Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study
Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The propo...
Ausführliche Beschreibung
Autor*in: |
Tiba, Fabrice [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2011 |
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Anmerkung: |
© Tiba et al; licensee BioMed Central Ltd. 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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Übergeordnetes Werk: |
Enthalten in: Journal of the International AIDS Society - Berlin : Springer, 2004, 14(2011), 1 vom: 17. Dez. |
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Übergeordnetes Werk: |
volume:14 ; year:2011 ; number:1 ; day:17 ; month:12 |
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DOI / URN: |
10.1186/1758-2652-14-57 |
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Katalog-ID: |
SPR029700418 |
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100 | 1 | |a Tiba, Fabrice |e verfasserin |4 aut | |
245 | 1 | 0 | |a Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study |
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520 | |a Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. Conclusions Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in $ CD4^{+} $ T cell counts or HIV-1 plasma viral load levels alone. | ||
650 | 4 | |a Healthy Adult |7 (dpeaa)DE-He213 | |
650 | 4 | |a Urban Setting |7 (dpeaa)DE-He213 | |
650 | 4 | |a Rural Setting |7 (dpeaa)DE-He213 | |
650 | 4 | |a Median Fluorescence Intensity |7 (dpeaa)DE-He213 | |
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700 | 1 | |a Nauwelaers, Frans |4 aut | |
700 | 1 | |a Sangaré, Lassana |4 aut | |
700 | 1 | |a Coulibaly, Boubacar |4 aut | |
700 | 1 | |a Kräusslich, Hans-Georg |4 aut | |
700 | 1 | |a Böhler, Thomas |4 aut | |
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10.1186/1758-2652-14-57 doi (DE-627)SPR029700418 (SPR)1758-2652-14-57-e DE-627 ger DE-627 rakwb eng Tiba, Fabrice verfasserin aut Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tiba et al; licensee BioMed Central Ltd. 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. Conclusions Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in $ CD4^{+} $ T cell counts or HIV-1 plasma viral load levels alone. Healthy Adult (dpeaa)DE-He213 Urban Setting (dpeaa)DE-He213 Rural Setting (dpeaa)DE-He213 Median Fluorescence Intensity (dpeaa)DE-He213 Activation Marker CD95 (dpeaa)DE-He213 Nauwelaers, Frans aut Sangaré, Lassana aut Coulibaly, Boubacar aut Kräusslich, Hans-Georg aut Böhler, Thomas aut Enthalten in Journal of the International AIDS Society Berlin : Springer, 2004 14(2011), 1 vom: 17. Dez. (DE-627)585798125 (DE-600)2467110-1 1758-2652 nnns volume:14 year:2011 number:1 day:17 month:12 https://dx.doi.org/10.1186/1758-2652-14-57 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2011 1 17 12 |
spelling |
10.1186/1758-2652-14-57 doi (DE-627)SPR029700418 (SPR)1758-2652-14-57-e DE-627 ger DE-627 rakwb eng Tiba, Fabrice verfasserin aut Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tiba et al; licensee BioMed Central Ltd. 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. Conclusions Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in $ CD4^{+} $ T cell counts or HIV-1 plasma viral load levels alone. Healthy Adult (dpeaa)DE-He213 Urban Setting (dpeaa)DE-He213 Rural Setting (dpeaa)DE-He213 Median Fluorescence Intensity (dpeaa)DE-He213 Activation Marker CD95 (dpeaa)DE-He213 Nauwelaers, Frans aut Sangaré, Lassana aut Coulibaly, Boubacar aut Kräusslich, Hans-Georg aut Böhler, Thomas aut Enthalten in Journal of the International AIDS Society Berlin : Springer, 2004 14(2011), 1 vom: 17. Dez. (DE-627)585798125 (DE-600)2467110-1 1758-2652 nnns volume:14 year:2011 number:1 day:17 month:12 https://dx.doi.org/10.1186/1758-2652-14-57 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2011 1 17 12 |
allfields_unstemmed |
10.1186/1758-2652-14-57 doi (DE-627)SPR029700418 (SPR)1758-2652-14-57-e DE-627 ger DE-627 rakwb eng Tiba, Fabrice verfasserin aut Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tiba et al; licensee BioMed Central Ltd. 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. Conclusions Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in $ CD4^{+} $ T cell counts or HIV-1 plasma viral load levels alone. Healthy Adult (dpeaa)DE-He213 Urban Setting (dpeaa)DE-He213 Rural Setting (dpeaa)DE-He213 Median Fluorescence Intensity (dpeaa)DE-He213 Activation Marker CD95 (dpeaa)DE-He213 Nauwelaers, Frans aut Sangaré, Lassana aut Coulibaly, Boubacar aut Kräusslich, Hans-Georg aut Böhler, Thomas aut Enthalten in Journal of the International AIDS Society Berlin : Springer, 2004 14(2011), 1 vom: 17. Dez. (DE-627)585798125 (DE-600)2467110-1 1758-2652 nnns volume:14 year:2011 number:1 day:17 month:12 https://dx.doi.org/10.1186/1758-2652-14-57 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2011 1 17 12 |
