Epigenetic changes during sepsis: on your marks!

Abstract Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the dev...
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Autor*in:	Bataille, Aurélien [verfasserIn] Galichon, Pierre Ziliotis, Marie-Julia Sadia, Iman Hertig, Alexandre

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Histone Modification Epigenetic Change Multiple Organ Dysfunction Syndrome Epigenetic Mark Histone Mark

Anmerkung:	© Bataille et al. 2015

Übergeordnetes Werk:	Enthalten in: Critical care - London : BioMed Central, 1997, 19(2015), 1 vom: 01. Dez.
Übergeordnetes Werk:	volume:19 ; year:2015 ; number:1 ; day:01 ; month:12

Links:	Volltext

DOI / URN:	10.1186/s13054-015-1068-5

Katalog-ID:	SPR029880971

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allfields	10.1186/s13054-015-1068-5 doi (DE-627)SPR029880971 (SPR)s13054-015-1068-5-e DE-627 ger DE-627 rakwb eng Bataille, Aurélien verfasserin aut Epigenetic changes during sepsis: on your marks! 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bataille et al. 2015 Abstract Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury. Decrease in mRNA of key genes involved in endothelial function was found to be associated with (and potentially explained by) a decrease in permissive histone marks, while repressive marks were unchanged. We discuss here the limitations of a whole-organ as opposed to a cell-specific approach, the nature of the controls that were chosen, and the pitfalls of histone modifications as a cause of the eventual phenotype. While the use of ‘epidrugs’ is definitely welcome in the clinic, how and when they will be used in sepsis-related multiple organ dysfunction will require further experimental studies. Histone Modification (dpeaa)DE-He213 Epigenetic Change (dpeaa)DE-He213 Multiple Organ Dysfunction Syndrome (dpeaa)DE-He213 Epigenetic Mark (dpeaa)DE-He213 Histone Mark (dpeaa)DE-He213 Galichon, Pierre aut Ziliotis, Marie-Julia aut Sadia, Iman aut Hertig, Alexandre aut Enthalten in Critical care London : BioMed Central, 1997 19(2015), 1 vom: 01. Dez. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:19 year:2015 number:1 day:01 month:12 https://dx.doi.org/10.1186/s13054-015-1068-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2015 1 01 12
spelling	10.1186/s13054-015-1068-5 doi (DE-627)SPR029880971 (SPR)s13054-015-1068-5-e DE-627 ger DE-627 rakwb eng Bataille, Aurélien verfasserin aut Epigenetic changes during sepsis: on your marks! 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bataille et al. 2015 Abstract Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury. Decrease in mRNA of key genes involved in endothelial function was found to be associated with (and potentially explained by) a decrease in permissive histone marks, while repressive marks were unchanged. We discuss here the limitations of a whole-organ as opposed to a cell-specific approach, the nature of the controls that were chosen, and the pitfalls of histone modifications as a cause of the eventual phenotype. While the use of ‘epidrugs’ is definitely welcome in the clinic, how and when they will be used in sepsis-related multiple organ dysfunction will require further experimental studies. Histone Modification (dpeaa)DE-He213 Epigenetic Change (dpeaa)DE-He213 Multiple Organ Dysfunction Syndrome (dpeaa)DE-He213 Epigenetic Mark (dpeaa)DE-He213 Histone Mark (dpeaa)DE-He213 Galichon, Pierre aut Ziliotis, Marie-Julia aut Sadia, Iman aut Hertig, Alexandre aut Enthalten in Critical care London : BioMed Central, 1997 19(2015), 1 vom: 01. Dez. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:19 year:2015 number:1 day:01 month:12 https://dx.doi.org/10.1186/s13054-015-1068-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2015 1 01 12
