A high utility integrated map of the pig genome

Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical clone maps have underpinned large-scale genomic sequencing and enabled focused cloning efforts for many genomes....
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Autor*in:	Humphray, Sean J [verfasserIn] Scott, Carol E Clark, Richard Marron, Brandy Bender, Clare Camm, Nick Davis, Jayne Jenks, Andrew Noon, Angela Patel, Manish Sehra, Harminder Yang, Fengtang Rogatcheva, Margarita B Milan, Denis Chardon, Patrick Rohrer, Gary Nonneman, Dan de Jong, Pieter Meyers, Stacey N Archibald, Alan Beever, Jonathan E Schook, Lawrence B Rogers, Jane

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Bacterial Artificial Chromosome Additional Data File Bacterial Artificial Chromosome Clone Radiation Hybrid Minimum Tile Path

Anmerkung:	© Humphray et al.; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (

Übergeordnetes Werk:	Enthalten in: Genome biology - London : BioMed Central, 2000, 8(2007), 7 vom: 11. Juli
Übergeordnetes Werk:	volume:8 ; year:2007 ; number:7 ; day:11 ; month:07

Links:	Volltext

DOI / URN:	10.1186/gb-2007-8-7-r139

Katalog-ID:	SPR030000068

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520			\|a Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical clone maps have underpinned large-scale genomic sequencing and enabled focused cloning efforts for many genomes. Comparative genetic maps indicate that there is more structural similarity between pig and human than, for example, mouse and human, and we have used this close relationship between human and pig as a way of facilitating map construction. Results Here we report the construction of the most highly continuous bacterial artificial chromosome (BAC) map of any mammalian genome, for the pig (Sus scrofa domestica) genome. The map provides a template for the generation and assembly of high-quality anchored sequence across the genome. The physical map integrates previous landmark maps with restriction fingerprints and BAC end sequences from over 260,000 BACs derived from 4 BAC libraries and takes advantage of alignments to the human genome to improve the continuity and local ordering of the clone contigs. We estimate that over 98% of the euchromatin of the 18 pig autosomes and the X chromosome along with localized coverage on Y is represented in 172 contigs, with chromosome 13 (218 Mb) represented by a single contig. The map is accessible through pre-Ensembl, where links to marker and sequence data can be found. Conclusion The map will enable immediate electronic positional cloning of genes, benefiting the pig research community and further facilitating use of the pig as an alternative animal model for human disease. The clone map and BAC end sequence data can also help to support the assembly of maps and genome sequences of other artiodactyls.
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700	1		\|a Milan, Denis \|4 aut
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700	1		\|a Meyers, Stacey N \|4 aut
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700	1		\|a Beever, Jonathan E \|4 aut
700	1		\|a Schook, Lawrence B \|4 aut
700	1		\|a Rogers, Jane \|4 aut
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allfields	10.1186/gb-2007-8-7-r139 doi (DE-627)SPR030000068 (SPR)gb-2007-8-7-r139-e DE-627 ger DE-627 rakwb eng Humphray, Sean J verfasserin aut A high utility integrated map of the pig genome 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Humphray et al.; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical clone maps have underpinned large-scale genomic sequencing and enabled focused cloning efforts for many genomes. Comparative genetic maps indicate that there is more structural similarity between pig and human than, for example, mouse and human, and we have used this close relationship between human and pig as a way of facilitating map construction. Results Here we report the construction of the most highly continuous bacterial artificial chromosome (BAC) map of any mammalian genome, for the pig (Sus scrofa domestica) genome. The map provides a template for the generation and assembly of high-quality anchored sequence across the genome. The physical map integrates previous landmark maps with restriction fingerprints and BAC end sequences from over 260,000 BACs derived from 4 BAC libraries and takes advantage of alignments to the human