Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis

Background This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hFSRT) for skull base meningiomas. Methods Overall, 341 patients across three cent...
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Autor*in:	Alfredo, Conti [verfasserIn] Carolin, Senger Güliz, Acker Anne, Kluge Antonio, Pontoriero Alberto, Cacciola Stefano, Pergolizzi Antonino, Germanò Harun, Badakhshi Markus, Kufeld Franziska, Meinert Phuong, Nguyen Franziska, Loebel Peter, Vajkoczy Volker, Budach David, Kaul

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Meningioma Skull Base Radiosurgery Fractionated stereotactic radiotherapy Hypofractionated stereotactic radiotherapy CyberKnife

Anmerkung:	© The Author(s). 2019

Übergeordnetes Werk:	Enthalten in: Radiation oncology - London : BioMed Central, 2006, 14(2019), 1 vom: 12. Nov.
Übergeordnetes Werk:	volume:14 ; year:2019 ; number:1 ; day:12 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s13014-019-1397-7

Katalog-ID:	SPR029821274

Internformat


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520			\|a Background This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hFSRT) for skull base meningiomas. Methods Overall, 341 patients across three centers were treated with either nFSRT or CK-hFSRT for skull base meningioma. Treatment planning was based on computed tomography (CT) and magnetic resonance imaging (MRI) following institutional guidelines. Most nFSRT patients received 33 × 1.8 Gy, and most CK-hFSRT patients received 5 × 5 Gy. The median follow-up time was 36 months (range: 1–232 months). Results In the CK-hFSRT group, the 1-, 3-, and 10-year local control (LC) rates were 99.4, 96.8, and 80.3%, respectively. In the nFSRT group, the 1-, 3-, and 10-year LC rates were 100, 99, and 79.1%, respectively. There were no significant differences in LC rates between the nFSRT and CK-hFSRT groups (p = 0.56, hazard ratio = 0.76, 95% confidence interval, 0.3–1.9). In the CK-hFSRT group, only one case (0.49%) of severe toxicity (CTCAE 4.0 ≥ 3) was observed. In the nFSRT group, three cases (2.1%) of grade III toxicity were observed. Conclusion This analysis of pooled data from three centers showed excellent LC and low side effect rates for patients treated with CK-hFSRT or nFSRT. The efficacy, safety, and convenience of a shortened treatment period provide a compelling case for the use of CK-hFSRT in patients with moderate size skull base meningioma and provided that OAR constraints are met.
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allfields	10.1186/s13014-019-1397-7 doi (DE-627)SPR029821274 (SPR)s13014-019-1397-7-e DE-627 ger DE-627 rakwb eng Alfredo, Conti verfasserin aut Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hFSRT) for skull base meningiomas. Methods Overall, 341 patients across three centers were treated with either nFSRT or CK-hFSRT for skull base meningioma. Treatment planning was based on computed tomography (CT) and magnetic resonance imaging (MRI) following institutional guidelines. Most nFSRT patients received 33 × 1.8 Gy, and most CK-hFSRT patients received 5 × 5 Gy. The median follow-up time was 36 months (range: 1–232 months). Results In the CK-hFSRT group, the 1-, 3-, and 10-year local control (LC) rates were 99.4, 96.8, and 80.3%, respectively. In the nFSRT group, the 1-, 3-, and 10-year LC rates were 100, 99, and 79.1%, respectively. There were no significant differences in LC rates between the nFSRT and CK-hFSRT groups (p = 0.56, hazard ratio = 0.76, 95% confidence interval, 0.3–1.9). In the CK-hFSRT group, only one case (0.49%) of severe toxicity (CTCAE 4.0 ≥ 3) was observed. In the nFSRT group, three cases (2.1%) of grade III toxicity were observed. Conclusion This analysis of pooled data from three centers showed excellent LC and low side effect rates for patients treated with CK-hFSRT or nFSRT. The efficacy, safety, and convenience of a shortened treatment period provide a compelling case for the use of CK-hFSRT in patients with moderate size skull base meningioma and