The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer

Objectives To study the impact of time factors on local and distant metastases in stomach cancer. Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or dista...
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Autor*in:	Soyfer, Viacheslav [verfasserIn] Geva, Ravit Michelson, Michael Inbar, Moshe Shacham-Shmueli, Einat Corn, Benjamin W

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Stomach Radiation Time Recurrence

Anmerkung:	© Soyfer et al.; licensee BioMed Central Ltd. 2014

Übergeordnetes Werk:	Enthalten in: Radiation oncology - London : BioMed Central, 2006, 9(2014), 1 vom: 23. März
Übergeordnetes Werk:	volume:9 ; year:2014 ; number:1 ; day:23 ; month:03

Links:	Volltext

DOI / URN:	10.1186/1748-717X-9-81

Katalog-ID:	SPR029672775

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245	1	4	\|a The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer
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520			\|a Objectives To study the impact of time factors on local and distant metastases in stomach cancer. Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or distant metastasis. Results The risk probability of local recurrence is increased by 10% (HR = 1.1, p = 0.0009) in association with each additional day of radiotherapy and by 3.8% (HR = 1.038, p = 0.13) per increased day of waiting time before the initiation of RT. The risk probability of distant recurrence was associated with an increase of 7.4% (HR = 1.074 p = 0.0031) with each additional day of RT time and by 2.3% (HR = 1.023, p = 0.0598) following the increase of a day of waiting time. Each day of prolongation of RT beyond 36 days was associated with an increased risk of local recurrence by 10% (OR = 1.1, p = 0.015). Prolongation of waiting time prior to initiation of irradiation retained significance in multivariate analysis. Conclusion There is an association between total treatment time and, to some extent, the time between the surgery and the initiation of radiation on local control and distant metastases.
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allfields	10.1186/1748-717X-9-81 doi (DE-627)SPR029672775 (SPR)1748-717X-9-81-e DE-627 ger DE-627 rakwb eng Soyfer, Viacheslav verfasserin aut The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Soyfer et al.; licensee BioMed Central Ltd. 2014 Objectives To study the impact of time factors on local and distant metastases in stomach cancer. Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or distant metastasis. Results The risk probability of local recurrence is increased by 10% (HR = 1.1, p = 0.0009) in association with each additional day of radiotherapy and by 3.8% (HR = 1.038, p = 0.13) per increased day of waiting time before the initiation of RT. The risk probability of distant recurrence was associated with an increase of 7.4% (HR = 1.074 p = 0.0031) with each additional day of RT time and by 2.3% (HR = 1.023, p = 0.0598) following the increase of a day of waiting time. Each day of prolongation of RT beyond 36 days was associated with an increased risk of local recurrence by 10% (OR = 1.1, p = 0.015). Prolongation of waiting time prior to initiation of irradiation retained significance in multivariate analysis. Conclusion There is an association between total treatment time and, to some extent, the time between the surgery and the initiation of radiation on local control and distant metastases. Stomach (dpeaa)DE-He213 Radiation (dpeaa)DE-He213 Time (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Geva, Ravit aut Michelson, Michael aut Inbar, Moshe aut Shacham-Shmueli, Einat aut Corn, Benjamin W aut Enthalten in Radiation oncology London : BioMed Central, 2006 9(2014), 1 vom: 23. März (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:9 year:2014 number:1 day:23 month:03 https://dx.doi.org/10.1186/1748-717X-9-81 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 1 23 03
