Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report
Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dominguez-Valentin, Mev [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2019 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s). 2019 |
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| Übergeordnetes Werk: |
Enthalten in: Hereditary cancer in clinical practice - Berlin : Springer, 2003, 17(2019), 1 vom: 14. Okt. |
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| Übergeordnetes Werk: |
volume:17 ; year:2019 ; number:1 ; day:14 ; month:10 |
| Links: |
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| DOI / URN: |
10.1186/s13053-019-0127-3 |
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| Katalog-ID: |
SPR02972600X |
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| 100 | 1 | |a Dominguez-Valentin, Mev |e verfasserin |0 (orcid)0000-0001-7856-0057 |4 aut | |
| 245 | 1 | 0 | |a Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report |
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| 520 | |a Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated. Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR carriers had no cancer prior to or at first colonoscopy, but subsequently developed colon cancer. Among these, 96 were 65 years of age or younger at diagnosis, and included 77 path_MLH1, 17 path_MSH2, and 2 path_MSH6 carriers. The number of cancers detected within < 1.5, 1.5–2.5, 2.5–3.5 and at > 3.5 years after previous colonoscopy were 9, 43, 31 and 13, respectively. Of these, 2, 8, 4 and 3 were stage III, respectively, and only one stage IV (interval 2.5–3.5 years) disease. Ten-year crude survival after colon cancer were 93, 94 and 82% for stage I, II and III disease, respectively (p < 0.001). Ten-year crude survival when the last colonoscopy had been < 1.5, 1.5–2.5, 2.5–3.5 or > 3.5 years before diagnosis, was 89, 90, 90 and 92%, respectively (p = 0.91). Conclusions In path_MLH1 and path_MSH2 carriers, more advanced colon cancer stage was associated with poorer survival, whereas time since previous colonoscopy was not. Although the numbers are limited, together with our previously reported findings, these results may be in conflict with the view that follow-up of path_MMR variant carriers with colonoscopy intervals of less than 3 years provides significant benefit. | ||
| 650 | 4 | |a Lynch syndrome |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Survival |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Colonoscopy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Surveillance |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cancer stage |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Colon cancer |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Seppälä, Toni T. |4 aut | |
| 700 | 1 | |a Sampson, Julian R. |4 aut | |
| 700 | 1 | |a Macrae, Finlay |4 aut | |
| 700 | 1 | |a Winship, Ingrid |4 aut | |
| 700 | 1 | |a Evans, D. Gareth |4 aut | |
| 700 | 1 | |a Scott, Rodney J. |4 aut | |
| 700 | 1 | |a Burn, John |4 aut | |
| 700 | 1 | |a Möslein, Gabriela |4 aut | |
| 700 | 1 | |a Bernstein, Inge |4 aut | |
| 700 | 1 | |a Pylvänäinen, Kirsi |4 aut | |
| 700 | 1 | |a Renkonen-Sinisalo, Laura |4 aut | |
| 700 | 1 | |a Lepistö, Anna |4 aut | |
| 700 | 1 | |a Lindblom, Annika |4 aut | |
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| 700 | 1 | |a Tjandra, Douglas |4 aut | |
| 700 | 1 | |a Thomas, Huw |4 aut | |
| 700 | 1 | |a Green, Kate |4 aut | |
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| 700 | 1 | |a Hill, James |4 aut | |
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| 700 | 1 | |a Pineda, Marta |4 aut | |
