Subclinical AKI is still AKI

Abstract The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when mor...
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Gespeichert in:

Autor*in:	Ronco, Claudio [verfasserIn] Kellum, John A Haase, Michael

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Acute Kidney Injury Tubular Damage Filtration Function Acute Kidney Injury Network Acute Kidney Injury Diagnosis

Anmerkung:	© BioMed Central Ltd 2012

Übergeordnetes Werk:	Enthalten in: Critical care - London : BioMed Central, 1997, 16(2012), 3 vom: 21. Juni
Übergeordnetes Werk:	volume:16 ; year:2012 ; number:3 ; day:21 ; month:06

Links:	Volltext

DOI / URN:	10.1186/cc11240

Katalog-ID:	SPR029842298

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allfields	10.1186/cc11240 doi (DE-627)SPR029842298 (SPR)cc11240-e DE-627 ger DE-627 rakwb eng Ronco, Claudio verfasserin aut Subclinical AKI is still AKI 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2012 Abstract The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when more than 50% of the renal mass is compromised. Recent AKI classifications include even slight changes in serum creatinine, acknowledging that this condition is associated with worse outcomes. This, however, still represents a functional criterion for AKI and implies a glomerular filtration rate alteration that may be a late phenomenon in the time course of the syndrome. An early diagnosis of AKI by using tubular damage biomarkers preceding filtration function loss is possible today. Some studies have shown evidence that there is an additional value of new biomarkers not only because they allow a diagnosis to be made earlier but also because they allow a kidney injury to be diagnosed even in the absence of subsequent dysfunction. Only recently, tubular damage without glomerular function loss was demonstrated to be associated with worse renal and overall outcomes. For this condition, the term 'subclinical' AKI has been introduced, challenging the traditional view that a kidney problem is clinically relevant, only when a loss of filtration function becomes apparent. A new domain of AKI diagnosis could then include functional criteria and damage criteria. This may have an impact on the epidemiology, prevention, and management of AKI. Acute Kidney Injury (dpeaa)DE-He213 Tubular Damage (dpeaa)DE-He213 Filtration Function (dpeaa)DE-He213 Acute Kidney Injury Network (dpeaa)DE-He213 Acute Kidney Injury Diagnosis (dpeaa)DE-He213 Kellum, John A aut Haase, Michael aut Enthalten in Critical care London : BioMed Central, 1997 16(2012), 3 vom: 21. Juni (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:16 year:2012 number:3 day:21 month:06 https://dx.doi.org/10.1186/cc11240 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2012 3 21 06
spelling	10.1186/cc11240 doi (DE-627)SPR029842298 (SPR)cc11240-e DE-627 ger DE-627 rakwb eng Ronco, Claudio verfasserin aut Subclinical AKI is still AKI 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2012 Abstract The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when more than 50% of the renal mass is compromised. Recent AKI classifications include even slight changes in serum creatinine, acknowledging that this condition is associated with worse outcomes. This, however, still represents a functional criterion for AKI and implies a glomerular filtration rate alteration that may be a late phenomenon in the time course of the syndrome. An early diagnosis of AKI by using tubular damage biomarkers preceding filtration function loss is possible today. Some studies have shown evidence that there is an additional value of new biomarkers not only because they allow a diagnosis to be made earlier but also because they allow a kidney injury to be diagnosed even in the absence of subsequent dysfunction. Only recently, tubular damage without glomerular function loss was demonstrated to be associated with worse renal and overall outcomes. For this condition, the term 'subclinical' AKI has been introduced, challenging the traditional view that a kidney problem is clinically relevant, only when a loss of filtration function becomes apparent. A new domain of AKI diagnosis could then include functional criteria and damage criteria. This may have an impact on the epidemiology, prevention, and management of AKI. Acute Kidney Injury (dpeaa)DE-He213 Tubular Damage (dpeaa)DE-He213 Filtration Function (dpeaa)DE-He213 Acute Kidney Injury Network (dpeaa)DE-He213 Acute Kidney Injury Diagnosis (dpeaa)DE-He213 Kellum, John A aut Haase, Michael aut Enthalten in Critical care London : BioMed Central, 1997 16(2012), 3 vom: 21. Juni (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:16 year:2012 number:3 day:21 month:06 https://dx.doi.org/10.1186/cc11240 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2012 3 21 06
allfields_unstemmed	10.1186/cc11240 doi (DE-627)SPR029842298 (SPR)cc11240-e DE-627 ger DE-627 rakwb eng Ronco, Claudio verfasserin aut Subclinical AKI is still AKI 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2012 Abstract The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when more than 50% of the renal mass is compromised. Recent AKI classifications include even slight changes in serum creatinine, acknowledging that this condition is associated with worse outcomes. This, however, still represents a functional criterion for AKI and implies a glomerular filtration rate alteration that may be a late phenomenon in the time course of the syndrome. An early diagnosis of AKI by using tubular damage biomarkers preceding filtration function loss is possible today. Some studies have shown evidence that there is an additional value of new biomarkers not only because they allow a diagnosis to be made earlier but also