Are estrogen-related drugs new alternatives for the management of osteoarthritis?

Abstract Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues suggest that estrogen could help prevent development of OA. This review summarizes O...
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Autor*in:	Xiao, Ya-Ping [verfasserIn] Tian, Fa-Ming Dai, Mu-Wei Wang, Wen-Ya Shao, Li-Tao Zhang, Liu

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Osteoarthritis Estrogen Selective estrogen receptor modulators Joint Bazedoxifene

Anmerkung:	© The Author(s). 2016

Übergeordnetes Werk:	Enthalten in: Arthritis Research & Therapy - London : BioMed Central, 1999, 18(2016), 1 vom: 28. Juni
Übergeordnetes Werk:	volume:18 ; year:2016 ; number:1 ; day:28 ; month:06

Links:	Volltext

DOI / URN:	10.1186/s13075-016-1045-7

Katalog-ID:	SPR030220246

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allfields	10.1186/s13075-016-1045-7 doi (DE-627)SPR030220246 (SPR)s13075-016-1045-7-e DE-627 ger DE-627 rakwb eng Xiao, Ya-Ping verfasserin aut Are estrogen-related drugs new alternatives for the management of osteoarthritis? 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Abstract Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues suggest that estrogen could help prevent development of OA. This review summarizes OA research with a focus on the effects of estrogen and selective estrogen receptor modulators (SERMs). Preclinical studies and clinical trials of estrogen therapy have reported inconsistent results. However, almost all studies assessing SERM treatment have obtained more consistent and favorable effects in OA with a relatively safety and tolerability profiles. At present, some SERMs including raloxifene and bazedoxifene have been approved for the treatment of osteoporosis. In summary, estrogen-related agents may exert both a direct effect on subchondral bone and direct and/or indirect effects upon the surrounding tissues, including the articular cartilage, synovium, and muscle, to name a few. Estrogen and SERMs may be particularly favorable for postmenopausal patients with early-stage OA or osteoporotic OA, a phenotype defined by reduced bone mineral density related to high remodeling in subchondral bone. At present, no single drug exists that can prevent OA progression. Although estrogen-related drugs provide insight into the continued work in the field of OA drug administration, further research is required before SERMs can become therapeutic alternatives for OA treatment. Osteoarthritis (dpeaa)DE-He213 Estrogen (dpeaa)DE-He213 Selective estrogen receptor modulators (dpeaa)DE-He213 Joint (dpeaa)DE-He213 Bazedoxifene (dpeaa)DE-He213 Tian, Fa-Ming aut Dai, Mu-Wei aut Wang, Wen-Ya aut Shao, Li-Tao aut Zhang, Liu aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 18(2016), 1 vom: 28. Juni (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:18 year:2016 number:1 day:28 month:06 https://dx.doi.org/10.1186/s13075-016-1045-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2016 1 28 06
spelling	10.1186/s13075-016-1045-7 doi (DE-627)SPR030220246 (SPR)s13075-016-1045-7-e DE-627 ger DE-627 rakwb eng Xiao, Ya-Ping verfasserin aut Are estrogen-related drugs new alternatives for the management of osteoarthritis? 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Abstract Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues suggest that estrogen could help prevent development of OA. This review summarizes OA research with a focus on the effects of estrogen and selective estrogen receptor modulators (SERMs). Preclinical studies and clinical trials of estrogen therapy have reported inconsistent results. However, almost all studies assessing SERM treatment have obtained more consistent and favorable effects in OA with a relatively safety and tolerability profiles. At present, some SERMs including raloxifene and bazedoxifene have been approved for the treatment of osteoporosis. In summary, estrogen-related agents may exert both a direct effect on subchondral bone and direct and/or indirect effects upon the surrounding tissues, including the articular cartilage, synovium, and muscle, to name a few. Estrogen and SERMs may be particularly favorable for postmenopausal patients with early-stage OA or osteoporotic OA, a phenotype defined by reduced bone mineral density related to high remodeling in subchondral bone. At present, no single drug exists that can prevent OA progression. Although estrogen-related drugs provide insight into