| 700 | 1 | |a Navarro, Matilde |4 aut | |
| 700 | 1 | |a Vidal, Joan Brunet |4 aut | |
| 700 | 1 | |a Rønlund, Karina |4 aut | |
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| 700 | 1 | |a Katz, Lior |4 aut | |
| 700 | 1 | |a Nielsen, Maartje |4 aut | |
| 700 | 1 | |a ten Broeke, Sanne W. |4 aut | |
| 700 | 1 | |a Nakken, Sigve |4 aut | |
| 700 | 1 | |a Hovig, Eivind |4 aut | |
| 700 | 1 | |a Sunde, Lone |4 aut | |
| 700 | 1 | |a Kloor, Matthias |4 aut | |
| 700 | 1 | |a Knebel Doeberitz, Magnus v |4 aut | |
| 700 | 1 | |a Ahadova, Aysel |4 aut | |
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| 700 | 1 | |a Møller, Pål |4 aut | |
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10.1186/s13053-019-0127-3 doi (DE-627)SPR02972600X (SPR)s13053-019-0127-3-e DE-627 ger DE-627 rakwb eng Dominguez-Valentin, Mev verfasserin (orcid)0000-0001-7856-0057 aut Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated. Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR carriers had no cancer prior to or at first colonoscopy, but subsequently developed colon cancer. Among these, 96 were 65 years of age or younger at diagnosis, and included 77 path_MLH1, 17 path_MSH2, and 2 path_MSH6 carriers. The number of cancers detected within < 1.5, 1.5–2.5, 2.5–3.5 and at > 3.5 years after previous colonoscopy were 9, 43, 31 and 13, respectively. Of these, 2, 8, 4 and 3 were stage III, respectively, and only one stage IV (interval 2.5–3.5 years) disease. Ten-year crude survival after colon cancer were 93, 94 and 82% for stage I, II and III disease, respectively (p < 0.001). Ten-year crude survival when the last colonoscopy had been < 1.5, 1.5–2.5, 2.5–3.5 or > 3.5 years before diagnosis, was 89, 90, 90 and 92%, respectively (p = 0.91). Conclusions In path_MLH1 and path_MSH2 carriers, more advanced colon cancer stage was associated with poorer survival, whereas time since previous colonoscopy was not. Although the numbers are limited, together with our previously reported findings, these results may be in conflict with the view that follow-up of path_MMR variant carriers with colonoscopy intervals of less than 3 years provides significant benefit. Lynch syndrome (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Colonoscopy (dpeaa)DE-He213 Surveillance (dpeaa)DE-He213 Cancer stage (dpeaa)DE-He213 Colon cancer (dpeaa)DE-He213 Seppälä, Toni T. aut Sampson, Julian R. aut Macrae, Finlay aut Winship, Ingrid aut Evans, D. Gareth aut Scott, Rodney J. aut Burn, John aut Möslein, Gabriela aut Bernstein, Inge aut Pylvänäinen, Kirsi aut Renkonen-Sinisalo, Laura aut Lepistö, Anna aut Lindblom, Annika aut Plazzer, John-Paul aut Tjandra, Douglas aut Thomas, Huw aut Green, Kate aut Lalloo, Fiona aut Crosbie, Emma J. aut Hill, James aut Capella, Gabriel aut Pineda, Marta aut Navarro, Matilde aut Vidal, Joan Brunet aut Rønlund, Karina aut Nielsen, Randi Thyregaard aut Yilmaz, Mette aut Elvang, Louise Laurberg aut Katz, Lior aut Nielsen, Maartje aut ten Broeke, Sanne W. aut Nakken, Sigve aut Hovig, Eivind aut Sunde, Lone aut Kloor, Matthias aut Knebel Doeberitz, Magnus v aut Ahadova, Aysel aut Lindor, Noralane aut Steinke-Lange, Verena aut Holinski-Feder, Elke aut Mecklin, Jukka-Pekka aut Møller, Pål aut Enthalten in Hereditary cancer in clinical practice Berlin : Springer, 2003 17(2019), 1 vom: 14. Okt. (DE-627)511229925 (DE-600)2233352-6 1897-4287 nnns volume:17 year:2019 number:1 day:14 month:10 https://dx.doi.org/10.1186/s13053-019-0127-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 14 10 |
| spelling |