spelling	10.1186/1748-717X-9-81 doi (DE-627)SPR029672775 (SPR)1748-717X-9-81-e DE-627 ger DE-627 rakwb eng Soyfer, Viacheslav verfasserin aut The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Soyfer et al.; licensee BioMed Central Ltd. 2014 Objectives To study the impact of time factors on local and distant metastases in stomach cancer. Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or distant metastasis. Results The risk probability of local recurrence is increased by 10% (HR = 1.1, p = 0.0009) in association with each additional day of radiotherapy and by 3.8% (HR = 1.038, p = 0.13) per increased day of waiting time before the initiation of RT. The risk probability of distant recurrence was associated with an increase of 7.4% (HR = 1.074 p = 0.0031) with each additional day of RT time and by 2.3% (HR = 1.023, p = 0.0598) following the increase of a day of waiting time. Each day of prolongation of RT beyond 36 days was associated with an increased risk of local recurrence by 10% (OR = 1.1, p = 0.015). Prolongation of waiting time prior to initiation of irradiation retained significance in multivariate analysis. Conclusion There is an association between total treatment time and, to some extent, the time between the surgery and the initiation of radiation on local control and distant metastases. Stomach (dpeaa)DE-He213 Radiation (dpeaa)DE-He213 Time (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Geva, Ravit aut Michelson, Michael aut Inbar, Moshe aut Shacham-Shmueli, Einat aut Corn, Benjamin W aut Enthalten in Radiation oncology London : BioMed Central, 2006 9(2014), 1 vom: 23. März (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:9 year:2014 number:1 day:23 month:03 https://dx.doi.org/10.1186/1748-717X-9-81 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 1 23 03
allfields_unstemmed	10.1186/1748-717X-9-81 doi (DE-627)SPR029672775 (SPR)1748-717X-9-81-e DE-627 ger DE-627 rakwb eng Soyfer, Viacheslav verfasserin aut The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Soyfer et al.; licensee BioMed Central Ltd. 2014 Objectives To study the impact of time factors on local and distant metastases in stomach cancer. Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or distant metastasis. Results The risk probability of local recurrence is increased by 10% (HR = 1.1, p = 0.0009) in association with each additional day of radiotherapy and by 3.8% (HR = 1.038, p = 0.13) per increased day of waiting time before the initiation of RT. The risk probability of distant recurrence was associated with an increase of 7.4% (HR = 1.074 p = 0.0031) with each additional day of RT time and by 2.3% (HR = 1.023, p = 0.0598) following the increase of a day of waiting time. Each day of prolongation of RT beyond 36 days was associated with an increased risk of local recurrence by 10% (OR = 1.1, p = 0.015). Prolongation of waiting time prior to initiation of irradiation retained significance in multivariate analysis. Conclusion There is an association between total treatment time and, to some extent, the time between the surgery and the initiation of radiation on local control and distant metastases. Stomach (dpeaa)DE-He213 Radiation (dpeaa)DE-He213 Time (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Geva, Ravit aut Michelson, Michael aut Inbar, Moshe aut Shacham-Shmueli, Einat aut Corn, Benjamin W aut Enthalten in Radiation oncology London : BioMed Central, 2006 9(2014), 1 vom: 23. März (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:9 year:2014 number:1 day:23 month:03 https://dx.doi.org/10.1186/1748-717X-9-81 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 1 23 03
allfieldsGer	10.1186/1748-717X-9-81 doi (DE-627)SPR029672775 (SPR)1748-717X-9-81-e DE-627 ger DE-627 rakwb eng Soyfer, Viacheslav verfasserin aut The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Soyfer et al.; licensee BioMed Central Ltd. 2014 Objectives To study the impact of time factors on local and distant metastases in stomach cancer. Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or distant metastasis. Results The risk probability of local recurrence is increased by 10% (HR = 1.1, p = 0.0009) in association with each additional day of radiotherapy and by 3.8% (HR = 1.038, p = 0.13) per increased day of waiting time before the initiation of RT. The risk probability of distant recurrence was associated with an increase of 7.4% (HR = 1.074 p = 0.0031) with each additional day of RT time and by 2.3% (HR = 1.023, p = 0.0598) following the increase of a day of waiting time. Each day of prolongation of RT beyond 36 days was associated with an increased risk of local recurrence by 10% (OR = 1.1, p = 0.015). Prolongation of waiting time prior to initiation of irradiation retained significance in multivariate analysis. Conclusion There is an association between total treatment time and, to some extent, the time between the surgery and the initiation of radiation on local control and distant metastases. Stomach (dpeaa)DE-He213 Radiation (dpeaa)DE-He213 Time (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Geva, Ravit aut Michelson, Michael aut Inbar, Moshe aut Shacham-Shmueli, Einat aut Corn, Benjamin W aut Enthalten in Radiation oncology London : BioMed Central, 2006 9(2014), 1 vom: 23. März (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:9 year:2014 number:1 day:23 month:03 https://dx.doi.org/10.1186/1748-717X-9-81 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 1 23 03