genome to improve the continuity and local ordering of the clone contigs. We estimate that over 98% of the euchromatin of the 18 pig autosomes and the X chromosome along with localized coverage on Y is represented in 172 contigs, with chromosome 13 (218 Mb) represented by a single contig. The map is accessible through pre-Ensembl, where links to marker and sequence data can be found. Conclusion The map will enable immediate electronic positional cloning of genes, benefiting the pig research community and further facilitating use of the pig as an alternative animal model for human disease. The clone map and BAC end sequence data can also help to support the assembly of maps and genome sequences of other artiodactyls. Bacterial Artificial Chromosome (dpeaa)DE-He213 Additional Data File (dpeaa)DE-He213 Bacterial Artificial Chromosome Clone (dpeaa)DE-He213 Radiation Hybrid (dpeaa)DE-He213 Minimum Tile Path (dpeaa)DE-He213 Scott, Carol E aut Clark, Richard aut Marron, Brandy aut Bender, Clare aut Camm, Nick aut Davis, Jayne aut Jenks, Andrew aut Noon, Angela aut Patel, Manish aut Sehra, Harminder aut Yang, Fengtang aut Rogatcheva, Margarita B aut Milan, Denis aut Chardon, Patrick aut Rohrer, Gary aut Nonneman, Dan aut de Jong, Pieter aut Meyers, Stacey N aut Archibald, Alan aut Beever, Jonathan E aut Schook, Lawrence B aut Rogers, Jane aut Enthalten in Genome biology London : BioMed Central, 2000 8(2007), 7 vom: 11. Juli (DE-627)326173617 (DE-600)2040529-7 1474-760X nnns volume:8 year:2007 number:7 day:11 month:07 https://dx.doi.org/10.1186/gb-2007-8-7-r139 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2007 7 11 07
spelling	10.1186/gb-2007-8-7-r139 doi (DE-627)SPR030000068 (SPR)gb-2007-8-7-r139-e DE-627 ger DE-627 rakwb eng Humphray, Sean J verfasserin aut A high utility integrated map of the pig genome 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Humphray et al.; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical clone maps have underpinned large-scale genomic sequencing and enabled focused cloning efforts for many genomes. Comparative genetic maps indicate that there is more structural similarity between pig and human than, for example, mouse and human, and we have used this close relationship between human and pig as a way of facilitating map construction. Results Here we report the construction of the most highly continuous bacterial artificial chromosome (BAC) map of any mammalian genome, for the pig (Sus scrofa domestica) genome. The map provides a template for the generation and assembly of high-quality anchored sequence across the genome. The physical map integrates previous landmark maps with restriction fingerprints and BAC end sequences from over 260,000 BACs derived from 4 BAC libraries and takes advantage of alignments to the human genome to improve the continuity and local ordering of the clone contigs. We estimate that over 98% of the euchromatin of the 18 pig autosomes and the X chromosome along with localized coverage on Y is represented in 172 contigs, with chromosome 13 (218 Mb) represented by a single contig. The map is accessible through pre-Ensembl, where links to marker and sequence data can be found. Conclusion The map will enable immediate electronic positional cloning of genes, benefiting the pig research community and further facilitating use of the pig as an alternative animal model for human disease. The clone map and BAC end sequence data can also help to support the assembly of maps and genome sequences of other artiodactyls. Bacterial Artificial Chromosome (dpeaa)DE-He213 Additional Data File (dpeaa)DE-He213 Bacterial Artificial Chromosome Clone (dpeaa)DE-He213 Radiation Hybrid (dpeaa)DE-He213 Minimum Tile Path (dpeaa)DE-He213 Scott, Carol E aut Clark, Richard aut Marron, Brandy aut Bender, Clare aut Camm, Nick aut Davis, Jayne aut Jenks, Andrew aut Noon, Angela aut Patel, Manish aut Sehra, Harminder aut Yang, Fengtang aut Rogatcheva, Margarita B aut Milan, Denis aut Chardon, Patrick aut Rohrer, Gary aut Nonneman, Dan aut de Jong, Pieter aut Meyers, Stacey N aut Archibald, Alan aut Beever, Jonathan E aut Schook, Lawrence B aut Rogers, Jane aut Enthalten in Genome biology London : BioMed Central, 2000 8(2007), 7 vom: 11. Juli (DE-627)326173617 (DE-600)2040529-7 1474-760X nnns volume:8 year:2007 number:7 day:11 month:07 https://dx.doi.org/10.1186/gb-2007-8-7-r139 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2007 7 11 07
