High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent

Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Celotto, Andrea Carla [verfasserIn] Capellini, Verena Kise Albuquerque, Agnes Afrodite Sumarelli Ferreira, Luciana Garros Silveira, Ana Paula Cassiano de Nadai, Tales Rubens Evora, Paulo Roberto Barbosa

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Potassium channels Endothelium Paxilline Rat aortic rings

Anmerkung:	© Celotto et al. 2015

Übergeordnetes Werk:	Enthalten in: BMC Research Notes - London, 2008, 8(2015), 1 vom: 19. Sept.
Übergeordnetes Werk:	volume:8 ; year:2015 ; number:1 ; day:19 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s13104-015-1422-3

Katalog-ID:	SPR03030881X

Internformat


LEADER	01000caa a22002652 4500
001	SPR03030881X
003	DE-627
005	20230519190953.0
007	cr uuu---uuuuu
008	201007s2015 xx \|\|\|\|\|o 00\| \|\|eng c
024	7		\|a 10.1186/s13104-015-1422-3 \|2 doi
035			\|a (DE-627)SPR03030881X
035			\|a (SPR)s13104-015-1422-3-e
040			\|a DE-627 \|b ger \|c DE-627 \|e rakwb
041			\|a eng
100	1		\|a Celotto, Andrea Carla \|e verfasserin \|4 aut
245	1	0	\|a High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent
264		1	\|c 2015
336			\|a Text \|b txt \|2 rdacontent
337			\|a Computermedien \|b c \|2 rdamedia
338			\|a Online-Ressource \|b cr \|2 rdacarrier
500			\|a © Celotto et al. 2015
520			\|a Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent.
650		4	\|a Potassium channels \|7 (dpeaa)DE-He213
650		4	\|a Endothelium \|7 (dpeaa)DE-He213
650		4	\|a Paxilline \|7 (dpeaa)DE-He213
650		4	\|a Rat aortic rings \|7 (dpeaa)DE-He213
700	1		\|a Capellini, Verena Kise \|4 aut
700	1		\|a Albuquerque, Agnes Afrodite Sumarelli \|4 aut
700	1		\|a Ferreira, Luciana Garros \|4 aut
700	1		\|a Silveira, Ana Paula Cassiano \|4 aut
700	1		\|a de Nadai, Tales Rubens \|4 aut
700	1		\|a Evora, Paulo Roberto Barbosa \|4 aut
773	0	8	\|i Enthalten in \|t BMC Research Notes \|d London, 2008 \|g 8(2015), 1 vom: 19. Sept. \|w (DE-627)559431805 \|w (DE-600)2413336-X \|x 1756-0500 \|7 nnns
773	1	8	\|g volume:8 \|g year:2015 \|g number:1 \|g day:19 \|g month:09
856	4	0	\|u https://dx.doi.org/10.1186/s13104-015-1422-3 \|z kostenfrei \|3 Volltext
912			\|a GBV_USEFLAG_A
912			\|a SYSFLAG_A
912			\|a GBV_SPRINGER
912			\|a SSG-OLC-PHA
912			\|a GBV_ILN_11
912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
952			\|d 8 \|j 2015 \|e 1 \|b 19 \|c 09

