Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?

Abstract Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells an...
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Autor*in:	Souza-Fonseca-Guimaraes, Fernando [verfasserIn] Cavaillon, Jean-Marc Adib-Conquy, Minou

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Natural Killer Cell Systemic Inflammatory Response Syndrome Endotoxin Tolerance CD56bright Natural Killer Cell Systemic Inflammatory Response Syndrome Patient

Anmerkung:	© BioMed Central Ltd 2013

Übergeordnetes Werk:	Enthalten in: Critical care - London : BioMed Central, 1997, 17(2013), 4 vom: 27. Aug.
Übergeordnetes Werk:	volume:17 ; year:2013 ; number:4 ; day:27 ; month:08

Links:	Volltext

DOI / URN:	10.1186/cc12700

Katalog-ID:	SPR029856558

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allfields	10.1186/cc12700 doi (DE-627)SPR029856558 (SPR)cc12700-e DE-627 ger DE-627 rakwb eng Souza-Fonseca-Guimaraes, Fernando verfasserin aut Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty? 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known as a 'cytokine storm', leads to deleterious effects such as organ dysfunction and even death. By the end of the 20th century, natural killer (NK) cells were for the first time identified as important players during sepsis. The role of this cell type was, however, double-edged, either 'angel' or 'devil' depending upon the bacterial infection model under study. Bacterial sensors (such as Toll-like receptors) have recently been shown to be expressed at the protein level in these cells. In addition, NK cells are important sources of interferon-γ and granulocyte-macrophage colony-stimulating factor, which are pro-inflammatory cytokines necessary to fight infection but can contribute to deleterious inflammation as well. Interestingly, an adaptative response occurs aimed to silence them, similar to the well-known phenomenon of endotoxin reprogramming. Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Endotoxin Tolerance (dpeaa)DE-He213 CD56bright Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome Patient (dpeaa)DE-He213 Cavaillon, Jean-Marc aut Adib-Conquy, Minou aut Enthalten in Critical care London : BioMed Central, 1997 17(2013), 4 vom: 27. Aug. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:17 year:2013 number:4 day:27 month:08 https://dx.doi.org/10.1186/cc12700 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2013 4 27 08
spelling	10.1186/cc12700 doi (DE-627)SPR029856558 (SPR)cc12700-e DE-627 ger DE-627 rakwb eng Souza-Fonseca-Guimaraes, Fernando verfasserin aut Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty? 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known as a 'cytokine storm', leads to deleterious effects such as organ dysfunction and even death. By the end of the 20th century, natural killer (NK) cells were for the first time identified as important players during sepsis. The role of this cell type was, however, double-edged, either 'angel' or 'devil' depending upon the bacterial infection model under study. Bacterial sensors (such as Toll-like receptors) have recently been shown to be expressed at the protein level in these cells. In addition, NK cells are important sources of interferon-γ and granulocyte-macrophage colony-stimulating factor, which are pro-inflammatory cytokines necessary to fight infection but can contribute to deleterious inflammation as well. Interestingly, an adaptative response occurs aimed to silence them, similar to the well-known phenomenon of endotoxin reprogramming. Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Endotoxin Tolerance (dpeaa)DE-He213 CD56bright Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome Patient (dpeaa)DE-He213 Cavaillon, Jean-Marc aut Adib-Conquy, Minou aut Enthalten in Critical care London : BioMed Central, 1997 17(2013), 4 vom: 27. Aug. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:17 year:2013 number:4 day:27 month:08 https://dx.doi.org/10.1186/cc12700 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2013 4 27 08
allfields_unstemmed	10.1186/cc12700 doi (DE-627)SPR029856558 (SPR)cc12700-e DE-627 ger DE-627 rakwb eng Souza-Fonseca-Guimaraes, Fernando verfasserin aut Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty? 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known as a 'cytokine storm', leads to deleterious effects such as organ dysfunction and even death. By the end of the 20th century, natural killer (NK) cells were for the first time identified as important players during sepsis. The role of this cell type was, however, double-edged, either 'angel' or 'devil' depending upon the bacterial infection model under study. Bacterial sensors (such as Toll-like receptors) have recently been shown to be expressed at the protein level in these cells. In addition, NK cells are important sources of interferon-γ and granulocyte-macrophage colony-stimulating factor, which are pro-inflammatory cytokines necessary to fight infection but can contribute to deleterious inflammation as well. Interestingly, an adaptative response occurs aimed to silence them, similar to the well-known phenomenon of endotoxin reprogramming. Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Endotoxin Tolerance (dpeaa)DE-He213 CD56bright Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome Patient (dpeaa)DE-He213 Cavaillon, Jean-Marc aut Adib-Conquy, Minou aut Enthalten in Critical care London : BioMed Central, 1997 17(2013), 4 vom: 27. Aug. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:17 year:2013 number:4 day:27 month:08 https://dx.doi.org/10.1186/cc12700 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2013 4 27 08
allfieldsGer	10.1186/cc12700 doi (DE-627)SPR029856558 (SPR)cc12700-e DE-627 ger DE-627 rakwb eng Souza-Fonseca-Guimaraes, Fernando verfasserin aut Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty? 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known as a 'cytokine storm', leads to deleterious effects such as organ dysfunction and even death. By the end of the 20th century, natural killer (NK) cells were for the first time identified as important players during sepsis. The role of this cell type was, however, double-edged, either 'angel' or 'devil' depending upon the bacterial infection model under study. Bacterial sensors (such as Toll-like receptors) have recently been shown to be expressed at the protein level in these cells. In addition, NK cells are important sources of interferon-γ and granulocyte-macrophage colony-stimulating factor, which are pro-inflammatory cytokines necessary to fight infection but can contribute to deleterious inflammation as well. Interestingly, an adaptative response occurs aimed to silence them, similar to the well-known phenomenon of endotoxin reprogramming. Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Endotoxin Tolerance (dpeaa)DE-He213 CD56bright Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome Patient (dpeaa)DE-He213 Cavaillon, Jean-Marc aut Adib-Conquy, Minou aut Enthalten in Critical care London : BioMed Central, 1997 17(2013), 4 vom: 27. Aug. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:17 year:2013 number:4 day:27 month:08 https://dx.doi.org/10.1186/cc12700 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2013 4 27 08
allfieldsSound	10.1186/cc12700 doi (DE-627)SPR029856558 (SPR)cc12700-e DE-627 ger DE-627 rakwb eng Souza-Fonseca-Guimaraes, Fernando verfasserin aut Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty? 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known as a 'cytokine storm', leads to deleterious effects such as organ dysfunction and even death. By the end of the 20th century, natural killer (NK) cells were for the first time identified as important players during sepsis. The role of this cell type was, however, double-edged, either 'angel' or 'devil' depending upon the bacterial infection model under study. Bacterial sensors (such as Toll-like receptors) have recently been shown to be expressed at the protein level in these cells. In addition, NK cells are important sources of interferon-γ and granulocyte-macrophage colony-stimulating factor, which are pro-inflammatory cytokines necessary to fight infection but can contribute to deleterious inflammation as well. Interestingly, an adaptative response occurs aimed to silence them, similar to the well-known phenomenon of endotoxin reprogramming. Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Endotoxin Tolerance (dpeaa)DE-He213 CD56bright Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome Patient (dpeaa)DE-He213 Cavaillon, Jean-Marc aut Adib-Conquy, Minou aut Enthalten in Critical care London : BioMed Central, 1997 17(2013), 4 vom: 27. Aug. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:17 year:2013 number:4 day:27 month:08 https://dx.doi.org/10.1186/cc12700 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2013 4 27 08
language	English
source	Enthalten in Critical care 17(2013), 4 vom: 27. Aug. volume:17 year:2013 number:4 day:27 month:08
sourceStr	Enthalten in Critical care 17(2013), 4 vom: 27. Aug. volume:17 year:2013 number:4 day:27 month:08
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Natural Killer Cell Systemic Inflammatory Response Syndrome Endotoxin Tolerance CD56bright Natural Killer Cell Systemic Inflammatory Response Syndrome Patient
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container_title	Critical care
authorswithroles_txt_mv	Souza-Fonseca-Guimaraes, Fernando @@aut@@ Cavaillon, Jean-Marc @@aut@@ Adib-Conquy, Minou @@aut@@
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author	Souza-Fonseca-Guimaraes, Fernando
spellingShingle	Souza-Fonseca-Guimaraes, Fernando misc Natural Killer Cell misc Systemic Inflammatory Response Syndrome misc Endotoxin Tolerance misc CD56bright Natural Killer Cell misc Systemic Inflammatory Response Syndrome Patient Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?