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10.1186/1758-2652-14-57 doi (DE-627)SPR029700418 (SPR)1758-2652-14-57-e DE-627 ger DE-627 rakwb eng Tiba, Fabrice verfasserin aut Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tiba et al; licensee BioMed Central Ltd. 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. Conclusions Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in $ CD4^{+} $ T cell counts or HIV-1 plasma viral load levels alone. Healthy Adult (dpeaa)DE-He213 Urban Setting (dpeaa)DE-He213 Rural Setting (dpeaa)DE-He213 Median Fluorescence Intensity (dpeaa)DE-He213 Activation Marker CD95 (dpeaa)DE-He213 Nauwelaers, Frans aut Sangaré, Lassana aut Coulibaly, Boubacar aut Kräusslich, Hans-Georg aut Böhler, Thomas aut Enthalten in Journal of the International AIDS Society Berlin : Springer, 2004 14(2011), 1 vom: 17. Dez. (DE-627)585798125 (DE-600)2467110-1 1758-2652 nnns volume:14 year:2011 number:1 day:17 month:12 https://dx.doi.org/10.1186/1758-2652-14-57 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2011 1 17 12 |
allfieldsSound |
10.1186/1758-2652-14-57 doi (DE-627)SPR029700418 (SPR)1758-2652-14-57-e DE-627 ger DE-627 rakwb eng Tiba, Fabrice verfasserin aut Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tiba et al; licensee BioMed Central Ltd. 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. Conclusions Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in $ CD4^{+} $ T cell counts or HIV-1 plasma viral load levels alone. Healthy Adult (dpeaa)DE-He213 Urban Setting (dpeaa)DE-He213 Rural Setting (dpeaa)DE-He213 Median Fluorescence Intensity (dpeaa)DE-He213 Activation Marker CD95 (dpeaa)DE-He213 Nauwelaers, Frans aut Sangaré, Lassana aut Coulibaly, Boubacar aut Kräusslich, Hans-Georg aut Böhler, Thomas aut Enthalten in Journal of the International AIDS Society Berlin : Springer, 2004 14(2011), 1 vom: 17. Dez. (DE-627)585798125 (DE-600)2467110-1 1758-2652 nnns volume:14 year:2011 number:1 day:17 month:12 https://dx.doi.org/10.1186/1758-2652-14-57 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2011 1 17 12 |
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Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. 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Tiba, Fabrice misc Healthy Adult misc Urban Setting misc Rural Setting misc Median Fluorescence Intensity misc Activation Marker CD95 Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study |
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Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study Healthy Adult (dpeaa)DE-He213 Urban Setting (dpeaa)DE-He213 Rural Setting (dpeaa)DE-He213 Median Fluorescence Intensity (dpeaa)DE-He213 Activation Marker CD95 (dpeaa)DE-He213 |
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Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study |
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Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study |
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Tiba, Fabrice Nauwelaers, Frans Sangaré, Lassana Coulibaly, Boubacar Kräusslich, Hans-Georg Böhler, Thomas |
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Tiba, Fabrice |
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activation and maturation of peripheral blood t cells in hiv-1-infected and hiv-1-uninfected adults in burkina faso: a cross-sectional study |
title_auth |
Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study |
abstract |
Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. Conclusions Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in $ CD4^{+} $ T cell counts or HIV-1 plasma viral load levels alone. © Tiba et al; licensee BioMed Central Ltd. 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
abstractGer |
Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. Conclusions Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in $ CD4^{+} $ T cell counts or HIV-1 plasma viral load levels alone. © Tiba et al; licensee BioMed Central Ltd. 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
