Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 10...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Eccles, Suzanne A [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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© Eccles et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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| Übergeordnetes Werk: |
Enthalten in: Breast cancer research - London : BioMed Central, 1999, 15(2013), 5 vom: 01. Okt. |
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| Übergeordnetes Werk: |
volume:15 ; year:2013 ; number:5 ; day:01 ; month:10 |
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| DOI / URN: |
10.1186/bcr3493 |
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SPR029950325 |
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| 100 | 1 | |a Eccles, Suzanne A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer |
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| 520 | |a Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. | ||
| 700 | 1 | |a Aboagye, Eric O |4 aut | |
| 700 | 1 | |a Ali, Simak |4 aut | |
| 700 | 1 | |a Anderson, Annie S |4 aut | |
| 700 | 1 | |a Armes, Jo |4 aut | |
| 700 | 1 | |a Berditchevski, Fedor |4 aut | |
| 700 | 1 | |a Blaydes, Jeremy P |4 aut | |
| 700 | 1 | |a Brennan, Keith |4 aut | |
| 700 | 1 | |a Brown, Nicola J |4 aut | |
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| 700 | 1 | |a Bundred, Nigel J |4 aut | |
| 700 | 1 | |a Burchell, Joy M |4 aut | |
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| 700 | 1 | |a Carroll, Jason S |4 aut | |
| 700 | 1 | |a Clarke, Robert B |4 aut | |
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| 700 | 1 | |a Dekker, Lodewijk V |4 aut | |
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10.1186/bcr3493 doi (DE-627)SPR029950325 (SPR)bcr3493-e DE-627 ger DE-627 rakwb eng Eccles, Suzanne A verfasserin aut Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Eccles et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. Aboagye, Eric O aut Ali, Simak aut Anderson, Annie S aut Armes, Jo aut Berditchevski, Fedor aut Blaydes, Jeremy P aut Brennan, Keith aut Brown, Nicola J aut Bryant, Helen E aut Bundred, Nigel J aut Burchell, Joy M aut Campbell, Anna M aut Carroll, Jason S aut Clarke, Robert B aut Coles, Charlotte E aut Cook, Gary JR aut Cox, Angela aut Curtin, Nicola J aut Dekker, Lodewijk V aut dos Santos Silva, Isabel aut Duffy, Stephen W aut Easton, Douglas F aut Eccles, Diana M aut Edwards, Dylan R aut Edwards, Joanne aut Evans, D Gareth aut Fenlon, Deborah F aut Flanagan, James M aut Foster, Claire aut Gallagher, William M aut Garcia-Closas, Montserrat aut Gee, Julia M W aut Gescher, Andy J aut Goh, Vicky aut Groves, Ashley M aut Harvey, Amanda J aut Harvie, Michelle aut Hennessy, Bryan T aut Hiscox, Stephen aut Holen, Ingunn aut Howell, Sacha J aut Howell, Anthony aut Hubbard, Gill aut Hulbert-Williams, Nick aut Hunter, Myra S aut Jasani, Bharat aut Jones, Louise J aut Key, Timothy J aut Kirwan, Cliona C aut Kong, Anthony aut Kunkler, Ian H aut Langdon, Simon P aut Leach, Martin O aut Mann, David J aut Marshall, John F aut Martin, Lesley Ann aut Martin, Stewart G aut Macdougall, Jennifer E aut Miles, David W aut Miller, William R aut Morris, Joanna R aut Moss, Sue M aut Mullan, Paul aut Natrajan, Rachel aut O’Connor, James PB aut O’Connor, Rosemary aut Palmieri, Carlo aut Pharoah, Paul D P aut Rakha, Emad A aut Reed, Elizabeth aut Robinson, Simon P aut Sahai, Erik aut Saxton, John M aut Schmid, Peter aut Smalley, Matthew J aut