the continued work in the field of OA drug administration, further research is required before SERMs can become therapeutic alternatives for OA treatment. Osteoarthritis (dpeaa)DE-He213 Estrogen (dpeaa)DE-He213 Selective estrogen receptor modulators (dpeaa)DE-He213 Joint (dpeaa)DE-He213 Bazedoxifene (dpeaa)DE-He213 Tian, Fa-Ming aut Dai, Mu-Wei aut Wang, Wen-Ya aut Shao, Li-Tao aut Zhang, Liu aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 18(2016), 1 vom: 28. Juni (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:18 year:2016 number:1 day:28 month:06 https://dx.doi.org/10.1186/s13075-016-1045-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2016 1 28 06
allfields_unstemmed	10.1186/s13075-016-1045-7 doi (DE-627)SPR030220246 (SPR)s13075-016-1045-7-e DE-627 ger DE-627 rakwb eng Xiao, Ya-Ping verfasserin aut Are estrogen-related drugs new alternatives for the management of osteoarthritis? 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Abstract Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues suggest that estrogen could help prevent development of OA. This review summarizes OA research with a focus on the effects of estrogen and selective estrogen receptor modulators (SERMs). Preclinical studies and clinical trials of estrogen therapy have reported inconsistent results. However, almost all studies assessing SERM treatment have obtained more consistent and favorable effects in OA with a relatively safety and tolerability profiles. At present, some SERMs including raloxifene and bazedoxifene have been approved for the treatment of osteoporosis. In summary, estrogen-related agents may exert both a direct effect on subchondral bone and direct and/or indirect effects upon the surrounding tissues, including the articular cartilage, synovium, and muscle, to name a few. Estrogen and SERMs may be particularly favorable for postmenopausal patients with early-stage OA or osteoporotic OA, a phenotype defined by reduced bone mineral density related to high remodeling in subchondral bone. At present, no single drug exists that can prevent OA progression. Although estrogen-related drugs provide insight into the continued work in the field of OA drug administration, further research is required before SERMs can become therapeutic alternatives for OA treatment. Osteoarthritis (dpeaa)DE-He213 Estrogen (dpeaa)DE-He213 Selective estrogen receptor modulators (dpeaa)DE-He213 Joint (dpeaa)DE-He213 Bazedoxifene (dpeaa)DE-He213 Tian, Fa-Ming aut Dai, Mu-Wei aut Wang, Wen-Ya aut Shao, Li-Tao aut Zhang, Liu aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 18(2016), 1 vom: 28. Juni (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:18 year:2016 number:1 day:28 month:06 https://dx.doi.org/10.1186/s13075-016-1045-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2016 1 28 06
allfieldsGer	10.1186/s13075-016-1045-7 doi (DE-627)SPR030220246 (SPR)s13075-016-1045-7-e DE-627 ger DE-627 rakwb eng Xiao, Ya-Ping verfasserin aut Are estrogen-related drugs new alternatives for the management of osteoarthritis? 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Abstract Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues suggest that estrogen could help prevent development of OA. This review summarizes OA research with a focus on the effects of estrogen and selective estrogen receptor modulators (SERMs). Preclinical studies and clinical trials of estrogen therapy have reported inconsistent results. However, almost all studies assessing SERM treatment have obtained more consistent and favorable effects in OA with a relatively safety and tolerability profiles. At present, some SERMs including raloxifene and bazedoxifene have been approved for the treatment of osteoporosis. In summary, estrogen-related agents may exert both a direct effect on subchondral bone and direct and/or indirect effects upon the surrounding tissues, including the articular cartilage, synovium, and muscle, to name a few. Estrogen and SERMs may be particularly favorable for postmenopausal patients with early-stage OA or osteoporotic OA, a phenotype defined by reduced bone mineral density related to high remodeling in subchondral bone. At present, no single drug exists that can prevent OA progression. Although estrogen-related drugs provide insight into the continued work in the field of OA drug administration, further research is required before SERMs can become therapeutic alternatives for OA treatment. Osteoarthritis (dpeaa)DE-He213 Estrogen (dpeaa)DE-He213 Selective estrogen receptor modulators (dpeaa)DE-He213 Joint (dpeaa)DE-He213 Bazedoxifene (dpeaa)DE-He213 Tian, Fa-Ming aut Dai, Mu-Wei aut Wang, Wen-Ya aut Shao, Li-Tao aut Zhang, Liu aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 18(2016), 1 vom: 28. Juni (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:18 year:2016 number:1 day:28 month:06 https://dx.doi.org/10.1186/s13075-016-1045-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2016 1 28 06