abstract_unstemmed |
Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. Conclusions Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in $ CD4^{+} $ T cell counts or HIV-1 plasma viral load levels alone. © Tiba et al; licensee BioMed Central Ltd. 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR029700418</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519170232.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2011 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/1758-2652-14-57</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR029700418</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)1758-2652-14-57-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Tiba, Fabrice</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Activation and maturation of peripheral blood T cells in HIV-1-infected and HIV-1-uninfected adults in Burkina Faso: a cross-sectional study</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2011</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Tiba et al; licensee BioMed Central Ltd. 2011. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background We wanted to explore to what extent environmental exposure to immune stimulants, which is expected to be more present in rural than in urban settings, influences T cell activation and maturation in healthy and in HIV-1-infected individuals in Burkina Faso in west Africa. Methods The proportion of circulating naïve T cells and the expression of the T cell activation markers, CD95 and CD38, were analyzed by immunophenotyping and three-colour flow cytometry in 63 healthy individuals and 137 treatment-naïve HIV-1-infected subjects from Ouagadougou (urban setting) and 26 healthy adults and 61 treatment-naïve patients from Nouna (rural). Results A slightly higher activation level of $ CD4^{+} $ and $ CD8^{+} $ peripheral blood T cells was seen in healthy adults living in Nouna than in those living in Ouagadougou. The percentages of naïve $ CD45RA^{bright} $ $ CCR7^{+} $ T cells were not significantly different between both study sites. Taking into consideration that relatively more HIV-1-infected patients in Nouna were in an advanced disease stage, no relevant differences were seen in T cell activation and maturation between patients at both study sites. As expected, the percentage of $ CD95^{+} $ $ CD4^{+} $ and $ CD38^{+} $ $ CD8^{+} $ T cells and the respective antigen density on these cells was significantly higher in patients than in controls in both settings. The percentage of naïve $ CD8^{+} $ T cells was lower in HIV-1-infected subjects than in healthy controls irrespective of the study site, while a lower proportion of naïve $ CD4^{+} $ T cells in patients compared with controls was seen only in Nouna. Conclusions Environmentally triggered immune activation may contribute to the increased expression of the activation markers CD95 and CD38 on peripheral blood T cells from healthy adults living in rural versus urban settings in Burkina Faso. T cell activation is further increased in HIV-1-infected individuals due to T cell loss and high plasma viral load levels. The observed variations in T cell activation levels or the proportion of naïve T cells in our study patients, however, are not explained by differences in $ CD4^{+} $ T cell counts or HIV-1 plasma viral load levels alone.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Healthy Adult</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Urban Setting</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Rural Setting</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Median Fluorescence Intensity</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Activation Marker CD95</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nauwelaers, Frans</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sangaré, Lassana</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Coulibaly, Boubacar</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kräusslich, Hans-Georg</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Böhler, Thomas</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of the International AIDS Society</subfield><subfield code="d">Berlin : Springer, 2004</subfield><subfield code="g">14(2011), 1 vom: 17. 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