10.1186/s13053-019-0127-3 doi (DE-627)SPR02972600X (SPR)s13053-019-0127-3-e DE-627 ger DE-627 rakwb eng Dominguez-Valentin, Mev verfasserin (orcid)0000-0001-7856-0057 aut Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated. Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR carriers had no cancer prior to or at first colonoscopy, but subsequently developed colon cancer. Among these, 96 were 65 years of age or younger at diagnosis, and included 77 path_MLH1, 17 path_MSH2, and 2 path_MSH6 carriers. The number of cancers detected within < 1.5, 1.5–2.5, 2.5–3.5 and at > 3.5 years after previous colonoscopy were 9, 43, 31 and 13, respectively. Of these, 2, 8, 4 and 3 were stage III, respectively, and only one stage IV (interval 2.5–3.5 years) disease. Ten-year crude survival after colon cancer were 93, 94 and 82% for stage I, II and III disease, respectively (p < 0.001). Ten-year crude survival when the last colonoscopy had been < 1.5, 1.5–2.5, 2.5–3.5 or > 3.5 years before diagnosis, was 89, 90, 90 and 92%, respectively (p = 0.91). Conclusions In path_MLH1 and path_MSH2 carriers, more advanced colon cancer stage was associated with poorer survival, whereas time since previous colonoscopy was not. Although the numbers are limited, together with our previously reported findings, these results may be in conflict with the view that follow-up of path_MMR variant carriers with colonoscopy intervals of less than 3 years provides significant benefit. Lynch syndrome (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Colonoscopy (dpeaa)DE-He213 Surveillance (dpeaa)DE-He213 Cancer stage (dpeaa)DE-He213 Colon cancer (dpeaa)DE-He213 Seppälä, Toni T. aut Sampson, Julian R. aut Macrae, Finlay aut Winship, Ingrid aut Evans, D. Gareth aut Scott, Rodney J. aut Burn, John aut Möslein, Gabriela aut Bernstein, Inge aut Pylvänäinen, Kirsi aut Renkonen-Sinisalo, Laura aut Lepistö, Anna aut Lindblom, Annika aut Plazzer, John-Paul aut Tjandra, Douglas aut Thomas, Huw aut Green, Kate aut Lalloo, Fiona aut Crosbie, Emma J. aut Hill, James aut Capella, Gabriel aut Pineda, Marta aut Navarro, Matilde aut Vidal, Joan Brunet aut Rønlund, Karina aut Nielsen, Randi Thyregaard aut Yilmaz, Mette aut Elvang, Louise Laurberg aut Katz, Lior aut Nielsen, Maartje aut ten Broeke, Sanne W. aut Nakken, Sigve aut Hovig, Eivind aut Sunde, Lone aut Kloor, Matthias aut Knebel Doeberitz, Magnus v aut Ahadova, Aysel aut Lindor, Noralane aut Steinke-Lange, Verena aut Holinski-Feder, Elke aut Mecklin, Jukka-Pekka aut Møller, Pål aut Enthalten in Hereditary cancer in clinical practice Berlin : Springer, 2003 17(2019), 1 vom: 14. Okt. (DE-627)511229925 (DE-600)2233352-6 1897-4287 nnns volume:17 year:2019 number:1 day:14 month:10 https://dx.doi.org/10.1186/s13053-019-0127-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 14 10 |
| allfields_unstemmed |
10.1186/s13053-019-0127-3 doi (DE-627)SPR02972600X (SPR)s13053-019-0127-3-e DE-627 ger DE-627 rakwb eng Dominguez-Valentin, Mev verfasserin (orcid)0000-0001-7856-0057 aut Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated. Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR carriers had no cancer prior to or at first colonoscopy, but subsequently developed colon cancer. Among these, 96 were 65 years of age or younger at diagnosis, and included 77 path_MLH1, 17 path_MSH2, and 2 path_MSH6 carriers. The number of cancers detected within < 1.5, 1.5–2.5, 2.5–3.5 and at > 3.5 years after previous colonoscopy were 9, 43, 31 and 13, respectively. Of these, 2, 8, 4 and 3 were stage III, respectively, and only one stage IV (interval 2.5–3.5 years) disease. Ten-year crude survival after colon cancer