Speirs, Valerie aut Stein, Robert aut Stingl, John aut Streuli, Charles H aut Tutt, Andrew N J aut Velikova, Galina aut Walker, Rosemary A aut Watson, Christine J aut Williams, Kaye J aut Young, Leonie S aut Thompson, Alastair M aut Enthalten in Breast cancer research London : BioMed Central, 1999 15(2013), 5 vom: 01. Okt. (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:15 year:2013 number:5 day:01 month:10 https://dx.doi.org/10.1186/bcr3493 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2106 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2013 5 01 10 |
| spelling |
10.1186/bcr3493 doi (DE-627)SPR029950325 (SPR)bcr3493-e DE-627 ger DE-627 rakwb eng Eccles, Suzanne A verfasserin aut Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Eccles et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. Aboagye, Eric O aut Ali, Simak aut Anderson, Annie S aut Armes, Jo aut Berditchevski, Fedor aut Blaydes, Jeremy P aut Brennan, Keith aut Brown, Nicola J aut Bryant, Helen E aut Bundred, Nigel J aut Burchell, Joy M aut Campbell, Anna M aut Carroll, Jason S aut Clarke, Robert B aut Coles, Charlotte E aut Cook, Gary JR aut Cox, Angela aut Curtin, Nicola J aut Dekker, Lodewijk V aut dos Santos Silva, Isabel aut Duffy, Stephen W aut Easton, Douglas F aut Eccles, Diana M aut Edwards, Dylan R aut Edwards, Joanne aut Evans, D Gareth aut Fenlon, Deborah F aut Flanagan, James M aut Foster, Claire aut Gallagher, William M aut Garcia-Closas, Montserrat aut Gee, Julia M W aut Gescher, Andy J aut Goh, Vicky aut Groves, Ashley M aut Harvey, Amanda J aut Harvie, Michelle aut Hennessy, Bryan T aut Hiscox, Stephen aut Holen, Ingunn aut Howell, Sacha J aut Howell, Anthony aut Hubbard, Gill aut Hulbert-Williams, Nick aut Hunter, Myra S aut Jasani, Bharat aut Jones, Louise J aut Key, Timothy J aut Kirwan, Cliona C aut Kong, Anthony aut Kunkler, Ian H aut Langdon, Simon P aut Leach, Martin O aut Mann, David J aut Marshall, John F aut Martin, Lesley Ann aut Martin, Stewart G aut Macdougall, Jennifer E aut Miles, David W aut Miller, William R aut Morris, Joanna R aut Moss, Sue M aut Mullan, Paul aut Natrajan, Rachel aut O’Connor, James PB aut O’Connor, Rosemary aut Palmieri, Carlo aut Pharoah, Paul D P aut Rakha, Emad A aut Reed, Elizabeth aut Robinson, Simon P aut Sahai, Erik aut Saxton, John M aut Schmid, Peter aut Smalley, Matthew J aut Speirs, Valerie aut Stein, Robert aut Stingl, John aut Streuli, Charles H aut Tutt, Andrew N J aut Velikova, Galina aut Walker, Rosemary A aut Watson, Christine J aut Williams, Kaye J aut Young, Leonie S aut Thompson, Alastair M aut Enthalten in Breast cancer research London : BioMed Central, 1999 15(2013), 5 vom: 01. Okt. (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:15 year:2013 number:5 day:01 month:10 https://dx.doi.org/10.1186/bcr3493 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2106 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2013 5 01 10 |
| allfields_unstemmed |
10.1186/bcr3493 doi (DE-627)SPR029950325 (SPR)bcr3493-e DE-627 ger DE-627 rakwb eng Eccles, Suzanne A verfasserin aut Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Eccles et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. Aboagye, Eric O aut Ali, Simak aut Anderson, Annie S aut Armes, Jo aut Berditchevski, Fedor aut Blaydes, Jeremy P aut Brennan, Keith aut Brown, Nicola J aut Bryant, Helen E aut Bundred, Nigel J aut Burchell, Joy M aut Campbell, Anna M aut Carroll, Jason S aut Clarke, Robert B aut Coles, Charlotte E aut Cook, Gary JR aut Cox, Angela aut Curtin, Nicola J aut