because they allow a kidney injury to be diagnosed even in the absence of subsequent dysfunction. Only recently, tubular damage without glomerular function loss was demonstrated to be associated with worse renal and overall outcomes. For this condition, the term 'subclinical' AKI has been introduced, challenging the traditional view that a kidney problem is clinically relevant, only when a loss of filtration function becomes apparent. A new domain of AKI diagnosis could then include functional criteria and damage criteria. This may have an impact on the epidemiology, prevention, and management of AKI. Acute Kidney Injury (dpeaa)DE-He213 Tubular Damage (dpeaa)DE-He213 Filtration Function (dpeaa)DE-He213 Acute Kidney Injury Network (dpeaa)DE-He213 Acute Kidney Injury Diagnosis (dpeaa)DE-He213 Kellum, John A aut Haase, Michael aut Enthalten in Critical care London : BioMed Central, 1997 16(2012), 3 vom: 21. Juni (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:16 year:2012 number:3 day:21 month:06 https://dx.doi.org/10.1186/cc11240 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2012 3 21 06
allfieldsGer	10.1186/cc11240 doi (DE-627)SPR029842298 (SPR)cc11240-e DE-627 ger DE-627 rakwb eng Ronco, Claudio verfasserin aut Subclinical AKI is still AKI 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2012 Abstract The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when more than 50% of the renal mass is compromised. Recent AKI classifications include even slight changes in serum creatinine, acknowledging that this condition is associated with worse outcomes. This, however, still represents a functional criterion for AKI and implies a glomerular filtration rate alteration that may be a late phenomenon in the time course of the syndrome. An early diagnosis of AKI by using tubular damage biomarkers preceding filtration function loss is possible today. Some studies have shown evidence that there is an additional value of new biomarkers not only because they allow a diagnosis to be made earlier but also because they allow a kidney injury to be diagnosed even in the absence of subsequent dysfunction. Only recently, tubular damage without glomerular function loss was demonstrated to be associated with worse renal and overall outcomes. For this condition, the term 'subclinical' AKI has been introduced, challenging the traditional view that a kidney problem is clinically relevant, only when a loss of filtration function becomes apparent. A new domain of AKI diagnosis could then include functional criteria and damage criteria. This may have an impact on the epidemiology, prevention, and management of AKI. Acute Kidney Injury (dpeaa)DE-He213 Tubular Damage (dpeaa)DE-He213 Filtration Function (dpeaa)DE-He213 Acute Kidney Injury Network (dpeaa)DE-He213 Acute Kidney Injury Diagnosis (dpeaa)DE-He213 Kellum, John A aut Haase, Michael aut Enthalten in Critical care London : BioMed Central, 1997 16(2012), 3 vom: 21. Juni (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:16 year:2012 number:3 day:21 month:06 https://dx.doi.org/10.1186/cc11240 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2012 3 21 06
allfieldsSound	10.1186/cc11240 doi (DE-627)SPR029842298 (SPR)cc11240-e DE-627 ger DE-627 rakwb eng Ronco, Claudio verfasserin aut Subclinical AKI is still AKI 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2012 Abstract The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when more than 50% of the renal mass is compromised. Recent AKI classifications include even slight changes in serum creatinine, acknowledging that this condition is associated with worse outcomes. This, however, still represents a functional criterion for AKI and implies a glomerular filtration rate alteration that may be a late phenomenon in the time course of the syndrome. An early diagnosis of AKI by using tubular damage biomarkers preceding filtration function loss is possible today. Some studies have shown evidence that there is an additional value of new biomarkers not only because they allow a diagnosis to be made earlier but also because they allow a kidney injury to be diagnosed even in the absence of subsequent dysfunction. Only recently, tubular damage without glomerular function loss was demonstrated to be associated with worse renal and overall outcomes. For this condition, the term 'subclinical' AKI has been introduced, challenging the traditional view that a kidney problem is clinically relevant, only when a loss of filtration function becomes apparent. A new domain of AKI diagnosis could then include functional criteria and damage criteria. This may have an impact on the epidemiology, prevention, and management of AKI. Acute Kidney Injury (dpeaa)DE-He213 Tubular Damage (dpeaa)DE-He213 Filtration Function (dpeaa)DE-He213 Acute Kidney Injury Network (dpeaa)DE-He213 Acute Kidney Injury Diagnosis (dpeaa)DE-He213 Kellum, John A aut Haase, Michael aut Enthalten in Critical care London : BioMed Central, 1997 16(2012), 3 vom: 21. Juni (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:16 year:2012 number:3 day:21 month:06 https://dx.doi.org/10.1186/cc11240 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2012 3 21 06
language	English
source	Enthalten in Critical care 16(2012), 3 vom: 21. Juni volume:16 year:2012 number:3 day:21 month:06
sourceStr	Enthalten in Critical care 16(2012), 3 vom: 21. Juni volume:16 year:2012 number:3 day:21 month:06
format_phy_str_mv	Article
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topic_facet	Acute Kidney Injury Tubular Damage Filtration Function Acute Kidney Injury Network Acute Kidney Injury Diagnosis
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authorswithroles_txt_mv	Ronco, Claudio @@aut@@ Kellum, John A @@aut@@ Haase, Michael @@aut@@