allfields_unstemmed	10.1186/s13054-015-1068-5 doi (DE-627)SPR029880971 (SPR)s13054-015-1068-5-e DE-627 ger DE-627 rakwb eng Bataille, Aurélien verfasserin aut Epigenetic changes during sepsis: on your marks! 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bataille et al. 2015 Abstract Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury. Decrease in mRNA of key genes involved in endothelial function was found to be associated with (and potentially explained by) a decrease in permissive histone marks, while repressive marks were unchanged. We discuss here the limitations of a whole-organ as opposed to a cell-specific approach, the nature of the controls that were chosen, and the pitfalls of histone modifications as a cause of the eventual phenotype. While the use of ‘epidrugs’ is definitely welcome in the clinic, how and when they will be used in sepsis-related multiple organ dysfunction will require further experimental studies. Histone Modification (dpeaa)DE-He213 Epigenetic Change (dpeaa)DE-He213 Multiple Organ Dysfunction Syndrome (dpeaa)DE-He213 Epigenetic Mark (dpeaa)DE-He213 Histone Mark (dpeaa)DE-He213 Galichon, Pierre aut Ziliotis, Marie-Julia aut Sadia, Iman aut Hertig, Alexandre aut Enthalten in Critical care London : BioMed Central, 1997 19(2015), 1 vom: 01. Dez. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:19 year:2015 number:1 day:01 month:12 https://dx.doi.org/10.1186/s13054-015-1068-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2015 1 01 12
allfieldsGer	10.1186/s13054-015-1068-5 doi (DE-627)SPR029880971 (SPR)s13054-015-1068-5-e DE-627 ger DE-627 rakwb eng Bataille, Aurélien verfasserin aut Epigenetic changes during sepsis: on your marks! 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bataille et al. 2015 Abstract Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury. Decrease in mRNA of key genes involved in endothelial function was found to be associated with (and potentially explained by) a decrease in permissive histone marks, while repressive marks were unchanged. We discuss here the limitations of a whole-organ as opposed to a cell-specific approach, the nature of the controls that were chosen, and the pitfalls of histone modifications as a cause of the eventual phenotype. While the use of ‘epidrugs’ is definitely welcome in the clinic, how and when they will be used in sepsis-related multiple organ dysfunction will require further experimental studies. Histone Modification (dpeaa)DE-He213 Epigenetic Change (dpeaa)DE-He213 Multiple Organ Dysfunction Syndrome (dpeaa)DE-He213 Epigenetic Mark (dpeaa)DE-He213 Histone Mark (dpeaa)DE-He213 Galichon, Pierre aut Ziliotis, Marie-Julia aut Sadia, Iman aut Hertig, Alexandre aut Enthalten in Critical care London : BioMed Central, 1997 19(2015), 1 vom: 01. Dez. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:19 year:2015 number:1 day:01 month:12 https://dx.doi.org/10.1186/s13054-015-1068-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2015 1 01 12
allfieldsSound	10.1186/s13054-015-1068-5 doi (DE-627)SPR029880971 (SPR)s13054-015-1068-5-e DE-627 ger DE-627 rakwb eng Bataille, Aurélien verfasserin aut Epigenetic changes during sepsis: on your marks! 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Bataille et al. 2015 Abstract Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury. Decrease in mRNA of key genes involved in endothelial function was found to be associated with (and potentially explained by) a decrease in permissive histone marks, while repressive marks were unchanged. We discuss here the limitations of a whole-organ as opposed to a cell-specific approach, the nature of the controls that were chosen, and the pitfalls of histone modifications as a cause of the eventual phenotype. While the use of ‘epidrugs’ is definitely welcome in the clinic, how and when they will be used in sepsis-related multiple organ dysfunction will require further experimental studies. Histone Modification (dpeaa)DE-He213 Epigenetic Change (dpeaa)DE-He213 Multiple Organ Dysfunction Syndrome (dpeaa)DE-He213 Epigenetic Mark (dpeaa)DE-He213 Histone Mark (dpeaa)DE-He213 Galichon, Pierre aut Ziliotis, Marie-Julia aut Sadia, Iman aut Hertig, Alexandre aut Enthalten in Critical care London : BioMed Central, 1997 19(2015), 1 vom: 01. Dez. (DE-627)331258269 (DE-600)2051256-9 1364-8535 nnns volume:19 year:2015 number:1 day:01 month:12 https://dx.doi.org/10.1186/s13054-015-1068-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2015 1 01 12
language	English
source	Enthalten in Critical care 19(2015), 1 vom: 01. Dez. volume:19 year:2015 number:1 day:01 month:12
sourceStr	Enthalten in Critical care 19(2015), 1 vom: 01. Dez. volume:19 year:2015 number:1 day:01 month:12
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topic_facet	Histone Modification Epigenetic Change Multiple Organ Dysfunction Syndrome Epigenetic Mark Histone Mark
