Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations

Abstract Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A stron...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Williams, Kaye J [verfasserIn] Cowen, Rachel L Stratford, Ian J

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2001

Schlagwörter:	bioreductive drugs hypoxia hypoxia responsive element reductase enzymes

Anmerkung:	© BioMed Central Ltd 2001

Übergeordnetes Werk:	Enthalten in: Breast cancer research - London : BioMed Central, 1999, 3(2001), 5 vom: 07. Aug.
Übergeordnetes Werk:	volume:3 ; year:2001 ; number:5 ; day:07 ; month:08

Links:	Volltext

DOI / URN:	10.1186/bcr316

Katalog-ID:	SPR029915783

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allfields	10.1186/bcr316 doi (DE-627)SPR029915783 (SPR)bcr316-e DE-627 ger DE-627 rakwb eng Williams, Kaye J verfasserin aut Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2001 Abstract Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies. bioreductive drugs (dpeaa)DE-He213 hypoxia (dpeaa)DE-He213 hypoxia responsive element (dpeaa)DE-He213 reductase enzymes (dpeaa)DE-He213 Cowen, Rachel L aut Stratford, Ian J aut Enthalten in Breast cancer research London : BioMed Central, 1999 3(2001), 5 vom: 07. Aug. (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:3 year:2001 number:5 day:07 month:08 https://dx.doi.org/10.1186/bcr316 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2001 5 07 08
spelling	10.1186/bcr316 doi (DE-627)SPR029915783 (SPR)bcr316-e DE-627 ger DE-627 rakwb eng Williams, Kaye J verfasserin aut Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2001 Abstract Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies. bioreductive drugs (dpeaa)DE-He213 hypoxia (dpeaa)DE-He213 hypoxia responsive element (dpeaa)DE-He213 reductase enzymes (dpeaa)DE-He213 Cowen, Rachel L aut Stratford, Ian J aut Enthalten in Breast cancer research London : BioMed Central, 1999 3(2001), 5 vom: 07. Aug. (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:3 year:2001 number:5 day:07 month:08 https://dx.doi.org/10.1186/bcr316 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2001 5 07 08
allfields_unstemmed	10.1186/bcr316 doi (DE-627)SPR029915783 (SPR)bcr316-e DE-627 ger DE-627 rakwb eng Williams, Kaye J verfasserin aut Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2001 Abstract Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies. bioreductive drugs (dpeaa)DE-He213 hypoxia (dpeaa)DE-He213 hypoxia responsive element (dpeaa)DE-He213 reductase enzymes (dpeaa)DE-He213 Cowen, Rachel L aut Stratford, Ian J aut Enthalten in Breast cancer research London : BioMed Central, 1999 3(2001), 5 vom: 07. Aug. (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:3 year:2001 number:5 day:07 month:08 https://dx.doi.org/10.1186/bcr316 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2001 5 07 08
allfieldsGer	10.1186/bcr316 doi (DE-627)SPR029915783 (SPR)bcr316-e DE-627 ger DE-627 rakwb eng Williams, Kaye J verfasserin aut Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2001 Abstract Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies. bioreductive drugs (dpeaa)DE-He213 hypoxia (dpeaa)DE-He213 hypoxia responsive element (dpeaa)DE-He213 reductase enzymes (dpeaa)DE-He213 Cowen, Rachel L aut Stratford, Ian J aut Enthalten in Breast cancer research London : BioMed Central, 1999 3(2001), 5 vom: 07. Aug. (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:3 year:2001 number:5 day:07 month:08 https://dx.doi.org/10.1186/bcr316 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2001 5 07 08
allfieldsSound	10.1186/bcr316 doi (DE-627)SPR029915783 (SPR)bcr316-e DE-627 ger DE-627 rakwb eng Williams, Kaye J verfasserin aut Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations 2001 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2001 Abstract Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies. bioreductive drugs (dpeaa)DE-He213 hypoxia (dpeaa)DE-He213 hypoxia responsive element (dpeaa)DE-He213 reductase enzymes (dpeaa)DE-He213 Cowen, Rachel L aut Stratford, Ian J aut Enthalten in Breast cancer research London : BioMed Central, 1999 3(2001), 5 vom: 07. Aug. (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:3 year:2001 number:5 day:07 month:08 https://dx.doi.org/10.1186/bcr316 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2001 5 07 08
language	English
source	Enthalten in Breast cancer research 3(2001), 5 vom: 07. Aug. volume:3 year:2001 number:5 day:07 month:08
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author	Williams, Kaye J
spellingShingle	Williams, Kaye J misc bioreductive drugs misc hypoxia misc hypoxia responsive element misc reductase enzymes Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations
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topic_title	Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations bioreductive drugs (dpeaa)DE-He213 hypoxia (dpeaa)DE-He213 hypoxia responsive element (dpeaa)DE-He213 reductase enzymes (dpeaa)DE-He213
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title	Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations
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title_full	Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations
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title_sort	hypoxia and oxidative stress in breast cancer tumour hypoxia – therapeutic considerations
title_auth	Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations
abstract	Abstract Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies. © BioMed Central Ltd 2001
abstractGer	Abstract Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies. © BioMed Central Ltd 2001
abstract_unstemmed	Abstract Conclusive research has shown that regions of acute/chronic hypoxia, which exist within the majority of solid tumours, have a profound influence on the therapeutic outcome of cancer chemotherapy and radiotherapy and are a strong prognostic factor of disease progression and survival. A strong argument therefore exists for assessing the hypoxic fraction of tumours, prior to patient treatment, and to tailor this treatment accordingly. Tumour hypoxia also provides a powerful physiological stimulus that can be exploited as a tumour-specific condition, allowing for the rationale design of hypoxia-activated anticancer drugs or novel hypoxia-regulated gene therapy strategies. © BioMed Central Ltd 2001
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title_short	Hypoxia and oxidative stress in breast cancer Tumour hypoxia – therapeutic considerations
url	https://dx.doi.org/10.1186/bcr316
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up_date	2024-07-04T02:41:26.962Z
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