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spellingShingle	Ronco, Claudio misc Acute Kidney Injury misc Tubular Damage misc Filtration Function misc Acute Kidney Injury Network misc Acute Kidney Injury Diagnosis Subclinical AKI is still AKI
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topic_title	Subclinical AKI is still AKI Acute Kidney Injury (dpeaa)DE-He213 Tubular Damage (dpeaa)DE-He213 Filtration Function (dpeaa)DE-He213 Acute Kidney Injury Network (dpeaa)DE-He213 Acute Kidney Injury Diagnosis (dpeaa)DE-He213
topic	misc Acute Kidney Injury misc Tubular Damage misc Filtration Function misc Acute Kidney Injury Network misc Acute Kidney Injury Diagnosis
topic_unstemmed	misc Acute Kidney Injury misc Tubular Damage misc Filtration Function misc Acute Kidney Injury Network misc Acute Kidney Injury Diagnosis
topic_browse	misc Acute Kidney Injury misc Tubular Damage misc Filtration Function misc Acute Kidney Injury Network misc Acute Kidney Injury Diagnosis
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title	Subclinical AKI is still AKI
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title_full	Subclinical AKI is still AKI
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title_sort	subclinical aki is still aki
title_auth	Subclinical AKI is still AKI
abstract	Abstract The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when more than 50% of the renal mass is compromised. Recent AKI classifications include even slight changes in serum creatinine, acknowledging that this condition is associated with worse outcomes. This, however, still represents a functional criterion for AKI and implies a glomerular filtration rate alteration that may be a late phenomenon in the time course of the syndrome. An early diagnosis of AKI by using tubular damage biomarkers preceding filtration function loss is possible today. Some studies have shown evidence that there is an additional value of new biomarkers not only because they allow a diagnosis to be made earlier but also because they allow a kidney injury to be diagnosed even in the absence of subsequent dysfunction. Only recently, tubular damage without glomerular function loss was demonstrated to be associated with worse renal and overall outcomes. For this condition, the term 'subclinical' AKI has been introduced, challenging the traditional view that a kidney problem is clinically relevant, only when a loss of filtration function becomes apparent. A new domain of AKI diagnosis could then include functional criteria and damage criteria. This may have an impact on the epidemiology, prevention, and management of AKI. © BioMed Central Ltd 2012
abstractGer	Abstract The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when more than 50% of the renal mass is compromised. Recent AKI classifications include even slight changes in serum creatinine, acknowledging that this condition is associated with worse outcomes. This, however, still represents a functional criterion for AKI and implies a glomerular filtration rate alteration that may be a late phenomenon in the time course of the syndrome. An early diagnosis of AKI by using tubular damage biomarkers preceding filtration function loss is possible today. Some studies have shown evidence that there is an additional value of new biomarkers not only because they allow a diagnosis to be made earlier but also because they allow a kidney injury to be diagnosed even in the absence of subsequent dysfunction. Only recently, tubular damage without glomerular function loss was demonstrated to be associated with worse renal and overall outcomes. For this condition, the term 'subclinical' AKI has been introduced, challenging the traditional view that a kidney problem is clinically relevant, only when a loss of filtration function becomes apparent. A new domain of AKI diagnosis could then include functional criteria and damage criteria. This may have an impact on the epidemiology, prevention, and management of AKI. © BioMed Central Ltd 2012
abstract_unstemmed	Abstract The concept of acute kidney syndromes has shifted in recent years from acute renal failure to acute kidney injury (AKI). AKI implies injury or damage but not necessarily dysfunction. The human kidney has an important glomerular function reserve, and dysfunction becomes evident only when more than 50% of the renal mass is compromised. Recent AKI classifications include even slight changes in serum creatinine, acknowledging that this condition is associated with worse outcomes. This, however, still represents a functional criterion for AKI and implies a glomerular filtration rate alteration that may be a late phenomenon in the time course of the syndrome. An early diagnosis of AKI by using tubular damage biomarkers preceding filtration function loss is possible today. Some studies have shown evidence that there is an additional value of new biomarkers not only because they allow a diagnosis to be made earlier but also because they allow a kidney injury to be diagnosed even in the absence of subsequent dysfunction. Only recently, tubular damage without glomerular function loss was demonstrated to be associated with worse renal and overall outcomes. For this condition, the term 'subclinical' AKI has been introduced, challenging the traditional view that a kidney problem is clinically relevant, only when a loss of filtration function becomes apparent. A new domain of AKI diagnosis could then include functional criteria and damage criteria. This may have an impact on the epidemiology, prevention, and management of AKI. © BioMed Central Ltd 2012
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title_short	Subclinical AKI is still AKI
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