allfields_unstemmed	10.1186/gb-2007-8-7-r139 doi (DE-627)SPR030000068 (SPR)gb-2007-8-7-r139-e DE-627 ger DE-627 rakwb eng Humphray, Sean J verfasserin aut A high utility integrated map of the pig genome 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Humphray et al.; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical clone maps have underpinned large-scale genomic sequencing and enabled focused cloning efforts for many genomes. Comparative genetic maps indicate that there is more structural similarity between pig and human than, for example, mouse and human, and we have used this close relationship between human and pig as a way of facilitating map construction. Results Here we report the construction of the most highly continuous bacterial artificial chromosome (BAC) map of any mammalian genome, for the pig (Sus scrofa domestica) genome. The map provides a template for the generation and assembly of high-quality anchored sequence across the genome. The physical map integrates previous landmark maps with restriction fingerprints and BAC end sequences from over 260,000 BACs derived from 4 BAC libraries and takes advantage of alignments to the human genome to improve the continuity and local ordering of the clone contigs. We estimate that over 98% of the euchromatin of the 18 pig autosomes and the X chromosome along with localized coverage on Y is represented in 172 contigs, with chromosome 13 (218 Mb) represented by a single contig. The map is accessible through pre-Ensembl, where links to marker and sequence data can be found. Conclusion The map will enable immediate electronic positional cloning of genes, benefiting the pig research community and further facilitating use of the pig as an alternative animal model for human disease. The clone map and BAC end sequence data can also help to support the assembly of maps and genome sequences of other artiodactyls. Bacterial Artificial Chromosome (dpeaa)DE-He213 Additional Data File (dpeaa)DE-He213 Bacterial Artificial Chromosome Clone (dpeaa)DE-He213 Radiation Hybrid (dpeaa)DE-He213 Minimum Tile Path (dpeaa)DE-He213 Scott, Carol E aut Clark, Richard aut Marron, Brandy aut Bender, Clare aut Camm, Nick aut Davis, Jayne aut Jenks, Andrew aut Noon, Angela aut Patel, Manish aut Sehra, Harminder aut Yang, Fengtang aut Rogatcheva, Margarita B aut Milan, Denis aut Chardon, Patrick aut Rohrer, Gary aut Nonneman, Dan aut de Jong, Pieter aut Meyers, Stacey N aut Archibald, Alan aut Beever, Jonathan E aut Schook, Lawrence B aut Rogers, Jane aut Enthalten in Genome biology London : BioMed Central, 2000 8(2007), 7 vom: 11. Juli (DE-627)326173617 (DE-600)2040529-7 1474-760X nnns volume:8 year:2007 number:7 day:11 month:07 https://dx.doi.org/10.1186/gb-2007-8-7-r139 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2007 7 11 07
allfieldsGer	10.1186/gb-2007-8-7-r139 doi (DE-627)SPR030000068 (SPR)gb-2007-8-7-r139-e DE-627 ger DE-627 rakwb eng Humphray, Sean J verfasserin aut A high utility integrated map of the pig genome 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Humphray et al.; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical clone maps have underpinned large-scale genomic sequencing and enabled focused cloning efforts for many genomes. Comparative genetic maps indicate that there is more structural similarity between pig and human than, for example, mouse and human, and we have used this close relationship between human and pig as a way of facilitating map construction. Results Here we report the construction of the most highly continuous bacterial artificial chromosome (BAC) map of any mammalian genome, for the pig (Sus scrofa domestica) genome. The map provides a template for the generation and assembly of high-quality anchored sequence across the genome. The physical map integrates previous landmark maps with restriction fingerprints and BAC end sequences from over 260,000 BACs derived from 4 BAC libraries and takes advantage of alignments to the human genome to improve the continuity and local ordering of the clone contigs. We estimate that over 98% of the euchromatin of the 18 pig autosomes and the X chromosome along with localized coverage on Y is represented in 172 contigs, with chromosome 13 (218 Mb) represented by a single contig. The map is accessible through pre-Ensembl, where links to marker and sequence data can be found. Conclusion The map