Commensal Clostridia: leading players in the maintenance of gut homeostasis

Abstract The gastrointestinal tract is a complex and dynamic network where an intricate and mutualistic symbiosis modulates the relationship between the host and the microbiota in order to establish and ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria in the...
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Autor*in:	Lopetuso, Loris R [verfasserIn] Scaldaferri, Franco Petito, Valentina Gasbarrini, Antonio

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Gut microbiota Clostridia spp Dysbiosis Gut homeostasis

Anmerkung:	© Lopetuso et al.; licensee BioMed Central Ltd. 2013

Übergeordnetes Werk:	Enthalten in: Gut pathogens - London : BioMed Central, 2009, 5(2013), 1 vom: 13. Aug.
Übergeordnetes Werk:	volume:5 ; year:2013 ; number:1 ; day:13 ; month:08

Links:	Volltext

DOI / URN:	10.1186/1757-4749-5-23

Katalog-ID:	SPR030252393

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spelling	10.1186/1757-4749-5-23 doi (DE-627)SPR030252393 (SPR)1757-4749-5-23-e DE-627 ger DE-627 rakwb eng Lopetuso, Loris R verfasserin aut Commensal Clostridia: leading players in the maintenance of gut homeostasis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Lopetuso et al.; licensee BioMed Central Ltd. 2013 Abstract The gastrointestinal tract is a complex and dynamic network where an intricate and mutualistic symbiosis modulates the relationship between the host and the microbiota in order to establish and ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes and make up a substantial part of the total bacteria in the gut microbiota. They start to colonize the intestine of breastfed infants during the first month of life and populate a specific region in the intestinal mucosa in close relationship with intestinal cells. This position allows them to participate as crucial factors in modulating physiologic, metabolic and immune processes in the gut during the entire lifespan, by interacting with the other resident microbe populations, but also by providing specific and essential functions. This review focus on what is currently known regarding the role of commensal Clostridia in the maintenance of overall gut function, as well as touch on their potential contribution in the unfavorable alteration of microbiota composition (dysbiosis) that has been implicated in several gastrointestinal disorders. Commensal Clostridia are strongly involved in the maintenance of overall gut function. This leads to important translational implications in regard to the prevention and treatment of dysbiosis, to drug efficacy and toxicity, and to the development of therapies that may modulate the composition of the microflora, capitalizing on the key role of commensal Clostridia, with the end goal of promoting gut health. Gut microbiota (dpeaa)DE-He213 Clostridia spp (dpeaa)DE-He213 Dysbiosis (dpeaa)DE-He213 Gut homeostasis (dpeaa)DE-He213 Scaldaferri, Franco aut Petito, Valentina aut Gasbarrini, Antonio aut Enthalten in Gut pathogens London : BioMed Central, 2009 5(2013), 1 vom: 13. Aug. (DE-627)591514133 (DE-600)2478277-4 1757-4749 nnns volume:5 year:2013 number:1 day:13 month:08 https://dx.doi.org/10.1186/1757-4749-5-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2013 1 13 08
allfields_unstemmed	10.1186/1757-4749-5-23 doi (DE-627)SPR030252393 (SPR)1757-4749-5-23-e DE-627 ger DE-627 rakwb eng Lopetuso, Loris R verfasserin aut Commensal Clostridia: leading players in the maintenance of gut homeostasis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Lopetuso et al.; licensee BioMed Central Ltd. 2013 Abstract The gastrointestinal tract is a complex and dynamic network where an intricate and mutualistic symbiosis modulates the relationship between the host and the microbiota in order to establish and ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes and make up a substantial part of the total bacteria in the gut microbiota. They start to colonize the intestine of breastfed infants during the first month of life and populate a specific region in the intestinal mucosa in close relationship with intestinal cells. This position allows them to participate as crucial factors in modulating physiologic, metabolic and immune processes in the gut during the entire lifespan, by interacting with the other resident microbe populations, but also by providing specific and essential functions. This review focus on what is currently known regarding the role of commensal Clostridia in the maintenance of overall gut function, as well as touch on their potential contribution in the unfavorable alteration of microbiota composition (dysbiosis) that has been implicated in several gastrointestinal disorders. Commensal Clostridia are strongly involved in the maintenance of overall gut function. This leads to important translational implications in regard to the prevention and treatment of dysbiosis, to drug efficacy and toxicity, and to the development of therapies that may modulate the composition of the microflora, capitalizing on the key role of commensal Clostridia, with the end goal of promoting gut health. Gut microbiota (dpeaa)DE-He213 Clostridia spp (dpeaa)DE-He213 Dysbiosis (dpeaa)DE-He213 Gut homeostasis (dpeaa)DE-He213 Scaldaferri, Franco aut Petito, Valentina aut Gasbarrini, Antonio aut Enthalten in Gut pathogens London : BioMed Central, 2009 5(2013), 1 vom: 13. Aug. (DE-627)591514133 (DE-600)2478277-4 1757-4749 nnns volume:5 year:2013 number:1 day:13 month:08 https://dx.doi.org/10.1186/1757-4749-5-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2013 1 13 08
