Effects of chronic sleep deprivation on bone mass and bone metabolism in rats

Background This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establi...
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Autor*in:	Xu, Xiaowen [verfasserIn] Wang, Liang Chen, Liying Su, Tianjiao Zhang, Yan Wang, Tiantian Ma, Weifeng Yang, Fan Zhai, Wujie Xie, Yuanyuan Li, Dan Chen, Qiong Fu, Xuemei Ma, Yuanzheng

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Chronic sleep deprivation Bone mineral density Bone microstructure Bone turnover Vitamin D

Anmerkung:	© The Author(s). 2016

Übergeordnetes Werk:	Enthalten in: Journal of orthopaedic surgery and research - London : Biomed Central, 2006, 11(2016), 1 vom: 02. Aug.
Übergeordnetes Werk:	volume:11 ; year:2016 ; number:1 ; day:02 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s13018-016-0418-6

Katalog-ID:	SPR030038561

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520			\|a Background This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). Conclusions CSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers.
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650		4	\|a Bone mineral density \|7 (dpeaa)DE-He213
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650		4	\|a Bone turnover \|7 (dpeaa)DE-He213
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700	1		\|a Fu, Xuemei \|4 aut
700	1		\|a Ma, Yuanzheng \|4 aut
700	1		\|a Zhang, Yan \|4 aut
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allfields	10.1186/s13018-016-0418-6 doi (DE-627)SPR030038561 (SPR)s13018-016-0418-6-e DE-627 ger DE-627 rakwb eng Xu, Xiaowen verfasserin aut Effects of chronic sleep deprivation on bone mass and bone metabolism in rats 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). Conclusions CSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers. Chronic sleep deprivation (dpeaa)DE-He213 Bone mineral density (dpeaa)DE-He213 Bone microstructure (dpeaa)DE-He213 Bone turnover (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213 Wang, Liang aut Chen, Liying aut Su, Tianjiao aut Zhang, Yan aut Wang, Tiantian aut Ma, Weifeng aut Yang, Fan aut Zhai, Wujie aut Xie, Yuanyuan aut Li, Dan aut Chen, Qiong aut Fu, Xuemei aut Ma, Yuanzheng aut Zhang, Yan aut Enthalten in Journal of orthopaedic surgery and research London : Biomed Central, 2006 11(2016), 1 vom: 02. Aug. (DE-627)518346145 (DE-600)2252548-8 1749-799X nnns volume:11 year:2016 number:1 day:02 month:08 https://dx.doi.org/10.1186/s13018-016-0418-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 1 02 08
spelling	10.1186/s13018-016-0418-6 doi (DE-627)SPR030038561 (SPR)s13018-016-0418-6-e DE-627 ger DE-627 rakwb eng Xu, Xiaowen verfasserin aut Effects of chronic sleep deprivation on bone mass and bone metabolism in rats 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). Conclusions CSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers. Chronic sleep deprivation (dpeaa)DE-He213 Bone mineral density (dpeaa)DE-He213 Bone microstructure (dpeaa)DE-He213 Bone turnover (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213 Wang, Liang aut Chen, Liying aut Su, Tianjiao aut Zhang, Yan aut Wang, Tiantian aut Ma, Weifeng aut Yang, Fan aut Zhai, Wujie aut Xie, Yuanyuan aut Li, Dan aut Chen, Qiong aut Fu, Xuemei aut Ma, Yuanzheng aut Zhang, Yan aut Enthalten in Journal of orthopaedic surgery and research London : Biomed Central, 2006 11(2016), 1 vom: 02. Aug. (DE-627)518346145 (DE-600)2252548-8 1749-799X nnns volume:11 year:2016 number:1 day:02 month:08 https://dx.doi.org/10.1186/s13018-016-0418-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 1 02 08
allfields_unstemmed	10.1186/s13018-016-0418-6 doi (DE-627)SPR030038561 (SPR)s13018-016-0418-6-e DE-627 ger DE-627 rakwb eng Xu, Xiaowen verfasserin aut Effects of chronic sleep deprivation on bone mass and bone metabolism in rats 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). Conclusions CSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers. Chronic sleep deprivation (dpeaa)DE-He213 Bone mineral density (dpeaa)DE-He213 Bone microstructure (dpeaa)DE-He213 Bone turnover (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213 Wang, Liang aut Chen, Liying aut Su, Tianjiao aut Zhang, Yan aut Wang, Tiantian aut Ma, Weifeng aut Yang, Fan aut Zhai, Wujie aut Xie, Yuanyuan aut Li, Dan aut Chen, Qiong aut Fu, Xuemei aut Ma, Yuanzheng aut Zhang, Yan aut Enthalten in Journal of orthopaedic surgery and research London : Biomed Central, 2006 11(2016), 1 vom: 02. Aug. (DE-627)518346145 (DE-600)2252548-8 1749-799X nnns volume:11 year:2016 number:1 day:02 month:08 https://dx.doi.org/10.1186/s13018-016-0418-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 1 02 08
