The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs
Introduction The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen ($ O_{2} $) supply during acute normovolemic anemia has not been investigated so far. Methods Thirty-six anesthet...
Ausführliche Beschreibung
Autor*in: |
Pape, Andreas [verfasserIn] |
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2012 |
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© Pape et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( |
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Enthalten in: Critical care - London : BioMed Central, 1997, 16(2012), 2 vom: 30. Apr. |
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volume:16 ; year:2012 ; number:2 ; day:30 ; month:04 |
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DOI / URN: |
10.1186/cc11324 |
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SPR029841607 |
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245 | 1 | 4 | |a The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs |
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520 | |a Introduction The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen ($ O_{2} $) supply during acute normovolemic anemia has not been investigated so far. Methods Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration ($ Hb_{crit} $). $ Hb_{crit} $ was defined as the Hb-concentration corresponding with the onset of supply-dependency of total body $ O_{2} $-consumption ($ VO_{2} $). The hemodilution protocol was randomly performed with either tetrastarch (6% HES 130/0.4, TS-group, n = 9), gelatin (3.5% urea-crosslinked polygeline, GEL-group, n = 9), hetastarch (6% HES 450/0.7, HS-group, n = 9) or Ringer's solution (RS-group, n = 9). The primary endpoint was the dimension of $ Hb_{crit} $, secondary endpoints were parameters of central hemodynamics, $ O_{2} $ transport and tissue oxygenation. Results In each animal, normovolemia was maintained throughout the protocol. $ Hb_{crit} $ was met at 3.7 ± 0.6 g/dl (RS), 3.0 ± 0.6 g/dl (HS P < 0.05 vs. RS), 2.7 ± 0.6 g/dl (GEL, P < 0.05 vs. RS) and 2.1 ± 0.4 g/dl (TS, P < 0.05 vs. GEL, HS and RS). Hemodilution with RS resulted in a significant increase of extravascular lung water index (EVLWI) and a decrease of arterial oxygen partial pressure ($ paO_{2} $), and $ O_{2} $ extraction ratio was increased, when animals of the TS-, GEL- and HS-groups met their individual $ Hb_{crit} $. Conclusions The choice of the intravenous fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function. | ||
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700 | 1 | |a Kutschker, Saskia |4 aut | |
700 | 1 | |a Kertscho, Harry |4 aut | |
700 | 1 | |a Stein, Peter |4 aut | |
700 | 1 | |a Horn, Oliver |4 aut | |
700 | 1 | |a Lossen, Mischa |4 aut | |
700 | 1 | |a Zwissler, Bernhard |4 aut | |
700 | 1 | |a Habler, Oliver |4 aut | |
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10.1186/cc11324 doi (DE-627)SPR029841607 (SPR)cc11324-e DE-627 ger DE-627 rakwb eng Pape, Andreas verfasserin aut The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pape et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Introduction The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen ($ O_{2} $) supply during acute normovolemic anemia has not been investigated so far. Methods Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration ($ Hb_{crit} $). $ Hb_{crit} $ was defined as the Hb-concentration corresponding with the onset of supply-dependency of total body $ O_{2} $-consumption ($ VO_{2} $). The hemodilution protocol was randomly performed with either tetrastarch (6% HES 130/0.4, TS-group, n = 9), gelatin (3.5% urea-crosslinked polygeline, GEL-group, n = 9), hetastarch (6% HES 450/0.7, HS-group, n = 9) or Ringer's solution (RS-group, n = 9). The primary endpoint was the dimension of $ Hb_{crit} $, secondary endpoints were parameters of central hemodynamics, $ O_{2} $ transport and tissue oxygenation. Results In each animal, normovolemia was maintained