Lactate as a marker of energy failure in critically ill patients: hypothesis

Abstract Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does no...
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Autor*in:	Valenza, Franco [verfasserIn] Aletti, Gabriele Fossali, Tommaso Chevallard, Giorgio Sacconi, Francesca Irace, Manuela Gattinoni, Luciano

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Schlagwörter:	Lactate Lactic Acidosis Plasma Lactate Energy Failure Lactate Measurement

Anmerkung:	© BioMed Central Ltd 2005

Übergeordnetes Werk:	Enthalten in: Critical care - London : BioMed Central, 1997, 9(2005), 6 vom: 28. Sept.
Übergeordnetes Werk:	volume:9 ; year:2005 ; number:6 ; day:28 ; month:09

Links:	Volltext

DOI / URN:	10.1186/cc3818

Katalog-ID:	SPR029765315

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allfields	10.1186/cc3818 doi (DE-627)SPR029765315 (SPR)cc3818-e DE-627 ger DE-627 rakwb eng Valenza, Franco verfasserin aut Lactate as a marker of energy failure in critically ill patients: hypothesis 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2005 Abstract Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mithocondria) is intact. Conversely, once the mithocondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state. Lactate (dpeaa)DE-He213 Lactic Acidosis (dpeaa)DE-He213 Plasma Lactate (dpeaa)DE-He213 Energy Failure (dpeaa)DE-He213 Lactate Measurement (dpeaa)DE-He213 Aletti, Gabriele aut Fossali, Tommaso aut Chevallard, Giorgio aut Sacconi, Francesca aut Irace, Manuela aut Gattinoni, Luciano aut Enthalten in Critical care London : BioMed Central, 1997 9(2005), 6 vom: 28. Sept. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:9 year:2005 number:6 day:28 month:09 https://dx.doi.org/10.1186/cc3818 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2005 6 28 09
spelling	10.1186/cc3818 doi (DE-627)SPR029765315 (SPR)cc3818-e DE-627 ger DE-627 rakwb eng Valenza, Franco verfasserin aut Lactate as a marker of energy failure in critically ill patients: hypothesis 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2005 Abstract Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mithocondria) is intact. Conversely, once the mithocondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state. Lactate (dpeaa)DE-He213 Lactic Acidosis (dpeaa)DE-He213 Plasma Lactate (dpeaa)DE-He213 Energy Failure (dpeaa)DE-He213 Lactate Measurement (dpeaa)DE-He213 Aletti, Gabriele aut Fossali, Tommaso aut Chevallard, Giorgio aut Sacconi, Francesca aut Irace, Manuela aut Gattinoni, Luciano aut Enthalten in Critical care London : BioMed Central, 1997 9(2005), 6 vom: 28. Sept. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:9 year:2005 number:6 day:28 month:09 https://dx.doi.org/10.1186/cc3818 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2005 6 28 09
allfields_unstemmed	10.1186/cc3818 doi (DE-627)SPR029765315 (SPR)cc3818-e DE-627 ger DE-627 rakwb eng Valenza, Franco verfasserin aut Lactate as a marker of energy failure in critically ill patients: hypothesis 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2005 Abstract Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mithocondria) is intact. Conversely, once the mithocondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state. Lactate (dpeaa)DE-He213 Lactic Acidosis (dpeaa)DE-He213 Plasma Lactate (dpeaa)DE-He213 Energy Failure (dpeaa)DE-He213 Lactate Measurement (dpeaa)DE-He213 Aletti, Gabriele aut Fossali, Tommaso aut Chevallard, Giorgio aut Sacconi, Francesca aut Irace, Manuela aut Gattinoni, Luciano aut Enthalten in Critical care London : BioMed Central, 1997 9(2005), 6 vom: 28. Sept. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:9 year:2005 number:6 day:28 month:09 https://dx.doi.org/10.1186/cc3818 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2005 6 28 09
allfieldsGer	10.1186/cc3818 doi (DE-627)SPR029765315 (SPR)cc3818-e DE-627 ger DE-627 rakwb eng Valenza, Franco verfasserin aut Lactate as a marker of energy failure in critically ill patients: hypothesis 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2005 Abstract Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mithocondria) is intact. Conversely, once the mithocondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state. Lactate (dpeaa)DE-He213 Lactic Acidosis (dpeaa)DE-He213 Plasma Lactate (dpeaa)DE-He213 Energy Failure (dpeaa)DE-He213 Lactate Measurement (dpeaa)DE-He213 Aletti, Gabriele aut Fossali, Tommaso aut Chevallard, Giorgio aut Sacconi, Francesca aut Irace, Manuela aut Gattinoni, Luciano aut Enthalten in Critical care London : BioMed Central, 1997 9(2005), 6 vom: 28. Sept. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:9 year:2005 number:6 day:28 month:09 https://dx.doi.org/10.1186/cc3818 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2005 6 28 09