provided that OAR constraints are met. Meningioma (dpeaa)DE-He213 Skull Base (dpeaa)DE-He213 Radiosurgery (dpeaa)DE-He213 Fractionated stereotactic radiotherapy (dpeaa)DE-He213 Hypofractionated stereotactic radiotherapy (dpeaa)DE-He213 CyberKnife (dpeaa)DE-He213 Carolin, Senger aut Güliz, Acker aut Anne, Kluge aut Antonio, Pontoriero aut Alberto, Cacciola aut Stefano, Pergolizzi aut Antonino, Germanò aut Harun, Badakhshi aut Markus, Kufeld aut Franziska, Meinert aut Phuong, Nguyen aut Franziska, Loebel aut Peter, Vajkoczy aut Volker, Budach aut David, Kaul (orcid)0000-0002-7906-5629 aut Enthalten in Radiation oncology London : BioMed Central, 2006 14(2019), 1 vom: 12. Nov. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:14 year:2019 number:1 day:12 month:11 https://dx.doi.org/10.1186/s13014-019-1397-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 1 12 11
spelling	10.1186/s13014-019-1397-7 doi (DE-627)SPR029821274 (SPR)s13014-019-1397-7-e DE-627 ger DE-627 rakwb eng Alfredo, Conti verfasserin aut Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hFSRT) for skull base meningiomas. Methods Overall, 341 patients across three centers were treated with either nFSRT or CK-hFSRT for skull base meningioma. Treatment planning was based on computed tomography (CT) and magnetic resonance imaging (MRI) following institutional guidelines. Most nFSRT patients received 33 × 1.8 Gy, and most CK-hFSRT patients received 5 × 5 Gy. The median follow-up time was 36 months (range: 1–232 months). Results In the CK-hFSRT group, the 1-, 3-, and 10-year local control (LC) rates were 99.4, 96.8, and 80.3%, respectively. In the nFSRT group, the 1-, 3-, and 10-year LC rates were 100, 99, and 79.1%, respectively. There were no significant differences in LC rates between the nFSRT and CK-hFSRT groups (p = 0.56, hazard ratio = 0.76, 95% confidence interval, 0.3–1.9). In the CK-hFSRT group, only one case (0.49%) of severe toxicity (CTCAE 4.0 ≥ 3) was observed. In the nFSRT group, three cases (2.1%) of grade III toxicity were observed. Conclusion This analysis of pooled data from three centers showed excellent LC and low side effect rates for patients treated with CK-hFSRT or nFSRT. The efficacy, safety, and convenience of a shortened treatment period provide a compelling case for the use of CK-hFSRT in patients with moderate size skull base meningioma and provided that OAR constraints are met. Meningioma (dpeaa)DE-He213 Skull Base (dpeaa)DE-He213 Radiosurgery (dpeaa)DE-He213 Fractionated stereotactic radiotherapy (dpeaa)DE-He213 Hypofractionated stereotactic radiotherapy (dpeaa)DE-He213 CyberKnife (dpeaa)DE-He213 Carolin, Senger aut Güliz, Acker aut Anne, Kluge aut Antonio, Pontoriero aut Alberto, Cacciola aut Stefano, Pergolizzi aut Antonino, Germanò aut Harun, Badakhshi aut Markus, Kufeld aut Franziska, Meinert aut Phuong, Nguyen aut Franziska, Loebel aut Peter, Vajkoczy aut Volker, Budach aut David, Kaul (orcid)0000-0002-7906-5629 aut Enthalten in Radiation oncology London : BioMed Central, 2006 14(2019), 1 vom: 12. Nov. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:14 year:2019 number:1 day:12 month:11 https://dx.doi.org/10.1186/s13014-019-1397-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 1 12 11
allfields_unstemmed	10.1186/s13014-019-1397-7 doi (DE-627)SPR029821274 (SPR)s13014-019-1397-7-e DE-627 ger DE-627 rakwb eng Alfredo, Conti verfasserin aut Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hFSRT) for skull base meningiomas. Methods Overall, 341 patients across three centers were treated with either nFSRT or CK-hFSRT for skull base meningioma. Treatment planning was based on computed tomography (CT) and magnetic resonance imaging (MRI) following institutional guidelines. Most nFSRT patients received 33 × 1.8 Gy, and most CK-hFSRT patients received 5 × 5 Gy. The median follow-up time was 36 months (range: 1–232 months). Results In the CK-hFSRT group, the 1-, 3-, and 10-year local control (LC) rates were 99.4, 96.8, and 80.3%, respectively. In the nFSRT group, the 1-, 3-, and 10-year LC rates were 100, 