Potential for false positive HIV test results with the serial rapid HIV testing algorithm

Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of...
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Autor*in:	Baveewo, Steven [verfasserIn] Kamya, Moses R Mayanja-Kizza, Harriet Fatch, Robin Bangsberg, David R Coates, Thomas Hahn, Judith A Wanyenze, Rhoda K

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	False positive HIV testing algorithm Rapid diagnostic tests Qualitative PCR testing

Anmerkung:	© Baveewo et al; licensee BioMed Central Ltd. 2012

Übergeordnetes Werk:	Enthalten in: BMC Research Notes - London, 2008, 5(2012), 1 vom: 19. März
Übergeordnetes Werk:	volume:5 ; year:2012 ; number:1 ; day:19 ; month:03

Links:	Volltext

DOI / URN:	10.1186/1756-0500-5-154

Katalog-ID:	SPR03028144X

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520			\|a Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals.
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allfields	10.1186/1756-0500-5-154 doi (DE-627)SPR03028144X (SPR)1756-0500-5-154-e DE-627 ger DE-627 rakwb eng Baveewo, Steven verfasserin aut Potential for false positive HIV test results with the serial rapid HIV testing algorithm 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Baveewo et al; licensee BioMed Central Ltd. 2012 Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals. False positive (dpeaa)DE-He213 HIV testing algorithm (dpeaa)DE-He213 Rapid diagnostic tests (dpeaa)DE-He213 Qualitative PCR testing (dpeaa)DE-He213 Kamya, Moses R aut Mayanja-Kizza, Harriet aut Fatch, Robin aut Bangsberg, David R aut Coates, Thomas aut Hahn, Judith A aut Wanyenze, Rhoda K aut Enthalten in BMC Research Notes London, 2008 5(2012), 1 vom: 19. März (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:5 year:2012 number:1 day:19 month:03 https://dx.doi.org/10.1186/1756-0500-5-154 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1 19 03
spelling	10.1186/1756-0500-5-154 doi (DE-627)SPR03028144X (SPR)1756-0500-5-154-e DE-627 ger DE-627 rakwb eng Baveewo, Steven verfasserin aut Potential for false positive HIV test results with the serial rapid HIV testing algorithm 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Baveewo et al; licensee BioMed Central Ltd. 2012 Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals. False positive (dpeaa)DE-He213 HIV testing algorithm (dpeaa)DE-He213 Rapid diagnostic tests (dpeaa)DE-He213 Qualitative PCR testing (dpeaa)DE-He213 Kamya, Moses R aut Mayanja-Kizza, Harriet aut Fatch, Robin aut Bangsberg, David R aut Coates, Thomas aut Hahn, Judith A aut Wanyenze, Rhoda K aut Enthalten in BMC Research Notes London, 2008 5(2012), 1 vom: 19. März (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:5 year:2012 number:1 day:19 month:03 https://dx.doi.org/10.1186/1756-0500-5-154 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1 19 03
allfields_unstemmed	10.1186/1756-0500-5-154 doi (DE-627)SPR03028144X (SPR)1756-0500-5-154-e DE-627 ger DE-627 rakwb eng Baveewo, Steven verfasserin aut Potential for false positive HIV test results with the serial rapid HIV testing algorithm 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Baveewo et al; licensee BioMed Central Ltd. 2012 Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals. False positive (dpeaa)DE-He213 HIV testing algorithm (dpeaa)DE-He213 Rapid diagnostic tests (dpeaa)DE-He213 Qualitative PCR testing (dpeaa)DE-He213 Kamya, Moses R aut Mayanja-Kizza, Harriet aut Fatch, Robin aut Bangsberg, David R aut Coates, Thomas aut Hahn, Judith A aut Wanyenze, Rhoda K aut Enthalten in BMC Research Notes London, 2008 5(2012), 1 vom: 19. März (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:5 year:2012 number:1 day:19 month:03 https://dx.doi.org/10.1186/1756-0500-5-154 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1 19 03
allfieldsGer	10.1186/1756-0500-5-154 doi (DE-627)SPR03028144X (SPR)1756-0500-5-154-e DE-627 ger DE-627 rakwb eng Baveewo, Steven verfasserin aut Potential for false positive HIV test results with the serial rapid HIV testing algorithm 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Baveewo et al; licensee BioMed Central Ltd. 2012 Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals. False positive (dpeaa)DE-He213 HIV testing algorithm (dpeaa)DE-He213 Rapid diagnostic tests (dpeaa)DE-He213 Qualitative PCR testing (dpeaa)DE-He213 Kamya, Moses R aut Mayanja-Kizza, Harriet aut Fatch, Robin aut Bangsberg, David R aut Coates, Thomas aut Hahn, Judith A aut Wanyenze, Rhoda K aut Enthalten in BMC Research Notes London, 2008 5(2012), 1 vom: 19. März (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:5 year:2012 number:1 day:19 month:03 https://dx.doi.org/10.1186/1756-0500-5-154 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1 19 03