were 93, 94 and 82% for stage I, II and III disease, respectively (p < 0.001). Ten-year crude survival when the last colonoscopy had been < 1.5, 1.5–2.5, 2.5–3.5 or > 3.5 years before diagnosis, was 89, 90, 90 and 92%, respectively (p = 0.91). Conclusions In path_MLH1 and path_MSH2 carriers, more advanced colon cancer stage was associated with poorer survival, whereas time since previous colonoscopy was not. Although the numbers are limited, together with our previously reported findings, these results may be in conflict with the view that follow-up of path_MMR variant carriers with colonoscopy intervals of less than 3 years provides significant benefit. Lynch syndrome (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Colonoscopy (dpeaa)DE-He213 Surveillance (dpeaa)DE-He213 Cancer stage (dpeaa)DE-He213 Colon cancer (dpeaa)DE-He213 Seppälä, Toni T. aut Sampson, Julian R. aut Macrae, Finlay aut Winship, Ingrid aut Evans, D. Gareth aut Scott, Rodney J. aut Burn, John aut Möslein, Gabriela aut Bernstein, Inge aut Pylvänäinen, Kirsi aut Renkonen-Sinisalo, Laura aut Lepistö, Anna aut Lindblom, Annika aut Plazzer, John-Paul aut Tjandra, Douglas aut Thomas, Huw aut Green, Kate aut Lalloo, Fiona aut Crosbie, Emma J. aut Hill, James aut Capella, Gabriel aut Pineda, Marta aut Navarro, Matilde aut Vidal, Joan Brunet aut Rønlund, Karina aut Nielsen, Randi Thyregaard aut Yilmaz, Mette aut Elvang, Louise Laurberg aut Katz, Lior aut Nielsen, Maartje aut ten Broeke, Sanne W. aut Nakken, Sigve aut Hovig, Eivind aut Sunde, Lone aut Kloor, Matthias aut Knebel Doeberitz, Magnus v aut Ahadova, Aysel aut Lindor, Noralane aut Steinke-Lange, Verena aut Holinski-Feder, Elke aut Mecklin, Jukka-Pekka aut Møller, Pål aut Enthalten in Hereditary cancer in clinical practice Berlin : Springer, 2003 17(2019), 1 vom: 14. Okt. (DE-627)511229925 (DE-600)2233352-6 1897-4287 nnns volume:17 year:2019 number:1 day:14 month:10 https://dx.doi.org/10.1186/s13053-019-0127-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 14 10 |
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10.1186/s13053-019-0127-3 doi (DE-627)SPR02972600X (SPR)s13053-019-0127-3-e DE-627 ger DE-627 rakwb eng Dominguez-Valentin, Mev verfasserin (orcid)0000-0001-7856-0057 aut Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated. Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR carriers had no cancer prior to or at first colonoscopy, but subsequently developed colon cancer. Among these, 96 were 65 years of age or younger at diagnosis, and included 77 path_MLH1, 17 path_MSH2, and 2 path_MSH6 carriers. The number of cancers detected within < 1.5, 1.5–2.5, 2.5–3.5 and at > 3.5 years after previous colonoscopy were 9, 43, 31 and 13, respectively. Of these, 2, 8, 4 and 3 were stage III, respectively, and only one stage IV (interval 2.5–3.5 years) disease. Ten-year crude survival after colon cancer were 93, 94 and 82% for stage I, II and III disease, respectively (p < 0.001). Ten-year crude survival when the last colonoscopy had been < 1.5, 1.5–2.5, 2.5–3.5 or > 3.5 years before diagnosis, was 89, 90, 90 and 92%, respectively (p = 0.91). Conclusions In path_MLH1 and path_MSH2 carriers, more advanced colon cancer stage was associated with poorer survival, whereas time since previous colonoscopy was not. Although the numbers are limited, together with our previously reported findings, these results may be in conflict with the view that follow-up of path_MMR variant carriers with colonoscopy intervals of less than 3 years provides significant benefit. Lynch syndrome (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Colonoscopy (dpeaa)DE-He213 Surveillance (dpeaa)DE-He213 Cancer stage (dpeaa)DE-He213 Colon cancer (dpeaa)DE-He213 Seppälä, Toni T. aut Sampson, Julian R. aut Macrae, Finlay aut Winship, Ingrid aut Evans, D. Gareth aut Scott, Rodney J. aut Burn, John aut Möslein, Gabriela aut Bernstein, Inge aut Pylvänäinen, Kirsi aut Renkonen-Sinisalo, Laura aut Lepistö, Anna aut Lindblom, Annika aut Plazzer, John-Paul aut Tjandra, Douglas aut Thomas, Huw aut Green, Kate aut Lalloo, Fiona aut Crosbie, Emma J. aut Hill, James aut Capella, Gabriel aut Pineda, Marta aut Navarro, Matilde aut Vidal, Joan Brunet aut Rønlund, Karina aut Nielsen, Randi Thyregaard aut Yilmaz, Mette aut Elvang, Louise Laurberg aut Katz, Lior aut Nielsen, Maartje aut ten Broeke, Sanne W. aut Nakken, Sigve aut Hovig, Eivind aut Sunde, Lone aut Kloor, Matthias aut Knebel Doeberitz, Magnus v aut Ahadova, Aysel aut Lindor, Noralane aut Steinke-Lange, Verena aut Holinski-Feder, Elke aut Mecklin, Jukka-Pekka aut Møller, Pål aut Enthalten in Hereditary cancer in clinical practice Berlin : Springer, 2003 17(2019), 1 vom: 14. Okt. (DE-627)511229925 (DE-600)2233352-6 1897-4287 nnns volume:17 year:2019 number:1 day:14 month:10 https://dx.doi.org/10.1186/s13053-019-0127-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 14 10 |
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10.1186/s13053-019-0127-3 doi (DE-627)SPR02972600X (SPR)s13053-019-0127-3-e DE-627 ger DE-627 rakwb eng Dominguez-Valentin, Mev verfasserin (orcid)0000-0001-7856-0057 aut Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated. Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR carriers had no cancer prior to or at first colonoscopy, but subsequently developed colon cancer. Among these, 96 were 65 years of age or younger at diagnosis, and included 77 path_MLH1, 17 path_MSH2, and 2 path_MSH6 carriers. The number of cancers detected within < 1.5, 1.5–2.5, 2.5–3.5 and at > 3.5 years after previous colonoscopy were 9, 43, 31 and 13, respectively. Of these, 2, 8, 4 and 3 were stage III, respectively, and only one stage IV (interval 2.5–3.5 years) disease. Ten-year crude survival after colon cancer were 93, 94 and 82% for stage I, II and III disease, respectively (p < 0.001). Ten-year crude survival when the last colonoscopy had been < 1.5, 1.5–2.5, 2.5–3.5 or > 3.5 years before diagnosis, was 89, 90, 90 and 92%, respectively (p = 0.91). Conclusions In path_MLH1 and path_MSH2 carriers, more advanced colon cancer stage was associated with poorer survival, whereas time since previous colonoscopy was not. Although the numbers are limited, together with our previously reported findings, these results may be in conflict with the view that follow-up of path_MMR variant carriers with colonoscopy intervals of less than 3 years provides significant benefit. Lynch syndrome (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Colonoscopy (dpeaa)DE-He213 Surveillance (dpeaa)DE-He213 Cancer stage (dpeaa)DE-He213 Colon cancer (dpeaa)DE-He213 Seppälä, Toni T. aut Sampson, Julian R. aut Macrae, Finlay aut Winship, Ingrid aut Evans, D. Gareth aut Scott, Rodney J. aut Burn, John aut Möslein, Gabriela aut Bernstein, Inge aut Pylvänäinen, Kirsi aut Renkonen-Sinisalo, Laura aut Lepistö, Anna aut Lindblom, Annika aut Plazzer, John-Paul aut Tjandra, Douglas aut Thomas, Huw aut Green, Kate aut Lalloo, Fiona aut Crosbie, Emma J. aut Hill, James aut Capella, Gabriel aut Pineda, Marta aut Navarro, Matilde aut Vidal, Joan Brunet aut Rønlund, Karina aut Nielsen, Randi Thyregaard aut Yilmaz, Mette aut Elvang, Louise Laurberg aut Katz, Lior aut Nielsen, Maartje aut ten Broeke, Sanne