Synthesis and biological profile of substituted benzimidazoles

Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The syn...
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Autor*in:	Vashist, Neelam [verfasserIn] Sambi, Surinder Singh Narasimhan, Balasubramanian Kumar, Sanjiv Lim, Siong Meng Shah, Syed Adnan Ali Ramasamy, Kalavathy Mani, Vasudevan

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Benzimidazoles Synthesis Antimicrobial activity Anticancer activity

Anmerkung:	© The Author(s) 2018

Übergeordnetes Werk:	Enthalten in: Chemistry central journal - London : BioMed Central, 2007, 12(2018), 1 vom: 01. Dez.
Übergeordnetes Werk:	volume:12 ; year:2018 ; number:1 ; day:01 ; month:12

Links:	Volltext

DOI / URN:	10.1186/s13065-018-0498-y

Katalog-ID:	SPR03013689X

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520			\|a Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Conclusion Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their $ IC_{50} $ values were more potent than 5-fluorouracil.
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allfields	10.1186/s13065-018-0498-y doi (DE-627)SPR03013689X (SPR)s13065-018-0498-y-e DE-627 ger DE-627 rakwb eng Vashist, Neelam verfasserin aut Synthesis and biological profile of substituted benzimidazoles 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Conclusion Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their $ IC_{50} $ values were more potent than 5-fluorouracil. Benzimidazoles (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Antimicrobial activity (dpeaa)DE-He213 Anticancer activity (dpeaa)DE-He213 Sambi, Surinder Singh aut Narasimhan, Balasubramanian (orcid)0000-0002-9627-094X aut Kumar, Sanjiv aut Lim, Siong Meng aut Shah, Syed Adnan Ali aut Ramasamy, Kalavathy aut Mani, Vasudevan aut Enthalten in Chemistry central journal London : BioMed Central, 2007 12(2018), 1 vom: 01. Dez. (DE-627)525475176 (DE-600)2272440-0 1752-153X nnns volume:12 year:2018 number:1 day:01 month:12 https://dx.doi.org/10.1186/s13065-018-0498-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018 1 01 12
spelling	10.1186/s13065-018-0498-y doi (DE-627)SPR03013689X (SPR)s13065-018-0498-y-e DE-627 ger DE-627 rakwb eng Vashist, Neelam verfasserin aut Synthesis and biological profile of substituted benzimidazoles 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Conclusion Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their $ IC_{50} $ values were more potent than 5-fluorouracil. Benzimidazoles (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Antimicrobial activity (dpeaa)DE-He213 Anticancer activity (dpeaa)DE-He213 Sambi, Surinder Singh aut Narasimhan, Balasubramanian (orcid)0000-0002-9627-094X aut Kumar, Sanjiv aut Lim, Siong Meng aut Shah, Syed Adnan Ali aut Ramasamy, Kalavathy aut Mani, Vasudevan aut Enthalten in Chemistry central journal London : BioMed Central, 2007 12(2018), 1 vom: 01. Dez. (DE-627)525475176 (DE-600)2272440-0 1752-153X nnns volume:12 year:2018 number:1 day:01 month:12 https://dx.doi.org/10.1186/s13065-018-0498-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018 1 01 12
allfields_unstemmed	10.1186/s13065-018-0498-y doi (DE-627)SPR03013689X (SPR)s13065-018-0498-y-e DE-627 ger DE-627 rakwb eng Vashist, Neelam verfasserin aut Synthesis and biological profile of substituted benzimidazoles 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Conclusion Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their $ IC_{50} $ values were more potent than 5-fluorouracil. Benzimidazoles (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Antimicrobial activity (dpeaa)DE-He213 Anticancer activity (dpeaa)DE-He213 Sambi, Surinder Singh aut Narasimhan, Balasubramanian (orcid)0000-0002-9627-094X aut Kumar, Sanjiv aut Lim, Siong Meng aut Shah, Syed Adnan Ali aut Ramasamy, Kalavathy aut Mani, Vasudevan aut Enthalten in Chemistry central journal London : BioMed Central, 2007 12(2018), 1 vom: 01. Dez. (DE-627)525475176 (DE-600)2272440-0 1752-153X nnns volume:12 year:2018 number:1 day:01 month:12 https://dx.doi.org/10.1186/s13065-018-0498-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018 1 01 12
allfieldsGer	10.1186/s13065-018-0498-y doi (DE-627)SPR03013689X (SPR)s13065-018-0498-y-e DE-627 ger DE-627 rakwb eng Vashist, Neelam verfasserin aut Synthesis and biological profile of substituted benzimidazoles 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Conclusion Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their $ IC_{50} $ values were more potent than 5-fluorouracil. Benzimidazoles (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Antimicrobial activity (dpeaa)DE-He213 Anticancer activity (dpeaa)DE-He213 Sambi, Surinder Singh aut Narasimhan, Balasubramanian (orcid)0000-0002-9627-094X aut Kumar, Sanjiv aut Lim, Siong Meng aut Shah, Syed Adnan Ali aut Ramasamy, Kalavathy aut Mani, Vasudevan aut Enthalten in Chemistry central journal London : BioMed Central, 2007 12(2018), 1 vom: 01. Dez. (DE-627)525475176 (DE-600)2272440-0 1752-153X nnns volume:12 year:2018 number:1 day:01 month:12 https://dx.doi.org/10.1186/s13065-018-0498-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018 1 01 12