99, and 79.1%, respectively. There were no significant differences in LC rates between the nFSRT and CK-hFSRT groups (p = 0.56, hazard ratio = 0.76, 95% confidence interval, 0.3–1.9). In the CK-hFSRT group, only one case (0.49%) of severe toxicity (CTCAE 4.0 ≥ 3) was observed. In the nFSRT group, three cases (2.1%) of grade III toxicity were observed. Conclusion This analysis of pooled data from three centers showed excellent LC and low side effect rates for patients treated with CK-hFSRT or nFSRT. The efficacy, safety, and convenience of a shortened treatment period provide a compelling case for the use of CK-hFSRT in patients with moderate size skull base meningioma and provided that OAR constraints are met. Meningioma (dpeaa)DE-He213 Skull Base (dpeaa)DE-He213 Radiosurgery (dpeaa)DE-He213 Fractionated stereotactic radiotherapy (dpeaa)DE-He213 Hypofractionated stereotactic radiotherapy (dpeaa)DE-He213 CyberKnife (dpeaa)DE-He213 Carolin, Senger aut Güliz, Acker aut Anne, Kluge aut Antonio, Pontoriero aut Alberto, Cacciola aut Stefano, Pergolizzi aut Antonino, Germanò aut Harun, Badakhshi aut Markus, Kufeld aut Franziska, Meinert aut Phuong, Nguyen aut Franziska, Loebel aut Peter, Vajkoczy aut Volker, Budach aut David, Kaul (orcid)0000-0002-7906-5629 aut Enthalten in Radiation oncology London : BioMed Central, 2006 14(2019), 1 vom: 12. Nov. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:14 year:2019 number:1 day:12 month:11 https://dx.doi.org/10.1186/s13014-019-1397-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 1 12 11
allfieldsGer	10.1186/s13014-019-1397-7 doi (DE-627)SPR029821274 (SPR)s13014-019-1397-7-e DE-627 ger DE-627 rakwb eng Alfredo, Conti verfasserin aut Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hFSRT) for skull base meningiomas. Methods Overall, 341 patients across three centers were treated with either nFSRT or CK-hFSRT for skull base meningioma. Treatment planning was based on computed tomography (CT) and magnetic resonance imaging (MRI) following institutional guidelines. Most nFSRT patients received 33 × 1.8 Gy, and most CK-hFSRT patients received 5 × 5 Gy. The median follow-up time was 36 months (range: 1–232 months). Results In the CK-hFSRT group, the 1-, 3-, and 10-year local control (LC) rates were 99.4, 96.8, and 80.3%, respectively. In the nFSRT group, the 1-, 3-, and 10-year LC rates were 100, 99, and 79.1%, respectively. There were no significant differences in LC rates between the nFSRT and CK-hFSRT groups (p = 0.56, hazard ratio = 0.76, 95% confidence interval, 0.3–1.9). In the CK-hFSRT group, only one case (0.49%) of severe toxicity (CTCAE 4.0 ≥ 3) was observed. In the nFSRT group, three cases (2.1%) of grade III toxicity were observed. Conclusion This analysis of pooled data from three centers showed excellent LC and low side effect rates for patients treated with CK-hFSRT or nFSRT. The efficacy, safety, and convenience of a shortened treatment period provide a compelling case for the use of CK-hFSRT in patients with moderate size skull base meningioma and provided that OAR constraints are met. Meningioma (dpeaa)DE-He213 Skull Base (dpeaa)DE-He213 Radiosurgery (dpeaa)DE-He213 Fractionated stereotactic radiotherapy (dpeaa)DE-He213 Hypofractionated stereotactic radiotherapy (dpeaa)DE-He213 CyberKnife (dpeaa)DE-He213 Carolin, Senger aut Güliz, Acker aut Anne, Kluge aut Antonio, Pontoriero aut Alberto, Cacciola aut Stefano, Pergolizzi aut Antonino, Germanò aut Harun, Badakhshi aut Markus, Kufeld aut Franziska, Meinert aut Phuong, Nguyen aut Franziska, Loebel aut Peter, Vajkoczy aut Volker, Budach aut David, Kaul (orcid)0000-0002-7906-5629 aut Enthalten in Radiation oncology London : BioMed Central, 2006 14(2019), 1 vom: 12. Nov. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:14 year:2019 number:1 day:12 month:11 https://dx.doi.org/10.1186/s13014-019-1397-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 1 12 11