will enable immediate electronic positional cloning of genes, benefiting the pig research community and further facilitating use of the pig as an alternative animal model for human disease. The clone map and BAC end sequence data can also help to support the assembly of maps and genome sequences of other artiodactyls. Bacterial Artificial Chromosome (dpeaa)DE-He213 Additional Data File (dpeaa)DE-He213 Bacterial Artificial Chromosome Clone (dpeaa)DE-He213 Radiation Hybrid (dpeaa)DE-He213 Minimum Tile Path (dpeaa)DE-He213 Scott, Carol E aut Clark, Richard aut Marron, Brandy aut Bender, Clare aut Camm, Nick aut Davis, Jayne aut Jenks, Andrew aut Noon, Angela aut Patel, Manish aut Sehra, Harminder aut Yang, Fengtang aut Rogatcheva, Margarita B aut Milan, Denis aut Chardon, Patrick aut Rohrer, Gary aut Nonneman, Dan aut de Jong, Pieter aut Meyers, Stacey N aut Archibald, Alan aut Beever, Jonathan E aut Schook, Lawrence B aut Rogers, Jane aut Enthalten in Genome biology London : BioMed Central, 2000 8(2007), 7 vom: 11. Juli (DE-627)326173617 (DE-600)2040529-7 1474-760X nnns volume:8 year:2007 number:7 day:11 month:07 https://dx.doi.org/10.1186/gb-2007-8-7-r139 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2007 7 11 07
allfieldsSound	10.1186/gb-2007-8-7-r139 doi (DE-627)SPR030000068 (SPR)gb-2007-8-7-r139-e DE-627 ger DE-627 rakwb eng Humphray, Sean J verfasserin aut A high utility integrated map of the pig genome 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Humphray et al.; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical clone maps have underpinned large-scale genomic sequencing and enabled focused cloning efforts for many genomes. Comparative genetic maps indicate that there is more structural similarity between pig and human than, for example, mouse and human, and we have used this close relationship between human and pig as a way of facilitating map construction. Results Here we report the construction of the most highly continuous bacterial artificial chromosome (BAC) map of any mammalian genome, for the pig (Sus scrofa domestica) genome. The map provides a template for the generation and assembly of high-quality anchored sequence across the genome. The physical map integrates previous landmark maps with restriction fingerprints and BAC end sequences from over 260,000 BACs derived from 4 BAC libraries and takes advantage of alignments to the human genome to improve the continuity and local ordering of the clone contigs. We estimate that over 98% of the euchromatin of the 18 pig autosomes and the X chromosome along with localized coverage on Y is represented in 172 contigs, with chromosome 13 (218 Mb) represented by a single contig. The map is accessible through pre-Ensembl, where links to marker and sequence data can be found. Conclusion The map will enable immediate electronic positional cloning of genes, benefiting the pig research community and further facilitating use of the pig as an alternative animal model for human disease. The clone map and BAC end sequence data can also help to support the assembly of maps and genome sequences of other artiodactyls. Bacterial Artificial Chromosome (dpeaa)DE-He213 Additional Data File (dpeaa)DE-He213 Bacterial Artificial Chromosome Clone (dpeaa)DE-He213 Radiation Hybrid (dpeaa)DE-He213 Minimum Tile Path (dpeaa)DE-He213 Scott, Carol E aut Clark, Richard aut Marron, Brandy aut Bender, Clare aut Camm, Nick aut Davis, Jayne aut Jenks, Andrew aut Noon, Angela aut Patel, Manish aut Sehra, Harminder aut Yang, Fengtang aut Rogatcheva, Margarita B aut Milan, Denis aut Chardon, Patrick aut Rohrer, Gary aut Nonneman, Dan aut de Jong, Pieter aut Meyers, Stacey N aut Archibald, Alan aut Beever, Jonathan E aut Schook, Lawrence B aut Rogers, Jane aut Enthalten in Genome biology London : BioMed Central, 2000 8(2007), 7 vom: 11. Juli (DE-627)326173617 (DE-600)2040529-7 1474-760X nnns volume:8 year:2007 number:7 day:11 month:07 https://dx.doi.org/10.1186/gb-2007-8-7-r139 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2007 7 11 07
language	English
source	Enthalten in Genome biology 8(2007), 7 vom: 11. Juli volume:8 year:2007 number:7 day:11 month:07
sourceStr	Enthalten in Genome biology 8(2007), 7 vom: 11. Juli volume:8 year:2007 number:7 day:11 month:07
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Bacterial Artificial Chromosome Additional Data File Bacterial Artificial Chromosome Clone Radiation Hybrid Minimum Tile Path
