Cooperation between Wnt and Notch signalling in human breast cancer

Abstract The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary ep...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Collu, Giovanna M [verfasserIn] Brennan, Keith

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Notch Signalling Notch Pathway Wnt1 Expression Promote Stem Cell Adult Stem Cell Population

Anmerkung:	© BioMed Central Ltd 2007

Übergeordnetes Werk:	Enthalten in: Breast cancer research - London : BioMed Central, 1999, 9(2007), 3 vom: 11. Mai
Übergeordnetes Werk:	volume:9 ; year:2007 ; number:3 ; day:11 ; month:05

Links:	Volltext

DOI / URN:	10.1186/bcr1671

Katalog-ID:	SPR029930472

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allfields	10.1186/bcr1671 doi (DE-627)SPR029930472 (SPR)bcr1671-e DE-627 ger DE-627 rakwb eng Collu, Giovanna M verfasserin aut Cooperation between Wnt and Notch signalling in human breast cancer 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2007 Abstract The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary epithelial cells, and that this is in part due to activation of the Notch pathway. This indicates that during tumourigenesis the two pathways cooperate. Here we ask why activation of Wnt signalling alone is sufficient to cause transformation; whether there is evidence for inhibitory crosstalk between the pathways during tumourigenesis; and whether cooperation between these pathways occurs in other forms of cancer. Notch Signalling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Wnt1 Expression (dpeaa)DE-He213 Promote Stem Cell (dpeaa)DE-He213 Adult Stem Cell Population (dpeaa)DE-He213 Brennan, Keith aut Enthalten in Breast cancer research London : BioMed Central, 1999 9(2007), 3 vom: 11. Mai (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:9 year:2007 number:3 day:11 month:05 https://dx.doi.org/10.1186/bcr1671 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2007 3 11 05
spelling	10.1186/bcr1671 doi (DE-627)SPR029930472 (SPR)bcr1671-e DE-627 ger DE-627 rakwb eng Collu, Giovanna M verfasserin aut Cooperation between Wnt and Notch signalling in human breast cancer 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2007 Abstract The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary epithelial cells, and that this is in part due to activation of the Notch pathway. This indicates that during tumourigenesis the two pathways cooperate. Here we ask why activation of Wnt signalling alone is sufficient to cause transformation; whether there is evidence for inhibitory crosstalk between the pathways during tumourigenesis; and whether cooperation between these pathways occurs in other forms of cancer. Notch Signalling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Wnt1 Expression (dpeaa)DE-He213 Promote Stem Cell (dpeaa)DE-He213 Adult Stem Cell Population (dpeaa)DE-He213 Brennan, Keith aut Enthalten in Breast cancer research London : BioMed Central, 1999 9(2007), 3 vom: 11. Mai (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:9 year:2007 number:3 day:11 month:05 https://dx.doi.org/10.1186/bcr1671 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2007 3 11 05
allfields_unstemmed	10.1186/bcr1671 doi (DE-627)SPR029930472 (SPR)bcr1671-e DE-627 ger DE-627 rakwb eng Collu, Giovanna M verfasserin aut Cooperation between Wnt and Notch signalling in human breast cancer 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2007 Abstract The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary epithelial cells, and that this is in part due to activation of the Notch pathway. This indicates that during tumourigenesis the two pathways cooperate. Here we ask why activation of Wnt signalling alone is sufficient to cause transformation; whether there is evidence for inhibitory crosstalk between the pathways during tumourigenesis; and whether cooperation between these pathways occurs in other forms of cancer. Notch Signalling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Wnt1 Expression (dpeaa)DE-He213 Promote Stem Cell (dpeaa)DE-He213 Adult Stem Cell Population (dpeaa)DE-He213 Brennan, Keith aut Enthalten in Breast cancer research London : BioMed Central, 1999 9(2007), 3 vom: 11. Mai (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:9 year:2007 number:3 day:11 month:05 https://dx.doi.org/10.1186/bcr1671 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2007 3 11 05
allfieldsGer	10.1186/bcr1671 doi (DE-627)SPR029930472 (SPR)bcr1671-e DE-627 ger DE-627 rakwb eng Collu, Giovanna M verfasserin aut Cooperation between Wnt and Notch signalling in human breast cancer 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2007 Abstract The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary epithelial cells, and that this is in part due to activation of the Notch pathway. This indicates that during tumourigenesis the two pathways cooperate. Here we ask why activation of Wnt signalling alone is sufficient to cause transformation; whether there is evidence for inhibitory crosstalk between the pathways during tumourigenesis; and whether cooperation between these pathways occurs in other forms of cancer. Notch Signalling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Wnt1 Expression (dpeaa)DE-He213 Promote Stem Cell (dpeaa)DE-He213 Adult Stem Cell Population (dpeaa)DE-He213 Brennan, Keith aut Enthalten in Breast cancer research London : BioMed Central, 1999 9(2007), 3 vom: 11. Mai (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:9 year:2007 number:3 day:11 month:05 https://dx.doi.org/10.1186/bcr1671 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2007 3 11 05
