Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial

Background Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but the...
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Autor*in:	Reinhold, Stephan W [verfasserIn] Reichle, Albrecht Leiminger, Sonja Bergler, Tobias Hoffmann, Ute Krüger, Bernd Banas, Bernhard Krämer, Bernhard K

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Capecitabine Celecoxib Pioglitazone Rofecoxib Edema Formation

Anmerkung:	© Reinhold et al; licensee BioMed Central Ltd. 2011

Übergeordnetes Werk:	Enthalten in: BMC Research Notes - London, 2008, 4(2011), 1 vom: 05. Jan.
Übergeordnetes Werk:	volume:4 ; year:2011 ; number:1 ; day:05 ; month:01

Links:	Volltext

DOI / URN:	10.1186/1756-0500-4-2

Katalog-ID:	SPR030276888

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520			\|a Background Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. Trial registration number German Clinical Trials Register DRKS: DRKS00000119
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allfields	10.1186/1756-0500-4-2 doi (DE-627)SPR030276888 (SPR)1756-0500-4-2-e DE-627 ger DE-627 rakwb eng Reinhold, Stephan W verfasserin aut Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Reinhold et al; licensee BioMed Central Ltd. 2011 Background Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. Trial registration number German Clinical Trials Register DRKS: DRKS00000119 Capecitabine (dpeaa)DE-He213 Celecoxib (dpeaa)DE-He213 Pioglitazone (dpeaa)DE-He213 Rofecoxib (dpeaa)DE-He213 Edema Formation (dpeaa)DE-He213 Reichle, Albrecht aut Leiminger, Sonja aut Bergler, Tobias aut Hoffmann, Ute aut Krüger, Bernd aut Banas, Bernhard aut Krämer, Bernhard K aut Enthalten in BMC Research Notes London, 2008 4(2011), 1 vom: 05. Jan. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:4 year:2011 number:1 day:05 month:01 https://dx.doi.org/10.1186/1756-0500-4-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2011 1 05 01
spelling	10.1186/1756-0500-4-2 doi (DE-627)SPR030276888 (SPR)1756-0500-4-2-e DE-627 ger DE-627 rakwb eng Reinhold, Stephan W verfasserin aut Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Reinhold et al; licensee BioMed Central Ltd. 2011 Background Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. Trial registration number German Clinical Trials Register DRKS: DRKS00000119 Capecitabine (dpeaa)DE-He213 Celecoxib (dpeaa)DE-He213 Pioglitazone (dpeaa)DE-He213 Rofecoxib (dpeaa)DE-He213 Edema Formation (dpeaa)DE-He213 Reichle, Albrecht aut Leiminger, Sonja aut Bergler, Tobias aut Hoffmann, Ute aut Krüger, Bernd aut Banas, Bernhard aut Krämer, Bernhard K aut Enthalten in BMC Research Notes London, 2008 4(2011), 1 vom: 05. Jan. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:4 year:2011 number:1 day:05 month:01 https://dx.doi.org/10.1186/1756-0500-4-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2011 1 05 01
allfields_unstemmed	10.1186/1756-0500-4-2 doi (DE-627)SPR030276888 (SPR)1756-0500-4-2-e DE-627 ger DE-627 rakwb eng Reinhold, Stephan W verfasserin aut Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Reinhold et al; licensee BioMed Central Ltd. 2011 Background Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. Trial registration number German Clinical Trials Register DRKS: DRKS00000119 Capecitabine (dpeaa)DE-He213 Celecoxib (dpeaa)DE-He213 Pioglitazone (dpeaa)DE-He213 Rofecoxib (dpeaa)DE-He213 Edema Formation (dpeaa)DE-He213 Reichle, Albrecht aut Leiminger, Sonja aut Bergler, Tobias aut Hoffmann, Ute aut Krüger, Bernd aut Banas, Bernhard aut Krämer, Bernhard K aut Enthalten in BMC Research Notes London, 2008 4(2011), 1 vom: 05. Jan. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:4 year:2011 number:1 day:05 month:01 https://dx.doi.org/10.1186/1756-0500-4-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2011 1 05 01
allfieldsGer	10.1186/1756-0500-4-2 doi (DE-627)SPR030276888 (SPR)1756-0500-4-2-e DE-627 ger DE-627 rakwb eng Reinhold, Stephan W verfasserin aut Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Reinhold et al; licensee BioMed Central Ltd. 2011 Background Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. Trial registration number German Clinical Trials Register DRKS: DRKS00000119 Capecitabine (dpeaa)DE-He213 Celecoxib (dpeaa)DE-He213 Pioglitazone (dpeaa)DE-He213 Rofecoxib (dpeaa)DE-He213 Edema Formation (dpeaa)DE-He213 Reichle, Albrecht aut Leiminger, Sonja aut Bergler, Tobias aut Hoffmann, Ute aut Krüger, Bernd aut Banas, Bernhard aut Krämer, Bernhard K aut Enthalten in BMC Research Notes London, 2008 4(2011), 1 vom: 05. Jan. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:4 year:2011 number:1 day:05 month:01 https://dx.doi.org/10.1186/1756-0500-4-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2011 1 05 01