allfieldsSound	10.1186/s13014-019-1397-7 doi (DE-627)SPR029821274 (SPR)s13014-019-1397-7-e DE-627 ger DE-627 rakwb eng Alfredo, Conti verfasserin aut Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2019 Background This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hFSRT) for skull base meningiomas. Methods Overall, 341 patients across three centers were treated with either nFSRT or CK-hFSRT for skull base meningioma. Treatment planning was based on computed tomography (CT) and magnetic resonance imaging (MRI) following institutional guidelines. Most nFSRT patients received 33 × 1.8 Gy, and most CK-hFSRT patients received 5 × 5 Gy. The median follow-up time was 36 months (range: 1–232 months). Results In the CK-hFSRT group, the 1-, 3-, and 10-year local control (LC) rates were 99.4, 96.8, and 80.3%, respectively. In the nFSRT group, the 1-, 3-, and 10-year LC rates were 100, 99, and 79.1%, respectively. There were no significant differences in LC rates between the nFSRT and CK-hFSRT groups (p = 0.56, hazard ratio = 0.76, 95% confidence interval, 0.3–1.9). In the CK-hFSRT group, only one case (0.49%) of severe toxicity (CTCAE 4.0 ≥ 3) was observed. In the nFSRT group, three cases (2.1%) of grade III toxicity were observed. Conclusion This analysis of pooled data from three centers showed excellent LC and low side effect rates for patients treated with CK-hFSRT or nFSRT. The efficacy, safety, and convenience of a shortened treatment period provide a compelling case for the use of CK-hFSRT in patients with moderate size skull base meningioma and provided that OAR constraints are met. Meningioma (dpeaa)DE-He213 Skull Base (dpeaa)DE-He213 Radiosurgery (dpeaa)DE-He213 Fractionated stereotactic radiotherapy (dpeaa)DE-He213 Hypofractionated stereotactic radiotherapy (dpeaa)DE-He213 CyberKnife (dpeaa)DE-He213 Carolin, Senger aut Güliz, Acker aut Anne, Kluge aut Antonio, Pontoriero aut Alberto, Cacciola aut Stefano, Pergolizzi aut Antonino, Germanò aut Harun, Badakhshi aut Markus, Kufeld aut Franziska, Meinert aut Phuong, Nguyen aut Franziska, Loebel aut Peter, Vajkoczy aut Volker, Budach aut David, Kaul (orcid)0000-0002-7906-5629 aut Enthalten in Radiation oncology London : BioMed Central, 2006 14(2019), 1 vom: 12. Nov. (DE-627)508725739 (DE-600)2224965-5 1748-717X nnns volume:14 year:2019 number:1 day:12 month:11 https://dx.doi.org/10.1186/s13014-019-1397-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2119 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2019 1 12 11
language	English
source	Enthalten in Radiation oncology 14(2019), 1 vom: 12. Nov. volume:14 year:2019 number:1 day:12 month:11
sourceStr	Enthalten in Radiation oncology 14(2019), 1 vom: 12. Nov. volume:14 year:2019 number:1 day:12 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Meningioma Skull Base Radiosurgery Fractionated stereotactic radiotherapy Hypofractionated stereotactic radiotherapy CyberKnife
isfreeaccess_bool	true
container_title	Radiation oncology
authorswithroles_txt_mv	Alfredo, Conti @@aut@@ Carolin, Senger @@aut@@ Güliz, Acker @@aut@@ Anne, Kluge @@aut@@ Antonio, Pontoriero @@aut@@ Alberto, Cacciola @@aut@@ Stefano, Pergolizzi @@aut@@ Antonino, Germanò @@aut@@ Harun, Badakhshi @@aut@@ Markus, Kufeld @@aut@@ Franziska, Meinert @@aut@@ Phuong, Nguyen @@aut@@ Franziska, Loebel @@aut@@ Peter, Vajkoczy @@aut@@ Volker, Budach @@aut@@ David, Kaul @@aut@@
publishDateDaySort_date	2019-11-12T00:00:00Z
hierarchy_top_id	508725739
id	SPR029821274
language_de	englisch
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Methods Overall, 341 patients across three centers were treated with either nFSRT or CK-hFSRT for skull base meningioma. Treatment planning was based on computed tomography (CT) and magnetic resonance imaging (MRI) following institutional guidelines. Most nFSRT patients received 33 × 1.8 Gy, and most CK-hFSRT patients received 5 × 5 Gy. The median follow-up time was 36 months (range: 1–232 months). Results In the CK-hFSRT group, the 1-, 3-, and 10-year local control (LC) rates were 99.4, 96.8, and 80.3%, respectively. In the nFSRT group, the 1-, 3-, and 10-year LC rates were 100, 99, and 79.1%, respectively. There were no significant differences in LC rates between the nFSRT and CK-hFSRT groups (p = 0.56, hazard ratio = 0.76, 95% confidence interval, 0.3–1.9). In the CK-hFSRT group, only one case (0.49%) of severe toxicity (CTCAE 4.0 ≥ 3) was observed. In the nFSRT group, three cases (2.1%) of grade III toxicity were observed. Conclusion This analysis of pooled data from three centers showed excellent LC and low side effect rates for patients treated with CK-hFSRT or nFSRT. 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author	Alfredo, Conti
