Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
Abstract We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs....
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Veitia, Reiner A [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2009 |
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| Schlagwörter: |
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| Anmerkung: |
© Veitia and Caburet; licensee BioMed Central Ltd. 2009 |
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| Übergeordnetes Werk: |
Enthalten in: Biology direct - London : BioMed Central, 2006, 4(2009), 1 vom: 16. Juli |
|---|---|
| Übergeordnetes Werk: |
volume:4 ; year:2009 ; number:1 ; day:16 ; month:07 |
| Links: |
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| DOI / URN: |
10.1186/1745-6150-4-22 |
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| 520 | |a Abstract We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence. Reviewers: This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin. | ||
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10.1186/1745-6150-4-22 doi (DE-627)SPR03004197X (SPR)1745-6150-4-22-e DE-627 ger DE-627 rakwb eng Veitia, Reiner A verfasserin aut Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Veitia and Caburet; licensee BioMed Central Ltd. 2009 Abstract We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence. Reviewers: This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin. Signal Peptide (dpeaa)DE-He213 Fitness Landscape (dpeaa)DE-He213 Compensatory Mutation (dpeaa)DE-He213 Neutral Network (dpeaa)DE-He213 Functional Convergence (dpeaa)DE-He213 Caburet, Sandrine aut Enthalten in Biology direct London : BioMed Central, 2006 4(2009), 1 vom: 16. Juli (DE-627)507522516 (DE-600)2221028-3 1745-6150 nnns volume:4 year:2009 number:1 day:16 month:07 https://dx.doi.org/10.1186/1745-6150-4-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 07 |
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10.1186/1745-6150-4-22 doi (DE-627)SPR03004197X (SPR)1745-6150-4-22-e DE-627 ger DE-627 rakwb eng Veitia, Reiner A verfasserin aut Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Veitia and Caburet; licensee BioMed Central Ltd. 2009 Abstract We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence. Reviewers: This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin. Signal Peptide (dpeaa)DE-He213 Fitness Landscape (dpeaa)DE-He213 Compensatory Mutation (dpeaa)DE-He213 Neutral Network (dpeaa)DE-He213 Functional Convergence (dpeaa)DE-He213 Caburet, Sandrine aut Enthalten in Biology direct London : BioMed Central, 2006 4(2009), 1 vom: 16. Juli (DE-627)507522516 (DE-600)2221028-3 1745-6150 nnns volume:4 year:2009 number:1 day:16 month:07 https://dx.doi.org/10.1186/1745-6150-4-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 07 |
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10.1186/1745-6150-4-22 doi (DE-627)SPR03004197X (SPR)1745-6150-4-22-e DE-627 ger DE-627 rakwb eng Veitia, Reiner A verfasserin aut Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Veitia and Caburet; licensee BioMed Central Ltd. 2009 Abstract We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence. Reviewers: This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin. Signal Peptide (dpeaa)DE-He213 Fitness Landscape (dpeaa)DE-He213 Compensatory Mutation (dpeaa)DE-He213 Neutral Network (dpeaa)DE-He213 Functional Convergence (dpeaa)DE-He213 Caburet, Sandrine aut Enthalten in Biology direct London : BioMed Central, 2006 4(2009), 1 vom: 16. Juli (DE-627)507522516 (DE-600)2221028-3 1745-6150 nnns volume:4 year:2009 number:1 day:16 month:07 https://dx.doi.org/10.1186/1745-6150-4-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 07 |
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10.1186/1745-6150-4-22 doi (DE-627)SPR03004197X (SPR)1745-6150-4-22-e DE-627 ger DE-627 rakwb eng Veitia, Reiner A verfasserin aut Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Veitia and Caburet; licensee BioMed Central Ltd. 2009 Abstract We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence. Reviewers: This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin. Signal Peptide (dpeaa)DE-He213 Fitness Landscape (dpeaa)DE-He213 Compensatory Mutation (dpeaa)DE-He213 Neutral Network (dpeaa)DE-He213 Functional Convergence (dpeaa)DE-He213 Caburet, Sandrine aut Enthalten in Biology direct London : BioMed Central, 2006 4(2009), 1 vom: 16. Juli (DE-627)507522516 (DE-600)2221028-3 1745-6150 nnns volume:4 year:2009 number:1 day:16 month:07 https://dx.doi.org/10.1186/1745-6150-4-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 07 |
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10.1186/1745-6150-4-22 doi (DE-627)SPR03004197X (SPR)1745-6150-4-22-e DE-627 ger DE-627 rakwb eng Veitia, Reiner A verfasserin aut Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Veitia and Caburet; licensee BioMed Central Ltd. 2009 Abstract We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence. Reviewers: This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin. Signal Peptide (dpeaa)DE-He213 Fitness Landscape (dpeaa)DE-He213 Compensatory Mutation (dpeaa)DE-He213 Neutral Network (dpeaa)DE-He213 Functional Convergence (dpeaa)DE-He213 Caburet, Sandrine aut Enthalten in Biology direct London : BioMed Central, 2006 4(2009), 1 vom: 16. Juli (DE-627)507522516 (DE-600)2221028-3 1745-6150 nnns volume:4 year:2009 number:1 day:16 month:07 https://dx.doi.org/10.1186/1745-6150-4-22 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 07 |
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Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape |
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Abstract We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence. Reviewers: This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin. © Veitia and Caburet; licensee BioMed Central Ltd. 2009 |
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Abstract We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence. Reviewers: This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin. © Veitia and Caburet; licensee BioMed Central Ltd. 2009 |
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Abstract We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence. Reviewers: This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin. © Veitia and Caburet; licensee BioMed Central Ltd. 2009 |
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| score |
7.3981476 |