Intraoperative radiotherapy (IORT) as boost in breast cancer

Abstract The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatment...
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Autor*in:	Sedlmayer, Felix [verfasserIn] Reitsamer, Roland Wenz, Frederik Sperk, Elena Fussl, Christoph Kaiser, Julia Ziegler, Ingrid Zehentmayr, Franz Deutschmann, Heinz Kopp, Peter Fastner, Gerd

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	IORT Intraoperative radiotherapy IOERT Boost Electrons Orthovoltage Breast cancer Tumor bed Cosmesis hypofractionation

Anmerkung:	© The Author(s). 2017

Übergeordnetes Werk:	Enthalten in: Radiation oncology - London : BioMed Central, 2006, 12(2017), 1 vom: 19. Jan.
Übergeordnetes Werk:	volume:12 ; year:2017 ; number:1 ; day:19 ; month:01

Links:	Volltext

DOI / URN:	10.1186/s13014-016-0749-9

Katalog-ID:	SPR029749506

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520			\|a Abstract The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments (IOERT) with single doses around 10 Gy. At median follow-up periods at 6 years, outstandingly low local recurrence rates of less than 1% are observed. Higher local relapse rates were described for G3 tumors and triple negative breast cancers as well as for IORT following primary systemic treatment for locally advanced tumors. Even there, long term (>5y) local tumor control rates mostly beyond 95% were maintained. Compared to other boost methods, an intraoperative treatment has evident advantages in terms of precision (by avoiding a “spatial and/or temporal miss”), cosmetic outcome and patient comfort. Direct visualisation of a tumor bed during surgery guarantees for an accurate dose delivery, which has additionally gained importance in times of primary reconstruction techniques after lumpectomy, since IORT is performed before breast tissue including parts of the tumor bed is mobilized for plastic purposes. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with external beam radiotherapy to the whole breast (WBI) is currently tested in two multicentric prospective trials: as kV-IORT in the multicentric TARGIT-B (oost) study, and as IOERT in the HIOB trial (3 weeks hypofractionated WBI preceded by IORT electron boost).
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allfields	10.1186/s13014-016-0749-9 doi (DE-627)SPR029749506 (SPR)s13014-016-0749-9-e DE-627 ger DE-627 rakwb eng Sedlmayer, Felix verfasserin aut Intraoperative radiotherapy (IORT) as boost in breast cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments (IOERT) with single doses around 10 Gy. At median follow-up periods at 6 years, outstandingly low local recurrence rates of less than 1% are observed. Higher local relapse rates were described for G3 tumors and triple negative breast cancers as well as for IORT following primary systemic treatment for locally advanced tumors. Even there, long term (>5y) local tumor control rates mostly beyond 95% were maintained. Compared to other boost methods, an intraoperative treatment has evident advantages in terms of precision (by avoiding a “spatial and/or temporal miss”), cosmetic outcome and patient comfort. Direct visualisation of a tumor bed during surgery guarantees for an accurate dose delivery, which has additionally gained importance in times of primary reconstruction techniques after lumpectomy, since IORT is performed before breast tissue including parts of the tumor bed is mobilized for plastic purposes. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with external beam radiotherapy to the whole breast (WBI) is currently tested in two multicentric prospective trials: as kV-IORT in the multicentric TARGIT-B (oost) study, and as IOERT in the HIOB trial (3 weeks hypofractionated WBI preceded by IORT electron boost). IORT (dpeaa)DE-He213 Intraoperative radiotherapy (dpeaa)DE-He213 IOERT (dpeaa)DE-He213 Boost (dpeaa)DE-He213 Electrons (dpeaa)DE-He213 Orthovoltage (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Tumor bed (dpeaa)DE-He213 Cosmesis (dpeaa)DE-He213 hypofractionation (dpeaa)DE-He213 Reitsamer, Roland aut Wenz, Frederik aut Sperk, Elena aut Fussl, Christoph aut Kaiser, Julia aut Ziegler, Ingrid aut Zehentmayr, Franz aut Deutschmann, Heinz aut Kopp, Peter aut Fastner, Gerd aut Enthalten in Radiation oncology London : BioMed Central, 2006 12(2017), 1 vom: 19. Jan. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:12 year:2017 number:1 day:19 month:01 https://dx.doi.org/10.1186/s13014-016-0749-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 1 19 01
