Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands

Abstract Four novel complexes [Co($ H_{2} $O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co($ H_{2} $O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and charac...
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Gespeichert in:

Autor*in:	Shalash, Asia M. [verfasserIn] Abu Ali, Hijazi I.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Cobalt(II) complexes Nitrogen donor ligands Sulindac Anti-bacterial activity

Anmerkung:	© The Author(s) 2017

Übergeordnetes Werk:	Enthalten in: Chemistry central journal - London : BioMed Central, 2007, 11(2017), 1 vom: 10. Mai
Übergeordnetes Werk:	volume:11 ; year:2017 ; number:1 ; day:10 ; month:05

Links:	Volltext

DOI / URN:	10.1186/s13065-017-0268-2

Katalog-ID:	SPR030134382

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520			\|a Abstract Four novel complexes [Co($ H_{2} $O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co($ H_{2} $O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV–Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Graphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction. In-vitro anti-bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram-positive and Gram-negative bacteria using agar diffusion method
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Indexfelder

author_variant	a m s am ams a h i a ahi ahia
matchkey_str	article:1752153X:2017----::yteicytlorpisetocpctdeadilgclciiyfecblicmlxsihiatvm
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allfields	10.1186/s13065-017-0268-2 doi (DE-627)SPR030134382 (SPR)s13065-017-0268-2-e DE-627 ger DE-627 rakwb eng Shalash, Asia M. verfasserin aut Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Abstract Four novel complexes [Co($ H_{2} $O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co($ H_{2} $O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV–Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Graphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction. In-vitro anti-bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram-positive and Gram-negative bacteria using agar diffusion method Cobalt(II) complexes (dpeaa)DE-He213 Nitrogen donor ligands (dpeaa)DE-He213 Sulindac (dpeaa)DE-He213 Anti-bacterial activity (dpeaa)DE-He213 Abu Ali, Hijazi I. (orcid)0000-0002-6315-6868 aut Enthalten in Chemistry central journal London : BioMed Central, 2007 11(2017), 1 vom: 10. Mai (DE-627)525475176 (DE-600)2272440-0 1752-153X nnns volume:11 year:2017 number:1 day:10 month:05 https://dx.doi.org/10.1186/s13065-017-0268-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017 1 10 05
spelling	10.1186/s13065-017-0268-2 doi (DE-627)SPR030134382 (SPR)s13065-017-0268-2-e DE-627 ger DE-627 rakwb eng Shalash, Asia M. verfasserin aut Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Abstract Four novel complexes [Co($ H_{2} $O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co($ H_{2} $O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV–Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Graphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction. In-vitro anti-bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram-positive and Gram-negative bacteria using agar diffusion method Cobalt(II) complexes (dpeaa)DE-He213 Nitrogen donor ligands (dpeaa)DE-He213 Sulindac (dpeaa)DE-He213 Anti-bacterial activity (dpeaa)DE-He213 Abu Ali, Hijazi I. (orcid)0000-0002-6315-6868 aut Enthalten in Chemistry central journal London : BioMed Central, 2007 11(2017), 1 vom: 10. Mai (DE-627)525475176 (DE-600)2272440-0 1752-153X nnns volume:11 year:2017 number:1 day:10 month:05 https://dx.doi.org/10.1186/s13065-017-0268-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017 1 10 05
allfields_unstemmed	10.1186/s13065-017-0268-2 doi (DE-627)SPR030134382 (SPR)s13065-017-0268-2-e DE-627 ger DE-627 rakwb eng Shalash, Asia M. verfasserin aut Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Abstract Four novel complexes [Co($ H_{2} $O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co($ H_{2} $O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV–Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Graphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction. In-vitro anti-bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram-positive and Gram-negative bacteria using agar diffusion method Cobalt(II) complexes (dpeaa)DE-He213 Nitrogen donor ligands (dpeaa)DE-He213 Sulindac (dpeaa)DE-He213 Anti-bacterial activity (dpeaa)DE-He213 Abu Ali, Hijazi I. (orcid)0000-0002-6315-6868 aut Enthalten in Chemistry central journal London : BioMed Central, 2007 11(2017), 1 vom: 10. Mai (DE-627)525475176 (DE-600)2272440-0 1752-153X nnns volume:11 year:2017 number:1 day:10 month:05 https://dx.doi.org/10.1186/s13065-017-0268-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017 1 10 05
allfieldsGer	10.1186/s13065-017-0268-2 doi (DE-627)SPR030134382 (SPR)s13065-017-0268-2-e DE-627 ger DE-627 rakwb eng Shalash, Asia M. verfasserin aut Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Abstract Four novel complexes [Co($ H_{2} $O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co($ H_{2} $O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV–Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Graphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction. In-vitro anti-bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram-positive and Gram-negative bacteria using agar diffusion method Cobalt(II) complexes (dpeaa)DE-He213 Nitrogen donor ligands (dpeaa)DE-He213 Sulindac (dpeaa)DE-He213 Anti-bacterial activity (dpeaa)DE-He213 Abu Ali, Hijazi I. (orcid)0000-0002-6315-6868 aut Enthalten in Chemistry central journal London : BioMed Central, 2007 11(2017), 1 vom: 10. Mai (DE-627)525475176 (DE-600)2272440-0 1752-153X nnns volume:11 year:2017 number:1 day:10 month:05 https://dx.doi.org/10.1186/s13065-017-0268-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017 1 10 05
