Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility

Background Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the ab...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Fleskens, Stijn [verfasserIn] Slootweg, Piet

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Oral Lesion Atypical Hyperplasia Severe Dysplasia Mild Dysplasia Moderate Dysplasia

Anmerkung:	© Fleskens and Slootweg; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: Head & neck oncology - London : BioMed Central, 2009, 1(2009), 1 vom: 11. Mai
Übergeordnetes Werk:	volume:1 ; year:2009 ; number:1 ; day:11 ; month:05

Links:	Volltext

DOI / URN:	10.1186/1758-3284-1-11

Katalog-ID:	SPR029700817

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520			\|a Background Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed. Objectives The aims of this review are to: 1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck. 2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck. 3) Discuss and review quality requirements for these grading systems. Conclusion Regarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck.
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allfields	10.1186/1758-3284-1-11 doi (DE-627)SPR029700817 (SPR)1758-3284-1-11-e DE-627 ger DE-627 rakwb eng Fleskens, Stijn verfasserin aut Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Fleskens and Slootweg; licensee BioMed Central Ltd. 2009 Background Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed. Objectives The aims of this review are to: 1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck. 2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck. 3) Discuss and review quality requirements for these grading systems. Conclusion Regarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck. Oral Lesion (dpeaa)DE-He213 Atypical Hyperplasia (dpeaa)DE-He213 Severe Dysplasia (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Moderate Dysplasia (dpeaa)DE-He213 Slootweg, Piet aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 11. Mai (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:11 month:05 https://dx.doi.org/10.1186/1758-3284-1-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 11 05
spelling	10.1186/1758-3284-1-11 doi (DE-627)SPR029700817 (SPR)1758-3284-1-11-e DE-627 ger DE-627 rakwb eng Fleskens, Stijn verfasserin aut Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Fleskens and Slootweg; licensee BioMed Central Ltd. 2009 Background Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed. Objectives The aims of this review are to: 1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck. 2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck. 3) Discuss and review quality requirements for these grading systems. Conclusion Regarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck. Oral Lesion (dpeaa)DE-He213 Atypical Hyperplasia (dpeaa)DE-He213 Severe Dysplasia (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Moderate Dysplasia (dpeaa)DE-He213 Slootweg, Piet aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 11. Mai (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:11 month:05 https://dx.doi.org/10.1186/1758-3284-1-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 11 05
allfields_unstemmed	10.1186/1758-3284-1-11 doi (DE-627)SPR029700817 (SPR)1758-3284-1-11-e DE-627 ger DE-627 rakwb eng Fleskens, Stijn verfasserin aut Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Fleskens and Slootweg; licensee BioMed Central Ltd. 2009 Background Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed. Objectives The aims of this review are to: 1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck. 2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck. 3) Discuss and review quality requirements for these grading systems. Conclusion Regarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck. Oral Lesion (dpeaa)DE-He213 Atypical Hyperplasia (dpeaa)DE-He213 Severe Dysplasia (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Moderate Dysplasia (dpeaa)DE-He213 Slootweg, Piet aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 11. Mai (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:11 month:05 https://dx.doi.org/10.1186/1758-3284-1-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 11 05
allfieldsGer	10.1186/1758-3284-1-11 doi (DE-627)SPR029700817 (SPR)1758-3284-1-11-e DE-627 ger DE-627 rakwb eng Fleskens, Stijn verfasserin aut Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Fleskens and Slootweg; licensee BioMed Central Ltd. 2009 Background Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed. Objectives The aims of this review are to: 1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck. 2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck. 3) Discuss and review quality requirements for these grading systems. Conclusion Regarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck. Oral Lesion (dpeaa)DE-He213 Atypical Hyperplasia (dpeaa)DE-He213 Severe Dysplasia (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Moderate Dysplasia (dpeaa)DE-He213 Slootweg, Piet aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 11. Mai (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:11 month:05 https://dx.doi.org/10.1186/1758-3284-1-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 11 05
allfieldsSound	10.1186/1758-3284-1-11 doi (DE-627)SPR029700817 (SPR)1758-3284-1-11-e DE-627 ger DE-627 rakwb eng Fleskens, Stijn verfasserin aut Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Fleskens and Slootweg; licensee BioMed Central Ltd. 2009 Background Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed. Objectives The aims of this review are to: 1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck. 2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck. 3) Discuss and review quality requirements for these grading systems. Conclusion Regarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck. Oral Lesion (dpeaa)DE-He213 Atypical Hyperplasia (dpeaa)DE-He213 Severe Dysplasia (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Moderate Dysplasia (dpeaa)DE-He213 Slootweg, Piet aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 11. Mai (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:11 month:05 https://dx.doi.org/10.1186/1758-3284-1-11 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 11 05
language	English
source	Enthalten in Head & neck oncology 1(2009), 1 vom: 11. Mai volume:1 year:2009 number:1 day:11 month:05
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topic_facet	Oral Lesion Atypical Hyperplasia Severe Dysplasia Mild Dysplasia Moderate Dysplasia
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container_title	Head & neck oncology
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author	Fleskens, Stijn
spellingShingle	Fleskens, Stijn misc Oral Lesion misc Atypical Hyperplasia misc Severe Dysplasia misc Mild Dysplasia misc Moderate Dysplasia Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility
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topic_title	Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility Oral Lesion (dpeaa)DE-He213 Atypical Hyperplasia (dpeaa)DE-He213 Severe Dysplasia (dpeaa)DE-He213 Mild Dysplasia (dpeaa)DE-He213 Moderate Dysplasia (dpeaa)DE-He213
topic	misc Oral Lesion misc Atypical Hyperplasia misc Severe Dysplasia misc Mild Dysplasia misc Moderate Dysplasia
topic_unstemmed	misc Oral Lesion misc Atypical Hyperplasia misc Severe Dysplasia misc Mild Dysplasia misc Moderate Dysplasia
topic_browse	misc Oral Lesion misc Atypical Hyperplasia misc Severe Dysplasia misc Mild Dysplasia misc Moderate Dysplasia
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title	Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility
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title_full	Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility
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title_sort	grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility
title_auth	Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility
abstract	Background Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed. Objectives The aims of this review are to: 1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck. 2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck. 3) Discuss and review quality requirements for these grading systems. Conclusion Regarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck. © Fleskens and Slootweg; licensee BioMed Central Ltd. 2009
abstractGer	Background Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed. Objectives The aims of this review are to: 1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck. 2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck. 3) Discuss and review quality requirements for these grading systems. Conclusion Regarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck. © Fleskens and Slootweg; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Background Grading of dysplasia, including head and neck lesions, continues to be a hotly debated subject. It is subjective and lacks intra- and inter-observer reproducibility due to the insufficiency of validated morphological criteria and the biological nature of dysplasia. Moreover, due to the absence of a consensus, several systems are currently employed. Objectives The aims of this review are to: 1) Highlight the significance of dysplasia and the importance of a valid method for assessing precursor lesions of the head and neck. 2) Review the different histopathological classification systems for grading intraepithelial lesions of the head and neck. 3) Discuss and review quality requirements for these grading systems. Conclusion Regarding the different classification systems, data concerning the WHO classification system are the most available in current literature. There is no simple relationship or overlapping between the classification systems. Further studies should be done to see whether other systems have advantages above the current WHO system and to discover indications that could lead to an universal classification system for intraepithelial lesions of the head and neck. © Fleskens and Slootweg; licensee BioMed Central Ltd. 2009
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title_short	Grading systems in head and neck dysplasia: their prognostic value, weaknesses and utility
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