allfieldsGer	10.1186/s13018-016-0418-6 doi (DE-627)SPR030038561 (SPR)s13018-016-0418-6-e DE-627 ger DE-627 rakwb eng Xu, Xiaowen verfasserin aut Effects of chronic sleep deprivation on bone mass and bone metabolism in rats 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). Conclusions CSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers. Chronic sleep deprivation (dpeaa)DE-He213 Bone mineral density (dpeaa)DE-He213 Bone microstructure (dpeaa)DE-He213 Bone turnover (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213 Wang, Liang aut Chen, Liying aut Su, Tianjiao aut Zhang, Yan aut Wang, Tiantian aut Ma, Weifeng aut Yang, Fan aut Zhai, Wujie aut Xie, Yuanyuan aut Li, Dan aut Chen, Qiong aut Fu, Xuemei aut Ma, Yuanzheng aut Zhang, Yan aut Enthalten in Journal of orthopaedic surgery and research London : Biomed Central, 2006 11(2016), 1 vom: 02. Aug. (DE-627)518346145 (DE-600)2252548-8 1749-799X nnns volume:11 year:2016 number:1 day:02 month:08 https://dx.doi.org/10.1186/s13018-016-0418-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 1 02 08
allfieldsSound	10.1186/s13018-016-0418-6 doi (DE-627)SPR030038561 (SPR)s13018-016-0418-6-e DE-627 ger DE-627 rakwb eng Xu, Xiaowen verfasserin aut Effects of chronic sleep deprivation on bone mass and bone metabolism in rats 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). Conclusions CSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers. Chronic sleep deprivation (dpeaa)DE-He213 Bone mineral density (dpeaa)DE-He213 Bone microstructure (dpeaa)DE-He213 Bone turnover (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213 Wang, Liang aut Chen, Liying aut Su, Tianjiao aut Zhang, Yan aut Wang, Tiantian aut Ma, Weifeng aut Yang, Fan aut Zhai, Wujie aut Xie, Yuanyuan aut Li, Dan aut Chen, Qiong aut Fu, Xuemei aut Ma, Yuanzheng aut Zhang, Yan aut Enthalten in Journal of orthopaedic surgery and research London : Biomed Central, 2006 11(2016), 1 vom: 02. Aug. (DE-627)518346145 (DE-600)2252548-8 1749-799X nnns volume:11 year:2016 number:1 day:02 month:08 https://dx.doi.org/10.1186/s13018-016-0418-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 1 02 08
language	English
source	Enthalten in Journal of orthopaedic surgery and research 11(2016), 1 vom: 02. Aug. volume:11 year:2016 number:1 day:02 month:08
sourceStr	Enthalten in Journal of orthopaedic surgery and research 11(2016), 1 vom: 02. Aug. volume:11 year:2016 number:1 day:02 month:08
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chronic sleep deprivation Bone mineral density Bone microstructure Bone turnover Vitamin D
isfreeaccess_bool	true
container_title	Journal of orthopaedic surgery and research
authorswithroles_txt_mv	Xu, Xiaowen @@aut@@ Wang, Liang @@aut@@ Chen, Liying @@aut@@ Su, Tianjiao @@aut@@ Zhang, Yan @@aut@@ Wang, Tiantian @@aut@@ Ma, Weifeng @@aut@@ Yang, Fan @@aut@@ Zhai, Wujie @@aut@@ Xie, Yuanyuan @@aut@@ Li, Dan @@aut@@ Chen, Qiong @@aut@@ Fu, Xuemei @@aut@@ Ma, Yuanzheng @@aut@@
publishDateDaySort_date	2016-08-02T00:00:00Z
hierarchy_top_id	518346145
id	SPR030038561
language_de	englisch
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Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). Conclusions CSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Chronic sleep deprivation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bone mineral density</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bone microstructure</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bone turnover</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Vitamin D</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Liang</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Liying</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Su, Tianjiao</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Yan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Tiantian</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ma, Weifeng</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yang, Fan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhai, Wujie</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Xie, Yuanyuan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Li, Dan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chen, Qiong</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fu, Xuemei</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ma, Yuanzheng</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zhang, Yan</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of orthopaedic surgery and research</subfield><subfield code="d">London : Biomed Central, 2006</subfield><subfield code="g">11(2016), 1 vom: 02. 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author	Xu, Xiaowen
