Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice

Abstract Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effec...
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Autor*in:	Fujibe, Yuya [verfasserIn] Baba, Tsuyoshi Nagao, Sachiko Adachi, Sayaka Ikeda, Keiko Morishita, Miyuki Kuno, Yoshika Suzuki, Masahiro Mizuuchi, Masahito Honnma, Hiroyuki Endo, Toshiaki Saito, Tsuyoshi

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Androgens Follicle-stimulating hormone Follicular development Gene expression Rodents

Anmerkung:	© The Author(s). 2019

Übergeordnetes Werk:	Enthalten in: Journal of ovarian research - London : BioMed Central, 2008, 12(2019), 1 vom: 04. Apr.
Übergeordnetes Werk:	volume:12 ; year:2019 ; number:1 ; day:04 ; month:04

Links:	Volltext

DOI / URN:	10.1186/s13048-019-0505-5

Katalog-ID:	SPR029671965

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matchkey_str	article:17572215:2019----::nrgnoetaetexrsinfsrcpoaduprsrataf
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allfields	10.1186/s13048-019-0505-5 doi (DE-627)SPR029671965 (SPR)s13048-019-0505-5-e DE-627 ger DE-627 rakwb eng Fujibe, Yuya verfasserin aut Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Abstract Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Androgen did not affect the growth of follicles smaller than 160–180 μm in the presence of follicle-stimulating hormone (FSH). However, in the presence of low FSH, androgen supported the growth of follicles larger than 160–180 μm, a size at which growing follicles acquire FSH-dependency. Androgen did not change the mRNA expression of various growth-promoting factors but did increase mRNA expression of the FSH receptor. We suggest that androgen has a positive impact on follicle development by augmentation of the actions of FSH. Therefore, FSH-responsive but FSH-independent follicles grow in the presence of a certain level of FSH or androgen, and androgen compensates for FSH deficiency in FSH-dependent follicles. Androgens (dpeaa)DE-He213 Follicle-stimulating hormone (dpeaa)DE-He213 Follicular development (dpeaa)DE-He213 Gene expression (dpeaa)DE-He213 Rodents (dpeaa)DE-He213 Baba, Tsuyoshi aut Nagao, Sachiko aut Adachi, Sayaka aut Ikeda, Keiko aut Morishita, Miyuki aut Kuno, Yoshika aut Suzuki, Masahiro aut Mizuuchi, Masahito aut Honnma, Hiroyuki aut Endo, Toshiaki aut Saito, Tsuyoshi aut Enthalten in Journal of ovarian research London : BioMed Central, 2008 12(2019), 1 vom: 04. Apr. (DE-627)581041070 (DE-600)2455679-8 1757-2215 nnns volume:12 year:2019 number:1 day:04 month:04 https://dx.doi.org/10.1186/s13048-019-0505-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1 04 04
spelling	10.1186/s13048-019-0505-5 doi (DE-627)SPR029671965 (SPR)s13048-019-0505-5-e DE-627 ger DE-627 rakwb eng Fujibe, Yuya verfasserin aut Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Abstract Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Androgen did not affect the growth of follicles smaller than 160–180 μm in the presence of follicle-stimulating hormone (FSH). However, in the presence of low FSH, androgen supported the growth of follicles larger than 160–180 μm, a size at which growing follicles acquire FSH-dependency. Androgen did not change the mRNA expression of various growth-promoting factors but did increase mRNA expression of the FSH receptor. We suggest that androgen has a positive impact on follicle development by augmentation of the actions of FSH. Therefore, FSH-responsive but FSH-independent follicles grow in the presence of a certain level of FSH or androgen, and androgen compensates for FSH deficiency in FSH-dependent follicles. Androgens (dpeaa)DE-He213 Follicle-stimulating hormone (dpeaa)DE-He213 Follicular development (dpeaa)DE-He213 Gene expression (dpeaa)DE-He213 Rodents (dpeaa)DE-He213 Baba, Tsuyoshi aut Nagao, Sachiko aut Adachi, Sayaka aut Ikeda, Keiko aut Morishita, Miyuki aut Kuno, Yoshika aut Suzuki, Masahiro aut Mizuuchi, Masahito aut Honnma, Hiroyuki aut Endo, Toshiaki aut Saito, Tsuyoshi aut Enthalten in Journal of ovarian research London : BioMed Central, 2008 12(2019), 1 vom: 04. Apr. (DE-627)581041070 (DE-600)2455679-8 1757-2215 nnns volume:12 year:2019 number:1 day:04 month:04 https://dx.doi.org/10.1186/s13048-019-0505-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1 04 04
