The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population

Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians,...
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Gespeichert in:

Autor*in:	Мirrakhimov, Erkin М [verfasserIn] Kerimkulova, Alina S Lunegova, Оlga S Mirrakhimov, Aibek E Nabiev, Malik P Neronova, Kseniya V Bayramukova, Asiyat A Alibaeva, Nazira T Satarov, Nurdin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Leptin Abdominal obesity Dyslipidemia Arterial hypertension

Anmerkung:	© Мirrakhimov et al.; licensee BioMed Central Ltd. 2014

Übergeordnetes Werk:	Enthalten in: BMC Research Notes - London, 2008, 7(2014), 1 vom: 30. Juni
Übergeordnetes Werk:	volume:7 ; year:2014 ; number:1 ; day:30 ; month:06

Links:	Volltext

DOI / URN:	10.1186/1756-0500-7-411

Katalog-ID:	SPR030297982

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520			\|a Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. Conclusion Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients.
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allfields	10.1186/1756-0500-7-411 doi (DE-627)SPR030297982 (SPR)1756-0500-7-411-e DE-627 ger DE-627 rakwb eng Мirrakhimov, Erkin М verfasserin aut The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Мirrakhimov et al.; licensee BioMed Central Ltd. 2014 Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. Conclusion Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. Leptin (dpeaa)DE-He213 Abdominal obesity (dpeaa)DE-He213 Dyslipidemia (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Kerimkulova, Alina S aut Lunegova, Оlga S aut Mirrakhimov, Aibek E aut Nabiev, Malik P aut Neronova, Kseniya V aut Bayramukova, Asiyat A aut Alibaeva, Nazira T aut Satarov, Nurdin aut Enthalten in BMC Research Notes London, 2008 7(2014), 1 vom: 30. Juni (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:7 year:2014 number:1 day:30 month:06 https://dx.doi.org/10.1186/1756-0500-7-411 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 30 06
spelling	10.1186/1756-0500-7-411 doi (DE-627)SPR030297982 (SPR)1756-0500-7-411-e DE-627 ger DE-627 rakwb eng Мirrakhimov, Erkin М verfasserin aut The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Мirrakhimov et al.; licensee BioMed Central Ltd. 2014 Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. Conclusion Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. Leptin (dpeaa)DE-He213 Abdominal obesity (dpeaa)DE-He213 Dyslipidemia (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Kerimkulova, Alina S aut Lunegova, Оlga S aut Mirrakhimov, Aibek E aut Nabiev, Malik P aut Neronova, Kseniya V aut Bayramukova, Asiyat A aut Alibaeva, Nazira T aut Satarov, Nurdin aut Enthalten in BMC Research Notes London, 2008 7(2014), 1 vom: 30. Juni (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:7 year:2014 number:1 day:30 month:06 https://dx.doi.org/10.1186/1756-0500-7-411 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 30 06
allfields_unstemmed	10.1186/1756-0500-7-411 doi (DE-627)SPR030297982 (SPR)1756-0500-7-411-e DE-627 ger DE-627 rakwb eng Мirrakhimov, Erkin М verfasserin aut The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Мirrakhimov et al.; licensee BioMed Central Ltd. 2014 Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. Conclusion Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. Leptin (dpeaa)DE-He213 Abdominal obesity (dpeaa)DE-He213 Dyslipidemia (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Kerimkulova, Alina S aut Lunegova, Оlga S aut Mirrakhimov, Aibek E aut Nabiev, Malik P aut Neronova, Kseniya V aut Bayramukova, Asiyat A aut Alibaeva, Nazira T aut Satarov, Nurdin aut Enthalten in BMC Research Notes London, 2008 7(2014), 1 vom: 30. Juni (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:7 year:2014 number:1 day:30 month:06 https://dx.doi.org/10.1186/1756-0500-7-411 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 30 06
allfieldsGer	10.1186/1756-0500-7-411 doi (DE-627)SPR030297982 (SPR)1756-0500-7-411-e DE-627 ger DE-627 rakwb eng Мirrakhimov, Erkin М verfasserin aut The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Мirrakhimov et al.; licensee BioMed Central Ltd. 2014 Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. Conclusion Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. Leptin (dpeaa)DE-He213 Abdominal obesity (dpeaa)DE-He213 Dyslipidemia (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Kerimkulova, Alina S aut Lunegova, Оlga S aut Mirrakhimov, Aibek E aut Nabiev, Malik P aut Neronova, Kseniya V aut Bayramukova, Asiyat A aut Alibaeva, Nazira T aut Satarov, Nurdin aut Enthalten in BMC Research Notes London, 2008 7(2014), 1 vom: 30. Juni (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:7 year:2014 number:1 day:30 month:06 https://dx.doi.org/10.1186/1756-0500-7-411 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 30 06
