Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges

Abstract Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal. There is a growing body of evidence that a younger patient with a low to moderate degree of organ dysfunction typic...
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Gespeichert in:

Autor*in:	Carlier, Mieke [verfasserIn] De Waele, Jan J

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Creatinine Clearance Cardiac Index Glycopeptide Sequential Organ Failure Assessment Therapeutic Drug Monitoring

Anmerkung:	© BioMed Central Ltd 2013

Übergeordnetes Werk:	Enthalten in: Critical care - London : BioMed Central, 1997, 17(2013), 2 vom: 16. Apr.
Übergeordnetes Werk:	volume:17 ; year:2013 ; number:2 ; day:16 ; month:04

Links:	Volltext

DOI / URN:	10.1186/cc12573

Katalog-ID:	SPR02985430X

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allfields	10.1186/cc12573 doi (DE-627)SPR02985430X (SPR)cc12573-e DE-627 ger DE-627 rakwb eng Carlier, Mieke verfasserin aut Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal. There is a growing body of evidence that a younger patient with a low to moderate degree of organ dysfunction typically is at risk of ARC and therefore decreased exposure to renally eliminated antibiotics. Mechanisms potentially involved, such as increased cardiac output, have, however, not been identified as appropriate surrogate markers, and the search for suitable alternatives to readily identify patients with ARC continues. Creatinine Clearance (dpeaa)DE-He213 Cardiac Index (dpeaa)DE-He213 Glycopeptide (dpeaa)DE-He213 Sequential Organ Failure Assessment (dpeaa)DE-He213 Therapeutic Drug Monitoring (dpeaa)DE-He213 De Waele, Jan J aut Enthalten in Critical care London : BioMed Central, 1997 17(2013), 2 vom: 16. Apr. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:17 year:2013 number:2 day:16 month:04 https://dx.doi.org/10.1186/cc12573 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2013 2 16 04
spelling	10.1186/cc12573 doi (DE-627)SPR02985430X (SPR)cc12573-e DE-627 ger DE-627 rakwb eng Carlier, Mieke verfasserin aut Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal. There is a growing body of evidence that a younger patient with a low to moderate degree of organ dysfunction typically is at risk of ARC and therefore decreased exposure to renally eliminated antibiotics. Mechanisms potentially involved, such as increased cardiac output, have, however, not been identified as appropriate surrogate markers, and the search for suitable alternatives to readily identify patients with ARC continues. Creatinine Clearance (dpeaa)DE-He213 Cardiac Index (dpeaa)DE-He213 Glycopeptide (dpeaa)DE-He213 Sequential Organ Failure Assessment (dpeaa)DE-He213 Therapeutic Drug Monitoring (dpeaa)DE-He213 De Waele, Jan J aut Enthalten in Critical care London : BioMed Central, 1997 17(2013), 2 vom: 16. Apr. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:17 year:2013 number:2 day:16 month:04 https://dx.doi.org/10.1186/cc12573 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2013 2 16 04
allfields_unstemmed	10.1186/cc12573 doi (DE-627)SPR02985430X (SPR)cc12573-e DE-627 ger DE-627 rakwb eng Carlier, Mieke verfasserin aut Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal. There is a growing body of evidence that a younger patient with a low to moderate degree of organ dysfunction typically is at risk of ARC and therefore decreased exposure to renally eliminated antibiotics. Mechanisms potentially involved, such as increased cardiac output, have, however, not been identified as appropriate surrogate markers, and the search for suitable alternatives to readily identify patients with ARC continues. Creatinine Clearance (dpeaa)DE-He213 Cardiac Index (dpeaa)DE-He213 Glycopeptide (dpeaa)DE-He213 Sequential Organ Failure Assessment (dpeaa)DE-He213 Therapeutic Drug Monitoring (dpeaa)DE-He213 De Waele, Jan J aut Enthalten in Critical care London : BioMed Central, 1997 17(2013), 2 vom: 16. Apr. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:17 year:2013 number:2 day:16 month:04 https://dx.doi.org/10.1186/cc12573 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2013 2 16 04
allfieldsGer	10.1186/cc12573 doi (DE-627)SPR02985430X (SPR)cc12573-e DE-627 ger DE-627 rakwb eng Carlier, Mieke verfasserin aut Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal. There is a growing body of evidence that a younger patient with a low to moderate degree of organ dysfunction typically is at risk of ARC and therefore decreased exposure to renally eliminated antibiotics. Mechanisms potentially involved, such as increased cardiac output, have, however, not been identified as appropriate surrogate markers, and the search for suitable alternatives to readily identify patients with ARC continues. Creatinine Clearance (dpeaa)DE-He213 Cardiac Index (dpeaa)DE-He213 Glycopeptide (dpeaa)DE-He213 Sequential Organ Failure Assessment (dpeaa)DE-He213 Therapeutic Drug Monitoring (dpeaa)DE-He213 De Waele, Jan J aut Enthalten in Critical care London : BioMed Central, 1997 17(2013), 2 vom: 16. Apr. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:17 year:2013 number:2 day:16 month:04 https://dx.doi.org/10.1186/cc12573 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2013 2 16 04
