Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process

Abstract Traumatic injuries of the peripheral nerves are very common. Surgical repair of the damaged nerve is often complicated by scar tissue formation around the damaged nerve itself. The main objective of this study is to present the recent data from animal experimental studies where pharmacologi...
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Autor*in:	Mekaj, Agon Y [verfasserIn] Morina, Arsim A Bytyqi, Cen I Mekaj, Ymer H Duci, Shkelzen B

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Tacrolimus Hyaluronic acid Melatonin Vitamin B12 Peripheral nerve injury

Anmerkung:	© Mekaj et al.; licensee BioMed Central Ltd. 2014

Übergeordnetes Werk:	Enthalten in: Journal of orthopaedic surgery and research - London : Biomed Central, 2006, 9(2014), 1 vom: 11. Okt.
Übergeordnetes Werk:	volume:9 ; year:2014 ; number:1 ; day:11 ; month:10

Links:	Volltext

DOI / URN:	10.1186/s13018-014-0094-3

Katalog-ID:	SPR030007321

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allfields	10.1186/s13018-014-0094-3 doi (DE-627)SPR030007321 (SPR)s13018-014-0094-3-e DE-627 ger DE-627 rakwb eng Mekaj, Agon Y verfasserin aut Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mekaj et al.; licensee BioMed Central Ltd. 2014 Abstract Traumatic injuries of the peripheral nerves are very common. Surgical repair of the damaged nerve is often complicated by scar tissue formation around the damaged nerve itself. The main objective of this study is to present the recent data from animal experimental studies where pharmacological topical agents are used at the site of peripheral nerve repair. Some of the most commonly topical agents used are tacrolimus (FK506), hyaluronic acid and its derivatives, and melatonin, whereas methylprednisolone and vitamin B12 have been used less. These studies have shown that the abovementioned substances have neuroprotective and neuroregenerative properties though different mechanisms. The successes of the regenerative process of the nerve repair in experimental research, using topical agents, can be evaluated using variety of methods such as morphological, electrophysiologic, and functional evaluation. However, most authors agree that despite good microsurgical repair and topical application of these substances, full regeneration and functional recovery of the nerve injured are almost never achieved. Tacrolimus (dpeaa)DE-He213 Hyaluronic acid (dpeaa)DE-He213 Melatonin (dpeaa)DE-He213 Vitamin B12 (dpeaa)DE-He213 Peripheral nerve injury (dpeaa)DE-He213 Morina, Arsim A aut Bytyqi, Cen I aut Mekaj, Ymer H aut Duci, Shkelzen B aut Enthalten in Journal of orthopaedic surgery and research London : Biomed Central, 2006 9(2014), 1 vom: 11. Okt. (DE-627)518346145 (DE-600)2252548-8 1749-799X nnns volume:9 year:2014 number:1 day:11 month:10 https://dx.doi.org/10.1186/s13018-014-0094-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 1 11 10
spelling	10.1186/s13018-014-0094-3 doi (DE-627)SPR030007321 (SPR)s13018-014-0094-3-e DE-627 ger DE-627 rakwb eng Mekaj, Agon Y verfasserin aut Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mekaj et al.; licensee BioMed Central Ltd. 2014 Abstract Traumatic injuries of the peripheral nerves are very common. Surgical repair of the damaged nerve is often complicated by scar tissue formation around the damaged nerve itself. The main objective of this study is to present the recent data from animal experimental studies where pharmacological topical agents are used at the site of peripheral nerve repair. Some of the most commonly topical agents used are tacrolimus (FK506), hyaluronic acid and its derivatives, and melatonin, whereas methylprednisolone and vitamin B12 have been used less. These studies have shown that the abovementioned substances have neuroprotective and neuroregenerative properties though different mechanisms. The successes of the regenerative process of the nerve repair in experimental research, using topical agents, can be evaluated using variety of methods such as morphological, electrophysiologic, and functional evaluation. However, most authors agree that despite good microsurgical repair and topical application of these substances, full regeneration and functional recovery of the nerve injured are almost never achieved. Tacrolimus (dpeaa)DE-He213 Hyaluronic acid (dpeaa)DE-He213 Melatonin (dpeaa)DE-He213 Vitamin B12 (dpeaa)DE-He213 Peripheral nerve injury (dpeaa)DE-He213 Morina, Arsim A aut Bytyqi, Cen I aut Mekaj, Ymer H aut Duci, Shkelzen B aut Enthalten in Journal of orthopaedic surgery and research London : Biomed Central, 2006 9(2014), 1 vom: 11. Okt. (DE-627)518346145 (DE-600)2252548-8 1749-799X nnns volume:9 year:2014 number:1 day:11 month:10 https://dx.doi.org/10.1186/s13018-014-0094-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 1 11 10
