The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study

Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Usta, Engin [verfasserIn] Burgstahler, Christof Aebert, Hermann Schroeder, Stephen Helber, Uwe Kopp, Andreas F Ziemer, Gerhard

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Coronary Angiography Endomyocardial Biopsy Transplant Rejection Cardiac Allograft Cardiac Allograft Vasculopathy

Anmerkung:	© Usta et al; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: Journal of cardiothoracic surgery - London : BioMed Central, 2006, 4(2009), 1 vom: 16. Aug.
Übergeordnetes Werk:	volume:4 ; year:2009 ; number:1 ; day:16 ; month:08

Links:	Volltext

DOI / URN:	10.1186/1749-8090-4-43

Katalog-ID:	SPR030184746

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520			\|a Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods.
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allfields	10.1186/1749-8090-4-43 doi (DE-627)SPR030184746 (SPR)1749-8090-4-43-e DE-627 ger DE-627 rakwb eng Usta, Engin verfasserin aut The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Usta et al; licensee BioMed Central Ltd. 2009 Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 Burgstahler, Christof aut Aebert, Hermann aut Schroeder, Stephen aut Helber, Uwe aut Kopp, Andreas F aut Ziemer, Gerhard aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 4(2009), 1 vom: 16. Aug. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:4 year:2009 number:1 day:16 month:08 https://dx.doi.org/10.1186/1749-8090-4-43 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 08
spelling	10.1186/1749-8090-4-43 doi (DE-627)SPR030184746 (SPR)1749-8090-4-43-e DE-627 ger DE-627 rakwb eng Usta, Engin verfasserin aut The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Usta et al; licensee BioMed Central Ltd. 2009 Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 Burgstahler, Christof aut Aebert, Hermann aut Schroeder, Stephen aut Helber, Uwe aut Kopp, Andreas F aut Ziemer, Gerhard aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 4(2009), 1 vom: 16. Aug. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:4 year:2009 number:1 day:16 month:08 https://dx.doi.org/10.1186/1749-8090-4-43 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 08
allfields_unstemmed	10.1186/1749-8090-4-43 doi (DE-627)SPR030184746 (SPR)1749-8090-4-43-e DE-627 ger DE-627 rakwb eng Usta, Engin verfasserin aut The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Usta et al; licensee BioMed Central Ltd. 2009 Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 Burgstahler, Christof aut Aebert, Hermann aut Schroeder, Stephen aut Helber, Uwe aut Kopp, Andreas F aut Ziemer, Gerhard aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 4(2009), 1 vom: 16. Aug. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:4 year:2009 number:1 day:16 month:08 https://dx.doi.org/10.1186/1749-8090-4-43 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 08
allfieldsGer	10.1186/1749-8090-4-43 doi (DE-627)SPR030184746 (SPR)1749-8090-4-43-e DE-627 ger DE-627 rakwb eng Usta, Engin verfasserin aut The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Usta et al; licensee BioMed Central Ltd. 2009 Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 Burgstahler, Christof aut Aebert, Hermann aut Schroeder, Stephen aut Helber, Uwe aut Kopp, Andreas F aut Ziemer, Gerhard aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 4(2009), 1 vom: 16. Aug. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:4 year:2009 number:1 day:16 month:08 https://dx.doi.org/10.1186/1749-8090-4-43 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 08
allfieldsSound	10.1186/1749-8090-4-43 doi (DE-627)SPR030184746 (SPR)1749-8090-4-43-e DE-627 ger DE-627 rakwb eng Usta, Engin verfasserin aut The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Usta et al; licensee BioMed Central Ltd. 2009 Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213 Burgstahler, Christof aut Aebert, Hermann aut Schroeder, Stephen aut Helber, Uwe aut Kopp, Andreas F aut Ziemer, Gerhard aut Enthalten in Journal of cardiothoracic surgery London : BioMed Central, 2006 4(2009), 1 vom: 16. Aug. (DE-627)509401260 (DE-600)2227224-0 1749-8090 nnns volume:4 year:2009 number:1 day:16 month:08 https://dx.doi.org/10.1186/1749-8090-4-43 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2009 1 16 08
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author	Usta, Engin
spellingShingle	Usta, Engin misc Coronary Angiography misc Endomyocardial Biopsy misc Transplant Rejection misc Cardiac Allograft misc Cardiac Allograft Vasculopathy The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study
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topic_title	The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study Coronary Angiography (dpeaa)DE-He213 Endomyocardial Biopsy (dpeaa)DE-He213 Transplant Rejection (dpeaa)DE-He213 Cardiac Allograft (dpeaa)DE-He213 Cardiac Allograft Vasculopathy (dpeaa)DE-He213
topic	misc Coronary Angiography misc Endomyocardial Biopsy misc Transplant Rejection misc Cardiac Allograft misc Cardiac Allograft Vasculopathy
topic_unstemmed	misc Coronary Angiography misc Endomyocardial Biopsy misc Transplant Rejection misc Cardiac Allograft misc Cardiac Allograft Vasculopathy
topic_browse	misc Coronary Angiography misc Endomyocardial Biopsy misc Transplant Rejection misc Cardiac Allograft misc Cardiac Allograft Vasculopathy
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title	The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study
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title_full	The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study
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author_browse	Usta, Engin Burgstahler, Christof Aebert, Hermann Schroeder, Stephen Helber, Uwe Kopp, Andreas F Ziemer, Gerhard
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title_sort	challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study
title_auth	The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study
abstract	Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. © Usta et al; licensee BioMed Central Ltd. 2009
abstractGer	Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. © Usta et al; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Background Cardiac allograft rejection and vasculopathy are the main factors limiting long-term survival after heart transplantation. In this pilot study we investigated whether non-invasive methods are beneficial to detect cardiac allograft rejection (Grade 0-3 R) and cardiac allograft vasculopathy. Thus we compared multi-slice computed tomography and magnetic resonance imaging with invasive methods like coronary angiography and left endomyocardial biopsy. Methods 10 asymptomatic long-term survivors after heart transplantation (8 male, 2 female, mean age 52.1 ± 12 years, 73 ± 11 months after transplantation) were included. In a blinded fashion, coronary angiography and multi-slice computed tomography and ventricular endomyocardial biopsy and magnetic resonance imaging were compared against each other. Results Cardiac allograft vasculopathy and atherosclerosis were correctly detected by multi-slice computed tomography and coronary angiography with positive correlation (r = 1). Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. Conclusion A combined non-invasive approach using multi-slice computed tomography and magnetic resonance imaging may help to assess cardiac allograft vasculopathy and cardiac allograft rejection after heart transplantation before applying more invasive methods. © Usta et al; licensee BioMed Central Ltd. 2009
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title_short	The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study
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author2	Burgstahler, Christof Aebert, Hermann Schroeder, Stephen Helber, Uwe Kopp, Andreas F Ziemer, Gerhard
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up_date	2024-07-03T14:31:51.136Z
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Late contrast enchancement found by magnetic resonance imaging correlated positively (r = 0.92, $ r^{2} $ = 0.85, p < 0.05) with the histological diagnosis of transplant rejection revealed by myocardial biopsy. None of the examined endomyocardial specimen revealed cardiac allograft rejection greater than Grade 1 R. 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The challenge to detect heart transplant rejection and transplant vasculopathy non-invasively - a pilot study

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