isfreeaccess_bool	true
container_title	Genome biology
authorswithroles_txt_mv	Humphray, Sean J @@aut@@ Scott, Carol E @@aut@@ Clark, Richard @@aut@@ Marron, Brandy @@aut@@ Bender, Clare @@aut@@ Camm, Nick @@aut@@ Davis, Jayne @@aut@@ Jenks, Andrew @@aut@@ Noon, Angela @@aut@@ Patel, Manish @@aut@@ Sehra, Harminder @@aut@@ Yang, Fengtang @@aut@@ Rogatcheva, Margarita B @@aut@@ Milan, Denis @@aut@@ Chardon, Patrick @@aut@@ Rohrer, Gary @@aut@@ Nonneman, Dan @@aut@@ de Jong, Pieter @@aut@@ Meyers, Stacey N @@aut@@ Archibald, Alan @@aut@@ Beever, Jonathan E @@aut@@ Schook, Lawrence B @@aut@@ Rogers, Jane @@aut@@
publishDateDaySort_date	2007-07-11T00:00:00Z
hierarchy_top_id	326173617
id	SPR030000068
language_de	englisch
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spellingShingle	Humphray, Sean J misc Bacterial Artificial Chromosome misc Additional Data File misc Bacterial Artificial Chromosome Clone misc Radiation Hybrid misc Minimum Tile Path A high utility integrated map of the pig genome
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topic_title	A high utility integrated map of the pig genome Bacterial Artificial Chromosome (dpeaa)DE-He213 Additional Data File (dpeaa)DE-He213 Bacterial Artificial Chromosome Clone (dpeaa)DE-He213 Radiation Hybrid (dpeaa)DE-He213 Minimum Tile Path (dpeaa)DE-He213
topic	misc Bacterial Artificial Chromosome misc Additional Data File misc Bacterial Artificial Chromosome Clone misc Radiation Hybrid misc Minimum Tile Path
topic_unstemmed	misc Bacterial Artificial Chromosome misc Additional Data File misc Bacterial Artificial Chromosome Clone misc Radiation Hybrid misc Minimum Tile Path
topic_browse	misc Bacterial Artificial Chromosome misc Additional Data File misc Bacterial Artificial Chromosome Clone misc Radiation Hybrid misc Minimum Tile Path
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title	A high utility integrated map of the pig genome
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title_full	A high utility integrated map of the pig genome
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author_browse	Humphray, Sean J Scott, Carol E Clark, Richard Marron, Brandy Bender, Clare Camm, Nick Davis, Jayne Jenks, Andrew Noon, Angela Patel, Manish Sehra, Harminder Yang, Fengtang Rogatcheva, Margarita B Milan, Denis Chardon, Patrick Rohrer, Gary Nonneman, Dan de Jong, Pieter Meyers, Stacey N Archibald, Alan Beever, Jonathan E Schook, Lawrence B Rogers, Jane
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title_sort	high utility integrated map of the pig genome
title_auth	A high utility integrated map of the pig genome
abstract	Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical clone maps have underpinned large-scale genomic sequencing and enabled focused cloning efforts for many genomes. Comparative genetic maps indicate that there is more structural similarity between pig and human than, for example, mouse and human, and we have used this close relationship between human and pig as a way of facilitating map construction. Results Here we report the construction of the most highly continuous bacterial artificial chromosome (BAC) map of any mammalian genome, for the pig (Sus scrofa domestica) genome. The map provides a template for the generation and assembly of high-quality anchored sequence across the genome. The physical map integrates previous landmark maps with restriction fingerprints and BAC end sequences from over 260,000 BACs derived from 4 BAC libraries and takes advantage of alignments to the human genome to improve the continuity and local ordering of the clone contigs. We estimate that over 98% of the euchromatin of the 18 pig autosomes and the X chromosome along with localized coverage on Y is represented in 172 contigs, with chromosome 13 (218 Mb) represented by a single contig. The map is accessible through pre-Ensembl, where links to marker and sequence data can be found. Conclusion The map will enable immediate electronic positional cloning of genes, benefiting the pig research community and further facilitating use of the pig as an alternative animal model for human disease. The clone map and BAC end sequence data can also help to support the assembly of maps and genome sequences of other artiodactyls. © Humphray et al.; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