spellingShingle	Xu, Xiaowen misc Chronic sleep deprivation misc Bone mineral density misc Bone microstructure misc Bone turnover misc Vitamin D Effects of chronic sleep deprivation on bone mass and bone metabolism in rats
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topic_title	Effects of chronic sleep deprivation on bone mass and bone metabolism in rats Chronic sleep deprivation (dpeaa)DE-He213 Bone mineral density (dpeaa)DE-He213 Bone microstructure (dpeaa)DE-He213 Bone turnover (dpeaa)DE-He213 Vitamin D (dpeaa)DE-He213
topic	misc Chronic sleep deprivation misc Bone mineral density misc Bone microstructure misc Bone turnover misc Vitamin D
topic_unstemmed	misc Chronic sleep deprivation misc Bone mineral density misc Bone microstructure misc Bone turnover misc Vitamin D
topic_browse	misc Chronic sleep deprivation misc Bone mineral density misc Bone microstructure misc Bone turnover misc Vitamin D
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title	Effects of chronic sleep deprivation on bone mass and bone metabolism in rats
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title_full	Effects of chronic sleep deprivation on bone mass and bone metabolism in rats
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author_browse	Xu, Xiaowen Wang, Liang Chen, Liying Su, Tianjiao Zhang, Yan Wang, Tiantian Ma, Weifeng Yang, Fan Zhai, Wujie Xie, Yuanyuan Li, Dan Chen, Qiong Fu, Xuemei Ma, Yuanzheng
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title_sort	effects of chronic sleep deprivation on bone mass and bone metabolism in rats
title_auth	Effects of chronic sleep deprivation on bone mass and bone metabolism in rats
abstract	Background This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). Conclusions CSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers. © The Author(s). 2016
abstractGer	Background This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). Conclusions CSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers. © The Author(s). 2016
abstract_unstemmed	Background This study aimed to assess the effects of chronic sleep deprivation (CSD) on bone mass and bone metabolism in rats. Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). Conclusions CSD markedly affects bone health by decreasing BMD and 25(OH)D, deteriorating the bone microarchitecture, and decreasing bone formation and bone resorption markers. © The Author(s). 2016
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title_short	Effects of chronic sleep deprivation on bone mass and bone metabolism in rats
url	https://dx.doi.org/10.1186/s13018-016-0418-6
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author2	Wang, Liang Chen, Liying Su, Tianjiao Zhang, Yan Wang, Tiantian Ma, Weifeng Yang, Fan Zhai, Wujie Xie, Yuanyuan Li, Dan Chen, Qiong Fu, Xuemei Ma, Yuanzheng
author2Str	Wang, Liang Chen, Liying Su, Tianjiao Zhang, Yan Wang, Tiantian Ma, Weifeng Yang, Fan Zhai, Wujie Xie, Yuanyuan Li, Dan Chen, Qiong Fu, Xuemei Ma, Yuanzheng
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up_date	2024-07-03T13:30:02.538Z
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Methods Twenty-four rats were randomly divided into CSD and control (CON) groups. Rats were subjected to CSD by using the modified multiple platform method (MMPM) to establish an animal model of CSD. Biochemical parameters such as levels of serum N-terminal propeptide of type I procollagen (PINP), N-terminal cross-linking telopeptide of type I collagen (NTX), growth hormone (GH), estradiol ($ E_{2} $), serum 25(OH)D, and calcium (Ca) were evaluated at 0, 1, 2, and 3 months. After 3 months, each fourth lumbar vertebra and the distal femoral metaphysis of the left extremity of rats were harvested for micro-computed tomography scans and histological analysis, respectively, after the rats were sacrificed under an overdose of pentobarbital sodium. Results Compared with rats from the CON group, rats from the CSD group showed significant decreases in bone mineral density (BMD), bone volume over total volume, trabecular bone thickness, and trabecular bone number and significant increases in bone surface area over bone volume and trabecular bone separations (P < 0.05). Bone histomorphology studies showed that rats in the CSD group had decreased osteogenesis, impaired mineralization of newly formed bones, and deteriorative trabecular bone in the secondary spongiosa zone. In addition, they showed significantly decreased levels of serum PINP (1 month later) and NTX (3 months later) (P < 0.05). The serum 25(OH)D level of rats from the CSD group was lower than that of rats from the CON group after 1 month (P < 0.05). 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Effects of chronic sleep deprivation on bone mass and bone metabolism in rats

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