allfieldsGer	10.1186/1757-4749-5-23 doi (DE-627)SPR030252393 (SPR)1757-4749-5-23-e DE-627 ger DE-627 rakwb eng Lopetuso, Loris R verfasserin aut Commensal Clostridia: leading players in the maintenance of gut homeostasis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Lopetuso et al.; licensee BioMed Central Ltd. 2013 Abstract The gastrointestinal tract is a complex and dynamic network where an intricate and mutualistic symbiosis modulates the relationship between the host and the microbiota in order to establish and ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes and make up a substantial part of the total bacteria in the gut microbiota. They start to colonize the intestine of breastfed infants during the first month of life and populate a specific region in the intestinal mucosa in close relationship with intestinal cells. This position allows them to participate as crucial factors in modulating physiologic, metabolic and immune processes in the gut during the entire lifespan, by interacting with the other resident microbe populations, but also by providing specific and essential functions. This review focus on what is currently known regarding the role of commensal Clostridia in the maintenance of overall gut function, as well as touch on their potential contribution in the unfavorable alteration of microbiota composition (dysbiosis) that has been implicated in several gastrointestinal disorders. Commensal Clostridia are strongly involved in the maintenance of overall gut function. This leads to important translational implications in regard to the prevention and treatment of dysbiosis, to drug efficacy and toxicity, and to the development of therapies that may modulate the composition of the microflora, capitalizing on the key role of commensal Clostridia, with the end goal of promoting gut health. Gut microbiota (dpeaa)DE-He213 Clostridia spp (dpeaa)DE-He213 Dysbiosis (dpeaa)DE-He213 Gut homeostasis (dpeaa)DE-He213 Scaldaferri, Franco aut Petito, Valentina aut Gasbarrini, Antonio aut Enthalten in Gut pathogens London : BioMed Central, 2009 5(2013), 1 vom: 13. Aug. (DE-627)591514133 (DE-600)2478277-4 1757-4749 nnns volume:5 year:2013 number:1 day:13 month:08 https://dx.doi.org/10.1186/1757-4749-5-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2013 1 13 08
allfieldsSound	10.1186/1757-4749-5-23 doi (DE-627)SPR030252393 (SPR)1757-4749-5-23-e DE-627 ger DE-627 rakwb eng Lopetuso, Loris R verfasserin aut Commensal Clostridia: leading players in the maintenance of gut homeostasis 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Lopetuso et al.; licensee BioMed Central Ltd. 2013 Abstract The gastrointestinal tract is a complex and dynamic network where an intricate and mutualistic symbiosis modulates the relationship between the host and the microbiota in order to establish and ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes and make up a substantial part of the total bacteria in the gut microbiota. They start to colonize the intestine of breastfed infants during the first month of life and populate a specific region in the intestinal mucosa in close relationship with intestinal cells. This position allows them to participate as crucial factors in modulating physiologic, metabolic and immune processes in the gut during the entire lifespan, by interacting with the other resident microbe populations, but also by providing specific and essential functions. This review focus on what is currently known regarding the role of commensal Clostridia in the maintenance of overall gut function, as well as touch on their potential contribution in the unfavorable alteration of microbiota composition (dysbiosis) that has been implicated in several gastrointestinal disorders. Commensal Clostridia are strongly involved in the maintenance of overall gut function. This leads to important translational implications in regard to the prevention and treatment of dysbiosis, to drug efficacy and toxicity, and to the development of therapies that may modulate the composition of the microflora, capitalizing on the key role of commensal Clostridia, with the end goal of promoting gut health. Gut microbiota (dpeaa)DE-He213 Clostridia spp (dpeaa)DE-He213 Dysbiosis (dpeaa)DE-He213 Gut homeostasis (dpeaa)DE-He213 Scaldaferri, Franco aut Petito, Valentina aut Gasbarrini, Antonio aut Enthalten in Gut pathogens London : BioMed Central, 2009 5(2013), 1 vom: 13. Aug. (DE-627)591514133 (DE-600)2478277-4 1757-4749 nnns volume:5 year:2013 number:1 day:13 month:08 https://dx.doi.org/10.1186/1757-4749-5-23 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2013 1 13 08
language	English
source	Enthalten in Gut pathogens 5(2013), 1 vom: 13. Aug. volume:5 year:2013 number:1 day:13 month:08
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institution	findex.gbv.de
topic_facet	Gut microbiota Clostridia spp Dysbiosis Gut homeostasis
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author	Lopetuso, Loris R
spellingShingle	Lopetuso, Loris R misc Gut microbiota misc Clostridia spp misc Dysbiosis misc Gut homeostasis Commensal Clostridia: leading players in the maintenance of gut homeostasis
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topic_title	Commensal Clostridia: leading players in the maintenance of gut homeostasis Gut microbiota (dpeaa)DE-He213 Clostridia spp (dpeaa)DE-He213 Dysbiosis (dpeaa)DE-He213 Gut homeostasis (dpeaa)DE-He213
topic	misc Gut microbiota misc Clostridia spp misc Dysbiosis misc Gut homeostasis
topic_unstemmed	misc Gut microbiota misc Clostridia spp misc Dysbiosis misc Gut homeostasis