allfields_unstemmed	10.1186/s13018-014-0094-3 doi (DE-627)SPR030007321 (SPR)s13018-014-0094-3-e DE-627 ger DE-627 rakwb eng Mekaj, Agon Y verfasserin aut Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mekaj et al.; licensee BioMed Central Ltd. 2014 Abstract Traumatic injuries of the peripheral nerves are very common. Surgical repair of the damaged nerve is often complicated by scar tissue formation around the damaged nerve itself. The main objective of this study is to present the recent data from animal experimental studies where pharmacological topical agents are used at the site of peripheral nerve repair. Some of the most commonly topical agents used are tacrolimus (FK506), hyaluronic acid and its derivatives, and melatonin, whereas methylprednisolone and vitamin B12 have been used less. These studies have shown that the abovementioned substances have neuroprotective and neuroregenerative properties though different mechanisms. The successes of the regenerative process of the nerve repair in experimental research, using topical agents, can be evaluated using variety of methods such as morphological, electrophysiologic, and functional evaluation. However, most authors agree that despite good microsurgical repair and topical application of these substances, full regeneration and functional recovery of the nerve injured are almost never achieved. Tacrolimus (dpeaa)DE-He213 Hyaluronic acid (dpeaa)DE-He213 Melatonin (dpeaa)DE-He213 Vitamin B12 (dpeaa)DE-He213 Peripheral nerve injury (dpeaa)DE-He213 Morina, Arsim A aut Bytyqi, Cen I aut Mekaj, Ymer H aut Duci, Shkelzen B aut Enthalten in Journal of orthopaedic surgery and research London : Biomed Central, 2006 9(2014), 1 vom: 11. Okt. (DE-627)518346145 (DE-600)2252548-8 1749-799X nnns volume:9 year:2014 number:1 day:11 month:10 https://dx.doi.org/10.1186/s13018-014-0094-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 1 11 10
allfieldsGer	10.1186/s13018-014-0094-3 doi (DE-627)SPR030007321 (SPR)s13018-014-0094-3-e DE-627 ger DE-627 rakwb eng Mekaj, Agon Y verfasserin aut Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mekaj et al.; licensee BioMed Central Ltd. 2014 Abstract Traumatic injuries of the peripheral nerves are very common. Surgical repair of the damaged nerve is often complicated by scar tissue formation around the damaged nerve itself. The main objective of this study is to present the recent data from animal experimental studies where pharmacological topical agents are used at the site of peripheral nerve repair. Some of the most commonly topical agents used are tacrolimus (FK506), hyaluronic acid and its derivatives, and melatonin, whereas methylprednisolone and vitamin B12 have been used less. These studies have shown that the abovementioned substances have neuroprotective and neuroregenerative properties though different mechanisms. The successes of the regenerative process of the nerve repair in experimental research, using topical agents, can be evaluated using variety of methods such as morphological, electrophysiologic, and functional evaluation. However, most authors agree that despite good microsurgical repair and topical application of these substances, full regeneration and functional recovery of the nerve injured are almost never achieved. Tacrolimus (dpeaa)DE-He213 Hyaluronic acid (dpeaa)DE-He213 Melatonin (dpeaa)DE-He213 Vitamin B12 (dpeaa)DE-He213 Peripheral nerve injury (dpeaa)DE-He213 Morina, Arsim A aut Bytyqi, Cen I aut Mekaj, Ymer H aut Duci, Shkelzen B aut Enthalten in Journal of orthopaedic surgery and research London : Biomed Central, 2006 9(2014), 1 vom: 11. Okt. (DE-627)518346145 (DE-600)2252548-8 1749-799X nnns volume:9 year:2014 number:1 day:11 month:10 https://dx.doi.org/10.1186/s13018-014-0094-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 1 11 10
allfieldsSound	10.1186/s13018-014-0094-3 doi (DE-627)SPR030007321 (SPR)s13018-014-0094-3-e DE-627 ger DE-627 rakwb eng Mekaj, Agon Y verfasserin aut Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Mekaj et al.; licensee BioMed Central Ltd. 2014 Abstract Traumatic injuries of the peripheral nerves are very common. Surgical repair of the damaged nerve is often complicated by scar tissue formation around the damaged nerve itself. The main objective of this study is to present the recent data from animal experimental studies where pharmacological topical agents are used at the site of peripheral nerve repair. Some of the most commonly topical agents used are tacrolimus (FK506), hyaluronic acid and its derivatives, and melatonin, whereas methylprednisolone and vitamin B12 have been used less. These studies have shown that the abovementioned substances have neuroprotective and neuroregenerative properties though different mechanisms. The successes of the regenerative process of the nerve repair in experimental research, using topical agents, can be evaluated using variety of methods such as morphological, electrophysiologic, and functional evaluation. However, most authors agree that despite good microsurgical repair and topical application of these substances, full regeneration and functional recovery of the nerve injured are almost never achieved. Tacrolimus (dpeaa)DE-He213 Hyaluronic acid (dpeaa)DE-He213 Melatonin (dpeaa)DE-He213 Vitamin B12 (dpeaa)DE-He213 Peripheral nerve injury (dpeaa)DE-He213 Morina, Arsim A aut Bytyqi, Cen I aut Mekaj, Ymer H aut Duci, Shkelzen B aut Enthalten in Journal of orthopaedic surgery and research London : Biomed Central, 2006 9(2014), 1 vom: 11. Okt. (DE-627)518346145 (DE-600)2252548-8 1749-799X nnns volume:9 year:2014 number:1 day:11 month:10 https://dx.doi.org/10.1186/s13018-014-0094-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 1 11 10