spellingShingle	Alfredo, Conti misc Meningioma misc Skull Base misc Radiosurgery misc Fractionated stereotactic radiotherapy misc Hypofractionated stereotactic radiotherapy misc CyberKnife Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis
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topic_title	Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis Meningioma (dpeaa)DE-He213 Skull Base (dpeaa)DE-He213 Radiosurgery (dpeaa)DE-He213 Fractionated stereotactic radiotherapy (dpeaa)DE-He213 Hypofractionated stereotactic radiotherapy (dpeaa)DE-He213 CyberKnife (dpeaa)DE-He213
topic	misc Meningioma misc Skull Base misc Radiosurgery misc Fractionated stereotactic radiotherapy misc Hypofractionated stereotactic radiotherapy misc CyberKnife
topic_unstemmed	misc Meningioma misc Skull Base misc Radiosurgery misc Fractionated stereotactic radiotherapy misc Hypofractionated stereotactic radiotherapy misc CyberKnife
topic_browse	misc Meningioma misc Skull Base misc Radiosurgery misc Fractionated stereotactic radiotherapy misc Hypofractionated stereotactic radiotherapy misc CyberKnife
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title	Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis
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title_full	Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis
author_sort	Alfredo, Conti
journal	Radiation oncology
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author_browse	Alfredo, Conti Carolin, Senger Güliz, Acker Anne, Kluge Antonio, Pontoriero Alberto, Cacciola Stefano, Pergolizzi Antonino, Germanò Harun, Badakhshi Markus, Kufeld Franziska, Meinert Phuong, Nguyen Franziska, Loebel Peter, Vajkoczy Volker, Budach David, Kaul
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author-letter	Alfredo, Conti
doi_str_mv	10.1186/s13014-019-1397-7
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title_sort	normofractionated stereotactic radiotherapy versus cyberknife-based hypofractionation in skull base meningioma: a german and italian pooled cohort analysis
title_auth	Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis
abstract	Background This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hFSRT) for skull base meningiomas. Methods Overall, 341 patients across three centers were treated with either nFSRT or CK-hFSRT for skull base meningioma. Treatment planning was based on computed tomography (CT) and magnetic resonance imaging (MRI) following institutional guidelines. Most nFSRT patients received 33 × 1.8 Gy, and most CK-hFSRT patients received 5 × 5 Gy. The median follow-up time was 36 months (range: 1–232 months). Results In the CK-hFSRT group, the 1-, 3-, and 10-year local control (LC) rates were 99.4, 96.8, and 80.3%, respectively. In the nFSRT group, the 1-, 3-, and 10-year LC rates were 100, 99, and 79.1%, respectively. There were no significant differences in LC rates between the nFSRT and CK-hFSRT groups (p = 0.56, hazard ratio = 0.76, 95% confidence interval, 0.3–1.9). In the CK-hFSRT group, only one case (0.49%) of severe toxicity (CTCAE 4.0 ≥ 3) was observed. In the nFSRT group, three cases (2.1%) of grade III toxicity were observed. Conclusion This analysis of pooled data from three centers showed excellent LC and low side effect rates for patients treated with CK-hFSRT or nFSRT. The efficacy, safety, and convenience of a shortened treatment period provide a compelling case for the use of CK-hFSRT in patients with moderate size skull base meningioma and provided that OAR constraints are met. © The Author(s). 2019