allfieldsSound	10.1186/bcr1671 doi (DE-627)SPR029930472 (SPR)bcr1671-e DE-627 ger DE-627 rakwb eng Collu, Giovanna M verfasserin aut Cooperation between Wnt and Notch signalling in human breast cancer 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2007 Abstract The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary epithelial cells, and that this is in part due to activation of the Notch pathway. This indicates that during tumourigenesis the two pathways cooperate. Here we ask why activation of Wnt signalling alone is sufficient to cause transformation; whether there is evidence for inhibitory crosstalk between the pathways during tumourigenesis; and whether cooperation between these pathways occurs in other forms of cancer. Notch Signalling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Wnt1 Expression (dpeaa)DE-He213 Promote Stem Cell (dpeaa)DE-He213 Adult Stem Cell Population (dpeaa)DE-He213 Brennan, Keith aut Enthalten in Breast cancer research London : BioMed Central, 1999 9(2007), 3 vom: 11. Mai (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:9 year:2007 number:3 day:11 month:05 https://dx.doi.org/10.1186/bcr1671 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2007 3 11 05
language	English
source	Enthalten in Breast cancer research 9(2007), 3 vom: 11. Mai volume:9 year:2007 number:3 day:11 month:05
sourceStr	Enthalten in Breast cancer research 9(2007), 3 vom: 11. Mai volume:9 year:2007 number:3 day:11 month:05
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Notch Signalling Notch Pathway Wnt1 Expression Promote Stem Cell Adult Stem Cell Population
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container_title	Breast cancer research
authorswithroles_txt_mv	Collu, Giovanna M @@aut@@ Brennan, Keith @@aut@@
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author	Collu, Giovanna M
spellingShingle	Collu, Giovanna M misc Notch Signalling misc Notch Pathway misc Wnt1 Expression misc Promote Stem Cell misc Adult Stem Cell Population Cooperation between Wnt and Notch signalling in human breast cancer
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topic_title	Cooperation between Wnt and Notch signalling in human breast cancer Notch Signalling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Wnt1 Expression (dpeaa)DE-He213 Promote Stem Cell (dpeaa)DE-He213 Adult Stem Cell Population (dpeaa)DE-He213
topic	misc Notch Signalling misc Notch Pathway misc Wnt1 Expression misc Promote Stem Cell misc Adult Stem Cell Population
topic_unstemmed	misc Notch Signalling misc Notch Pathway misc Wnt1 Expression misc Promote Stem Cell misc Adult Stem Cell Population
topic_browse	misc Notch Signalling misc Notch Pathway misc Wnt1 Expression misc Promote Stem Cell misc Adult Stem Cell Population
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title	Cooperation between Wnt and Notch signalling in human breast cancer
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title_full	Cooperation between Wnt and Notch signalling in human breast cancer
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title_sort	cooperation between wnt and notch signalling in human breast cancer
title_auth	Cooperation between Wnt and Notch signalling in human breast cancer
abstract	Abstract The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary epithelial cells, and that this is in part due to activation of the Notch pathway. This indicates that during tumourigenesis the two pathways cooperate. Here we ask why activation of Wnt signalling alone is sufficient to cause transformation; whether there is evidence for inhibitory crosstalk between the pathways during tumourigenesis; and whether cooperation between these pathways occurs in other forms of cancer. © BioMed Central Ltd 2007
abstractGer	Abstract The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary epithelial cells, and that this is in part due to activation of the Notch pathway. This indicates that during tumourigenesis the two pathways cooperate. Here we ask why activation of Wnt signalling alone is sufficient to cause transformation; whether there is evidence for inhibitory crosstalk between the pathways during tumourigenesis; and whether cooperation between these pathways occurs in other forms of cancer. © BioMed Central Ltd 2007
abstract_unstemmed	Abstract The Wnt and Notch signalling pathways play major roles in mammary gland development and tumourigenesis. During development, these pathways have opposing effects. However, in a recent paper Ayyanan and coworkers show that expression of Wnt1 is sufficient to transform primary human mammary epithelial cells, and that this is in part due to activation of the Notch pathway. This indicates that during tumourigenesis the two pathways cooperate. Here we ask why activation of Wnt signalling alone is sufficient to cause transformation; whether there is evidence for inhibitory crosstalk between the pathways during tumourigenesis; and whether cooperation between these pathways occurs in other forms of cancer. © BioMed Central Ltd 2007
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title_short	Cooperation between Wnt and Notch signalling in human breast cancer
url	https://dx.doi.org/10.1186/bcr1671
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up_date	2024-07-04T02:43:56.906Z
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