abstractGer	Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical clone maps have underpinned large-scale genomic sequencing and enabled focused cloning efforts for many genomes. Comparative genetic maps indicate that there is more structural similarity between pig and human than, for example, mouse and human, and we have used this close relationship between human and pig as a way of facilitating map construction. Results Here we report the construction of the most highly continuous bacterial artificial chromosome (BAC) map of any mammalian genome, for the pig (Sus scrofa domestica) genome. The map provides a template for the generation and assembly of high-quality anchored sequence across the genome. The physical map integrates previous landmark maps with restriction fingerprints and BAC end sequences from over 260,000 BACs derived from 4 BAC libraries and takes advantage of alignments to the human genome to improve the continuity and local ordering of the clone contigs. We estimate that over 98% of the euchromatin of the 18 pig autosomes and the X chromosome along with localized coverage on Y is represented in 172 contigs, with chromosome 13 (218 Mb) represented by a single contig. The map is accessible through pre-Ensembl, where links to marker and sequence data can be found. Conclusion The map will enable immediate electronic positional cloning of genes, benefiting the pig research community and further facilitating use of the pig as an alternative animal model for human disease. The clone map and BAC end sequence data can also help to support the assembly of maps and genome sequences of other artiodactyls. © Humphray et al.; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
abstract_unstemmed	Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical clone maps have underpinned large-scale genomic sequencing and enabled focused cloning efforts for many genomes. Comparative genetic maps indicate that there is more structural similarity between pig and human than, for example, mouse and human, and we have used this close relationship between human and pig as a way of facilitating map construction. Results Here we report the construction of the most highly continuous bacterial artificial chromosome (BAC) map of any mammalian genome, for the pig (Sus scrofa domestica) genome. The map provides a template for the generation and assembly of high-quality anchored sequence across the genome. The physical map integrates previous landmark maps with restriction fingerprints and BAC end sequences from over 260,000 BACs derived from 4 BAC libraries and takes advantage of alignments to the human genome to improve the continuity and local ordering of the clone contigs. We estimate that over 98% of the euchromatin of the 18 pig autosomes and the X chromosome along with localized coverage on Y is represented in 172 contigs, with chromosome 13 (218 Mb) represented by a single contig. The map is accessible through pre-Ensembl, where links to marker and sequence data can be found. Conclusion The map will enable immediate electronic positional cloning of genes, benefiting the pig research community and further facilitating use of the pig as an alternative animal model for human disease. The clone map and BAC end sequence data can also help to support the assembly of maps and genome sequences of other artiodactyls. © Humphray et al.; licensee BioMed Central Ltd. 2007. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (
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title_short	A high utility integrated map of the pig genome
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author2	Scott, Carol E Clark, Richard Marron, Brandy Bender, Clare Camm, Nick Davis, Jayne Jenks, Andrew Noon, Angela Patel, Manish Sehra, Harminder Yang, Fengtang Rogatcheva, Margarita B Milan, Denis Chardon, Patrick Rohrer, Gary Nonneman, Dan de Jong, Pieter Meyers, Stacey N Archibald, Alan Beever, Jonathan E Schook, Lawrence B Rogers, Jane
author2Str	Scott, Carol E Clark, Richard Marron, Brandy Bender, Clare Camm, Nick Davis, Jayne Jenks, Andrew Noon, Angela Patel, Manish Sehra, Harminder Yang, Fengtang Rogatcheva, Margarita B Milan, Denis Chardon, Patrick Rohrer, Gary Nonneman, Dan de Jong, Pieter Meyers, Stacey N Archibald, Alan Beever, Jonathan E Schook, Lawrence B Rogers, Jane
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A high utility integrated map of the pig genome

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