Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle

Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skel...
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Autor*in:	Rachagani, Satyanarayana [verfasserIn] Cheng, Ye Reecy, James M

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	miRNA Expression Skeletal Muscle Mass Serum Response Factor Heterozygous Mouse Pectoralis Muscle

Anmerkung:	© Reecy et al; licensee BioMed Central Ltd. 2010

Übergeordnetes Werk:	Enthalten in: BMC Research Notes - London, 2008, 3(2010), 1 vom: 11. Nov.
Übergeordnetes Werk:	volume:3 ; year:2010 ; number:1 ; day:11 ; month:11

Links:	Volltext

DOI / URN:	10.1186/1756-0500-3-297

Katalog-ID:	SPR030272610

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520			\|a Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle. Findings Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5). Conclusions Myostatin may regulates the expression of miRNAs such as miR-133a, miR-133b, miR-1, and miR-206 in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue.
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allfields	10.1186/1756-0500-3-297 doi (DE-627)SPR030272610 (SPR)1756-0500-3-297-e DE-627 ger DE-627 rakwb eng Rachagani, Satyanarayana verfasserin aut Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Reecy et al; licensee BioMed Central Ltd. 2010 Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle. Findings Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5). Conclusions Myostatin may regulates the expression of miRNAs such as miR-133a, miR-133b, miR-1, and miR-206 in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue. miRNA Expression (dpeaa)DE-He213 Skeletal Muscle Mass (dpeaa)DE-He213 Serum Response Factor (dpeaa)DE-He213 Heterozygous Mouse (dpeaa)DE-He213 Pectoralis Muscle (dpeaa)DE-He213 Cheng, Ye aut Reecy, James M aut Enthalten in BMC Research Notes London, 2008 3(2010), 1 vom: 11. Nov. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:3 year:2010 number:1 day:11 month:11 https://dx.doi.org/10.1186/1756-0500-3-297 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2010 1 11 11
spelling	10.1186/1756-0500-3-297 doi (DE-627)SPR030272610 (SPR)1756-0500-3-297-e DE-627 ger DE-627 rakwb eng Rachagani, Satyanarayana verfasserin aut Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Reecy et al; licensee BioMed Central Ltd. 2010 Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle. Findings Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5). Conclusions Myostatin may regulates the expression of miRNAs such as miR-133a, miR-133b, miR-1, and miR-206 in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue. miRNA Expression (dpeaa)DE-He213 Skeletal Muscle Mass (dpeaa)DE-He213 Serum Response Factor (dpeaa)DE-He213 Heterozygous Mouse (dpeaa)DE-He213 Pectoralis Muscle (dpeaa)DE-He213 Cheng, Ye aut Reecy, James M aut Enthalten in BMC Research Notes London, 2008 3(2010), 1 vom: 11. Nov. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:3 year:2010 number:1 day:11 month:11 https://dx.doi.org/10.1186/1756-0500-3-297 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2010 1 11 11
allfields_unstemmed	10.1186/1756-0500-3-297 doi (DE-627)SPR030272610 (SPR)1756-0500-3-297-e DE-627 ger DE-627 rakwb eng Rachagani, Satyanarayana verfasserin aut Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Reecy et al; licensee BioMed Central Ltd. 2010 Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle. Findings Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5). Conclusions Myostatin may regulates the expression of miRNAs such as miR-133a, miR-133b, miR-1, and miR-206 in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue. miRNA Expression (dpeaa)DE-He213 Skeletal Muscle Mass (dpeaa)DE-He213 Serum Response Factor (dpeaa)DE-He213 Heterozygous Mouse (dpeaa)DE-He213 Pectoralis Muscle (dpeaa)DE-He213 Cheng, Ye aut Reecy, James M aut Enthalten in BMC Research Notes London, 2008 3(2010), 1 vom: 11. Nov. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:3 year:2010 number:1 day:11 month:11 https://dx.doi.org/10.1186/1756-0500-3-297 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2010 1 11 11
allfieldsGer	10.1186/1756-0500-3-297 doi (DE-627)SPR030272610 (SPR)1756-0500-3-297-e DE-627 ger DE-627 rakwb eng Rachagani, Satyanarayana verfasserin aut Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Reecy et al; licensee BioMed Central Ltd. 2010 Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle. Findings Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5). Conclusions Myostatin may regulates the expression of miRNAs such as miR-133a, miR-133b, miR-1, and miR-206 in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue. miRNA Expression (dpeaa)DE-He213 Skeletal Muscle Mass (dpeaa)DE-He213 Serum Response Factor (dpeaa)DE-He213 Heterozygous Mouse (dpeaa)DE-He213 Pectoralis Muscle (dpeaa)DE-He213 Cheng, Ye aut Reecy, James M aut Enthalten in BMC Research Notes London, 2008 3(2010), 1 vom: 11. Nov. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:3 year:2010 number:1 day:11 month:11 https://dx.doi.org/10.1186/1756-0500-3-297 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2010 1 11 11