allfieldsSound	10.1186/s13065-017-0268-2 doi (DE-627)SPR030134382 (SPR)s13065-017-0268-2-e DE-627 ger DE-627 rakwb eng Shalash, Asia M. verfasserin aut Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2017 Abstract Four novel complexes [Co($ H_{2} $O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co($ H_{2} $O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV–Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Graphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction. In-vitro anti-bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram-positive and Gram-negative bacteria using agar diffusion method Cobalt(II) complexes (dpeaa)DE-He213 Nitrogen donor ligands (dpeaa)DE-He213 Sulindac (dpeaa)DE-He213 Anti-bacterial activity (dpeaa)DE-He213 Abu Ali, Hijazi I. (orcid)0000-0002-6315-6868 aut Enthalten in Chemistry central journal London : BioMed Central, 2007 11(2017), 1 vom: 10. Mai (DE-627)525475176 (DE-600)2272440-0 1752-153X nnns volume:11 year:2017 number:1 day:10 month:05 https://dx.doi.org/10.1186/s13065-017-0268-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2017 1 10 05
language	English
source	Enthalten in Chemistry central journal 11(2017), 1 vom: 10. Mai volume:11 year:2017 number:1 day:10 month:05
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author	Shalash, Asia M.
spellingShingle	Shalash, Asia M. misc Cobalt(II) complexes misc Nitrogen donor ligands misc Sulindac misc Anti-bacterial activity Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands
authorStr	Shalash, Asia M.
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topic_title	Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands Cobalt(II) complexes (dpeaa)DE-He213 Nitrogen donor ligands (dpeaa)DE-He213 Sulindac (dpeaa)DE-He213 Anti-bacterial activity (dpeaa)DE-He213
topic	misc Cobalt(II) complexes misc Nitrogen donor ligands misc Sulindac misc Anti-bacterial activity
topic_unstemmed	misc Cobalt(II) complexes misc Nitrogen donor ligands misc Sulindac misc Anti-bacterial activity
topic_browse	misc Cobalt(II) complexes misc Nitrogen donor ligands misc Sulindac misc Anti-bacterial activity
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title	Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands
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title_full	Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands
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title_sort	synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(ii) complexes with bioactive mixed sulindac and nitrogen-donor ligands
title_auth	Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands
abstract	Abstract Four novel complexes [Co($ H_{2} $O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co($ H_{2} $O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV–Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Graphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction. In-vitro anti-bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram-positive and Gram-negative bacteria using agar diffusion method © The Author(s) 2017
abstractGer	Abstract Four novel complexes [Co($ H_{2} $O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co($ H_{2} $O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV–Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Graphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction. In-vitro anti-bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram-positive and Gram-negative bacteria using agar diffusion method © The Author(s) 2017
abstract_unstemmed	Abstract Four novel complexes [Co($ H_{2} $O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co($ H_{2} $O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-dimeph = 2,9-dimethyl-1,10-phenanthroline) were prepared and characterized by IR, UV–Visible spectroscopy and magnetic properties. The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Graphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction. In-vitro anti-bacterial activity of the prepared complexes and their parent ligands were investigated against different Gram-positive and Gram-negative bacteria using agar diffusion method © The Author(s) 2017
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title_short	Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands
url	https://dx.doi.org/10.1186/s13065-017-0268-2
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up_date	2024-07-03T14:10:32.871Z
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The crystal structures of complexes 1 and 4 were determined by single-crystal X-ray diffraction. In-vitro anti-bacterial activity for the prepared complexes against Gram-positive (Staphylococcus epidermidis, Staphylococcus aureus) and Gram-negative (Bordetella, Escherichia coli) bacteria and Yeast species (Saccharomyces and Candida) were performed using agar well-diffusion method. Only complex 4 showed reasonable activity against yeast. All compounds showed more anti-bacterial activity against Gram-positive bacteria than Gram-negative.Graphical abstractThis work reports synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands. The crystal structures of complexes 1 and 4 were determined using single-crystal X-ray diffraction. 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Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands

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