Dekker, Lodewijk V aut dos Santos Silva, Isabel aut Duffy, Stephen W aut Easton, Douglas F aut Eccles, Diana M aut Edwards, Dylan R aut Edwards, Joanne aut Evans, D Gareth aut Fenlon, Deborah F aut Flanagan, James M aut Foster, Claire aut Gallagher, William M aut Garcia-Closas, Montserrat aut Gee, Julia M W aut Gescher, Andy J aut Goh, Vicky aut Groves, Ashley M aut Harvey, Amanda J aut Harvie, Michelle aut Hennessy, Bryan T aut Hiscox, Stephen aut Holen, Ingunn aut Howell, Sacha J aut Howell, Anthony aut Hubbard, Gill aut Hulbert-Williams, Nick aut Hunter, Myra S aut Jasani, Bharat aut Jones, Louise J aut Key, Timothy J aut Kirwan, Cliona C aut Kong, Anthony aut Kunkler, Ian H aut Langdon, Simon P aut Leach, Martin O aut Mann, David J aut Marshall, John F aut Martin, Lesley Ann aut Martin, Stewart G aut Macdougall, Jennifer E aut Miles, David W aut Miller, William R aut Morris, Joanna R aut Moss, Sue M aut Mullan, Paul aut Natrajan, Rachel aut O’Connor, James PB aut O’Connor, Rosemary aut Palmieri, Carlo aut Pharoah, Paul D P aut Rakha, Emad A aut Reed, Elizabeth aut Robinson, Simon P aut Sahai, Erik aut Saxton, John M aut Schmid, Peter aut Smalley, Matthew J aut Speirs, Valerie aut Stein, Robert aut Stingl, John aut Streuli, Charles H aut Tutt, Andrew N J aut Velikova, Galina aut Walker, Rosemary A aut Watson, Christine J aut Williams, Kaye J aut Young, Leonie S aut Thompson, Alastair M aut Enthalten in Breast cancer research London : BioMed Central, 1999 15(2013), 5 vom: 01. Okt. (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:15 year:2013 number:5 day:01 month:10 https://dx.doi.org/10.1186/bcr3493 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2106 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2013 5 01 10 |
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10.1186/bcr3493 doi (DE-627)SPR029950325 (SPR)bcr3493-e DE-627 ger DE-627 rakwb eng Eccles, Suzanne A verfasserin aut Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Eccles et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. Aboagye, Eric O aut Ali, Simak aut Anderson, Annie S aut Armes, Jo aut Berditchevski, Fedor aut Blaydes, Jeremy P aut Brennan, Keith aut Brown, Nicola J aut Bryant, Helen E aut Bundred, Nigel J aut Burchell, Joy M aut Campbell, Anna M aut Carroll, Jason S aut Clarke, Robert B aut Coles, Charlotte E aut Cook, Gary JR aut Cox, Angela aut Curtin, Nicola J aut Dekker, Lodewijk V aut dos Santos Silva, Isabel aut Duffy, Stephen W aut Easton, Douglas F aut Eccles, Diana M aut Edwards, Dylan R aut Edwards, Joanne aut Evans, D Gareth aut Fenlon, Deborah F aut Flanagan, James M aut Foster, Claire aut Gallagher, William M aut Garcia-Closas, Montserrat aut Gee, Julia M W aut Gescher, Andy J aut Goh, Vicky aut Groves, Ashley M aut Harvey, Amanda J aut Harvie, Michelle aut Hennessy, Bryan T aut Hiscox, Stephen aut Holen, Ingunn aut Howell, Sacha J aut Howell, Anthony aut Hubbard, Gill aut Hulbert-Williams, Nick aut Hunter, Myra S aut Jasani, Bharat aut Jones, Louise J aut Key, Timothy J aut Kirwan, Cliona C aut Kong, Anthony aut Kunkler, Ian H aut Langdon, Simon P aut Leach, Martin O aut Mann, David J aut Marshall, John F aut Martin, Lesley Ann aut Martin, Stewart G aut Macdougall, Jennifer E aut Miles, David W aut Miller, William R aut Morris, Joanna R aut Moss, Sue M aut Mullan, Paul aut Natrajan, Rachel aut O’Connor, James PB aut O’Connor, Rosemary aut Palmieri, Carlo aut Pharoah, Paul D P aut Rakha, Emad A aut Reed, Elizabeth aut Robinson, Simon P aut Sahai, Erik aut Saxton, John M aut Schmid, Peter