allfieldsSound	10.1186/1748-717X-9-81 doi (DE-627)SPR029672775 (SPR)1748-717X-9-81-e DE-627 ger DE-627 rakwb eng Soyfer, Viacheslav verfasserin aut The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Soyfer et al.; licensee BioMed Central Ltd. 2014 Objectives To study the impact of time factors on local and distant metastases in stomach cancer. Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or distant metastasis. Results The risk probability of local recurrence is increased by 10% (HR = 1.1, p = 0.0009) in association with each additional day of radiotherapy and by 3.8% (HR = 1.038, p = 0.13) per increased day of waiting time before the initiation of RT. The risk probability of distant recurrence was associated with an increase of 7.4% (HR = 1.074 p = 0.0031) with each additional day of RT time and by 2.3% (HR = 1.023, p = 0.0598) following the increase of a day of waiting time. Each day of prolongation of RT beyond 36 days was associated with an increased risk of local recurrence by 10% (OR = 1.1, p = 0.015). Prolongation of waiting time prior to initiation of irradiation retained significance in multivariate analysis. Conclusion There is an association between total treatment time and, to some extent, the time between the surgery and the initiation of radiation on local control and distant metastases. Stomach (dpeaa)DE-He213 Radiation (dpeaa)DE-He213 Time (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213 Geva, Ravit aut Michelson, Michael aut Inbar, Moshe aut Shacham-Shmueli, Einat aut Corn, Benjamin W aut Enthalten in Radiation oncology London : BioMed Central, 2006 9(2014), 1 vom: 23. März (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:9 year:2014 number:1 day:23 month:03 https://dx.doi.org/10.1186/1748-717X-9-81 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 1 23 03
language	English
source	Enthalten in Radiation oncology 9(2014), 1 vom: 23. März volume:9 year:2014 number:1 day:23 month:03
sourceStr	Enthalten in Radiation oncology 9(2014), 1 vom: 23. März volume:9 year:2014 number:1 day:23 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Stomach Radiation Time Recurrence
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container_title	Radiation oncology
authorswithroles_txt_mv	Soyfer, Viacheslav @@aut@@ Geva, Ravit @@aut@@ Michelson, Michael @@aut@@ Inbar, Moshe @@aut@@ Shacham-Shmueli, Einat @@aut@@ Corn, Benjamin W @@aut@@
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Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or distant metastasis. Results The risk probability of local recurrence is increased by 10% (HR = 1.1, p = 0.0009) in association with each additional day of radiotherapy and by 3.8% (HR = 1.038, p = 0.13) per increased day of waiting time before the initiation of RT. The risk probability of distant recurrence was associated with an increase of 7.4% (HR = 1.074 p = 0.0031) with each additional day of RT time and by 2.3% (HR = 1.023, p = 0.0598) following the increase of a day of waiting time. Each day of prolongation of RT beyond 36 days was associated with an increased risk of local recurrence by 10% (OR = 1.1, p = 0.015). Prolongation of waiting time prior to initiation of irradiation retained significance in multivariate analysis. 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author	Soyfer, Viacheslav
spellingShingle	Soyfer, Viacheslav misc Stomach misc Radiation misc Time misc Recurrence The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer
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topic_title	The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer Stomach (dpeaa)DE-He213 Radiation (dpeaa)DE-He213 Time (dpeaa)DE-He213 Recurrence (dpeaa)DE-He213
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topic_unstemmed	misc Stomach misc Radiation misc Time misc Recurrence
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title	The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer
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title_full	The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer
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author_browse	Soyfer, Viacheslav Geva, Ravit Michelson, Michael Inbar, Moshe Shacham-Shmueli, Einat Corn, Benjamin W
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title_sort	impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer
title_auth	The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer
abstract	Objectives To study the impact of time factors on local and distant metastases in stomach cancer. Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or distant metastasis. Results The risk probability of local recurrence is increased by 10% (HR = 1.1, p = 0.0009) in association with each additional day of radiotherapy and by 3.8% (HR = 1.038, p = 0.13) per increased day of waiting time before the initiation of RT. The risk probability of distant recurrence was associated with an increase of 7.4% (HR = 1.074 p = 0.0031) with each additional day of RT time and by 2.3% (HR = 1.023, p = 0.0598) following the increase of a day of waiting time. Each day of prolongation of RT beyond 36 days was associated with an increased risk of local recurrence by 10% (OR = 1.1, p = 0.015). Prolongation of waiting time prior to initiation of irradiation retained significance in multivariate analysis. Conclusion There is an association between total treatment time and, to some extent, the time between the surgery and the initiation of radiation on local control and distant metastases. © Soyfer et al.; licensee BioMed Central Ltd. 2014
abstractGer	Objectives To study the impact of time factors on local and distant metastases in stomach cancer. Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or distant metastasis. Results The risk probability of local recurrence is increased by 10% (HR = 1.1, p = 0.0009) in association with each additional day of radiotherapy and by 3.8% (HR = 1.038, p = 0.13) per increased day of waiting time before the initiation of RT. The risk probability of distant recurrence was associated with an increase of 7.4% (HR = 1.074 p = 0.0031) with each additional day of RT time and by 2.3% (HR = 1.023, p = 0.0598) following the increase of a day of waiting time. Each day of prolongation of RT beyond 36 days was associated with an increased risk of local recurrence by 10% (OR = 1.1, p = 0.015). Prolongation of waiting time prior to initiation of irradiation retained significance in multivariate analysis. Conclusion There is an association between total treatment time and, to some extent, the time between the surgery and the initiation of radiation on local control and distant metastases. © Soyfer et al.; licensee BioMed Central Ltd. 2014
abstract_unstemmed	Objectives To study the impact of time factors on local and distant metastases in stomach cancer. Methods 67 patients with gastric cancer who received adjuvant treatment were reviewed for the time to initiation of radiotherapy, overall duration of RT and the events of first local recurrence or distant metastasis. Results The risk probability of local recurrence is increased by 10% (HR = 1.1, p = 0.0009) in association with each additional day of radiotherapy and by 3.8% (HR = 1.038, p = 0.13) per increased day of waiting time before the initiation of RT. The risk probability of distant recurrence was associated with an increase of 7.4% (HR = 1.074 p = 0.0031) with each additional day of RT time and by 2.3% (HR = 1.023, p = 0.0598) following the increase of a day of waiting time. Each day of prolongation of RT beyond 36 days was associated with an increased risk of local recurrence by 10% (OR = 1.1, p = 0.015). Prolongation of waiting time prior to initiation of irradiation retained significance in multivariate analysis. Conclusion There is an association between total treatment time and, to some extent, the time between the surgery and the initiation of radiation on local control and distant metastases. © Soyfer et al.; licensee BioMed Central Ltd. 2014
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title_short	The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer
url	https://dx.doi.org/10.1186/1748-717X-9-81
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author2	Geva, Ravit Michelson, Michael Inbar, Moshe Shacham-Shmueli, Einat Corn, Benjamin W
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up_date	2024-07-04T01:57:03.061Z
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The impact of overall radiotherapy treatment time and delay in initiation of radiotherapy on local control and distant metastases in gastric cancer

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