throughout the protocol. $ Hb_{crit} $ was met at 3.7 ± 0.6 g/dl (RS), 3.0 ± 0.6 g/dl (HS P < 0.05 vs. RS), 2.7 ± 0.6 g/dl (GEL, P < 0.05 vs. RS) and 2.1 ± 0.4 g/dl (TS, P < 0.05 vs. GEL, HS and RS). Hemodilution with RS resulted in a significant increase of extravascular lung water index (EVLWI) and a decrease of arterial oxygen partial pressure ($ paO_{2} $), and $ O_{2} $ extraction ratio was increased, when animals of the TS-, GEL- and HS-groups met their individual $ Hb_{crit} $. Conclusions The choice of the intravenous fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function. Mean Arterial Pressure (dpeaa)DE-He213 Stroke Volume Variation (dpeaa)DE-He213 Stroke Volume Index (dpeaa)DE-He213 Plasma Viscosity (dpeaa)DE-He213 Circulate Blood Volume (dpeaa)DE-He213 Kutschker, Saskia aut Kertscho, Harry aut Stein, Peter aut Horn, Oliver aut Lossen, Mischa aut Zwissler, Bernhard aut Habler, Oliver aut Enthalten in Critical care London : BioMed Central, 1997 16(2012), 2 vom: 30. Apr. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:16 year:2012 number:2 day:30 month:04 https://dx.doi.org/10.1186/cc11324 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2012 2 30 04 |
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10.1186/cc11324 doi (DE-627)SPR029841607 (SPR)cc11324-e DE-627 ger DE-627 rakwb eng Pape, Andreas verfasserin aut The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pape et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Introduction The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen ($ O_{2} $) supply during acute normovolemic anemia has not been investigated so far. Methods Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration ($ Hb_{crit} $). $ Hb_{crit} $ was defined as the Hb-concentration corresponding with the onset of supply-dependency of total body $ O_{2} $-consumption ($ VO_{2} $). The hemodilution protocol was randomly performed with either tetrastarch (6% HES 130/0.4, TS-group, n = 9), gelatin (3.5% urea-crosslinked polygeline, GEL-group, n = 9), hetastarch (6% HES 450/0.7, HS-group, n = 9) or Ringer's solution (RS-group, n = 9). The primary endpoint was the dimension of $ Hb_{crit} $, secondary endpoints were parameters of central hemodynamics, $ O_{2} $ transport and tissue oxygenation. Results In each animal, normovolemia was maintained throughout the protocol. $ Hb_{crit} $ was met at 3.7 ± 0.6 g/dl (RS), 3.0 ± 0.6 g/dl (HS P < 0.05 vs. RS), 2.7 ± 0.6 g/dl (GEL, P < 0.05 vs. RS) and 2.1 ± 0.4 g/dl (TS, P < 0.05 vs. GEL, HS and RS). Hemodilution with RS resulted in a significant increase of extravascular lung water index (EVLWI) and a decrease of arterial oxygen partial pressure ($ paO_{2} $), and $ O_{2} $ extraction ratio was increased, when animals of the TS-, GEL- and HS-groups met their individual $ Hb_{crit} $. Conclusions The choice of the intravenous fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function. Mean Arterial Pressure (dpeaa)DE-He213 Stroke Volume Variation (dpeaa)DE-He213 Stroke Volume Index (dpeaa)DE-He213 Plasma Viscosity (dpeaa)DE-He213 Circulate Blood Volume (dpeaa)DE-He213 Kutschker, Saskia aut Kertscho, Harry aut Stein, Peter aut Horn, Oliver aut Lossen, Mischa aut Zwissler, Bernhard aut Habler, Oliver aut Enthalten in Critical care London : BioMed Central, 1997 16(2012), 2 vom: 30. Apr. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:16 year:2012 number:2 day:30 month:04 https://dx.doi.org/10.1186/cc11324 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2012 2 30 04 |
allfields_unstemmed |