aut Smalley, Matthew J aut Speirs, Valerie aut Stein, Robert aut Stingl, John aut Streuli, Charles H aut Tutt, Andrew N J aut Velikova, Galina aut Walker, Rosemary A aut Watson, Christine J aut Williams, Kaye J aut Young, Leonie S aut Thompson, Alastair M aut Enthalten in Breast cancer research London : BioMed Central, 1999 15(2013), 5 vom: 01. Okt. (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:15 year:2013 number:5 day:01 month:10 https://dx.doi.org/10.1186/bcr3493 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2106 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2013 5 01 10 |
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10.1186/bcr3493 doi (DE-627)SPR029950325 (SPR)bcr3493-e DE-627 ger DE-627 rakwb eng Eccles, Suzanne A verfasserin aut Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Eccles et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. Aboagye, Eric O aut Ali, Simak aut Anderson, Annie S aut Armes, Jo aut Berditchevski, Fedor aut Blaydes, Jeremy P aut Brennan, Keith aut Brown, Nicola J aut Bryant, Helen E aut Bundred, Nigel J aut Burchell, Joy M aut Campbell, Anna M aut Carroll, Jason S aut Clarke, Robert B aut Coles, Charlotte E aut Cook, Gary JR aut Cox, Angela aut Curtin, Nicola J aut Dekker, Lodewijk V aut dos Santos Silva, Isabel aut Duffy, Stephen W aut Easton, Douglas F aut Eccles, Diana M aut Edwards, Dylan R aut Edwards, Joanne aut Evans, D Gareth aut Fenlon, Deborah F aut Flanagan, James M aut Foster, Claire aut Gallagher, William M aut Garcia-Closas, Montserrat aut Gee, Julia M W aut Gescher, Andy J aut Goh, Vicky aut Groves, Ashley M aut Harvey, Amanda J aut Harvie, Michelle aut Hennessy, Bryan T aut Hiscox, Stephen aut Holen, Ingunn aut Howell, Sacha J aut Howell, Anthony aut Hubbard, Gill aut Hulbert-Williams, Nick aut Hunter, Myra S aut Jasani, Bharat aut Jones, Louise J aut Key, Timothy J aut Kirwan, Cliona C aut Kong, Anthony aut Kunkler, Ian H aut Langdon, Simon P aut Leach, Martin O aut Mann, David J aut Marshall, John F aut Martin, Lesley Ann aut Martin, Stewart G aut Macdougall, Jennifer E aut Miles, David W aut Miller, William R aut Morris, Joanna R aut Moss, Sue M aut Mullan, Paul aut Natrajan, Rachel aut O’Connor, James PB aut O’Connor, Rosemary aut Palmieri, Carlo aut Pharoah, Paul D P aut Rakha, Emad A aut Reed, Elizabeth aut Robinson, Simon P aut Sahai, Erik aut Saxton, John M aut Schmid, Peter aut Smalley, Matthew J aut Speirs, Valerie aut Stein, Robert aut Stingl, John aut Streuli, Charles H aut Tutt, Andrew N J aut Velikova, Galina aut Walker, Rosemary A aut Watson, Christine J aut Williams, Kaye J aut Young, Leonie S aut Thompson, Alastair M aut Enthalten in Breast cancer research London : BioMed Central, 1999 15(2013), 5 vom: 01. Okt. (DE-627)326645950 (DE-600)2041618-0 1465-542X nnns volume:15 year:2013 number:5 day:01 month:10 https://dx.doi.org/10.1186/bcr3493 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2014 GBV_ILN_2106 GBV_ILN_2232 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2013 5 01 10 |