W. aut Nakken, Sigve aut Hovig, Eivind aut Sunde, Lone aut Kloor, Matthias aut Knebel Doeberitz, Magnus v aut Ahadova, Aysel aut Lindor, Noralane aut Steinke-Lange, Verena aut Holinski-Feder, Elke aut Mecklin, Jukka-Pekka aut Møller, Pål aut Enthalten in Hereditary cancer in clinical practice Berlin : Springer, 2003 17(2019), 1 vom: 14. Okt. (DE-627)511229925 (DE-600)2233352-6 1897-4287 nnns volume:17 year:2019 number:1 day:14 month:10 https://dx.doi.org/10.1186/s13053-019-0127-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2019 1 14 10 |
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Enthalten in Hereditary cancer in clinical practice 17(2019), 1 vom: 14. Okt. volume:17 year:2019 number:1 day:14 month:10 |
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Dominguez-Valentin, Mev @@aut@@ Seppälä, Toni T. @@aut@@ Sampson, Julian R. @@aut@@ Macrae, Finlay @@aut@@ Winship, Ingrid @@aut@@ Evans, D. Gareth @@aut@@ Scott, Rodney J. @@aut@@ Burn, John @@aut@@ Möslein, Gabriela @@aut@@ Bernstein, Inge @@aut@@ Pylvänäinen, Kirsi @@aut@@ Renkonen-Sinisalo, Laura @@aut@@ Lepistö, Anna @@aut@@ Lindblom, Annika @@aut@@ Plazzer, John-Paul @@aut@@ Tjandra, Douglas @@aut@@ Thomas, Huw @@aut@@ Green, Kate @@aut@@ Lalloo, Fiona @@aut@@ Crosbie, Emma J. @@aut@@ Hill, James @@aut@@ Capella, Gabriel @@aut@@ Pineda, Marta @@aut@@ Navarro, Matilde @@aut@@ Vidal, Joan Brunet @@aut@@ Rønlund, Karina @@aut@@ Nielsen, Randi Thyregaard @@aut@@ Yilmaz, Mette @@aut@@ Elvang, Louise Laurberg @@aut@@ Katz, Lior @@aut@@ Nielsen, Maartje @@aut@@ ten Broeke, Sanne W. @@aut@@ Nakken, Sigve @@aut@@ Hovig, Eivind @@aut@@ Sunde, Lone @@aut@@ Kloor, Matthias @@aut@@ Knebel Doeberitz, Magnus v @@aut@@ Ahadova, Aysel @@aut@@ Lindor, Noralane @@aut@@ Steinke-Lange, Verena @@aut@@ Holinski-Feder, Elke @@aut@@ Mecklin, Jukka-Pekka @@aut@@ Møller, Pål @@aut@@ |
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Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report Lynch syndrome (dpeaa)DE-He213 Survival (dpeaa)DE-He213 Colonoscopy (dpeaa)DE-He213 Surveillance (dpeaa)DE-He213 Cancer stage (dpeaa)DE-He213 Colon cancer (dpeaa)DE-He213 |
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Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report |
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Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report |
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Dominguez-Valentin, Mev Seppälä, Toni T. Sampson, Julian R. Macrae, Finlay Winship, Ingrid Evans, D. Gareth Scott, Rodney J. Burn, John Möslein, Gabriela Bernstein, Inge Pylvänäinen, Kirsi Renkonen-Sinisalo, Laura Lepistö, Anna Lindblom, Annika Plazzer, John-Paul Tjandra, Douglas Thomas, Huw Green, Kate Lalloo, Fiona Crosbie, Emma J. Hill, James Capella, Gabriel Pineda, Marta Navarro, Matilde Vidal, Joan Brunet Rønlund, Karina Nielsen, Randi Thyregaard Yilmaz, Mette Elvang, Louise Laurberg Katz, Lior Nielsen, Maartje ten Broeke, Sanne W. Nakken, Sigve Hovig, Eivind Sunde, Lone Kloor, Matthias Knebel Doeberitz, Magnus v Ahadova, Aysel Lindor, Noralane Steinke-Lange, Verena Holinski-Feder, Elke Mecklin, Jukka-Pekka Møller, Pål |
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survival by colon cancer stage and screening interval in lynch syndrome: a prospective lynch syndrome database report |
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Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report |
| abstract |
Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated. Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR carriers had no cancer prior to or at first colonoscopy, but subsequently developed colon cancer. Among these, 96 were 65 years of age or younger at diagnosis, and included 77 path_MLH1, 17 path_MSH2, and 2 path_MSH6 carriers. The number of cancers detected within < 1.5, 1.5–2.5, 2.5–3.5 and at > 3.5 years after previous colonoscopy were 9, 43, 31 and 13, respectively. Of these, 2, 8, 4 and 3 were stage III, respectively, and only one stage IV (interval 2.5–3.5 years) disease. Ten-year crude survival after colon cancer were 93, 94 and 82% for stage I, II and III disease, respectively (p < 0.001). Ten-year crude survival when the last colonoscopy had been < 1.5, 1.5–2.5, 2.5–3.5 or > 3.5 years before diagnosis, was 89, 90, 90 and 92%, respectively (p = 0.91). Conclusions In path_MLH1 and path_MSH2 carriers, more advanced colon cancer stage was associated with poorer survival, whereas time since previous colonoscopy was not. Although the numbers are limited, together with our previously reported findings, these results may be in conflict with the view that follow-up of path_MMR variant carriers with colonoscopy intervals of less than 3 years provides significant benefit. © The Author(s). 2019 |
| abstractGer |
Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated. Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR carriers had no cancer prior to or at first colonoscopy, but subsequently developed colon cancer. Among these, 96 were 65 years of age or younger at diagnosis, and included 77 path_MLH1, 17 path_MSH2, and 2 path_MSH6 carriers. The number of cancers detected within < 1.5, 1.5–2.5, 2.5–3.5 and at > 3.5 years after previous colonoscopy were 9, 43, 31 and 13, respectively. Of these, 2, 8, 4 and 3 were stage III, respectively, and only one stage IV (interval 2.5–3.5 years) disease. Ten-year crude survival after colon cancer were 93, 94 and 82% for stage I, II and III disease, respectively (p < 0.001). Ten-year crude survival when the last colonoscopy had been < 1.5, 1.5–2.5, 2.5–3.5 or > 3.5 years before diagnosis, was 89, 90, 90 and 92%, respectively (p = 0.91). Conclusions In path_MLH1 and path_MSH2 carriers, more advanced colon cancer stage was associated with poorer survival, whereas time since previous colonoscopy was not. Although the numbers are limited, together with our previously reported findings, these results may be in conflict with the view that follow-up of path_MMR variant carriers with colonoscopy intervals of less than 3 years provides significant benefit. © The Author(s). 2019 |
| abstract_unstemmed |
Background We previously reported that in pathogenic mismatch repair (path_MMR) variant carriers, the incidence of colorectal cancer (CRC) was not reduced when colonoscopy was undertaken more frequently than once every 3 years, and that CRC stage and interval since last colonoscopy were not correlated. Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR carriers had no cancer prior to or at first colonoscopy, but subsequently developed colon cancer. Among these, 96 were 65 years of age or younger at diagnosis, and included 77 path_MLH1, 17 path_MSH2, and 2 path_MSH6 carriers. The number of cancers detected within < 1.5, 1.5–2.5, 2.5–3.5 and at > 3.5 years after previous colonoscopy were 9, 43, 31 and 13, respectively. Of these, 2, 8, 4 and 3 were stage III, respectively, and only one stage IV (interval 2.5–3.5 years) disease. Ten-year crude survival after colon cancer were 93, 94 and 82% for stage I, II and III disease, respectively (p < 0.001). Ten-year crude survival when the last colonoscopy had been < 1.5, 1.5–2.5, 2.5–3.5 or > 3.5 years before diagnosis, was 89, 90, 90 and 92%, respectively (p = 0.91). Conclusions In path_MLH1 and path_MSH2 carriers, more advanced colon cancer stage was associated with poorer survival, whereas time since previous colonoscopy was not. Although the numbers are limited, together with our previously reported findings, these results may be in conflict with the view that follow-up of path_MMR variant carriers with colonoscopy intervals of less than 3 years provides significant benefit. © The Author(s). 2019 |
