Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis

Background To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival. Methods Retrospective study from 1986 to 2006, which re...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Luna-Ortiz, Kuauhyama [verfasserIn] Carmona-Luna, Tania Cano-Valdez, Ana María Mosqueda-Taylor, Adalberto Herrera-Gómez, Angel Villavicencio-Valencia, Verónica

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Salivary Gland Imatinib Adenoid Cystic Carcinoma Perineural Invasion Salivary Gland Neoplasm

Anmerkung:	© Luna-Ortiz et al; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: Head & neck oncology - London : BioMed Central, 2009, 1(2009), 1 vom: 29. Mai
Übergeordnetes Werk:	volume:1 ; year:2009 ; number:1 ; day:29 ; month:05

Links:	Volltext

DOI / URN:	10.1186/1758-3284-1-15

Katalog-ID:	SPR02970085X

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520			\|a Background To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival. Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. Hence, survival has not changed in the last years.
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allfields	10.1186/1758-3284-1-15 doi (DE-627)SPR02970085X (SPR)1758-3284-1-15-e DE-627 ger DE-627 rakwb eng Luna-Ortiz, Kuauhyama verfasserin aut Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Luna-Ortiz et al; licensee BioMed Central Ltd. 2009 Background To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival. Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. Hence, survival has not changed in the last years. Salivary Gland (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Adenoid Cystic Carcinoma (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Salivary Gland Neoplasm (dpeaa)DE-He213 Carmona-Luna, Tania aut Cano-Valdez, Ana María aut Mosqueda-Taylor, Adalberto aut Herrera-Gómez, Angel aut Villavicencio-Valencia, Verónica aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 29. Mai (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:29 month:05 https://dx.doi.org/10.1186/1758-3284-1-15 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 29 05
spelling	10.1186/1758-3284-1-15 doi (DE-627)SPR02970085X (SPR)1758-3284-1-15-e DE-627 ger DE-627 rakwb eng Luna-Ortiz, Kuauhyama verfasserin aut Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Luna-Ortiz et al; licensee BioMed Central Ltd. 2009 Background To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival. Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. Hence, survival has not changed in the last years. Salivary Gland (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Adenoid Cystic Carcinoma (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Salivary Gland Neoplasm (dpeaa)DE-He213 Carmona-Luna, Tania aut Cano-Valdez, Ana María aut Mosqueda-Taylor, Adalberto aut Herrera-Gómez, Angel aut Villavicencio-Valencia, Verónica aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 29. Mai (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:29 month:05 https://dx.doi.org/10.1186/1758-3284-1-15 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 29 05
allfields_unstemmed	10.1186/1758-3284-1-15 doi (DE-627)SPR02970085X (SPR)1758-3284-1-15-e DE-627 ger DE-627 rakwb eng Luna-Ortiz, Kuauhyama verfasserin aut Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Luna-Ortiz et al; licensee BioMed Central Ltd. 2009 Background To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival. Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. Hence, survival has not changed in the last years. Salivary Gland (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Adenoid Cystic Carcinoma (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Salivary Gland Neoplasm (dpeaa)DE-He213 Carmona-Luna, Tania aut Cano-Valdez, Ana María aut Mosqueda-Taylor, Adalberto aut Herrera-Gómez, Angel aut Villavicencio-Valencia, Verónica aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 29. Mai (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:29 month:05 https://dx.doi.org/10.1186/1758-3284-1-15 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 29 05
allfieldsGer	10.1186/1758-3284-1-15 doi (DE-627)SPR02970085X (SPR)1758-3284-1-15-e DE-627 ger DE-627 rakwb eng Luna-Ortiz, Kuauhyama verfasserin aut Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Luna-Ortiz et al; licensee BioMed Central Ltd. 2009 Background To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival. Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. Hence, survival has not changed in the last years. Salivary Gland (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Adenoid Cystic Carcinoma (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Salivary Gland Neoplasm (dpeaa)DE-He213 Carmona-Luna, Tania aut Cano-Valdez, Ana María aut Mosqueda-Taylor, Adalberto aut Herrera-Gómez, Angel aut Villavicencio-Valencia, Verónica aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 29. Mai (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:29 month:05 https://dx.doi.org/10.1186/1758-3284-1-15 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 29 05