allfields_unstemmed	10.1186/s13048-019-0505-5 doi (DE-627)SPR029671965 (SPR)s13048-019-0505-5-e DE-627 ger DE-627 rakwb eng Fujibe, Yuya verfasserin aut Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Abstract Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Androgen did not affect the growth of follicles smaller than 160–180 μm in the presence of follicle-stimulating hormone (FSH). However, in the presence of low FSH, androgen supported the growth of follicles larger than 160–180 μm, a size at which growing follicles acquire FSH-dependency. Androgen did not change the mRNA expression of various growth-promoting factors but did increase mRNA expression of the FSH receptor. We suggest that androgen has a positive impact on follicle development by augmentation of the actions of FSH. Therefore, FSH-responsive but FSH-independent follicles grow in the presence of a certain level of FSH or androgen, and androgen compensates for FSH deficiency in FSH-dependent follicles. Androgens (dpeaa)DE-He213 Follicle-stimulating hormone (dpeaa)DE-He213 Follicular development (dpeaa)DE-He213 Gene expression (dpeaa)DE-He213 Rodents (dpeaa)DE-He213 Baba, Tsuyoshi aut Nagao, Sachiko aut Adachi, Sayaka aut Ikeda, Keiko aut Morishita, Miyuki aut Kuno, Yoshika aut Suzuki, Masahiro aut Mizuuchi, Masahito aut Honnma, Hiroyuki aut Endo, Toshiaki aut Saito, Tsuyoshi aut Enthalten in Journal of ovarian research London : BioMed Central, 2008 12(2019), 1 vom: 04. Apr. (DE-627)581041070 (DE-600)2455679-8 1757-2215 nnns volume:12 year:2019 number:1 day:04 month:04 https://dx.doi.org/10.1186/s13048-019-0505-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1 04 04
allfieldsGer	10.1186/s13048-019-0505-5 doi (DE-627)SPR029671965 (SPR)s13048-019-0505-5-e DE-627 ger DE-627 rakwb eng Fujibe, Yuya verfasserin aut Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Abstract Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Androgen did not affect the growth of follicles smaller than 160–180 μm in the presence of follicle-stimulating hormone (FSH). However, in the presence of low FSH, androgen supported the growth of follicles larger than 160–180 μm, a size at which growing follicles acquire FSH-dependency. Androgen did not change the mRNA expression of various growth-promoting factors but did increase mRNA expression of the FSH receptor. We suggest that androgen has a positive impact on follicle development by augmentation of the actions of FSH. Therefore, FSH-responsive but FSH-independent follicles grow in the presence of a certain level of FSH or androgen, and androgen compensates for FSH deficiency in FSH-dependent follicles. Androgens (dpeaa)DE-He213 Follicle-stimulating hormone (dpeaa)DE-He213 Follicular development (dpeaa)DE-He213 Gene expression (dpeaa)DE-He213 Rodents (dpeaa)DE-He213 Baba, Tsuyoshi aut Nagao, Sachiko aut Adachi, Sayaka aut Ikeda, Keiko aut Morishita, Miyuki aut Kuno, Yoshika aut Suzuki, Masahiro aut Mizuuchi, Masahito aut Honnma, Hiroyuki aut Endo, Toshiaki aut Saito, Tsuyoshi aut Enthalten in Journal of ovarian research London : BioMed Central, 2008 12(2019), 1 vom: 04. Apr. (DE-627)581041070 (DE-600)2455679-8 1757-2215 nnns volume:12 year:2019 number:1 day:04 month:04 https://dx.doi.org/10.1186/s13048-019-0505-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1 04 04
