Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate

Abstract Inflammation and oxidative stress cause renal impairment. Renal failure exacerbates the effect of oxidative stress on many organ systems. Antioxidants can prevent or treat renal failure in various experimental models and clinical situations. Pyruvate is an endogenous antioxidant with benefi...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Reade, Michael C [verfasserIn] Fink, Mitchell P

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2005

Schlagwörter:	Acute Renal Failure Sodium Pyruvate Ethyl Pyruvate Haemorrhagic Shock Acute Renal Impairment

Anmerkung:	© BioMed Central Ltd 2005

Übergeordnetes Werk:	Enthalten in: Critical care - London : BioMed Central, 1997, 9(2005), 6 vom: 21. Okt.
Übergeordnetes Werk:	volume:9 ; year:2005 ; number:6 ; day:21 ; month:10

Links:	Volltext

DOI / URN:	10.1186/cc3892

Katalog-ID:	SPR029765560

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allfields	10.1186/cc3892 doi (DE-627)SPR029765560 (SPR)cc3892-e DE-627 ger DE-627 rakwb eng Reade, Michael C verfasserin aut Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2005 Abstract Inflammation and oxidative stress cause renal impairment. Renal failure exacerbates the effect of oxidative stress on many organ systems. Antioxidants can prevent or treat renal failure in various experimental models and clinical situations. Pyruvate is an endogenous antioxidant with beneficial effects in animal models of oxidative stress. Because sodium pyruvate rapidly degrades in solution, a simple derivative of pyruvic acid, namely ethyl pyruvate, has been investigated as a therapeutic agent in preclinical studies. Ethyl pyruvate reduces organ system damage in ischaemia/reperfusion injury and haemorrhagic and endotoxic shock, at least in part through its antioxidant action. In addition, ethyl pyruvate appears to have direct beneficial effects on cytokine expression and proinflammatory gene regulation. The effect is long lasting and, importantly, even when it is administered after the onset of inflammation it can ameliorate organ damage and improve survival. Ethyl pyruvate is a widely used as a food additive and was shown to be safe in phase I clinical trials. We suggest ethyl pyruvate warrants further evaluation in the management of acute renal impairment. Acute Renal Failure (dpeaa)DE-He213 Sodium Pyruvate (dpeaa)DE-He213 Ethyl Pyruvate (dpeaa)DE-He213 Haemorrhagic Shock (dpeaa)DE-He213 Acute Renal Impairment (dpeaa)DE-He213 Fink, Mitchell P aut Enthalten in Critical care London : BioMed Central, 1997 9(2005), 6 vom: 21. Okt. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:9 year:2005 number:6 day:21 month:10 https://dx.doi.org/10.1186/cc3892 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2005 6 21 10
spelling	10.1186/cc3892 doi (DE-627)SPR029765560 (SPR)cc3892-e DE-627 ger DE-627 rakwb eng Reade, Michael C verfasserin aut Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2005 Abstract Inflammation and oxidative stress cause renal impairment. Renal failure exacerbates the effect of oxidative stress on many organ systems. Antioxidants can prevent or treat renal failure in various experimental models and clinical situations. Pyruvate is an endogenous antioxidant with beneficial effects in animal models of oxidative stress. Because sodium pyruvate rapidly degrades in solution, a simple derivative of pyruvic acid, namely ethyl pyruvate, has been investigated as a therapeutic agent in preclinical studies. Ethyl pyruvate reduces organ system damage in ischaemia/reperfusion injury and haemorrhagic and endotoxic shock, at least in part through its antioxidant action. In addition, ethyl pyruvate appears to have direct beneficial effects on cytokine expression and proinflammatory gene regulation. The effect is long lasting and, importantly, even when it is administered after the onset of inflammation it can ameliorate organ damage and improve survival. Ethyl pyruvate is a widely used as a food additive and was shown to be safe in phase I clinical trials. We suggest ethyl pyruvate warrants further evaluation in the management of acute renal impairment. Acute Renal Failure (dpeaa)DE-He213 Sodium Pyruvate (dpeaa)DE-He213 Ethyl Pyruvate (dpeaa)DE-He213 Haemorrhagic Shock (dpeaa)DE-He213 Acute Renal Impairment (dpeaa)DE-He213 Fink, Mitchell P aut Enthalten in Critical care London : BioMed Central, 1997 9(2005), 6 vom: 21. Okt. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:9 year:2005 number:6 day:21 month:10 https://dx.doi.org/10.1186/cc3892 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2005 6 21 10