spelling	10.1186/s13014-016-0749-9 doi (DE-627)SPR029749506 (SPR)s13014-016-0749-9-e DE-627 ger DE-627 rakwb eng Sedlmayer, Felix verfasserin aut Intraoperative radiotherapy (IORT) as boost in breast cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments (IOERT) with single doses around 10 Gy. At median follow-up periods at 6 years, outstandingly low local recurrence rates of less than 1% are observed. Higher local relapse rates were described for G3 tumors and triple negative breast cancers as well as for IORT following primary systemic treatment for locally advanced tumors. Even there, long term (>5y) local tumor control rates mostly beyond 95% were maintained. Compared to other boost methods, an intraoperative treatment has evident advantages in terms of precision (by avoiding a “spatial and/or temporal miss”), cosmetic outcome and patient comfort. Direct visualisation of a tumor bed during surgery guarantees for an accurate dose delivery, which has additionally gained importance in times of primary reconstruction techniques after lumpectomy, since IORT is performed before breast tissue including parts of the tumor bed is mobilized for plastic purposes. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with external beam radiotherapy to the whole breast (WBI) is currently tested in two multicentric prospective trials: as kV-IORT in the multicentric TARGIT-B (oost) study, and as IOERT in the HIOB trial (3 weeks hypofractionated WBI preceded by IORT electron boost). IORT (dpeaa)DE-He213 Intraoperative radiotherapy (dpeaa)DE-He213 IOERT (dpeaa)DE-He213 Boost (dpeaa)DE-He213 Electrons (dpeaa)DE-He213 Orthovoltage (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Tumor bed (dpeaa)DE-He213 Cosmesis (dpeaa)DE-He213 hypofractionation (dpeaa)DE-He213 Reitsamer, Roland aut Wenz, Frederik aut Sperk, Elena aut Fussl, Christoph aut Kaiser, Julia aut Ziegler, Ingrid aut Zehentmayr, Franz aut Deutschmann, Heinz aut Kopp, Peter aut Fastner, Gerd aut Enthalten in Radiation oncology London : BioMed Central, 2006 12(2017), 1 vom: 19. Jan. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:12 year:2017 number:1 day:19 month:01 https://dx.doi.org/10.1186/s13014-016-0749-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 1 19 01
allfields_unstemmed	10.1186/s13014-016-0749-9 doi (DE-627)SPR029749506 (SPR)s13014-016-0749-9-e DE-627 ger DE-627 rakwb eng Sedlmayer, Felix verfasserin aut Intraoperative radiotherapy (IORT) as boost in breast cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments (IOERT) with single doses around 10 Gy. At median follow-up periods at 6 years, outstandingly low local recurrence rates of less than 1% are observed. Higher local relapse rates were described for G3 tumors and triple negative breast cancers as well as for IORT following primary systemic treatment for locally advanced tumors. Even there, long term (>5y) local tumor control rates mostly beyond 95% were maintained. Compared to other boost methods, an intraoperative treatment has evident advantages in terms of precision (by avoiding a “spatial and/or temporal miss”), cosmetic outcome and patient comfort. Direct visualisation of a tumor bed during surgery guarantees for an accurate dose delivery, which has additionally gained importance in times of primary reconstruction techniques after lumpectomy, since IORT is performed before breast tissue including parts of the tumor bed is mobilized for plastic purposes. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with external beam radiotherapy to the whole breast (WBI) is currently tested in two multicentric prospective trials: as kV-IORT in the multicentric TARGIT-B (oost) study, and as IOERT in the HIOB trial (3 weeks hypofractionated WBI preceded by IORT electron boost). IORT (dpeaa)DE-He213 Intraoperative radiotherapy (dpeaa)DE-He213 IOERT (dpeaa)DE-He213 Boost (dpeaa)DE-He213 Electrons (dpeaa)DE-He213 Orthovoltage (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Tumor bed (dpeaa)DE-He213 Cosmesis (dpeaa)DE-He213 hypofractionation (dpeaa)DE-He213 Reitsamer, Roland aut Wenz, Frederik aut Sperk, Elena aut Fussl, Christoph aut Kaiser, Julia aut Ziegler, Ingrid aut Zehentmayr, Franz aut Deutschmann, Heinz aut Kopp, Peter aut Fastner, Gerd aut Enthalten in Radiation oncology London : BioMed Central, 2006 12(2017), 1 vom: 19. Jan. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:12 year:2017 number:1 day:19 month:01 https://dx.doi.org/10.1186/s13014-016-0749-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 1 19 01
