The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study
Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy...
Ausführliche Beschreibung
Autor*in: |
Usta, Engin [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2009 |
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Anmerkung: |
© Usta et al; licensee BioMed Central Ltd. 2009 |
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Übergeordnetes Werk: |
Enthalten in: Journal of cardiothoracic surgery - London : BioMed Central, 2006, 4(2009), 1 vom: 16. Aug. |
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Übergeordnetes Werk: |
volume:4 ; year:2009 ; number:1 ; day:16 ; month:08 |
Links: |
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DOI / URN: |
10.1186/1749-8090-4-43 |
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Katalog-ID: |
SPR030184746 |
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520 | |a Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. | ||
650 | 4 | |a Coronary Angiography |7 (dpeaa)DE-He213 | |
650 | 4 | |a Endomyocardial Biopsy |7 (dpeaa)DE-He213 | |
650 | 4 | |a Transplant Rejection |7 (dpeaa)DE-He213 | |
650 | 4 | |a Cardiac Allograft |7 (dpeaa)DE-He213 | |
650 | 4 | |a Cardiac Allograft Vasculopathy |7 (dpeaa)DE-He213 | |
700 | 1 | |a Burgstahler, Christof |4 aut | |
700 | 1 | |a Aebert, Hermann |4 aut | |
700 | 1 | |a Schroeder, Stephen |4 aut | |
700 | 1 | |a Helber, Uwe |4 aut | |
700 | 1 | |a Kopp, Andreas F |4 aut | |
700 | 1 | |a Ziemer, Gerhard |4 aut | |
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10.1186/1749-8090-4-43 doi (DE-627)SPR030184746 (SPR)1749-8090-4-43-e DE-627 ger DE-627 rakwb eng Usta, Engin verfasserin aut The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Usta et al; licensee BioMed Central Ltd. 2009 Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 Burgstahler, Christof aut Aebert, Hermann aut Schroeder, Stephen aut Helber, Uwe aut Kopp, Andreas F aut Ziemer, Gerhard aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 4(2009), 1 vom: 16. Aug. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:4 year:2009 number:1 day:16 month:08 https://dx.doi.org/10.1186/1749-8090-4-43 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 08 |
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10.1186/1749-8090-4-43 doi (DE-627)SPR030184746 (SPR)1749-8090-4-43-e DE-627 ger DE-627 rakwb eng Usta, Engin verfasserin aut The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Usta et al; licensee BioMed Central Ltd. 2009 Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 Burgstahler, Christof aut Aebert, Hermann aut Schroeder, Stephen aut Helber, Uwe aut Kopp, Andreas F aut Ziemer, Gerhard aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 4(2009), 1 vom: 16. Aug. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:4 year:2009 number:1 day:16 month:08 https://dx.doi.org/10.1186/1749-8090-4-43 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 08 |
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10.1186/1749-8090-4-43 doi (DE-627)SPR030184746 (SPR)1749-8090-4-43-e DE-627 ger DE-627 rakwb eng Usta, Engin verfasserin aut The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Usta et al; licensee BioMed Central Ltd. 2009 Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 Burgstahler, Christof aut Aebert, Hermann aut Schroeder, Stephen aut Helber, Uwe aut Kopp, Andreas F aut Ziemer, Gerhard aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 4(2009), 1 vom: 16. Aug. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:4 year:2009 number:1 day:16 month:08 https://dx.doi.org/10.1186/1749-8090-4-43 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 08 |
allfieldsGer |
10.1186/1749-8090-4-43 doi (DE-627)SPR030184746 (SPR)1749-8090-4-43-e DE-627 ger DE-627 rakwb eng Usta, Engin verfasserin aut The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Usta et al; licensee BioMed Central Ltd. 2009 Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 Burgstahler, Christof aut Aebert, Hermann aut Schroeder, Stephen aut Helber, Uwe aut Kopp, Andreas F aut Ziemer, Gerhard aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 4(2009), 1 vom: 16. Aug. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:4 year:2009 number:1 day:16 month:08 https://dx.doi.org/10.1186/1749-8090-4-43 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 08 |
allfieldsSound |
10.1186/1749-8090-4-43 doi (DE-627)SPR030184746 (SPR)1749-8090-4-43-e DE-627 ger DE-627 rakwb eng Usta, Engin verfasserin aut The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Usta et al; licensee BioMed Central Ltd. 2009 Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 Burgstahler, Christof aut Aebert, Hermann aut Schroeder, Stephen aut Helber, Uwe aut Kopp, Andreas F aut Ziemer, Gerhard aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 4(2009), 1 vom: 16. Aug. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:4 year:2009 number:1 day:16 month:08 https://dx.doi.org/10.1186/1749-8090-4-43 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 08 |
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Usta, Engin misc Coronary Angiography misc Endomyocardial Biopsy misc Transplant Rejection misc Cardiac Allograft misc Cardiac Allograft Vasculopathy The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study |
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The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 |
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challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study |
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The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study |
abstract |
Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. © Usta et al; licensee BioMed Central Ltd. 2009 |
abstractGer |
Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. © Usta et al; licensee BioMed Central Ltd. 2009 |
abstract_unstemmed |
Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. © Usta et al; licensee BioMed Central Ltd. 2009 |
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Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. 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