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title	Commensal Clostridia: leading players in the maintenance of gut homeostasis
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title_full	Commensal Clostridia: leading players in the maintenance of gut homeostasis
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title_sort	commensal clostridia: leading players in the maintenance of gut homeostasis
title_auth	Commensal Clostridia: leading players in the maintenance of gut homeostasis
abstract	Abstract The gastrointestinal tract is a complex and dynamic network where an intricate and mutualistic symbiosis modulates the relationship between the host and the microbiota in order to establish and ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes and make up a substantial part of the total bacteria in the gut microbiota. They start to colonize the intestine of breastfed infants during the first month of life and populate a specific region in the intestinal mucosa in close relationship with intestinal cells. This position allows them to participate as crucial factors in modulating physiologic, metabolic and immune processes in the gut during the entire lifespan, by interacting with the other resident microbe populations, but also by providing specific and essential functions. This review focus on what is currently known regarding the role of commensal Clostridia in the maintenance of overall gut function, as well as touch on their potential contribution in the unfavorable alteration of microbiota composition (dysbiosis) that has been implicated in several gastrointestinal disorders. Commensal Clostridia are strongly involved in the maintenance of overall gut function. This leads to important translational implications in regard to the prevention and treatment of dysbiosis, to drug efficacy and toxicity, and to the development of therapies that may modulate the composition of the microflora, capitalizing on the key role of commensal Clostridia, with the end goal of promoting gut health. © Lopetuso et al.; licensee BioMed Central Ltd. 2013
abstractGer	Abstract The gastrointestinal tract is a complex and dynamic network where an intricate and mutualistic symbiosis modulates the relationship between the host and the microbiota in order to establish and ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes and make up a substantial part of the total bacteria in the gut microbiota. They start to colonize the intestine of breastfed infants during the first month of life and populate a specific region in the intestinal mucosa in close relationship with intestinal cells. This position allows them to participate as crucial factors in modulating physiologic, metabolic and immune processes in the gut during the entire lifespan, by interacting with the other resident microbe populations, but also by providing specific and essential functions. This review focus on what is currently known regarding the role of commensal Clostridia in the maintenance of overall gut function, as well as touch on their potential contribution in the unfavorable alteration of microbiota composition (dysbiosis) that has been implicated in several gastrointestinal disorders. Commensal Clostridia are strongly involved in the maintenance of overall gut function. This leads to important translational implications in regard to the prevention and treatment of dysbiosis, to drug efficacy and toxicity, and to the development of therapies that may modulate the composition of the microflora, capitalizing on the key role of commensal Clostridia, with the end goal of promoting gut health. © Lopetuso et al.; licensee BioMed Central Ltd. 2013
abstract_unstemmed	Abstract The gastrointestinal tract is a complex and dynamic network where an intricate and mutualistic symbiosis modulates the relationship between the host and the microbiota in order to establish and ensure gut homeostasis. Commensal Clostridia consist of gram-positive, rod-shaped bacteria in the phylum Firmicutes and make up a substantial part of the total bacteria in the gut microbiota. They start to colonize the intestine of breastfed infants during the first month of life and populate a specific region in the intestinal mucosa in close relationship with intestinal cells. This position allows them to participate as crucial factors in modulating physiologic, metabolic and immune processes in the gut during the entire lifespan, by interacting with the other resident microbe populations, but also by providing specific and essential functions. This review focus on what is currently known regarding the role of commensal Clostridia in the maintenance of overall gut function, as well as touch on their potential contribution in the unfavorable alteration of microbiota composition (dysbiosis) that has been implicated in several gastrointestinal disorders. Commensal Clostridia are strongly involved in the maintenance of overall gut function. This leads to important translational implications in regard to the prevention and treatment of dysbiosis, to drug efficacy and toxicity, and to the development of therapies that may modulate the composition of the microflora, capitalizing on the key role of commensal Clostridia, with the end goal of promoting gut health. © Lopetuso et al.; licensee BioMed Central Ltd. 2013
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title_short	Commensal Clostridia: leading players in the maintenance of gut homeostasis
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Commensal Clostridia: leading players in the maintenance of gut homeostasis

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