allfieldsSound	10.1186/cc3818 doi (DE-627)SPR029765315 (SPR)cc3818-e DE-627 ger DE-627 rakwb eng Valenza, Franco verfasserin aut Lactate as a marker of energy failure in critically ill patients: hypothesis 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2005 Abstract Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mithocondria) is intact. Conversely, once the mithocondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state. Lactate (dpeaa)DE-He213 Lactic Acidosis (dpeaa)DE-He213 Plasma Lactate (dpeaa)DE-He213 Energy Failure (dpeaa)DE-He213 Lactate Measurement (dpeaa)DE-He213 Aletti, Gabriele aut Fossali, Tommaso aut Chevallard, Giorgio aut Sacconi, Francesca aut Irace, Manuela aut Gattinoni, Luciano aut Enthalten in Critical care London : BioMed Central, 1997 9(2005), 6 vom: 28. Sept. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:9 year:2005 number:6 day:28 month:09 https://dx.doi.org/10.1186/cc3818 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2005 6 28 09
language	English
source	Enthalten in Critical care 9(2005), 6 vom: 28. Sept. volume:9 year:2005 number:6 day:28 month:09
sourceStr	Enthalten in Critical care 9(2005), 6 vom: 28. Sept. volume:9 year:2005 number:6 day:28 month:09
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topic_facet	Lactate Lactic Acidosis Plasma Lactate Energy Failure Lactate Measurement
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container_title	Critical care
authorswithroles_txt_mv	Valenza, Franco @@aut@@ Aletti, Gabriele @@aut@@ Fossali, Tommaso @@aut@@ Chevallard, Giorgio @@aut@@ Sacconi, Francesca @@aut@@ Irace, Manuela @@aut@@ Gattinoni, Luciano @@aut@@
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author	Valenza, Franco
spellingShingle	Valenza, Franco misc Lactate misc Lactic Acidosis misc Plasma Lactate misc Energy Failure misc Lactate Measurement Lactate as a marker of energy failure in critically ill patients: hypothesis
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topic_title	Lactate as a marker of energy failure in critically ill patients: hypothesis Lactate (dpeaa)DE-He213 Lactic Acidosis (dpeaa)DE-He213 Plasma Lactate (dpeaa)DE-He213 Energy Failure (dpeaa)DE-He213 Lactate Measurement (dpeaa)DE-He213
topic	misc Lactate misc Lactic Acidosis misc Plasma Lactate misc Energy Failure misc Lactate Measurement
topic_unstemmed	misc Lactate misc Lactic Acidosis misc Plasma Lactate misc Energy Failure misc Lactate Measurement
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title	Lactate as a marker of energy failure in critically ill patients: hypothesis
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title_full	Lactate as a marker of energy failure in critically ill patients: hypothesis
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author_browse	Valenza, Franco Aletti, Gabriele Fossali, Tommaso Chevallard, Giorgio Sacconi, Francesca Irace, Manuela Gattinoni, Luciano
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title_sort	lactate as a marker of energy failure in critically ill patients: hypothesis
title_auth	Lactate as a marker of energy failure in critically ill patients: hypothesis
abstract	Abstract Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mithocondria) is intact. Conversely, once the mithocondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state. © BioMed Central Ltd 2005
abstractGer	Abstract Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mithocondria) is intact. Conversely, once the mithocondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state. © BioMed Central Ltd 2005
abstract_unstemmed	Abstract Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mithocondria) is intact. Conversely, once the mithocondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state. © BioMed Central Ltd 2005
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title_short	Lactate as a marker of energy failure in critically ill patients: hypothesis
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