allfieldsSound	10.1186/s13065-018-0498-y doi (DE-627)SPR03013689X (SPR)s13065-018-0498-y-e DE-627 ger DE-627 rakwb eng Vashist, Neelam verfasserin aut Synthesis and biological profile of substituted benzimidazoles 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2018 Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Conclusion Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their $ IC_{50} $ values were more potent than 5-fluorouracil. Benzimidazoles (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Antimicrobial activity (dpeaa)DE-He213 Anticancer activity (dpeaa)DE-He213 Sambi, Surinder Singh aut Narasimhan, Balasubramanian (orcid)0000-0002-9627-094X aut Kumar, Sanjiv aut Lim, Siong Meng aut Shah, Syed Adnan Ali aut Ramasamy, Kalavathy aut Mani, Vasudevan aut Enthalten in Chemistry central journal London : BioMed Central, 2007 12(2018), 1 vom: 01. Dez. (DE-627)525475176 (DE-600)2272440-0 1752-153X nnns volume:12 year:2018 number:1 day:01 month:12 https://dx.doi.org/10.1186/s13065-018-0498-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018 1 01 12
language	English
source	Enthalten in Chemistry central journal 12(2018), 1 vom: 01. Dez. volume:12 year:2018 number:1 day:01 month:12
sourceStr	Enthalten in Chemistry central journal 12(2018), 1 vom: 01. Dez. volume:12 year:2018 number:1 day:01 month:12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Benzimidazoles Synthesis Antimicrobial activity Anticancer activity
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authorswithroles_txt_mv	Vashist, Neelam @@aut@@ Sambi, Surinder Singh @@aut@@ Narasimhan, Balasubramanian @@aut@@ Kumar, Sanjiv @@aut@@ Lim, Siong Meng @@aut@@ Shah, Syed Adnan Ali @@aut@@ Ramasamy, Kalavathy @@aut@@ Mani, Vasudevan @@aut@@
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spellingShingle	Vashist, Neelam misc Benzimidazoles misc Synthesis misc Antimicrobial activity misc Anticancer activity Synthesis and biological profile of substituted benzimidazoles
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topic_title	Synthesis and biological profile of substituted benzimidazoles Benzimidazoles (dpeaa)DE-He213 Synthesis (dpeaa)DE-He213 Antimicrobial activity (dpeaa)DE-He213 Anticancer activity (dpeaa)DE-He213
topic	misc Benzimidazoles misc Synthesis misc Antimicrobial activity misc Anticancer activity
topic_unstemmed	misc Benzimidazoles misc Synthesis misc Antimicrobial activity misc Anticancer activity
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title	Synthesis and biological profile of substituted benzimidazoles
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title_full	Synthesis and biological profile of substituted benzimidazoles
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author_browse	Vashist, Neelam Sambi, Surinder Singh Narasimhan, Balasubramanian Kumar, Sanjiv Lim, Siong Meng Shah, Syed Adnan Ali Ramasamy, Kalavathy Mani, Vasudevan
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title_sort	synthesis and biological profile of substituted benzimidazoles
title_auth	Synthesis and biological profile of substituted benzimidazoles
abstract	Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Conclusion Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their $ IC_{50} $ values were more potent than 5-fluorouracil. © The Author(s) 2018
abstractGer	Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Conclusion Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their $ IC_{50} $ values were more potent than 5-fluorouracil. © The Author(s) 2018
abstract_unstemmed	Background A series of benzimidazole derivatives was developed and its chemical scaffolds were authenticated by NMR, IR, elemental analyses and physicochemical properties. The synthesized compounds were screened for their antimicrobial and antiproliferative activities. Results and discussion The synthesized benzimidazole compounds were evaluated for their antimicrobial activity using the tube dilution method and were found to exhibit good antimicrobial potential against selected Gram negative and positive bacterial and fungal species. The compounds were also assessed for their anticancer activity exhibited using the SRB assay and were found to elicit antiproliferative activity against MCF7 breast cancer cell line, which was comparable to the standard drug. Conclusion Antimicrobial screening results indicated that compounds 1, 2 and 19 to be promising antimicrobial agents against selected microbial species and comparable to standard drugs which included norfloxacin and fluconazole. The anticancer screening results revealed that compounds, 12, 21, 22 and 29 to show the highest activity against MCF7 and their $ IC_{50} $ values were more potent than 5-fluorouracil. © The Author(s) 2018
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title_short	Synthesis and biological profile of substituted benzimidazoles
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author2	Sambi, Surinder Singh Narasimhan, Balasubramanian Kumar, Sanjiv Lim, Siong Meng Shah, Syed Adnan Ali Ramasamy, Kalavathy Mani, Vasudevan
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Synthesis and biological profile of substituted benzimidazoles

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