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authorswithroles_txt_mv	Bataille, Aurélien @@aut@@ Galichon, Pierre @@aut@@ Ziliotis, Marie-Julia @@aut@@ Sadia, Iman @@aut@@ Hertig, Alexandre @@aut@@
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author	Bataille, Aurélien
spellingShingle	Bataille, Aurélien misc Histone Modification misc Epigenetic Change misc Multiple Organ Dysfunction Syndrome misc Epigenetic Mark misc Histone Mark Epigenetic changes during sepsis: on your marks!
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topic_title	Epigenetic changes during sepsis: on your marks! Histone Modification (dpeaa)DE-He213 Epigenetic Change (dpeaa)DE-He213 Multiple Organ Dysfunction Syndrome (dpeaa)DE-He213 Epigenetic Mark (dpeaa)DE-He213 Histone Mark (dpeaa)DE-He213
topic	misc Histone Modification misc Epigenetic Change misc Multiple Organ Dysfunction Syndrome misc Epigenetic Mark misc Histone Mark
topic_unstemmed	misc Histone Modification misc Epigenetic Change misc Multiple Organ Dysfunction Syndrome misc Epigenetic Mark misc Histone Mark
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title	Epigenetic changes during sepsis: on your marks!
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title_full	Epigenetic changes during sepsis: on your marks!
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title_sort	epigenetic changes during sepsis: on your marks!
title_auth	Epigenetic changes during sepsis: on your marks!
abstract	Abstract Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury. Decrease in mRNA of key genes involved in endothelial function was found to be associated with (and potentially explained by) a decrease in permissive histone marks, while repressive marks were unchanged. We discuss here the limitations of a whole-organ as opposed to a cell-specific approach, the nature of the controls that were chosen, and the pitfalls of histone modifications as a cause of the eventual phenotype. While the use of ‘epidrugs’ is definitely welcome in the clinic, how and when they will be used in sepsis-related multiple organ dysfunction will require further experimental studies. © Bataille et al. 2015
abstractGer	Abstract Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury. Decrease in mRNA of key genes involved in endothelial function was found to be associated with (and potentially explained by) a decrease in permissive histone marks, while repressive marks were unchanged. We discuss here the limitations of a whole-organ as opposed to a cell-specific approach, the nature of the controls that were chosen, and the pitfalls of histone modifications as a cause of the eventual phenotype. While the use of ‘epidrugs’ is definitely welcome in the clinic, how and when they will be used in sepsis-related multiple organ dysfunction will require further experimental studies. © Bataille et al. 2015
abstract_unstemmed	Abstract Epigenetics is the study of how cells, organs, and even individuals utilize their genes over specific periods of time, and under specific environmental constraints. Very importantly, epigenetics is now expanding into the field of medicine and hence should provide new information for the development of drugs. Bomsztyk and colleagues have detected major epigenetic changes occurring in several organs as early as 6 h after the onset of a mouse model of multiple organ dysfunction syndrome induced by Staphylococcus aureus lung injury. Decrease in mRNA of key genes involved in endothelial function was found to be associated with (and potentially explained by) a decrease in permissive histone marks, while repressive marks were unchanged. We discuss here the limitations of a whole-organ as opposed to a cell-specific approach, the nature of the controls that were chosen, and the pitfalls of histone modifications as a cause of the eventual phenotype. While the use of ‘epidrugs’ is definitely welcome in the clinic, how and when they will be used in sepsis-related multiple organ dysfunction will require further experimental studies. © Bataille et al. 2015
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title_short	Epigenetic changes during sepsis: on your marks!
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Epigenetic changes during sepsis: on your marks!

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