MAGE-A as a novel approach in the diagnostic accuracy of oral squamous cell cancer: a case report
Background The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC). Case report We report of a 49-year old male patient who was referred to our department with a persistent-suspicious lo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Metzler, Philipp [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Anmerkung: |
© Metzler et al; licensee BioMed Central Ltd. 2009 |
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| Übergeordnetes Werk: |
Enthalten in: Head & neck oncology - London : BioMed Central, 2009, 1(2009), 1 vom: 16. Dez. |
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| Übergeordnetes Werk: |
volume:1 ; year:2009 ; number:1 ; day:16 ; month:12 |
| Links: |
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| DOI / URN: |
10.1186/1758-3284-1-39 |
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| Katalog-ID: |
SPR029701147 |
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| 520 | |a Background The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC). Case report We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified. Conclusion These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias. | ||
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10.1186/1758-3284-1-39 doi (DE-627)SPR029701147 (SPR)1758-3284-1-39-e DE-627 ger DE-627 rakwb eng Metzler, Philipp verfasserin aut MAGE-A as a novel approach in the diagnostic accuracy of oral squamous cell cancer: a case report 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Metzler et al; licensee BioMed Central Ltd. 2009 Background The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC). Case report We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified. Conclusion These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias. Oral Squamous Cell Carcinoma (dpeaa)DE-He213 Oral Squamous Cell Carcinoma (dpeaa)DE-He213 Oral Lesion (dpeaa)DE-He213 Oral Squamous Cell Carcinoma Patient (dpeaa)DE-He213 Oral Mucosal Lesion (dpeaa)DE-He213 Mollaoglu, Nur aut Schwarz, Stephan aut Neukam, Friedrich W aut Nkenke, Emeka aut Ries, Jutta aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 16. Dez. (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:16 month:12 https://dx.doi.org/10.1186/1758-3284-1-39 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 16 12 |
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10.1186/1758-3284-1-39 doi (DE-627)SPR029701147 (SPR)1758-3284-1-39-e DE-627 ger DE-627 rakwb eng Metzler, Philipp verfasserin aut MAGE-A as a novel approach in the diagnostic accuracy of oral squamous cell cancer: a case report 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Metzler et al; licensee BioMed Central Ltd. 2009 Background The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC). Case report We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified. Conclusion These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias. Oral Squamous Cell Carcinoma (dpeaa)DE-He213 Oral Squamous Cell Carcinoma (dpeaa)DE-He213 Oral Lesion (dpeaa)DE-He213 Oral Squamous Cell Carcinoma Patient (dpeaa)DE-He213 Oral Mucosal Lesion (dpeaa)DE-He213 Mollaoglu, Nur aut Schwarz, Stephan aut Neukam, Friedrich W aut Nkenke, Emeka aut Ries, Jutta aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 16. Dez. (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:16 month:12 https://dx.doi.org/10.1186/1758-3284-1-39 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 16 12 |
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10.1186/1758-3284-1-39 doi (DE-627)SPR029701147 (SPR)1758-3284-1-39-e DE-627 ger DE-627 rakwb eng Metzler, Philipp verfasserin aut MAGE-A as a novel approach in the diagnostic accuracy of oral squamous cell cancer: a case report 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Metzler et al; licensee BioMed Central Ltd. 2009 Background The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC). Case report We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified. Conclusion These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias. Oral Squamous Cell Carcinoma (dpeaa)DE-He213 Oral Squamous Cell Carcinoma (dpeaa)DE-He213 Oral Lesion (dpeaa)DE-He213 Oral Squamous Cell Carcinoma Patient (dpeaa)DE-He213 Oral Mucosal Lesion (dpeaa)DE-He213 Mollaoglu, Nur aut Schwarz, Stephan aut Neukam, Friedrich W aut Nkenke, Emeka aut Ries, Jutta aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 16. Dez. (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:16 month:12 https://dx.doi.org/10.1186/1758-3284-1-39 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 16 12 |
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10.1186/1758-3284-1-39 doi (DE-627)SPR029701147 (SPR)1758-3284-1-39-e DE-627 ger DE-627 rakwb eng Metzler, Philipp verfasserin aut MAGE-A as a novel approach in the diagnostic accuracy of oral squamous cell cancer: a case report 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Metzler et al; licensee BioMed Central Ltd. 2009 Background The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC). Case report We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified. Conclusion These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias. Oral Squamous Cell Carcinoma (dpeaa)DE-He213 Oral Squamous Cell Carcinoma (dpeaa)DE-He213 Oral Lesion (dpeaa)DE-He213 Oral Squamous Cell Carcinoma Patient (dpeaa)DE-He213 Oral Mucosal Lesion (dpeaa)DE-He213 Mollaoglu, Nur aut Schwarz, Stephan aut Neukam, Friedrich W aut Nkenke, Emeka aut Ries, Jutta aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 16. Dez. (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:16 month:12 https://dx.doi.org/10.1186/1758-3284-1-39 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 16 12 |
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10.1186/1758-3284-1-39 doi (DE-627)SPR029701147 (SPR)1758-3284-1-39-e DE-627 ger DE-627 rakwb eng Metzler, Philipp verfasserin aut MAGE-A as a novel approach in the diagnostic accuracy of oral squamous cell cancer: a case report 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Metzler et al; licensee BioMed Central Ltd. 2009 Background The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC). Case report We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified. Conclusion These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias. Oral Squamous Cell Carcinoma (dpeaa)DE-He213 Oral Squamous Cell Carcinoma (dpeaa)DE-He213 Oral Lesion (dpeaa)DE-He213 Oral Squamous Cell Carcinoma Patient (dpeaa)DE-He213 Oral Mucosal Lesion (dpeaa)DE-He213 Mollaoglu, Nur aut Schwarz, Stephan aut Neukam, Friedrich W aut Nkenke, Emeka aut Ries, Jutta aut Enthalten in Head & neck oncology London : BioMed Central, 2009 1(2009), 1 vom: 16. Dez. (DE-627)589902326 (DE-600)2473460-3 1758-3284 nnns volume:1 year:2009 number:1 day:16 month:12 https://dx.doi.org/10.1186/1758-3284-1-39 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 16 12 |
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Background The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC). Case report We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified. Conclusion These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias. © Metzler et al; licensee BioMed Central Ltd. 2009 |
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Background The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC). Case report We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified. Conclusion These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias. © Metzler et al; licensee BioMed Central Ltd. 2009 |
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Background The aim of this case report is to introduce the combined use of brush biopsy and measurement of MAGE-A expression in the diagnosis of oral squamous cell carcinoma (OSCC). Case report We report of a 49-year old male patient who was referred to our department with a persistent-suspicious looking leukoplakia. Brush biopsy and an incisional biopsy were performed following clinical diagnosis. Histopathological examination revealed no malignancy. Expression analysis of melanoma-associated antigens A (MAGE-A) using real time RT-PCR was applied to brush biopsy materials because of the high prevalence of MAGE-A determined previously in OSCC's. Results indicated significant MAGE-A3 and A4 expression pattern. Therefore, the lesion was excised completely and an early invasive carcinoma was identified. Conclusion These results emphasize the role of brush biopsy using a tumor marker with a high expression frequency combined with a high sensitive and high specific detection system in the early diagnosis of OSCC, particularly in widespread leukoplakias. © Metzler et al; licensee BioMed Central Ltd. 2009 |
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| score |
7.4020405 |