allfieldsSound	10.1186/1756-0500-4-2 doi (DE-627)SPR030276888 (SPR)1756-0500-4-2-e DE-627 ger DE-627 rakwb eng Reinhold, Stephan W verfasserin aut Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Reinhold et al; licensee BioMed Central Ltd. 2011 Background Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. Trial registration number German Clinical Trials Register DRKS: DRKS00000119 Capecitabine (dpeaa)DE-He213 Celecoxib (dpeaa)DE-He213 Pioglitazone (dpeaa)DE-He213 Rofecoxib (dpeaa)DE-He213 Edema Formation (dpeaa)DE-He213 Reichle, Albrecht aut Leiminger, Sonja aut Bergler, Tobias aut Hoffmann, Ute aut Krüger, Bernd aut Banas, Bernhard aut Krämer, Bernhard K aut Enthalten in BMC Research Notes London, 2008 4(2011), 1 vom: 05. Jan. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:4 year:2011 number:1 day:05 month:01 https://dx.doi.org/10.1186/1756-0500-4-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2011 1 05 01
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source	Enthalten in BMC Research Notes 4(2011), 1 vom: 05. Jan. volume:4 year:2011 number:1 day:05 month:01
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topic_facet	Capecitabine Celecoxib Pioglitazone Rofecoxib Edema Formation
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COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. 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author	Reinhold, Stephan W
spellingShingle	Reinhold, Stephan W misc Capecitabine misc Celecoxib misc Pioglitazone misc Rofecoxib misc Edema Formation Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial
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topic_title	Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial Capecitabine (dpeaa)DE-He213 Celecoxib (dpeaa)DE-He213 Pioglitazone (dpeaa)DE-He213 Rofecoxib (dpeaa)DE-He213 Edema Formation (dpeaa)DE-He213
topic	misc Capecitabine misc Celecoxib misc Pioglitazone misc Rofecoxib misc Edema Formation
topic_unstemmed	misc Capecitabine misc Celecoxib misc Pioglitazone misc Rofecoxib misc Edema Formation
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title	Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial
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title_full	Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial
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author_browse	Reinhold, Stephan W Reichle, Albrecht Leiminger, Sonja Bergler, Tobias Hoffmann, Ute Krüger, Bernd Banas, Bernhard Krämer, Bernhard K
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title_sort	renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase ii trial
title_auth	Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial
abstract	Background Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. Trial registration number German Clinical Trials Register DRKS: DRKS00000119 © Reinhold et al; licensee BioMed Central Ltd. 2011
abstractGer	Background Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. Trial registration number German Clinical Trials Register DRKS: DRKS00000119 © Reinhold et al; licensee BioMed Central Ltd. 2011
abstract_unstemmed	Background Angiostatic/antiinflammatory therapy with COX-II inhibitors and pioglitazone seems to be a well tolerated and promising regimen in patients with metastatic cancer. COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. Trial registration number German Clinical Trials Register DRKS: DRKS00000119 © Reinhold et al; licensee BioMed Central Ltd. 2011
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title_short	Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial
url	https://dx.doi.org/10.1186/1756-0500-4-2
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up_date	2024-07-03T15:07:31.620Z
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COX-II inhibitors may have less gastrointestinal side effects than conventional non-steroidal antiinflammatory drugs, but their impact on renal function seems to be similar. Methods 87 patients with metastatic/advanced cancer were treated up to 12 months (mean 19.5 weeks) with rofecoxib, pioglitazone and either capecitabine (group A with gastrointestinal and urological cancer, n = 50) or trofosfamide (group B with non-gastrointestinal/non-urological cancer, n = 37) and followed for further 6 months. Results Baseline serum creatinine concentration was 0.81 ± 0.28 mg/dl, and increased by about 0.15 mg/dl during months 1-3. Accordingly estimated glomerular filtration rate (eGFR) decreased from 90.3 ml/min ± 3.6 ml/min at baseline by about 10 ml/min during months 1-3. Renal function decreased in 75 patients (86%) in the first month (p < 0.0001). This decrease went along with clinical signs of volume expansion. Renal function tended to recover after discontinuation of the study medication. Conclusions Therapy with rofecoxib in an antiangiogenic/antiinflammatory setting results in a decrease of renal function in nearly every patient. 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Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial

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