allfieldsGer	10.1186/s13014-016-0749-9 doi (DE-627)SPR029749506 (SPR)s13014-016-0749-9-e DE-627 ger DE-627 rakwb eng Sedlmayer, Felix verfasserin aut Intraoperative radiotherapy (IORT) as boost in breast cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments (IOERT) with single doses around 10 Gy. At median follow-up periods at 6 years, outstandingly low local recurrence rates of less than 1% are observed. Higher local relapse rates were described for G3 tumors and triple negative breast cancers as well as for IORT following primary systemic treatment for locally advanced tumors. Even there, long term (>5y) local tumor control rates mostly beyond 95% were maintained. Compared to other boost methods, an intraoperative treatment has evident advantages in terms of precision (by avoiding a “spatial and/or temporal miss”), cosmetic outcome and patient comfort. Direct visualisation of a tumor bed during surgery guarantees for an accurate dose delivery, which has additionally gained importance in times of primary reconstruction techniques after lumpectomy, since IORT is performed before breast tissue including parts of the tumor bed is mobilized for plastic purposes. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with external beam radiotherapy to the whole breast (WBI) is currently tested in two multicentric prospective trials: as kV-IORT in the multicentric TARGIT-B (oost) study, and as IOERT in the HIOB trial (3 weeks hypofractionated WBI preceded by IORT electron boost). IORT (dpeaa)DE-He213 Intraoperative radiotherapy (dpeaa)DE-He213 IOERT (dpeaa)DE-He213 Boost (dpeaa)DE-He213 Electrons (dpeaa)DE-He213 Orthovoltage (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Tumor bed (dpeaa)DE-He213 Cosmesis (dpeaa)DE-He213 hypofractionation (dpeaa)DE-He213 Reitsamer, Roland aut Wenz, Frederik aut Sperk, Elena aut Fussl, Christoph aut Kaiser, Julia aut Ziegler, Ingrid aut Zehentmayr, Franz aut Deutschmann, Heinz aut Kopp, Peter aut Fastner, Gerd aut Enthalten in Radiation oncology London : BioMed Central, 2006 12(2017), 1 vom: 19. Jan. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:12 year:2017 number:1 day:19 month:01 https://dx.doi.org/10.1186/s13014-016-0749-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 1 19 01
allfieldsSound	10.1186/s13014-016-0749-9 doi (DE-627)SPR029749506 (SPR)s13014-016-0749-9-e DE-627 ger DE-627 rakwb eng Sedlmayer, Felix verfasserin aut Intraoperative radiotherapy (IORT) as boost in breast cancer 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2017 Abstract The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments (IOERT) with single doses around 10 Gy. At median follow-up periods at 6 years, outstandingly low local recurrence rates of less than 1% are observed. Higher local relapse rates were described for G3 tumors and triple negative breast cancers as well as for IORT following primary systemic treatment for locally advanced tumors. Even there, long term (>5y) local tumor control rates mostly beyond 95% were maintained. Compared to other boost methods, an intraoperative treatment has evident advantages in terms of precision (by avoiding a “spatial and/or temporal miss”), cosmetic outcome and patient comfort. Direct visualisation of a tumor bed during surgery guarantees for an accurate dose delivery, which has additionally gained importance in times of primary reconstruction techniques after lumpectomy, since IORT is performed before breast tissue including parts of the tumor bed is mobilized for plastic purposes. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with external beam radiotherapy to the whole breast (WBI) is currently tested in two multicentric prospective trials: as kV-IORT in the multicentric TARGIT-B (oost) study, and as IOERT in the HIOB trial (3 weeks hypofractionated WBI preceded by IORT electron boost). IORT (dpeaa)DE-He213 Intraoperative radiotherapy (dpeaa)DE-He213 IOERT (dpeaa)DE-He213 Boost (dpeaa)DE-He213 Electrons (dpeaa)DE-He213 Orthovoltage (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Tumor bed (dpeaa)DE-He213 Cosmesis (dpeaa)DE-He213 hypofractionation (dpeaa)DE-He213 Reitsamer, Roland aut Wenz, Frederik aut Sperk, Elena aut Fussl, Christoph aut Kaiser, Julia aut Ziegler, Ingrid aut Zehentmayr, Franz aut Deutschmann, Heinz aut Kopp, Peter aut Fastner, Gerd aut Enthalten in Radiation oncology London : BioMed Central, 2006 12(2017), 1 vom: 19. Jan. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:12 year:2017 number:1 day:19 month:01 https://dx.doi.org/10.1186/s13014-016-0749-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2017 1 19 01
language	English
source	Enthalten in Radiation oncology 12(2017), 1 vom: 19. Jan. volume:12 year:2017 number:1 day:19 month:01
sourceStr	Enthalten in Radiation oncology 12(2017), 1 vom: 19. Jan. volume:12 year:2017 number:1 day:19 month:01
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	IORT Intraoperative radiotherapy IOERT Boost Electrons Orthovoltage Breast cancer Tumor bed Cosmesis hypofractionation
isfreeaccess_bool	true
container_title	Radiation oncology
authorswithroles_txt_mv	Sedlmayer, Felix @@aut@@ Reitsamer, Roland @@aut@@ Wenz, Frederik @@aut@@ Sperk, Elena @@aut@@ Fussl, Christoph @@aut@@ Kaiser, Julia @@aut@@ Ziegler, Ingrid @@aut@@ Zehentmayr, Franz @@aut@@ Deutschmann, Heinz @@aut@@ Kopp, Peter @@aut@@ Fastner, Gerd @@aut@@
publishDateDaySort_date	2017-01-19T00:00:00Z
hierarchy_top_id	508725739
id	SPR029749506
language_de	englisch
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author	Sedlmayer, Felix
spellingShingle	Sedlmayer, Felix misc IORT misc Intraoperative radiotherapy misc IOERT misc Boost misc Electrons misc Orthovoltage misc Breast cancer misc Tumor bed misc Cosmesis misc hypofractionation Intraoperative radiotherapy (IORT) as boost in breast cancer
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topic_title	Intraoperative radiotherapy (IORT) as boost in breast cancer IORT (dpeaa)DE-He213 Intraoperative radiotherapy (dpeaa)DE-He213 IOERT (dpeaa)DE-He213 Boost (dpeaa)DE-He213 Electrons (dpeaa)DE-He213 Orthovoltage (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Tumor bed (dpeaa)DE-He213 Cosmesis (dpeaa)DE-He213 hypofractionation (dpeaa)DE-He213
topic	misc IORT misc Intraoperative radiotherapy misc IOERT misc Boost misc Electrons misc Orthovoltage misc Breast cancer misc Tumor bed misc Cosmesis misc hypofractionation
topic_unstemmed	misc IORT misc Intraoperative radiotherapy misc IOERT misc Boost misc Electrons misc Orthovoltage misc Breast cancer misc Tumor bed misc Cosmesis misc hypofractionation
topic_browse	misc IORT misc Intraoperative radiotherapy misc IOERT misc Boost misc Electrons misc Orthovoltage misc Breast cancer misc Tumor bed misc Cosmesis misc hypofractionation
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title	Intraoperative radiotherapy (IORT) as boost in breast cancer
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title_full	Intraoperative radiotherapy (IORT) as boost in breast cancer
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author_browse	Sedlmayer, Felix Reitsamer, Roland Wenz, Frederik Sperk, Elena Fussl, Christoph Kaiser, Julia Ziegler, Ingrid Zehentmayr, Franz Deutschmann, Heinz Kopp, Peter Fastner, Gerd
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title_sort	intraoperative radiotherapy (iort) as boost in breast cancer
title_auth	Intraoperative radiotherapy (IORT) as boost in breast cancer