allfieldsSound	10.1186/s13075-016-1045-7 doi (DE-627)SPR030220246 (SPR)s13075-016-1045-7-e DE-627 ger DE-627 rakwb eng Xiao, Ya-Ping verfasserin aut Are estrogen-related drugs new alternatives for the management of osteoarthritis? 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Abstract Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues suggest that estrogen could help prevent development of OA. This review summarizes OA research with a focus on the effects of estrogen and selective estrogen receptor modulators (SERMs). Preclinical studies and clinical trials of estrogen therapy have reported inconsistent results. However, almost all studies assessing SERM treatment have obtained more consistent and favorable effects in OA with a relatively safety and tolerability profiles. At present, some SERMs including raloxifene and bazedoxifene have been approved for the treatment of osteoporosis. In summary, estrogen-related agents may exert both a direct effect on subchondral bone and direct and/or indirect effects upon the surrounding tissues, including the articular cartilage, synovium, and muscle, to name a few. Estrogen and SERMs may be particularly favorable for postmenopausal patients with early-stage OA or osteoporotic OA, a phenotype defined by reduced bone mineral density related to high remodeling in subchondral bone. At present, no single drug exists that can prevent OA progression. Although estrogen-related drugs provide insight into the continued work in the field of OA drug administration, further research is required before SERMs can become therapeutic alternatives for OA treatment. Osteoarthritis (dpeaa)DE-He213 Estrogen (dpeaa)DE-He213 Selective estrogen receptor modulators (dpeaa)DE-He213 Joint (dpeaa)DE-He213 Bazedoxifene (dpeaa)DE-He213 Tian, Fa-Ming aut Dai, Mu-Wei aut Wang, Wen-Ya aut Shao, Li-Tao aut Zhang, Liu aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 18(2016), 1 vom: 28. Juni (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:18 year:2016 number:1 day:28 month:06 https://dx.doi.org/10.1186/s13075-016-1045-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2016 1 28 06
language	English
source	Enthalten in Arthritis Research & Therapy 18(2016), 1 vom: 28. Juni volume:18 year:2016 number:1 day:28 month:06
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topic_facet	Osteoarthritis Estrogen Selective estrogen receptor modulators Joint Bazedoxifene
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container_title	Arthritis Research & Therapy
authorswithroles_txt_mv	Xiao, Ya-Ping @@aut@@ Tian, Fa-Ming @@aut@@ Dai, Mu-Wei @@aut@@ Wang, Wen-Ya @@aut@@ Shao, Li-Tao @@aut@@ Zhang, Liu @@aut@@
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author	Xiao, Ya-Ping
spellingShingle	Xiao, Ya-Ping misc Osteoarthritis misc Estrogen misc Selective estrogen receptor modulators misc Joint misc Bazedoxifene Are estrogen-related drugs new alternatives for the management of osteoarthritis?
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topic_title	Are estrogen-related drugs new alternatives for the management of osteoarthritis? Osteoarthritis (dpeaa)DE-He213 Estrogen (dpeaa)DE-He213 Selective estrogen receptor modulators (dpeaa)DE-He213 Joint (dpeaa)DE-He213 Bazedoxifene (dpeaa)DE-He213
topic	misc Osteoarthritis misc Estrogen misc Selective estrogen receptor modulators misc Joint misc Bazedoxifene
topic_unstemmed	misc Osteoarthritis misc Estrogen misc Selective estrogen receptor modulators misc Joint misc Bazedoxifene
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title	Are estrogen-related drugs new alternatives for the management of osteoarthritis?
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title_full	Are estrogen-related drugs new alternatives for the management of osteoarthritis?
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title_sort	are estrogen-related drugs new alternatives for the management of osteoarthritis?
title_auth	Are estrogen-related drugs new alternatives for the management of osteoarthritis?