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Seppälä, Toni T. Sampson, Julian R. Macrae, Finlay Winship, Ingrid Evans, D. Gareth Scott, Rodney J. Burn, John Möslein, Gabriela Bernstein, Inge Pylvänäinen, Kirsi Renkonen-Sinisalo, Laura Lepistö, Anna Lindblom, Annika Plazzer, John-Paul Tjandra, Douglas Thomas, Huw Green, Kate Lalloo, Fiona Crosbie, Emma J. Hill, James Capella, Gabriel Pineda, Marta Navarro, Matilde Vidal, Joan Brunet Rønlund, Karina Nielsen, Randi Thyregaard Yilmaz, Mette Elvang, Louise Laurberg Katz, Lior Nielsen, Maartje ten Broeke, Sanne W. Nakken, Sigve Hovig, Eivind Sunde, Lone Kloor, Matthias Knebel Doeberitz, Magnus v Ahadova, Aysel Lindor, Noralane Steinke-Lange, Verena Holinski-Feder, Elke Mecklin, Jukka-Pekka Møller, Pål |
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Methods The Prospective Lynch Syndrome Database (PLSD) that records outcomes of surveillance was examined to determine survival after colon cancer in relation to the time since previous colonoscopy and pathological stage. Only path_MMR variants scored by the InSiGHT variant database as class 4 or 5 (clinically actionable) were included in the analysis. Results Ninety-nine path_MMR carriers had no cancer prior to or at first colonoscopy, but subsequently developed colon cancer. Among these, 96 were 65 years of age or younger at diagnosis, and included 77 path_MLH1, 17 path_MSH2, and 2 path_MSH6 carriers. The number of cancers detected within < 1.5, 1.5–2.5, 2.5–3.5 and at > 3.5 years after previous colonoscopy were 9, 43, 31 and 13, respectively. Of these, 2, 8, 4 and 3 were stage III, respectively, and only one stage IV (interval 2.5–3.5 years) disease. Ten-year crude survival after colon cancer were 93, 94 and 82% for stage I, II and III disease, respectively (p < 0.001). Ten-year crude survival when the last colonoscopy had been < 1.5, 1.5–2.5, 2.5–3.5 or > 3.5 years before diagnosis, was 89, 90, 90 and 92%, respectively (p = 0.91). Conclusions In path_MLH1 and path_MSH2 carriers, more advanced colon cancer stage was associated with poorer survival, whereas time since previous colonoscopy was not. Although the numbers are limited, together with our previously reported findings, these results may be in conflict with the view that follow-up of path_MMR variant carriers with colonoscopy intervals of less than 3 years provides significant benefit.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Lynch syndrome</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Survival</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Colonoscopy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Surveillance</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer stage</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Colon cancer</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Seppälä, Toni T.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sampson, Julian R.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Macrae, Finlay</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Winship, Ingrid</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Evans, D. 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