allfields_unstemmed	10.1186/cc3892 doi (DE-627)SPR029765560 (SPR)cc3892-e DE-627 ger DE-627 rakwb eng Reade, Michael C verfasserin aut Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2005 Abstract Inflammation and oxidative stress cause renal impairment. Renal failure exacerbates the effect of oxidative stress on many organ systems. Antioxidants can prevent or treat renal failure in various experimental models and clinical situations. Pyruvate is an endogenous antioxidant with beneficial effects in animal models of oxidative stress. Because sodium pyruvate rapidly degrades in solution, a simple derivative of pyruvic acid, namely ethyl pyruvate, has been investigated as a therapeutic agent in preclinical studies. Ethyl pyruvate reduces organ system damage in ischaemia/reperfusion injury and haemorrhagic and endotoxic shock, at least in part through its antioxidant action. In addition, ethyl pyruvate appears to have direct beneficial effects on cytokine expression and proinflammatory gene regulation. The effect is long lasting and, importantly, even when it is administered after the onset of inflammation it can ameliorate organ damage and improve survival. Ethyl pyruvate is a widely used as a food additive and was shown to be safe in phase I clinical trials. We suggest ethyl pyruvate warrants further evaluation in the management of acute renal impairment. Acute Renal Failure (dpeaa)DE-He213 Sodium Pyruvate (dpeaa)DE-He213 Ethyl Pyruvate (dpeaa)DE-He213 Haemorrhagic Shock (dpeaa)DE-He213 Acute Renal Impairment (dpeaa)DE-He213 Fink, Mitchell P aut Enthalten in Critical care London : BioMed Central, 1997 9(2005), 6 vom: 21. Okt. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:9 year:2005 number:6 day:21 month:10 https://dx.doi.org/10.1186/cc3892 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2005 6 21 10
allfieldsGer	10.1186/cc3892 doi (DE-627)SPR029765560 (SPR)cc3892-e DE-627 ger DE-627 rakwb eng Reade, Michael C verfasserin aut Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2005 Abstract Inflammation and oxidative stress cause renal impairment. Renal failure exacerbates the effect of oxidative stress on many organ systems. Antioxidants can prevent or treat renal failure in various experimental models and clinical situations. Pyruvate is an endogenous antioxidant with beneficial effects in animal models of oxidative stress. Because sodium pyruvate rapidly degrades in solution, a simple derivative of pyruvic acid, namely ethyl pyruvate, has been investigated as a therapeutic agent in preclinical studies. Ethyl pyruvate reduces organ system damage in ischaemia/reperfusion injury and haemorrhagic and endotoxic shock, at least in part through its antioxidant action. In addition, ethyl pyruvate appears to have direct beneficial effects on cytokine expression and proinflammatory gene regulation. The effect is long lasting and, importantly, even when it is administered after the onset of inflammation it can ameliorate organ damage and improve survival. Ethyl pyruvate is a widely used as a food additive and was shown to be safe in phase I clinical trials. We suggest ethyl pyruvate warrants further evaluation in the management of acute renal impairment. Acute Renal Failure (dpeaa)DE-He213 Sodium Pyruvate (dpeaa)DE-He213 Ethyl Pyruvate (dpeaa)DE-He213 Haemorrhagic Shock (dpeaa)DE-He213 Acute Renal Impairment (dpeaa)DE-He213 Fink, Mitchell P aut Enthalten in Critical care London : BioMed Central, 1997 9(2005), 6 vom: 21. Okt. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:9 year:2005 number:6 day:21 month:10 https://dx.doi.org/10.1186/cc3892 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2005 6 21 10
allfieldsSound	10.1186/cc3892 doi (DE-627)SPR029765560 (SPR)cc3892-e DE-627 ger DE-627 rakwb eng Reade, Michael C verfasserin aut Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate 2005 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2005 Abstract Inflammation and oxidative stress cause renal impairment. Renal failure exacerbates the effect of oxidative stress on many organ systems. Antioxidants can prevent or treat renal failure in various experimental models and clinical situations. Pyruvate is an endogenous antioxidant with beneficial effects in animal models of oxidative stress. Because sodium pyruvate rapidly degrades in solution, a simple derivative of pyruvic acid, namely ethyl pyruvate, has been investigated as a therapeutic agent in preclinical studies. Ethyl pyruvate reduces organ system damage in ischaemia/reperfusion injury and haemorrhagic and endotoxic shock, at least in part through its antioxidant action. In addition, ethyl pyruvate appears to have direct beneficial effects on cytokine expression and proinflammatory gene regulation. The effect is long lasting and, importantly, even when it is administered after the onset of inflammation it can ameliorate organ damage and improve survival. Ethyl pyruvate is a widely used as a food additive and was shown to be safe in phase I clinical trials. We suggest ethyl pyruvate warrants further evaluation in the management of acute renal impairment. Acute Renal Failure (dpeaa)DE-He213 Sodium Pyruvate (dpeaa)DE-He213 Ethyl Pyruvate (dpeaa)DE-He213 Haemorrhagic Shock (dpeaa)DE-He213 Acute Renal Impairment (dpeaa)DE-He213 Fink, Mitchell P aut Enthalten in Critical care London : BioMed Central, 1997 9(2005), 6 vom: 21. Okt. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:9 year:2005 number:6 day:21 month:10 https://dx.doi.org/10.1186/cc3892 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2005 6 21 10
language	English
source	Enthalten in Critical care 9(2005), 6 vom: 21. Okt. volume:9 year:2005 number:6 day:21 month:10
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topic_facet	Acute Renal Failure Sodium Pyruvate Ethyl Pyruvate Haemorrhagic Shock Acute Renal Impairment