10.1186/cc11324 doi (DE-627)SPR029841607 (SPR)cc11324-e DE-627 ger DE-627 rakwb eng Pape, Andreas verfasserin aut The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pape et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Introduction The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen ($ O_{2} $) supply during acute normovolemic anemia has not been investigated so far. Methods Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration ($ Hb_{crit} $). $ Hb_{crit} $ was defined as the Hb-concentration corresponding with the onset of supply-dependency of total body $ O_{2} $-consumption ($ VO_{2} $). The hemodilution protocol was randomly performed with either tetrastarch (6% HES 130/0.4, TS-group, n = 9), gelatin (3.5% urea-crosslinked polygeline, GEL-group, n = 9), hetastarch (6% HES 450/0.7, HS-group, n = 9) or Ringer's solution (RS-group, n = 9). The primary endpoint was the dimension of $ Hb_{crit} $, secondary endpoints were parameters of central hemodynamics, $ O_{2} $ transport and tissue oxygenation. Results In each animal, normovolemia was maintained throughout the protocol. $ Hb_{crit} $ was met at 3.7 ± 0.6 g/dl (RS), 3.0 ± 0.6 g/dl (HS P < 0.05 vs. RS), 2.7 ± 0.6 g/dl (GEL, P < 0.05 vs. RS) and 2.1 ± 0.4 g/dl (TS, P < 0.05 vs. GEL, HS and RS). Hemodilution with RS resulted in a significant increase of extravascular lung water index (EVLWI) and a decrease of arterial oxygen partial pressure ($ paO_{2} $), and $ O_{2} $ extraction ratio was increased, when animals of the TS-, GEL- and HS-groups met their individual $ Hb_{crit} $. Conclusions The choice of the intravenous fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function. Mean Arterial Pressure (dpeaa)DE-He213 Stroke Volume Variation (dpeaa)DE-He213 Stroke Volume Index (dpeaa)DE-He213 Plasma Viscosity (dpeaa)DE-He213 Circulate Blood Volume (dpeaa)DE-He213 Kutschker, Saskia aut Kertscho, Harry aut Stein, Peter aut Horn, Oliver aut Lossen, Mischa aut Zwissler, Bernhard aut Habler, Oliver aut Enthalten in Critical care London : BioMed Central, 1997 16(2012), 2 vom: 30. Apr. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:16 year:2012 number:2 day:30 month:04 https://dx.doi.org/10.1186/cc11324 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2012 2 30 04 |
allfieldsGer |
10.1186/cc11324 doi (DE-627)SPR029841607 (SPR)cc11324-e DE-627 ger DE-627 rakwb eng Pape, Andreas verfasserin aut The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pape et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Introduction The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen ($ O_{2} $) supply during acute normovolemic anemia has not been investigated so far. Methods Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration ($ Hb_{crit} $). $ Hb_{crit} $ was defined as the Hb-concentration corresponding with the onset of supply-dependency of total body $ O_{2} $-consumption ($ VO_{2} $). The hemodilution protocol was randomly performed with either tetrastarch (6% HES 130/0.4, TS-group, n = 9), gelatin (3.5% urea-crosslinked polygeline, GEL-group, n = 9), hetastarch (6% HES 450/0.7, HS-group, n = 9) or Ringer's solution (RS-group, n = 9). The primary endpoint was the dimension of $ Hb_{crit} $, secondary endpoints were parameters of central hemodynamics, $ O_{2} $ transport and tissue oxygenation. Results In each animal, normovolemia was maintained throughout the protocol. $ Hb_{crit} $ was met at 3.7 ± 0.6 g/dl (RS), 3.0 ± 0.6 g/dl (HS P < 0.05 vs. RS), 2.7 ± 0.6 g/dl (GEL, P < 0.05 vs. RS) and 2.1 ± 0.4 g/dl (TS, P < 0.05 vs. GEL, HS and RS). Hemodilution with RS resulted in a significant increase of extravascular lung water index (EVLWI) and a decrease of arterial oxygen partial pressure ($ paO_{2} $), and $ O_{2} $ extraction ratio was increased, when animals of the TS-, GEL- and HS-groups met their individual $ Hb_{crit} $. Conclusions The choice of the intravenous fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function. Mean Arterial Pressure (dpeaa)DE-He213 Stroke Volume Variation (dpeaa)DE-He213 Stroke Volume Index (dpeaa)DE-He213 Plasma Viscosity (dpeaa)DE-He213 Circulate Blood Volume (dpeaa)DE-He213 Kutschker, Saskia aut Kertscho, Harry aut Stein, Peter aut Horn, Oliver aut Lossen, Mischa aut Zwissler, Bernhard aut Habler, Oliver aut Enthalten in Critical care London : BioMed Central, 1997 16(2012), 2 vom: 30. Apr. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:16 year:2012 number:2 day:30 month:04 https://dx.doi.org/10.1186/cc11324 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2012 2 30 04 |