allfieldsSound	10.1186/cc12573 doi (DE-627)SPR02985430X (SPR)cc12573-e DE-627 ger DE-627 rakwb eng Carlier, Mieke verfasserin aut Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal. There is a growing body of evidence that a younger patient with a low to moderate degree of organ dysfunction typically is at risk of ARC and therefore decreased exposure to renally eliminated antibiotics. Mechanisms potentially involved, such as increased cardiac output, have, however, not been identified as appropriate surrogate markers, and the search for suitable alternatives to readily identify patients with ARC continues. Creatinine Clearance (dpeaa)DE-He213 Cardiac Index (dpeaa)DE-He213 Glycopeptide (dpeaa)DE-He213 Sequential Organ Failure Assessment (dpeaa)DE-He213 Therapeutic Drug Monitoring (dpeaa)DE-He213 De Waele, Jan J aut Enthalten in Critical care London : BioMed Central, 1997 17(2013), 2 vom: 16. Apr. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:17 year:2013 number:2 day:16 month:04 https://dx.doi.org/10.1186/cc12573 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2013 2 16 04
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author	Carlier, Mieke
spellingShingle	Carlier, Mieke misc Creatinine Clearance misc Cardiac Index misc Glycopeptide misc Sequential Organ Failure Assessment misc Therapeutic Drug Monitoring Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges
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topic_title	Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges Creatinine Clearance (dpeaa)DE-He213 Cardiac Index (dpeaa)DE-He213 Glycopeptide (dpeaa)DE-He213 Sequential Organ Failure Assessment (dpeaa)DE-He213 Therapeutic Drug Monitoring (dpeaa)DE-He213
topic	misc Creatinine Clearance misc Cardiac Index misc Glycopeptide misc Sequential Organ Failure Assessment misc Therapeutic Drug Monitoring
topic_unstemmed	misc Creatinine Clearance misc Cardiac Index misc Glycopeptide misc Sequential Organ Failure Assessment misc Therapeutic Drug Monitoring
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title	Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges
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title_full	Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges
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title_sort	identifying patients at risk for augmented renal clearance in the icu - limitations and challenges
title_auth	Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges
abstract	Abstract Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal. There is a growing body of evidence that a younger patient with a low to moderate degree of organ dysfunction typically is at risk of ARC and therefore decreased exposure to renally eliminated antibiotics. Mechanisms potentially involved, such as increased cardiac output, have, however, not been identified as appropriate surrogate markers, and the search for suitable alternatives to readily identify patients with ARC continues. © BioMed Central Ltd 2013
abstractGer	Abstract Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal. There is a growing body of evidence that a younger patient with a low to moderate degree of organ dysfunction typically is at risk of ARC and therefore decreased exposure to renally eliminated antibiotics. Mechanisms potentially involved, such as increased cardiac output, have, however, not been identified as appropriate surrogate markers, and the search for suitable alternatives to readily identify patients with ARC continues. © BioMed Central Ltd 2013
abstract_unstemmed	Abstract Augmented renal clearance (ARC) is an important determinant of antibiotic exposure in critically ill patients, and identifying patients at risk is therefore an important goal. There is a growing body of evidence that a younger patient with a low to moderate degree of organ dysfunction typically is at risk of ARC and therefore decreased exposure to renally eliminated antibiotics. Mechanisms potentially involved, such as increased cardiac output, have, however, not been identified as appropriate surrogate markers, and the search for suitable alternatives to readily identify patients with ARC continues. © BioMed Central Ltd 2013
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title_short	Identifying patients at risk for augmented renal clearance in the ICU - limitations and challenges
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