abstractGer	Background This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hFSRT) for skull base meningiomas. Methods Overall, 341 patients across three centers were treated with either nFSRT or CK-hFSRT for skull base meningioma. Treatment planning was based on computed tomography (CT) and magnetic resonance imaging (MRI) following institutional guidelines. Most nFSRT patients received 33 × 1.8 Gy, and most CK-hFSRT patients received 5 × 5 Gy. The median follow-up time was 36 months (range: 1–232 months). Results In the CK-hFSRT group, the 1-, 3-, and 10-year local control (LC) rates were 99.4, 96.8, and 80.3%, respectively. In the nFSRT group, the 1-, 3-, and 10-year LC rates were 100, 99, and 79.1%, respectively. There were no significant differences in LC rates between the nFSRT and CK-hFSRT groups (p = 0.56, hazard ratio = 0.76, 95% confidence interval, 0.3–1.9). In the CK-hFSRT group, only one case (0.49%) of severe toxicity (CTCAE 4.0 ≥ 3) was observed. In the nFSRT group, three cases (2.1%) of grade III toxicity were observed. Conclusion This analysis of pooled data from three centers showed excellent LC and low side effect rates for patients treated with CK-hFSRT or nFSRT. The efficacy, safety, and convenience of a shortened treatment period provide a compelling case for the use of CK-hFSRT in patients with moderate size skull base meningioma and provided that OAR constraints are met. © The Author(s). 2019
abstract_unstemmed	Background This retrospective German and Italian multicenter analysis aimed to compare the role of normofractionated stereotactic radiotherapy (nFSRT) to CyberKnife-based hypofractionated stereotactic radiotherapy (CK-hFSRT) for skull base meningiomas. Methods Overall, 341 patients across three centers were treated with either nFSRT or CK-hFSRT for skull base meningioma. Treatment planning was based on computed tomography (CT) and magnetic resonance imaging (MRI) following institutional guidelines. Most nFSRT patients received 33 × 1.8 Gy, and most CK-hFSRT patients received 5 × 5 Gy. The median follow-up time was 36 months (range: 1–232 months). Results In the CK-hFSRT group, the 1-, 3-, and 10-year local control (LC) rates were 99.4, 96.8, and 80.3%, respectively. In the nFSRT group, the 1-, 3-, and 10-year LC rates were 100, 99, and 79.1%, respectively. There were no significant differences in LC rates between the nFSRT and CK-hFSRT groups (p = 0.56, hazard ratio = 0.76, 95% confidence interval, 0.3–1.9). In the CK-hFSRT group, only one case (0.49%) of severe toxicity (CTCAE 4.0 ≥ 3) was observed. In the nFSRT group, three cases (2.1%) of grade III toxicity were observed. Conclusion This analysis of pooled data from three centers showed excellent LC and low side effect rates for patients treated with CK-hFSRT or nFSRT. The efficacy, safety, and convenience of a shortened treatment period provide a compelling case for the use of CK-hFSRT in patients with moderate size skull base meningioma and provided that OAR constraints are met. © The Author(s). 2019
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title_short	Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis
url	https://dx.doi.org/10.1186/s13014-019-1397-7
remote_bool	true
author2	Carolin, Senger Güliz, Acker Anne, Kluge Antonio, Pontoriero Alberto, Cacciola Stefano, Pergolizzi Antonino, Germanò Harun, Badakhshi Markus, Kufeld Franziska, Meinert Phuong, Nguyen Franziska, Loebel Peter, Vajkoczy Volker, Budach David, Kaul
author2Str	Carolin, Senger Güliz, Acker Anne, Kluge Antonio, Pontoriero Alberto, Cacciola Stefano, Pergolizzi Antonino, Germanò Harun, Badakhshi Markus, Kufeld Franziska, Meinert Phuong, Nguyen Franziska, Loebel Peter, Vajkoczy Volker, Budach David, Kaul
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up_date	2024-07-04T02:24:36.811Z
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Normofractionated stereotactic radiotherapy versus CyberKnife-based hypofractionation in skull base meningioma: a German and Italian pooled cohort analysis

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