets (dpeaa)DE-He213 Kaur, Gurbakhash aut Sankin, Alexander I. aut Chen, Fuxiang aut Guan, Fangxia aut Zang, Xingxing aut Enthalten in Journal of hematology & oncology London : Biomed Central, 2008 12(2019), 1 vom: 11. Juni (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:12 year:2019 number:1 day:11 month:06 https://dx.doi.org/10.1186/s13045-019-0746-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1 11 06
allfieldsGer	10.1186/s13045-019-0746-1 doi (DE-627)SPR029624371 (SPR)s13045-019-0746-1-e DE-627 ger DE-627 rakwb eng Wang, Hao verfasserin aut Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Abstract Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the preclinical and clinical advances of CTLA-4 and PD-L1/PD-1-based ICB and CD19-specific CAR-T cell therapy in hematologic malignancies. We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies. Hematologic malignancies (dpeaa)DE-He213 Immune checkpoints (dpeaa)DE-He213 CAR-T (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 CTLA-4 (dpeaa)DE-He213 PD-1 (dpeaa)DE-He213 New targets (dpeaa)DE-He213 Kaur, Gurbakhash aut Sankin, Alexander I. aut Chen, Fuxiang aut Guan, Fangxia aut Zang, Xingxing aut Enthalten in Journal of hematology & oncology London : Biomed Central, 2008 12(2019), 1 vom: 11. Juni (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:12 year:2019 number:1 day:11 month:06 https://dx.doi.org/10.1186/s13045-019-0746-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1 11 06
allfieldsSound	10.1186/s13045-019-0746-1 doi (DE-627)SPR029624371 (SPR)s13045-019-0746-1-e DE-627 ger DE-627 rakwb eng Wang, Hao verfasserin aut Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Abstract Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the preclinical and clinical advances of CTLA-4 and PD-L1/PD-1-based ICB and CD19-specific CAR-T cell therapy in hematologic malignancies. We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies. Hematologic malignancies (dpeaa)DE-He213 Immune checkpoints (dpeaa)DE-He213 CAR-T (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 CTLA-4 (dpeaa)DE-He213 PD-1 (dpeaa)DE-He213 New targets (dpeaa)DE-He213 Kaur, Gurbakhash aut Sankin, Alexander I. aut Chen, Fuxiang aut Guan, Fangxia aut Zang, Xingxing aut Enthalten in Journal of hematology & oncology London : Biomed Central, 2008 12(2019), 1 vom: 11. Juni (DE-627)568914813 (DE-600)2429631-4 1756-8722 nnns volume:12 year:2019 number:1 day:11 month:06 https://dx.doi.org/10.1186/s13045-019-0746-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1 11 06
language	English
source	Enthalten in Journal of hematology & oncology 12(2019), 1 vom: 11. Juni volume:12 year:2019 number:1 day:11 month:06
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institution	findex.gbv.de
topic_facet	Hematologic malignancies Immune checkpoints CAR-T Immunotherapy CTLA-4 PD-1 New targets
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container_title	Journal of hematology & oncology
authorswithroles_txt_mv	Wang, Hao @@aut@@ Kaur, Gurbakhash @@aut@@ Sankin, Alexander I. @@aut@@ Chen, Fuxiang @@aut@@ Guan, Fangxia @@aut@@ Zang, Xingxing @@aut@@
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author	Wang, Hao
spellingShingle	Wang, Hao misc Hematologic malignancies misc Immune checkpoints misc CAR-T misc Immunotherapy misc CTLA-4 misc PD-1 misc New targets Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies
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topic_title	Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies Hematologic malignancies (dpeaa)DE-He213 Immune checkpoints (dpeaa)DE-He213 CAR-T (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 CTLA-4 (dpeaa)DE-He213 PD-1 (dpeaa)DE-He213 New targets (dpeaa)DE-He213
topic	misc Hematologic malignancies misc Immune checkpoints misc CAR-T misc Immunotherapy misc CTLA-4 misc PD-1 misc New targets
topic_unstemmed	misc Hematologic malignancies misc Immune checkpoints misc CAR-T misc Immunotherapy misc CTLA-4 misc PD-1 misc New targets
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title	Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies
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title_full	Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies
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title_sort	immune checkpoint blockade and car-t cell therapy in hematologic malignancies
title_auth	Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies
abstract	Abstract Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the preclinical and clinical advances of CTLA-4 and PD-L1/PD-1-based ICB and CD19-specific CAR-T cell therapy in hematologic malignancies. We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies. © The Author(s). 2019
abstractGer	Abstract Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the preclinical and clinical advances of CTLA-4 and PD-L1/PD-1-based ICB and CD19-specific CAR-T cell therapy in hematologic malignancies. We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies. © The Author(s). 2019
abstract_unstemmed	Abstract Harnessing the power of the immune system to recognize and eliminate cancer cells is a longtime exploration. In the past decade, monoclonal antibody (mAb)-based immune checkpoint blockade (ICB) and chimeric antigen receptor T (CAR-T) cell therapy have proven to be safe and effective in hematologic malignancies. Despite the unprecedented success of ICB and CAR-T therapy, only a subset of patients can benefit partially due to immune dysfunction and lack of appropriate targets. Here, we review the preclinical and clinical advances of CTLA-4 and PD-L1/PD-1-based ICB and CD19-specific CAR-T cell therapy in hematologic malignancies. We also discuss the basic research and ongoing clinical trials on emerging immune checkpoints (Galectin-9/Tim-3, CD70/CD27, LAG-3, and LILRBs) and on new targets for CAR-T cell therapy (CD22, CD33, CD123, BCMA, CD38, and CD138) for the treatment of hematologic malignancies. © The Author(s). 2019
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title_short	Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies
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Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies

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