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Eccles, Suzanne A @@aut@@ Aboagye, Eric O @@aut@@ Ali, Simak @@aut@@ Anderson, Annie S @@aut@@ Armes, Jo @@aut@@ Berditchevski, Fedor @@aut@@ Blaydes, Jeremy P @@aut@@ Brennan, Keith @@aut@@ Brown, Nicola J @@aut@@ Bryant, Helen E @@aut@@ Bundred, Nigel J @@aut@@ Burchell, Joy M @@aut@@ Campbell, Anna M @@aut@@ Carroll, Jason S @@aut@@ Clarke, Robert B @@aut@@ Coles, Charlotte E @@aut@@ Cook, Gary JR @@aut@@ Cox, Angela @@aut@@ Curtin, Nicola J @@aut@@ Dekker, Lodewijk V @@aut@@ dos Santos Silva, Isabel @@aut@@ Duffy, Stephen W @@aut@@ Easton, Douglas F @@aut@@ Eccles, Diana M @@aut@@ Edwards, Dylan R @@aut@@ Edwards, Joanne @@aut@@ Evans, D Gareth @@aut@@ Fenlon, Deborah F @@aut@@ Flanagan, James M @@aut@@ Foster, Claire @@aut@@ Gallagher, William M @@aut@@ Garcia-Closas, Montserrat @@aut@@ Gee, Julia M W @@aut@@ Gescher, Andy J @@aut@@ Goh, Vicky @@aut@@ Groves, Ashley M @@aut@@ Harvey, Amanda J @@aut@@ Harvie, Michelle @@aut@@ Hennessy, Bryan T @@aut@@ Hiscox, Stephen @@aut@@ Holen, Ingunn @@aut@@ Howell, Sacha J @@aut@@ Howell, Anthony @@aut@@ Hubbard, Gill @@aut@@ Hulbert-Williams, Nick @@aut@@ Hunter, Myra S @@aut@@ Jasani, Bharat @@aut@@ Jones, Louise J @@aut@@ Key, Timothy J @@aut@@ Kirwan, Cliona C @@aut@@ Kong, Anthony @@aut@@ Kunkler, Ian H @@aut@@ Langdon, Simon P @@aut@@ Leach, Martin O @@aut@@ Mann, David J @@aut@@ Marshall, John F @@aut@@ Martin, Lesley Ann @@aut@@ Martin, Stewart G @@aut@@ Macdougall, Jennifer E @@aut@@ Miles, David W @@aut@@ Miller, William R @@aut@@ Morris, Joanna R @@aut@@ Moss, Sue M @@aut@@ Mullan, Paul @@aut@@ Natrajan, Rachel @@aut@@ O’Connor, James PB @@aut@@ O’Connor, Rosemary @@aut@@ Palmieri, Carlo @@aut@@ Pharoah, Paul D P @@aut@@ Rakha, Emad A @@aut@@ Reed, Elizabeth @@aut@@ Robinson, Simon P @@aut@@ Sahai, Erik @@aut@@ Saxton, John M @@aut@@ Schmid, Peter @@aut@@ Smalley, Matthew J @@aut@@ Speirs, Valerie @@aut@@ Stein, Robert @@aut@@ Stingl, John @@aut@@ Streuli, Charles H @@aut@@ Tutt, Andrew N J @@aut@@ Velikova, Galina @@aut@@ Walker, Rosemary A @@aut@@ Watson, Christine J @@aut@@ Williams, Kaye J @@aut@@ Young, Leonie S @@aut@@ Thompson, Alastair M @@aut@@ |
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Eccles, Suzanne A |
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Eccles, Suzanne A Aboagye, Eric O Ali, Simak Anderson, Annie S Armes, Jo Berditchevski, Fedor Blaydes, Jeremy P Brennan, Keith Brown, Nicola J Bryant, Helen E Bundred, Nigel J Burchell, Joy M Campbell, Anna M Carroll, Jason S Clarke, Robert B Coles, Charlotte E Cook, Gary JR Cox, Angela Curtin, Nicola J Dekker, Lodewijk V dos Santos Silva, Isabel Duffy, Stephen W Easton, Douglas F Eccles, Diana M Edwards, Dylan R Edwards, Joanne Evans, D Gareth Fenlon, Deborah F Flanagan, James M Foster, Claire Gallagher, William M Garcia-Closas, Montserrat Gee, Julia M W Gescher, Andy J Goh, Vicky Groves, Ashley M Harvey, Amanda J Harvie, Michelle Hennessy, Bryan T Hiscox, Stephen Holen, Ingunn Howell, Sacha J Howell, Anthony Hubbard, Gill Hulbert-Williams, Nick Hunter, Myra S Jasani, Bharat Jones, Louise J Key, Timothy J Kirwan, Cliona C Kong, Anthony Kunkler, Ian H Langdon, Simon P Leach, Martin O Mann, David J Marshall, John F Martin, Lesley Ann Martin, Stewart G Macdougall, Jennifer E Miles, David W Miller, William R Morris, Joanna R Moss, Sue M Mullan, Paul Natrajan, Rachel O’Connor, James PB O’Connor, Rosemary Palmieri, Carlo Pharoah, Paul D P Rakha, Emad A Reed, Elizabeth Robinson, Simon P Sahai, Erik Saxton, John M Schmid, Peter Smalley, Matthew J Speirs, Valerie Stein, Robert Stingl, John Streuli, Charles H Tutt, Andrew N J Velikova, Galina Walker, Rosemary A Watson, Christine J Williams, Kaye J Young, Leonie S Thompson, Alastair M |
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Eccles, Suzanne A |
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10.1186/bcr3493 |
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critical research gaps and translational priorities for the successful prevention and treatment of breast cancer |