allfieldsSound	10.1186/1756-0500-3-297 doi (DE-627)SPR030272610 (SPR)1756-0500-3-297-e DE-627 ger DE-627 rakwb eng Rachagani, Satyanarayana verfasserin aut Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Reecy et al; licensee BioMed Central Ltd. 2010 Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle. Findings Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5). Conclusions Myostatin may regulates the expression of miRNAs such as miR-133a, miR-133b, miR-1, and miR-206 in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue. miRNA Expression (dpeaa)DE-He213 Skeletal Muscle Mass (dpeaa)DE-He213 Serum Response Factor (dpeaa)DE-He213 Heterozygous Mouse (dpeaa)DE-He213 Pectoralis Muscle (dpeaa)DE-He213 Cheng, Ye aut Reecy, James M aut Enthalten in BMC Research Notes London, 2008 3(2010), 1 vom: 11. Nov. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:3 year:2010 number:1 day:11 month:11 https://dx.doi.org/10.1186/1756-0500-3-297 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2010 1 11 11
language	English
source	Enthalten in BMC Research Notes 3(2010), 1 vom: 11. Nov. volume:3 year:2010 number:1 day:11 month:11
sourceStr	Enthalten in BMC Research Notes 3(2010), 1 vom: 11. Nov. volume:3 year:2010 number:1 day:11 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	miRNA Expression Skeletal Muscle Mass Serum Response Factor Heterozygous Mouse Pectoralis Muscle
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container_title	BMC Research Notes
authorswithroles_txt_mv	Rachagani, Satyanarayana @@aut@@ Cheng, Ye @@aut@@ Reecy, James M @@aut@@
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It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle. Findings Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5). Conclusions Myostatin may regulates the expression of miRNAs such as miR-133a, miR-133b, miR-1, and miR-206 in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. 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author	Rachagani, Satyanarayana
spellingShingle	Rachagani, Satyanarayana misc miRNA Expression misc Skeletal Muscle Mass misc Serum Response Factor misc Heterozygous Mouse misc Pectoralis Muscle Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle
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topic_title	Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle miRNA Expression (dpeaa)DE-He213 Skeletal Muscle Mass (dpeaa)DE-He213 Serum Response Factor (dpeaa)DE-He213 Heterozygous Mouse (dpeaa)DE-He213 Pectoralis Muscle (dpeaa)DE-He213
topic	misc miRNA Expression misc Skeletal Muscle Mass misc Serum Response Factor misc Heterozygous Mouse misc Pectoralis Muscle
topic_unstemmed	misc miRNA Expression misc Skeletal Muscle Mass misc Serum Response Factor misc Heterozygous Mouse misc Pectoralis Muscle
topic_browse	misc miRNA Expression misc Skeletal Muscle Mass misc Serum Response Factor misc Heterozygous Mouse misc Pectoralis Muscle
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title	Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle
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title_full	Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle
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author_browse	Rachagani, Satyanarayana Cheng, Ye Reecy, James M
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title_sort	myostatin genotype regulates muscle-specific mirna expression in mouse pectoralis muscle
title_auth	Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle
abstract	Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle. Findings Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5). Conclusions Myostatin may regulates the expression of miRNAs such as miR-133a, miR-133b, miR-1, and miR-206 in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue. © Reecy et al; licensee BioMed Central Ltd. 2010
abstractGer	Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle. Findings Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5). Conclusions Myostatin may regulates the expression of miRNAs such as miR-133a, miR-133b, miR-1, and miR-206 in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue. © Reecy et al; licensee BioMed Central Ltd. 2010
abstract_unstemmed	Background Loss of functional Myostatin results in a dramatic increase in skeletal muscle mass. It is unknown what role miRNAs play in Myostatin mediated repression of skeletal muscle mass. We hypothesized that Myostatin genotype would be associated with the differential expression of miRNAs in skeletal muscle. Findings Loss of functional Myostatin resulted in a significant increase (p < .001) in miR-1, miR-133a, miR-133b, and miR-206 expression. In contrast, Myostatin genotype had no effect (P > .2) on miR-24 expression level. Myostatin genotype did not affect the expression level of MyoD or Myogenin (P > 0.5). Conclusions Myostatin may regulates the expression of miRNAs such as miR-133a, miR-133b, miR-1, and miR-206 in skeletal muscle as it has been observed that the expression of those miRNAs are significantly higher in myostatin null mice compared to wild type and heterozygous mice. In contrast, expression of myogenic factors such as MyoD or Myogenin has not been affected by myostatin in the muscle tissue. © Reecy et al; licensee BioMed Central Ltd. 2010
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title_short	Myostatin genotype regulates muscle-specific miRNA expression in mouse pectoralis muscle
url	https://dx.doi.org/10.1186/1756-0500-3-297
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author2	Cheng, Ye Reecy, James M
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