Indexfelder

author_variant	a c c ac acc v k c vk vkc a a s a aas aasa l g f lg lgf a p c s apc apcs n t r d ntr ntrd p r b e prb prbe
matchkey_str	article:17560500:2015----::ihodcacptsimhnesciainycdxouenaara
hierarchy_sort_str	2015
publishDate	2015
allfields	10.1186/s13104-015-1422-3 doi (DE-627)SPR03030881X (SPR)s13104-015-1422-3-e DE-627 ger DE-627 rakwb eng Celotto, Andrea Carla verfasserin aut High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Celotto et al. 2015 Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent. Potassium channels (dpeaa)DE-He213 Endothelium (dpeaa)DE-He213 Paxilline (dpeaa)DE-He213 Rat aortic rings (dpeaa)DE-He213 Capellini, Verena Kise aut Albuquerque, Agnes Afrodite Sumarelli aut Ferreira, Luciana Garros aut Silveira, Ana Paula Cassiano aut de Nadai, Tales Rubens aut Evora, Paulo Roberto Barbosa aut Enthalten in BMC Research Notes London, 2008 8(2015), 1 vom: 19. Sept. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:8 year:2015 number:1 day:19 month:09 https://dx.doi.org/10.1186/s13104-015-1422-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 1 19 09
spelling	10.1186/s13104-015-1422-3 doi (DE-627)SPR03030881X (SPR)s13104-015-1422-3-e DE-627 ger DE-627 rakwb eng Celotto, Andrea Carla verfasserin aut High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Celotto et al. 2015 Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent. Potassium channels (dpeaa)DE-He213 Endothelium (dpeaa)DE-He213 Paxilline (dpeaa)DE-He213 Rat aortic rings (dpeaa)DE-He213 Capellini, Verena Kise aut Albuquerque, Agnes Afrodite Sumarelli aut Ferreira, Luciana Garros aut Silveira, Ana Paula Cassiano aut de Nadai, Tales Rubens aut Evora, Paulo Roberto Barbosa aut Enthalten in BMC Research Notes London, 2008 8(2015), 1 vom: 19. Sept. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:8 year:2015 number:1 day:19 month:09 https://dx.doi.org/10.1186/s13104-015-1422-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 1 19 09
allfields_unstemmed	10.1186/s13104-015-1422-3 doi (DE-627)SPR03030881X (SPR)s13104-015-1422-3-e DE-627 ger DE-627 rakwb eng Celotto, Andrea Carla verfasserin aut High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Celotto et al. 2015 Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent. Potassium channels (dpeaa)DE-He213 Endothelium (dpeaa)DE-He213 Paxilline (dpeaa)DE-He213 Rat aortic rings (dpeaa)DE-He213 Capellini, Verena Kise aut Albuquerque, Agnes Afrodite Sumarelli aut Ferreira, Luciana Garros aut Silveira, Ana Paula Cassiano aut de Nadai, Tales Rubens aut Evora, Paulo Roberto Barbosa aut Enthalten in BMC Research Notes London, 2008 8(2015), 1 vom: 19. Sept. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:8 year:2015 number:1 day:19 month:09 https://dx.doi.org/10.1186/s13104-015-1422-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 1 19 09
allfieldsGer	10.1186/s13104-015-1422-3 doi (DE-627)SPR03030881X (SPR)s13104-015-1422-3-e DE-627 ger DE-627 rakwb eng Celotto, Andrea Carla verfasserin aut High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Celotto et al. 2015 Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent. Potassium channels (dpeaa)DE-He213 Endothelium (dpeaa)DE-He213 Paxilline (dpeaa)DE-He213 Rat aortic rings (dpeaa)DE-He213 Capellini, Verena Kise aut Albuquerque, Agnes Afrodite Sumarelli aut Ferreira, Luciana Garros aut Silveira, Ana Paula Cassiano aut de Nadai, Tales Rubens aut Evora, Paulo Roberto Barbosa aut Enthalten in BMC Research Notes London, 2008 8(2015), 1 vom: 19. Sept. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:8 year:2015 number:1 day:19 month:09 https://dx.doi.org/10.1186/s13104-015-1422-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 1 19 09
allfieldsSound	10.1186/s13104-015-1422-3 doi (DE-627)SPR03030881X (SPR)s13104-015-1422-3-e DE-627 ger DE-627 rakwb eng Celotto, Andrea Carla verfasserin aut High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Celotto et al. 2015 Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent. Potassium channels (dpeaa)DE-He213 Endothelium (dpeaa)DE-He213 Paxilline (dpeaa)DE-He213 Rat aortic rings (dpeaa)DE-He213 Capellini, Verena Kise aut Albuquerque, Agnes Afrodite Sumarelli aut Ferreira, Luciana Garros aut Silveira, Ana Paula Cassiano aut de Nadai, Tales Rubens aut Evora, Paulo Roberto Barbosa aut Enthalten in BMC Research Notes London, 2008 8(2015), 1 vom: 19. Sept. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:8 year:2015 number:1 day:19 month:09 https://dx.doi.org/10.1186/s13104-015-1422-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 1 19 09
language	English