allfieldsSound	10.1186/1758-3284-1-15 doi (DE-627)SPR02970085X (SPR)1758-3284-1-15-e DE-627 ger DE-627 rakwb eng Luna-Ortiz, Kuauhyama verfasserin aut Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Luna-Ortiz et al; licensee BioMed Central Ltd. 2009 Background To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival. Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. Hence, survival has not changed in the last years. Salivary Gland (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Adenoid Cystic Carcinoma (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Salivary Gland Neoplasm (dpeaa)DE-He213 Carmona-Luna, Tania aut Cano-Valdez, Ana María aut Mosqueda-Taylor, Adalberto aut Herrera-Gómez, Angel aut Villavicencio-Valencia, Verónica aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 29. Mai (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:29 month:05 https://dx.doi.org/10.1186/1758-3284-1-15 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 29 05
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Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. 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author	Luna-Ortiz, Kuauhyama
spellingShingle	Luna-Ortiz, Kuauhyama misc Salivary Gland misc Imatinib misc Adenoid Cystic Carcinoma misc Perineural Invasion misc Salivary Gland Neoplasm Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis
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topic_title	Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis Salivary Gland (dpeaa)DE-He213 Imatinib (dpeaa)DE-He213 Adenoid Cystic Carcinoma (dpeaa)DE-He213 Perineural Invasion (dpeaa)DE-He213 Salivary Gland Neoplasm (dpeaa)DE-He213
topic	misc Salivary Gland misc Imatinib misc Adenoid Cystic Carcinoma misc Perineural Invasion misc Salivary Gland Neoplasm
topic_unstemmed	misc Salivary Gland misc Imatinib misc Adenoid Cystic Carcinoma misc Perineural Invasion misc Salivary Gland Neoplasm
topic_browse	misc Salivary Gland misc Imatinib misc Adenoid Cystic Carcinoma misc Perineural Invasion misc Salivary Gland Neoplasm
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title	Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis
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title_full	Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis
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author_browse	Luna-Ortiz, Kuauhyama Carmona-Luna, Tania Cano-Valdez, Ana María Mosqueda-Taylor, Adalberto Herrera-Gómez, Angel Villavicencio-Valencia, Verónica
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title_sort	adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis
title_auth	Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis
abstract	Background To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival. Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. Hence, survival has not changed in the last years. © Luna-Ortiz et al; licensee BioMed Central Ltd. 2009
abstractGer	Background To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival. Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. Hence, survival has not changed in the last years. © Luna-Ortiz et al; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Background To review the demographic data of a series of adenoid cystic carcinoma (ACC) of the tongue, as well as to analyze c-kit expression, histopathologic patterns, prognostic factors, evolution, recurrences and/or persistence and survival. Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. Hence, survival has not changed in the last years. © Luna-Ortiz et al; licensee BioMed Central Ltd. 2009
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title_short	Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis
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Methods Retrospective study from 1986 to 2006, which reviews a database of 68 patients with diagnosis of head and neck ACC. Results We found eight cases of ACC of the tongue (11.7% of all head and neck ACCs). There were 7 female (87.5%) and 1 male (12.5%) patients, with an average age of 51 years (range 33 to 67 years). Seven patients were surgically treated, three of which required adjuvant treatment. Only one female patient did not accept treatment. Average follow-up time was 5.3 years. Metastases developed in 37% of cases during the follow-up period. Histopathologically, the cribriform pattern predominated (6/8 cases). All cases presented perineural invasion, and one patient also presented vascular invasion. c-kit positivity was observed in all cases. Global survival in the seven treated cases was 51% and 34% at 5 and 10 years, respectively, while the disease-free period was of 64% at 3 years and 42% at 10 years. Conclusion ACC of the tongue is a rare neoplasm, in which early diagnosis is important because these are slowly-growing tumors that produce diffuse invasion. As the role of c-kit could not be assesed in this series, surgery continues to be the cornerstone of treatment and radiotherapy is indicated when surgical margins are compromised. Metastatic disease is still hard to handle because of the lack of adequate therapies for these tumors. 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Adenoid cystic carcinoma of the tongue – clinicopathological study and survival analysis

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