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10.1186/cc11324 doi (DE-627)SPR029841607 (SPR)cc11324-e DE-627 ger DE-627 rakwb eng Pape, Andreas verfasserin aut The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Pape et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Introduction The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen ($ O_{2} $) supply during acute normovolemic anemia has not been investigated so far. Methods Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration ($ Hb_{crit} $). $ Hb_{crit} $ was defined as the Hb-concentration corresponding with the onset of supply-dependency of total body $ O_{2} $-consumption ($ VO_{2} $). The hemodilution protocol was randomly performed with either tetrastarch (6% HES 130/0.4, TS-group, n = 9), gelatin (3.5% urea-crosslinked polygeline, GEL-group, n = 9), hetastarch (6% HES 450/0.7, HS-group, n = 9) or Ringer's solution (RS-group, n = 9). The primary endpoint was the dimension of $ Hb_{crit} $, secondary endpoints were parameters of central hemodynamics, $ O_{2} $ transport and tissue oxygenation. Results In each animal, normovolemia was maintained throughout the protocol. $ Hb_{crit} $ was met at 3.7 ± 0.6 g/dl (RS), 3.0 ± 0.6 g/dl (HS P < 0.05 vs. RS), 2.7 ± 0.6 g/dl (GEL, P < 0.05 vs. RS) and 2.1 ± 0.4 g/dl (TS, P < 0.05 vs. GEL, HS and RS). Hemodilution with RS resulted in a significant increase of extravascular lung water index (EVLWI) and a decrease of arterial oxygen partial pressure ($ paO_{2} $), and $ O_{2} $ extraction ratio was increased, when animals of the TS-, GEL- and HS-groups met their individual $ Hb_{crit} $. Conclusions The choice of the intravenous fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function. Mean Arterial Pressure (dpeaa)DE-He213 Stroke Volume Variation (dpeaa)DE-He213 Stroke Volume Index (dpeaa)DE-He213 Plasma Viscosity (dpeaa)DE-He213 Circulate Blood Volume (dpeaa)DE-He213 Kutschker, Saskia aut Kertscho, Harry aut Stein, Peter aut Horn, Oliver aut Lossen, Mischa aut Zwissler, Bernhard aut Habler, Oliver aut Enthalten in Critical care London : BioMed Central, 1997 16(2012), 2 vom: 30. Apr. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:16 year:2012 number:2 day:30 month:04 https://dx.doi.org/10.1186/cc11324 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2012 2 30 04 |
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The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs |
abstract |
Introduction The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen ($ O_{2} $) supply during acute normovolemic anemia has not been investigated so far. Methods Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration ($ Hb_{crit} $). $ Hb_{crit} $ was defined as the Hb-concentration corresponding with the onset of supply-dependency of total body $ O_{2} $-consumption ($ VO_{2} $). The hemodilution protocol was randomly performed with either tetrastarch (6% HES 130/0.4, TS-group, n = 9), gelatin (3.5% urea-crosslinked polygeline, GEL-group, n = 9), hetastarch (6% HES 450/0.7, HS-group, n = 9) or Ringer's solution (RS-group, n = 9). The primary endpoint was the dimension of $ Hb_{crit} $, secondary endpoints were parameters of central hemodynamics, $ O_{2} $ transport and tissue oxygenation. Results In each animal, normovolemia was maintained throughout the protocol. $ Hb_{crit} $ was met at 3.7 ± 0.6 g/dl (RS), 3.0 ± 0.6 g/dl (HS P < 0.05 vs. RS), 2.7 ± 0.6 g/dl (GEL, P < 0.05 vs. RS) and 2.1 ± 0.4 g/dl (TS, P < 0.05 vs. GEL, HS and RS). Hemodilution with RS resulted in a significant increase of extravascular lung water index (EVLWI) and a decrease of arterial oxygen partial pressure ($ paO_{2} $), and $ O_{2} $ extraction ratio was increased, when animals of the TS-, GEL- and HS-groups met their individual $ Hb_{crit} $. Conclusions The choice of the intravenous fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function. © Pape et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( |