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container_title	Critical care
authorswithroles_txt_mv	Reade, Michael C @@aut@@ Fink, Mitchell P @@aut@@
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spellingShingle	Reade, Michael C misc Acute Renal Failure misc Sodium Pyruvate misc Ethyl Pyruvate misc Haemorrhagic Shock misc Acute Renal Impairment Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate
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topic_title	Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate Acute Renal Failure (dpeaa)DE-He213 Sodium Pyruvate (dpeaa)DE-He213 Ethyl Pyruvate (dpeaa)DE-He213 Haemorrhagic Shock (dpeaa)DE-He213 Acute Renal Impairment (dpeaa)DE-He213
topic	misc Acute Renal Failure misc Sodium Pyruvate misc Ethyl Pyruvate misc Haemorrhagic Shock misc Acute Renal Impairment
topic_unstemmed	misc Acute Renal Failure misc Sodium Pyruvate misc Ethyl Pyruvate misc Haemorrhagic Shock misc Acute Renal Impairment
topic_browse	misc Acute Renal Failure misc Sodium Pyruvate misc Ethyl Pyruvate misc Haemorrhagic Shock misc Acute Renal Impairment
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title	Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate
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title_sort	bench-to-bedside review: amelioration of acute renal impairment using ethyl pyruvate
title_auth	Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate
abstract	Abstract Inflammation and oxidative stress cause renal impairment. Renal failure exacerbates the effect of oxidative stress on many organ systems. Antioxidants can prevent or treat renal failure in various experimental models and clinical situations. Pyruvate is an endogenous antioxidant with beneficial effects in animal models of oxidative stress. Because sodium pyruvate rapidly degrades in solution, a simple derivative of pyruvic acid, namely ethyl pyruvate, has been investigated as a therapeutic agent in preclinical studies. Ethyl pyruvate reduces organ system damage in ischaemia/reperfusion injury and haemorrhagic and endotoxic shock, at least in part through its antioxidant action. In addition, ethyl pyruvate appears to have direct beneficial effects on cytokine expression and proinflammatory gene regulation. The effect is long lasting and, importantly, even when it is administered after the onset of inflammation it can ameliorate organ damage and improve survival. Ethyl pyruvate is a widely used as a food additive and was shown to be safe in phase I clinical trials. We suggest ethyl pyruvate warrants further evaluation in the management of acute renal impairment. © BioMed Central Ltd 2005
abstractGer	Abstract Inflammation and oxidative stress cause renal impairment. Renal failure exacerbates the effect of oxidative stress on many organ systems. Antioxidants can prevent or treat renal failure in various experimental models and clinical situations. Pyruvate is an endogenous antioxidant with beneficial effects in animal models of oxidative stress. Because sodium pyruvate rapidly degrades in solution, a simple derivative of pyruvic acid, namely ethyl pyruvate, has been investigated as a therapeutic agent in preclinical studies. Ethyl pyruvate reduces organ system damage in ischaemia/reperfusion injury and haemorrhagic and endotoxic shock, at least in part through its antioxidant action. In addition, ethyl pyruvate appears to have direct beneficial effects on cytokine expression and proinflammatory gene regulation. The effect is long lasting and, importantly, even when it is administered after the onset of inflammation it can ameliorate organ damage and improve survival. Ethyl pyruvate is a widely used as a food additive and was shown to be safe in phase I clinical trials. We suggest ethyl pyruvate warrants further evaluation in the management of acute renal impairment. © BioMed Central Ltd 2005
abstract_unstemmed	Abstract Inflammation and oxidative stress cause renal impairment. Renal failure exacerbates the effect of oxidative stress on many organ systems. Antioxidants can prevent or treat renal failure in various experimental models and clinical situations. Pyruvate is an endogenous antioxidant with beneficial effects in animal models of oxidative stress. Because sodium pyruvate rapidly degrades in solution, a simple derivative of pyruvic acid, namely ethyl pyruvate, has been investigated as a therapeutic agent in preclinical studies. Ethyl pyruvate reduces organ system damage in ischaemia/reperfusion injury and haemorrhagic and endotoxic shock, at least in part through its antioxidant action. In addition, ethyl pyruvate appears to have direct beneficial effects on cytokine expression and proinflammatory gene regulation. The effect is long lasting and, importantly, even when it is administered after the onset of inflammation it can ameliorate organ damage and improve survival. Ethyl pyruvate is a widely used as a food additive and was shown to be safe in phase I clinical trials. We suggest ethyl pyruvate warrants further evaluation in the management of acute renal impairment. © BioMed Central Ltd 2005
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title_short	Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate
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