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Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer |
| abstract |
Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. © Eccles et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
| abstractGer |
Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. © Eccles et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
| abstract_unstemmed |
Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. © Eccles et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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Aboagye, Eric O Ali, Simak Anderson, Annie S Armes, Jo Berditchevski, Fedor Blaydes, Jeremy P Brennan, Keith Brown, Nicola J Bryant, Helen E Bundred, Nigel J Burchell, Joy M Campbell, Anna M Carroll, Jason S Clarke, Robert B Coles, Charlotte E Cook, Gary JR Cox, Angela Curtin, Nicola J Dekker, Lodewijk V dos Santos Silva, Isabel Duffy, Stephen W Easton, Douglas F Eccles, Diana M Edwards, Dylan R Edwards, Joanne Evans, D Gareth Fenlon, Deborah F Flanagan, James M Foster, Claire Gallagher, William M Garcia-Closas, Montserrat Gee, Julia M W Gescher, Andy J Goh, Vicky Groves, Ashley M Harvey, Amanda J Harvie, Michelle Hennessy, Bryan T Hiscox, Stephen Holen, Ingunn Howell, Sacha J Howell, Anthony Hubbard, Gill Hulbert-Williams, Nick Hunter, Myra S Jasani, Bharat Jones, Louise J Key, Timothy J Kirwan, Cliona C Kong, Anthony Kunkler, Ian H Langdon, Simon P Leach, Martin O Mann, David J Marshall, John F Martin, Lesley Ann Martin, Stewart G Macdougall, Jennifer E Miles, David W Miller, William R Morris, Joanna R Moss, Sue M Mullan, Paul Natrajan, Rachel O’Connor, James PB O’Connor, Rosemary Palmieri, Carlo Pharoah, Paul D P Rakha, Emad A Reed, Elizabeth Robinson, Simon P Sahai, Erik Saxton, John M Schmid, Peter Smalley, Matthew J Speirs, Valerie Stein, Robert Stingl, John Streuli, Charles H Tutt, Andrew N J Velikova, Galina Walker, Rosemary A Watson, Christine J Williams, Kaye J Young, Leonie S Thompson, Alastair M |
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Aboagye, Eric O Ali, Simak Anderson, Annie S Armes, Jo Berditchevski, Fedor Blaydes, Jeremy P Brennan, Keith Brown, Nicola J Bryant, Helen E Bundred, Nigel J Burchell, Joy M Campbell, Anna M Carroll, Jason S Clarke, Robert B Coles, Charlotte E Cook, Gary JR Cox, Angela Curtin, Nicola J Dekker, Lodewijk V dos Santos Silva, Isabel Duffy, Stephen W Easton, Douglas F Eccles, Diana M Edwards, Dylan R Edwards, Joanne Evans, D Gareth Fenlon, Deborah F Flanagan, James M Foster, Claire Gallagher, William M Garcia-Closas, Montserrat Gee, Julia M W Gescher, Andy J Goh, Vicky Groves, Ashley M Harvey, Amanda J Harvie, Michelle Hennessy, Bryan T Hiscox, Stephen Holen, Ingunn Howell, Sacha J Howell, Anthony Hubbard, Gill Hulbert-Williams, Nick Hunter, Myra S Jasani, Bharat Jones, Louise J Key, Timothy J Kirwan, Cliona C Kong, Anthony Kunkler, Ian H Langdon, Simon P Leach, Martin O Mann, David J Marshall, John F Martin, Lesley Ann Martin, Stewart G Macdougall, Jennifer E Miles, David W Miller, William R Morris, Joanna R Moss, Sue M Mullan, Paul Natrajan, Rachel O’Connor, James PB O’Connor, Rosemary Palmieri, Carlo Pharoah, Paul D P Rakha, Emad A Reed, Elizabeth Robinson, Simon P Sahai, Erik Saxton, John M Schmid, Peter Smalley, Matthew J Speirs, Valerie Stein, Robert Stingl, John Streuli, Charles H Tutt, Andrew N J Velikova, Galina Walker, Rosemary A Watson, Christine J Williams, Kaye J Young, Leonie S Thompson, Alastair M |
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| score |
7.400526 |