abstractGer |
Introduction The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen ($ O_{2} $) supply during acute normovolemic anemia has not been investigated so far. Methods Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration ($ Hb_{crit} $). $ Hb_{crit} $ was defined as the Hb-concentration corresponding with the onset of supply-dependency of total body $ O_{2} $-consumption ($ VO_{2} $). The hemodilution protocol was randomly performed with either tetrastarch (6% HES 130/0.4, TS-group, n = 9), gelatin (3.5% urea-crosslinked polygeline, GEL-group, n = 9), hetastarch (6% HES 450/0.7, HS-group, n = 9) or Ringer's solution (RS-group, n = 9). The primary endpoint was the dimension of $ Hb_{crit} $, secondary endpoints were parameters of central hemodynamics, $ O_{2} $ transport and tissue oxygenation. Results In each animal, normovolemia was maintained throughout the protocol. $ Hb_{crit} $ was met at 3.7 ± 0.6 g/dl (RS), 3.0 ± 0.6 g/dl (HS P < 0.05 vs. RS), 2.7 ± 0.6 g/dl (GEL, P < 0.05 vs. RS) and 2.1 ± 0.4 g/dl (TS, P < 0.05 vs. GEL, HS and RS). Hemodilution with RS resulted in a significant increase of extravascular lung water index (EVLWI) and a decrease of arterial oxygen partial pressure ($ paO_{2} $), and $ O_{2} $ extraction ratio was increased, when animals of the TS-, GEL- and HS-groups met their individual $ Hb_{crit} $. Conclusions The choice of the intravenous fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function. © Pape et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( |
abstract_unstemmed |
Introduction The correction of hypovolemia with acellular fluids results in acute normovolemic anemia. Whether the choice of the infusion fluid has an impact on the maintenance of oxygen ($ O_{2} $) supply during acute normovolemic anemia has not been investigated so far. Methods Thirty-six anesthetized and mechanically ventilated pigs were hemodiluted to their physiological limit of anemia tolerance, reflected by the individual critical hemoglobin concentration ($ Hb_{crit} $). $ Hb_{crit} $ was defined as the Hb-concentration corresponding with the onset of supply-dependency of total body $ O_{2} $-consumption ($ VO_{2} $). The hemodilution protocol was randomly performed with either tetrastarch (6% HES 130/0.4, TS-group, n = 9), gelatin (3.5% urea-crosslinked polygeline, GEL-group, n = 9), hetastarch (6% HES 450/0.7, HS-group, n = 9) or Ringer's solution (RS-group, n = 9). The primary endpoint was the dimension of $ Hb_{crit} $, secondary endpoints were parameters of central hemodynamics, $ O_{2} $ transport and tissue oxygenation. Results In each animal, normovolemia was maintained throughout the protocol. $ Hb_{crit} $ was met at 3.7 ± 0.6 g/dl (RS), 3.0 ± 0.6 g/dl (HS P < 0.05 vs. RS), 2.7 ± 0.6 g/dl (GEL, P < 0.05 vs. RS) and 2.1 ± 0.4 g/dl (TS, P < 0.05 vs. GEL, HS and RS). Hemodilution with RS resulted in a significant increase of extravascular lung water index (EVLWI) and a decrease of arterial oxygen partial pressure ($ paO_{2} $), and $ O_{2} $ extraction ratio was increased, when animals of the TS-, GEL- and HS-groups met their individual $ Hb_{crit} $. Conclusions The choice of the intravenous fluid has an impact on the tolerance of acute normovolemic anemia induced by acellular volume replacement. Third-generation tetrastarch preparations (e.g., HES 130/0.4) appear most advantageous regarding maintenance of tissue oxygenation during progressive anemia. The underlying mechanism includes a lower degree of extravasation and favourable effects on microcirculatory function. © Pape et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( |
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The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs |
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Kutschker, Saskia Kertscho, Harry Stein, Peter Horn, Oliver Lossen, Mischa Zwissler, Bernhard Habler, Oliver |
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