allfieldsSound	10.1186/1756-0500-7-411 doi (DE-627)SPR030297982 (SPR)1756-0500-7-411-e DE-627 ger DE-627 rakwb eng Мirrakhimov, Erkin М verfasserin aut The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Мirrakhimov et al.; licensee BioMed Central Ltd. 2014 Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. Conclusion Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. Leptin (dpeaa)DE-He213 Abdominal obesity (dpeaa)DE-He213 Dyslipidemia (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213 Kerimkulova, Alina S aut Lunegova, Оlga S aut Mirrakhimov, Aibek E aut Nabiev, Malik P aut Neronova, Kseniya V aut Bayramukova, Asiyat A aut Alibaeva, Nazira T aut Satarov, Nurdin aut Enthalten in BMC Research Notes London, 2008 7(2014), 1 vom: 30. Juni (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:7 year:2014 number:1 day:30 month:06 https://dx.doi.org/10.1186/1756-0500-7-411 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2014 1 30 06
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source	Enthalten in BMC Research Notes 7(2014), 1 vom: 30. Juni volume:7 year:2014 number:1 day:30 month:06
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authorswithroles_txt_mv	Мirrakhimov, Erkin М @@aut@@ Kerimkulova, Alina S @@aut@@ Lunegova, Оlga S @@aut@@ Mirrakhimov, Aibek E @@aut@@ Nabiev, Malik P @@aut@@ Neronova, Kseniya V @@aut@@ Bayramukova, Asiyat A @@aut@@ Alibaeva, Nazira T @@aut@@ Satarov, Nurdin @@aut@@
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author	Мirrakhimov, Erkin М
spellingShingle	Мirrakhimov, Erkin М misc Leptin misc Abdominal obesity misc Dyslipidemia misc Arterial hypertension The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
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topic_title	The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population Leptin (dpeaa)DE-He213 Abdominal obesity (dpeaa)DE-He213 Dyslipidemia (dpeaa)DE-He213 Arterial hypertension (dpeaa)DE-He213
topic	misc Leptin misc Abdominal obesity misc Dyslipidemia misc Arterial hypertension
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title	The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
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title_full	The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
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author_browse	Мirrakhimov, Erkin М Kerimkulova, Alina S Lunegova, Оlga S Mirrakhimov, Aibek E Nabiev, Malik P Neronova, Kseniya V Bayramukova, Asiyat A Alibaeva, Nazira T Satarov, Nurdin
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title_sort	association of leptin with dyslipidemia, arterial hypertension and obesity in kyrgyz (central asian nation) population
title_auth	The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
abstract	Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. Conclusion Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. © Мirrakhimov et al.; licensee BioMed Central Ltd. 2014
abstractGer	Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. Conclusion Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. © Мirrakhimov et al.; licensee BioMed Central Ltd. 2014
abstract_unstemmed	Background Leptin, an adipocytokine produced by adipose tissue, along with the traditional cardiometabolic risk factors, contributes to the development of cardiovascular complications. At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. Conclusion Leptin is associated with general and abdominal obesity, dyslipidemia, and insulin resistance in Kyrgyz patients. © Мirrakhimov et al.; licensee BioMed Central Ltd. 2014
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title_short	The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population
url	https://dx.doi.org/10.1186/1756-0500-7-411
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author2	Kerimkulova, Alina S Lunegova, Оlga S Mirrakhimov, Aibek E Nabiev, Malik P Neronova, Kseniya V Bayramukova, Asiyat A Alibaeva, Nazira T Satarov, Nurdin
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up_date	2024-07-03T15:16:07.094Z
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At the same time, ethnic features of adipocytokines have been insufficiently investigated, especially among Asians, who have an increased risk of cardiovascular complications compared with Europeans. Aim of study was to investigate the relationship between leptin levels and age, gender, anthropometric parameters, lipid parameters, arterial hypertension (AH), and obesity in the adult population of ethnic Kyrgyz people living in Central Asia. Results In total, 322 ethnic Kyrgyz (145 men, 177 women) aged ≥ 30 years were studied. Waist and hip circumference, body mass index, blood glucose, lipids, leptin, and homeostatic model assessment were measured. Patients in the upper quartile of leptin levels had high values of BMI, WC, systolic and diastolic blood pressure, glucose, and HOMA index compared with patients with lower leptin levels. The prevalence of metabolic syndrome and AH increased with higher levels of leptin. Leptin positively correlated with BMI, WC, triglycerides, and glucose concentrations in patients of both sexes. According to the multivariate logistic regression analysis, elevated leptin levels increased by 30 times the risk of obesity in men, regardless of the presence of type 2 diabetes, and 17.7 times in women. 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The association of leptin with dyslipidemia, arterial hypertension and obesity in Kyrgyz (Central Asian nation) population

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