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source	Enthalten in Journal of orthopaedic surgery and research 9(2014), 1 vom: 11. Okt. volume:9 year:2014 number:1 day:11 month:10
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topic	misc Tacrolimus misc Hyaluronic acid misc Melatonin misc Vitamin B12 misc Peripheral nerve injury
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title_sort	application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process
title_auth	Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process
abstract	Abstract Traumatic injuries of the peripheral nerves are very common. Surgical repair of the damaged nerve is often complicated by scar tissue formation around the damaged nerve itself. The main objective of this study is to present the recent data from animal experimental studies where pharmacological topical agents are used at the site of peripheral nerve repair. Some of the most commonly topical agents used are tacrolimus (FK506), hyaluronic acid and its derivatives, and melatonin, whereas methylprednisolone and vitamin B12 have been used less. These studies have shown that the abovementioned substances have neuroprotective and neuroregenerative properties though different mechanisms. The successes of the regenerative process of the nerve repair in experimental research, using topical agents, can be evaluated using variety of methods such as morphological, electrophysiologic, and functional evaluation. However, most authors agree that despite good microsurgical repair and topical application of these substances, full regeneration and functional recovery of the nerve injured are almost never achieved. © Mekaj et al.; licensee BioMed Central Ltd. 2014
abstractGer	Abstract Traumatic injuries of the peripheral nerves are very common. Surgical repair of the damaged nerve is often complicated by scar tissue formation around the damaged nerve itself. The main objective of this study is to present the recent data from animal experimental studies where pharmacological topical agents are used at the site of peripheral nerve repair. Some of the most commonly topical agents used are tacrolimus (FK506), hyaluronic acid and its derivatives, and melatonin, whereas methylprednisolone and vitamin B12 have been used less. These studies have shown that the abovementioned substances have neuroprotective and neuroregenerative properties though different mechanisms. The successes of the regenerative process of the nerve repair in experimental research, using topical agents, can be evaluated using variety of methods such as morphological, electrophysiologic, and functional evaluation. However, most authors agree that despite good microsurgical repair and topical application of these substances, full regeneration and functional recovery of the nerve injured are almost never achieved. © Mekaj et al.; licensee BioMed Central Ltd. 2014
abstract_unstemmed	Abstract Traumatic injuries of the peripheral nerves are very common. Surgical repair of the damaged nerve is often complicated by scar tissue formation around the damaged nerve itself. The main objective of this study is to present the recent data from animal experimental studies where pharmacological topical agents are used at the site of peripheral nerve repair. Some of the most commonly topical agents used are tacrolimus (FK506), hyaluronic acid and its derivatives, and melatonin, whereas methylprednisolone and vitamin B12 have been used less. These studies have shown that the abovementioned substances have neuroprotective and neuroregenerative properties though different mechanisms. The successes of the regenerative process of the nerve repair in experimental research, using topical agents, can be evaluated using variety of methods such as morphological, electrophysiologic, and functional evaluation. However, most authors agree that despite good microsurgical repair and topical application of these substances, full regeneration and functional recovery of the nerve injured are almost never achieved. © Mekaj et al.; licensee BioMed Central Ltd. 2014
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title_short	Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process
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Application of topical pharmacological agents at the site of peripheral nerve injury and methods used for evaluating the success of the regenerative process

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