abstract	Abstract The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments (IOERT) with single doses around 10 Gy. At median follow-up periods at 6 years, outstandingly low local recurrence rates of less than 1% are observed. Higher local relapse rates were described for G3 tumors and triple negative breast cancers as well as for IORT following primary systemic treatment for locally advanced tumors. Even there, long term (>5y) local tumor control rates mostly beyond 95% were maintained. Compared to other boost methods, an intraoperative treatment has evident advantages in terms of precision (by avoiding a “spatial and/or temporal miss”), cosmetic outcome and patient comfort. Direct visualisation of a tumor bed during surgery guarantees for an accurate dose delivery, which has additionally gained importance in times of primary reconstruction techniques after lumpectomy, since IORT is performed before breast tissue including parts of the tumor bed is mobilized for plastic purposes. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with external beam radiotherapy to the whole breast (WBI) is currently tested in two multicentric prospective trials: as kV-IORT in the multicentric TARGIT-B (oost) study, and as IOERT in the HIOB trial (3 weeks hypofractionated WBI preceded by IORT electron boost). © The Author(s). 2017
abstractGer	Abstract The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments (IOERT) with single doses around 10 Gy. At median follow-up periods at 6 years, outstandingly low local recurrence rates of less than 1% are observed. Higher local relapse rates were described for G3 tumors and triple negative breast cancers as well as for IORT following primary systemic treatment for locally advanced tumors. Even there, long term (>5y) local tumor control rates mostly beyond 95% were maintained. Compared to other boost methods, an intraoperative treatment has evident advantages in terms of precision (by avoiding a “spatial and/or temporal miss”), cosmetic outcome and patient comfort. Direct visualisation of a tumor bed during surgery guarantees for an accurate dose delivery, which has additionally gained importance in times of primary reconstruction techniques after lumpectomy, since IORT is performed before breast tissue including parts of the tumor bed is mobilized for plastic purposes. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with external beam radiotherapy to the whole breast (WBI) is currently tested in two multicentric prospective trials: as kV-IORT in the multicentric TARGIT-B (oost) study, and as IOERT in the HIOB trial (3 weeks hypofractionated WBI preceded by IORT electron boost). © The Author(s). 2017
abstract_unstemmed	Abstract The term IORT (intraoperative radiotherapy) is currently used for various techniques that show huge differences in dose delivery and coverage of the tissue at risk. The largest evidence for boost IORT preceding whole breast irradiation (WBI) originates from intraoperative electron treatments (IOERT) with single doses around 10 Gy. At median follow-up periods at 6 years, outstandingly low local recurrence rates of less than 1% are observed. Higher local relapse rates were described for G3 tumors and triple negative breast cancers as well as for IORT following primary systemic treatment for locally advanced tumors. Even there, long term (>5y) local tumor control rates mostly beyond 95% were maintained. Compared to other boost methods, an intraoperative treatment has evident advantages in terms of precision (by avoiding a “spatial and/or temporal miss”), cosmetic outcome and patient comfort. Direct visualisation of a tumor bed during surgery guarantees for an accurate dose delivery, which has additionally gained importance in times of primary reconstruction techniques after lumpectomy, since IORT is performed before breast tissue including parts of the tumor bed is mobilized for plastic purposes. As a consequence of direct tissue exposure without distension by hematoma/seroma, IORT allows for small treatment volumes and complete skin sparing, both having a positive effect on late tissue tolerance and, hence, cosmetic appearance. Boost IORT marginally prolongs the surgical procedure, while significantly shortening postoperative radiotherapy. Its combination with external beam radiotherapy to the whole breast (WBI) is currently tested in two multicentric prospective trials: as kV-IORT in the multicentric TARGIT-B (oost) study, and as IOERT in the HIOB trial (3 weeks hypofractionated WBI preceded by IORT electron boost). © The Author(s). 2017
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title_short	Intraoperative radiotherapy (IORT) as boost in breast cancer
url	https://dx.doi.org/10.1186/s13014-016-0749-9
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