abstract	Abstract Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues suggest that estrogen could help prevent development of OA. This review summarizes OA research with a focus on the effects of estrogen and selective estrogen receptor modulators (SERMs). Preclinical studies and clinical trials of estrogen therapy have reported inconsistent results. However, almost all studies assessing SERM treatment have obtained more consistent and favorable effects in OA with a relatively safety and tolerability profiles. At present, some SERMs including raloxifene and bazedoxifene have been approved for the treatment of osteoporosis. In summary, estrogen-related agents may exert both a direct effect on subchondral bone and direct and/or indirect effects upon the surrounding tissues, including the articular cartilage, synovium, and muscle, to name a few. Estrogen and SERMs may be particularly favorable for postmenopausal patients with early-stage OA or osteoporotic OA, a phenotype defined by reduced bone mineral density related to high remodeling in subchondral bone. At present, no single drug exists that can prevent OA progression. Although estrogen-related drugs provide insight into the continued work in the field of OA drug administration, further research is required before SERMs can become therapeutic alternatives for OA treatment. © The Author(s). 2016
abstractGer	Abstract Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues suggest that estrogen could help prevent development of OA. This review summarizes OA research with a focus on the effects of estrogen and selective estrogen receptor modulators (SERMs). Preclinical studies and clinical trials of estrogen therapy have reported inconsistent results. However, almost all studies assessing SERM treatment have obtained more consistent and favorable effects in OA with a relatively safety and tolerability profiles. At present, some SERMs including raloxifene and bazedoxifene have been approved for the treatment of osteoporosis. In summary, estrogen-related agents may exert both a direct effect on subchondral bone and direct and/or indirect effects upon the surrounding tissues, including the articular cartilage, synovium, and muscle, to name a few. Estrogen and SERMs may be particularly favorable for postmenopausal patients with early-stage OA or osteoporotic OA, a phenotype defined by reduced bone mineral density related to high remodeling in subchondral bone. At present, no single drug exists that can prevent OA progression. Although estrogen-related drugs provide insight into the continued work in the field of OA drug administration, further research is required before SERMs can become therapeutic alternatives for OA treatment. © The Author(s). 2016
abstract_unstemmed	Abstract Osteoarthritis (OA) is a chronic degenerative disease involving multiple physiopathological mechanisms. The increased prevalence of OA after menopause and the presence of estrogen receptors in joint tissues suggest that estrogen could help prevent development of OA. This review summarizes OA research with a focus on the effects of estrogen and selective estrogen receptor modulators (SERMs). Preclinical studies and clinical trials of estrogen therapy have reported inconsistent results. However, almost all studies assessing SERM treatment have obtained more consistent and favorable effects in OA with a relatively safety and tolerability profiles. At present, some SERMs including raloxifene and bazedoxifene have been approved for the treatment of osteoporosis. In summary, estrogen-related agents may exert both a direct effect on subchondral bone and direct and/or indirect effects upon the surrounding tissues, including the articular cartilage, synovium, and muscle, to name a few. Estrogen and SERMs may be particularly favorable for postmenopausal patients with early-stage OA or osteoporotic OA, a phenotype defined by reduced bone mineral density related to high remodeling in subchondral bone. At present, no single drug exists that can prevent OA progression. Although estrogen-related drugs provide insight into the continued work in the field of OA drug administration, further research is required before SERMs can become therapeutic alternatives for OA treatment. © The Author(s). 2016
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title_short	Are estrogen-related drugs new alternatives for the management of osteoarthritis?
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