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topic_title	Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty? Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome (dpeaa)DE-He213 Endotoxin Tolerance (dpeaa)DE-He213 CD56bright Natural Killer Cell (dpeaa)DE-He213 Systemic Inflammatory Response Syndrome Patient (dpeaa)DE-He213
topic	misc Natural Killer Cell misc Systemic Inflammatory Response Syndrome misc Endotoxin Tolerance misc CD56bright Natural Killer Cell misc Systemic Inflammatory Response Syndrome Patient
topic_unstemmed	misc Natural Killer Cell misc Systemic Inflammatory Response Syndrome misc Endotoxin Tolerance misc CD56bright Natural Killer Cell misc Systemic Inflammatory Response Syndrome Patient
topic_browse	misc Natural Killer Cell misc Systemic Inflammatory Response Syndrome misc Endotoxin Tolerance misc CD56bright Natural Killer Cell misc Systemic Inflammatory Response Syndrome Patient
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title	Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?
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title_full	Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?
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title_sort	bench-to-bedside review: natural killer cells in sepsis - guilty or not guilty?
title_auth	Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?
abstract	Abstract Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known as a 'cytokine storm', leads to deleterious effects such as organ dysfunction and even death. By the end of the 20th century, natural killer (NK) cells were for the first time identified as important players during sepsis. The role of this cell type was, however, double-edged, either 'angel' or 'devil' depending upon the bacterial infection model under study. Bacterial sensors (such as Toll-like receptors) have recently been shown to be expressed at the protein level in these cells. In addition, NK cells are important sources of interferon-γ and granulocyte-macrophage colony-stimulating factor, which are pro-inflammatory cytokines necessary to fight infection but can contribute to deleterious inflammation as well. Interestingly, an adaptative response occurs aimed to silence them, similar to the well-known phenomenon of endotoxin reprogramming. © BioMed Central Ltd 2013
abstractGer	Abstract Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known as a 'cytokine storm', leads to deleterious effects such as organ dysfunction and even death. By the end of the 20th century, natural killer (NK) cells were for the first time identified as important players during sepsis. The role of this cell type was, however, double-edged, either 'angel' or 'devil' depending upon the bacterial infection model under study. Bacterial sensors (such as Toll-like receptors) have recently been shown to be expressed at the protein level in these cells. In addition, NK cells are important sources of interferon-γ and granulocyte-macrophage colony-stimulating factor, which are pro-inflammatory cytokines necessary to fight infection but can contribute to deleterious inflammation as well. Interestingly, an adaptative response occurs aimed to silence them, similar to the well-known phenomenon of endotoxin reprogramming. © BioMed Central Ltd 2013
abstract_unstemmed	Abstract Bacterial sepsis and septic shock are complex inflammatory disorders associated with a systemic inflammatory response syndrome. In the most severe cases of infection, an overzealous release of pro-inflammatory cytokines and inflammatory mediators by activated leukocytes, epithelial cells and endothelial cells, known as a 'cytokine storm', leads to deleterious effects such as organ dysfunction and even death. By the end of the 20th century, natural killer (NK) cells were for the first time identified as important players during sepsis. The role of this cell type was, however, double-edged, either 'angel' or 'devil' depending upon the bacterial infection model under study. Bacterial sensors (such as Toll-like receptors) have recently been shown to be expressed at the protein level in these cells. In addition, NK cells are important sources of interferon-γ and granulocyte-macrophage colony-stimulating factor, which are pro-inflammatory cytokines necessary to fight infection but can contribute to deleterious inflammation as well. Interestingly, an adaptative response occurs aimed to silence them, similar to the well-known phenomenon of endotoxin reprogramming. © BioMed Central Ltd 2013
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title_short	Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?
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Bench-to-bedside review: Natural killer cells in sepsis - guilty or not guilty?

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