allfieldsSound	10.1186/1756-0500-5-154 doi (DE-627)SPR03028144X (SPR)1756-0500-5-154-e DE-627 ger DE-627 rakwb eng Baveewo, Steven verfasserin aut Potential for false positive HIV test results with the serial rapid HIV testing algorithm 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Baveewo et al; licensee BioMed Central Ltd. 2012 Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals. False positive (dpeaa)DE-He213 HIV testing algorithm (dpeaa)DE-He213 Rapid diagnostic tests (dpeaa)DE-He213 Qualitative PCR testing (dpeaa)DE-He213 Kamya, Moses R aut Mayanja-Kizza, Harriet aut Fatch, Robin aut Bangsberg, David R aut Coates, Thomas aut Hahn, Judith A aut Wanyenze, Rhoda K aut Enthalten in BMC Research Notes London, 2008 5(2012), 1 vom: 19. März (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:5 year:2012 number:1 day:19 month:03 https://dx.doi.org/10.1186/1756-0500-5-154 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2012 1 19 03
language	English
source	Enthalten in BMC Research Notes 5(2012), 1 vom: 19. März volume:5 year:2012 number:1 day:19 month:03
sourceStr	Enthalten in BMC Research Notes 5(2012), 1 vom: 19. März volume:5 year:2012 number:1 day:19 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	False positive HIV testing algorithm Rapid diagnostic tests Qualitative PCR testing
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authorswithroles_txt_mv	Baveewo, Steven @@aut@@ Kamya, Moses R @@aut@@ Mayanja-Kizza, Harriet @@aut@@ Fatch, Robin @@aut@@ Bangsberg, David R @@aut@@ Coates, Thomas @@aut@@ Hahn, Judith A @@aut@@ Wanyenze, Rhoda K @@aut@@
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The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. 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author	Baveewo, Steven
spellingShingle	Baveewo, Steven misc False positive misc HIV testing algorithm misc Rapid diagnostic tests misc Qualitative PCR testing Potential for false positive HIV test results with the serial rapid HIV testing algorithm
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topic_title	Potential for false positive HIV test results with the serial rapid HIV testing algorithm False positive (dpeaa)DE-He213 HIV testing algorithm (dpeaa)DE-He213 Rapid diagnostic tests (dpeaa)DE-He213 Qualitative PCR testing (dpeaa)DE-He213
topic	misc False positive misc HIV testing algorithm misc Rapid diagnostic tests misc Qualitative PCR testing
topic_unstemmed	misc False positive misc HIV testing algorithm misc Rapid diagnostic tests misc Qualitative PCR testing
topic_browse	misc False positive misc HIV testing algorithm misc Rapid diagnostic tests misc Qualitative PCR testing
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title	Potential for false positive HIV test results with the serial rapid HIV testing algorithm
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title_full	Potential for false positive HIV test results with the serial rapid HIV testing algorithm
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author_browse	Baveewo, Steven Kamya, Moses R Mayanja-Kizza, Harriet Fatch, Robin Bangsberg, David R Coates, Thomas Hahn, Judith A Wanyenze, Rhoda K
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title_sort	potential for false positive hiv test results with the serial rapid hiv testing algorithm
title_auth	Potential for false positive HIV test results with the serial rapid HIV testing algorithm
abstract	Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals. © Baveewo et al; licensee BioMed Central Ltd. 2012
abstractGer	Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals. © Baveewo et al; licensee BioMed Central Ltd. 2012
abstract_unstemmed	Background Rapid HIV tests provide same-day results and are widely used in HIV testing programs in areas with limited personnel and laboratory infrastructure. The Uganda Ministry of Health currently recommends the serial rapid testing algorithm with Determine, STAT-PAK, and Uni-Gold for diagnosis of HIV infection. Using this algorithm, individuals who test positive on Determine, negative to STAT-PAK and positive to Uni-Gold are reported as HIV positive. We conducted further testing on this subgroup of samples using qualitative DNA PCR to assess the potential for false positive tests in this situation. Results Of the 3388 individuals who were tested, 984 were HIV positive on two consecutive tests, and 29 were considered positive by a tiebreaker (positive on Determine, negative on STAT-PAK, and positive on Uni-Gold). However, when the 29 samples were further tested using qualitative DNA PCR, 14 (48.2%) were HIV negative. Conclusion Although this study was not primarily designed to assess the validity of rapid HIV tests and thus only a subset of the samples were retested, the findings show a potential for false positive HIV results in the subset of individuals who test positive when a tiebreaker test is used in serial testing. These findings highlight a need for confirmatory testing for this category of individuals. © Baveewo et al; licensee BioMed Central Ltd. 2012
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title_short	Potential for false positive HIV test results with the serial rapid HIV testing algorithm
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author2	Kamya, Moses R Mayanja-Kizza, Harriet Fatch, Robin Bangsberg, David R Coates, Thomas Hahn, Judith A Wanyenze, Rhoda K
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Potential for false positive HIV test results with the serial rapid HIV testing algorithm

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