allfieldsSound	10.1186/s13048-019-0505-5 doi (DE-627)SPR029671965 (SPR)s13048-019-0505-5-e DE-627 ger DE-627 rakwb eng Fujibe, Yuya verfasserin aut Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Abstract Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Androgen did not affect the growth of follicles smaller than 160–180 μm in the presence of follicle-stimulating hormone (FSH). However, in the presence of low FSH, androgen supported the growth of follicles larger than 160–180 μm, a size at which growing follicles acquire FSH-dependency. Androgen did not change the mRNA expression of various growth-promoting factors but did increase mRNA expression of the FSH receptor. We suggest that androgen has a positive impact on follicle development by augmentation of the actions of FSH. Therefore, FSH-responsive but FSH-independent follicles grow in the presence of a certain level of FSH or androgen, and androgen compensates for FSH deficiency in FSH-dependent follicles. Androgens (dpeaa)DE-He213 Follicle-stimulating hormone (dpeaa)DE-He213 Follicular development (dpeaa)DE-He213 Gene expression (dpeaa)DE-He213 Rodents (dpeaa)DE-He213 Baba, Tsuyoshi aut Nagao, Sachiko aut Adachi, Sayaka aut Ikeda, Keiko aut Morishita, Miyuki aut Kuno, Yoshika aut Suzuki, Masahiro aut Mizuuchi, Masahito aut Honnma, Hiroyuki aut Endo, Toshiaki aut Saito, Tsuyoshi aut Enthalten in Journal of ovarian research London : BioMed Central, 2008 12(2019), 1 vom: 04. Apr. (DE-627)581041070 (DE-600)2455679-8 1757-2215 nnns volume:12 year:2019 number:1 day:04 month:04 https://dx.doi.org/10.1186/s13048-019-0505-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1 04 04
language	English
source	Enthalten in Journal of ovarian research 12(2019), 1 vom: 04. Apr. volume:12 year:2019 number:1 day:04 month:04
sourceStr	Enthalten in Journal of ovarian research 12(2019), 1 vom: 04. Apr. volume:12 year:2019 number:1 day:04 month:04
format_phy_str_mv	Article
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topic_facet	Androgens Follicle-stimulating hormone Follicular development Gene expression Rodents
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container_title	Journal of ovarian research
authorswithroles_txt_mv	Fujibe, Yuya @@aut@@ Baba, Tsuyoshi @@aut@@ Nagao, Sachiko @@aut@@ Adachi, Sayaka @@aut@@ Ikeda, Keiko @@aut@@ Morishita, Miyuki @@aut@@ Kuno, Yoshika @@aut@@ Suzuki, Masahiro @@aut@@ Mizuuchi, Masahito @@aut@@ Honnma, Hiroyuki @@aut@@ Endo, Toshiaki @@aut@@ Saito, Tsuyoshi @@aut@@
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author	Fujibe, Yuya
spellingShingle	Fujibe, Yuya misc Androgens misc Follicle-stimulating hormone misc Follicular development misc Gene expression misc Rodents Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice
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topic_title	Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice Androgens (dpeaa)DE-He213 Follicle-stimulating hormone (dpeaa)DE-He213 Follicular development (dpeaa)DE-He213 Gene expression (dpeaa)DE-He213 Rodents (dpeaa)DE-He213
topic	misc Androgens misc Follicle-stimulating hormone misc Follicular development misc Gene expression misc Rodents
topic_unstemmed	misc Androgens misc Follicle-stimulating hormone misc Follicular development misc Gene expression misc Rodents
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title	Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice
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title_full	Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice
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author_browse	Fujibe, Yuya Baba, Tsuyoshi Nagao, Sachiko Adachi, Sayaka Ikeda, Keiko Morishita, Miyuki Kuno, Yoshika Suzuki, Masahiro Mizuuchi, Masahito Honnma, Hiroyuki Endo, Toshiaki Saito, Tsuyoshi
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title_sort	androgen potentiates the expression of fsh receptor and supports preantral follicle development in mice
title_auth	Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice
abstract	Abstract Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Androgen did not affect the growth of follicles smaller than 160–180 μm in the presence of follicle-stimulating hormone (FSH). However, in the presence of low FSH, androgen supported the growth of follicles larger than 160–180 μm, a size at which growing follicles acquire FSH-dependency. Androgen did not change the mRNA expression of various growth-promoting factors but did increase mRNA expression of the FSH receptor. We suggest that androgen has a positive impact on follicle development by augmentation of the actions of FSH. Therefore, FSH-responsive but FSH-independent follicles grow in the presence of a certain level of FSH or androgen, and androgen compensates for FSH deficiency in FSH-dependent follicles. © The Author(s). 2019
abstractGer	Abstract Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Androgen did not affect the growth of follicles smaller than 160–180 μm in the presence of follicle-stimulating hormone (FSH). However, in the presence of low FSH, androgen supported the growth of follicles larger than 160–180 μm, a size at which growing follicles acquire FSH-dependency. Androgen did not change the mRNA expression of various growth-promoting factors but did increase mRNA expression of the FSH receptor. We suggest that androgen has a positive impact on follicle development by augmentation of the actions of FSH. Therefore, FSH-responsive but FSH-independent follicles grow in the presence of a certain level of FSH or androgen, and androgen compensates for FSH deficiency in FSH-dependent follicles. © The Author(s). 2019
abstract_unstemmed	Abstract Hyperandrogenism is one of the cardinal symptoms in polycystic ovary syndrome and plays a key role in the pathogenesis of polycystic ovary syndrome. However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Androgen did not affect the growth of follicles smaller than 160–180 μm in the presence of follicle-stimulating hormone (FSH). However, in the presence of low FSH, androgen supported the growth of follicles larger than 160–180 μm, a size at which growing follicles acquire FSH-dependency. Androgen did not change the mRNA expression of various growth-promoting factors but did increase mRNA expression of the FSH receptor. We suggest that androgen has a positive impact on follicle development by augmentation of the actions of FSH. Therefore, FSH-responsive but FSH-independent follicles grow in the presence of a certain level of FSH or androgen, and androgen compensates for FSH deficiency in FSH-dependent follicles. © The Author(s). 2019
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title_short	Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice
url	https://dx.doi.org/10.1186/s13048-019-0505-5
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author2	Baba, Tsuyoshi Nagao, Sachiko Adachi, Sayaka Ikeda, Keiko Morishita, Miyuki Kuno, Yoshika Suzuki, Masahiro Mizuuchi, Masahito Honnma, Hiroyuki Endo, Toshiaki Saito, Tsuyoshi
author2Str	Baba, Tsuyoshi Nagao, Sachiko Adachi, Sayaka Ikeda, Keiko Morishita, Miyuki Kuno, Yoshika Suzuki, Masahiro Mizuuchi, Masahito Honnma, Hiroyuki Endo, Toshiaki Saito, Tsuyoshi
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However, the precise effects and mechanisms of excess androgen during follicular development are still unclear. Here we investigated the effects of androgen on mouse follicle development in vitro. Androgen did not affect the growth of follicles smaller than 160–180 μm in the presence of follicle-stimulating hormone (FSH). However, in the presence of low FSH, androgen supported the growth of follicles larger than 160–180 μm, a size at which growing follicles acquire FSH-dependency. Androgen did not change the mRNA expression of various growth-promoting factors but did increase mRNA expression of the FSH receptor. We suggest that androgen has a positive impact on follicle development by augmentation of the actions of FSH. 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Androgen potentiates the expression of FSH receptor and supports preantral follicle development in mice

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