source	Enthalten in BMC Research Notes 8(2015), 1 vom: 19. Sept. volume:8 year:2015 number:1 day:19 month:09
sourceStr	Enthalten in BMC Research Notes 8(2015), 1 vom: 19. Sept. volume:8 year:2015 number:1 day:19 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Potassium channels Endothelium Paxilline Rat aortic rings
isfreeaccess_bool	true
container_title	BMC Research Notes
authorswithroles_txt_mv	Celotto, Andrea Carla @@aut@@ Capellini, Verena Kise @@aut@@ Albuquerque, Agnes Afrodite Sumarelli @@aut@@ Ferreira, Luciana Garros @@aut@@ Silveira, Ana Paula Cassiano @@aut@@ de Nadai, Tales Rubens @@aut@@ Evora, Paulo Roberto Barbosa @@aut@@
publishDateDaySort_date	2015-09-19T00:00:00Z
hierarchy_top_id	559431805
id	SPR03030881X
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR03030881X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519190953.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2015 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s13104-015-1422-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR03030881X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13104-015-1422-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Celotto, Andrea Carla</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Celotto et al. 2015</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Potassium channels</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Endothelium</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Paxilline</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Rat aortic rings</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Capellini, Verena Kise</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Albuquerque, Agnes Afrodite Sumarelli</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ferreira, Luciana Garros</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Silveira, Ana Paula Cassiano</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">de Nadai, Tales Rubens</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Evora, Paulo Roberto Barbosa</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">BMC Research Notes</subfield><subfield code="d">London, 2008</subfield><subfield code="g">8(2015), 1 vom: 19. Sept.</subfield><subfield code="w">(DE-627)559431805</subfield><subfield code="w">(DE-600)2413336-X</subfield><subfield code="x">1756-0500</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:8</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:1</subfield><subfield code="g">day:19</subfield><subfield code="g">month:09</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s13104-015-1422-3</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">8</subfield><subfield code="j">2015</subfield><subfield code="e">1</subfield><subfield code="b">19</subfield><subfield code="c">09</subfield></datafield></record></collection>
author	Celotto, Andrea Carla
spellingShingle	Celotto, Andrea Carla misc Potassium channels misc Endothelium misc Paxilline misc Rat aortic rings High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent
authorStr	Celotto, Andrea Carla
ppnlink_with_tag_str_mv	@@773@@(DE-627)559431805
format	electronic Article
delete_txt_mv	keep
author_role	aut aut aut aut aut aut aut
collection	springer
remote_str	true
illustrated	Not Illustrated
issn	1756-0500
topic_title	High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent Potassium channels (dpeaa)DE-He213 Endothelium (dpeaa)DE-He213 Paxilline (dpeaa)DE-He213 Rat aortic rings (dpeaa)DE-He213
topic	misc Potassium channels misc Endothelium misc Paxilline misc Rat aortic rings
topic_unstemmed	misc Potassium channels misc Endothelium misc Paxilline misc Rat aortic rings
topic_browse	misc Potassium channels misc Endothelium misc Paxilline misc Rat aortic rings
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
format_main_str_mv	Text Zeitschrift/Artikel
carriertype_str_mv	cr
hierarchy_parent_title	BMC Research Notes
hierarchy_parent_id	559431805
hierarchy_top_title	BMC Research Notes
isfreeaccess_txt	true
familylinks_str_mv	(DE-627)559431805 (DE-600)2413336-X
title	High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent
ctrlnum	(DE-627)SPR03030881X (SPR)s13104-015-1422-3-e
title_full	High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent
author_sort	Celotto, Andrea Carla
journal	BMC Research Notes
journalStr	BMC Research Notes
lang_code	eng
isOA_bool	true
recordtype	marc
publishDateSort	2015
contenttype_str_mv	txt
author_browse	Celotto, Andrea Carla Capellini, Verena Kise Albuquerque, Agnes Afrodite Sumarelli Ferreira, Luciana Garros Silveira, Ana Paula Cassiano de Nadai, Tales Rubens Evora, Paulo Roberto Barbosa
container_volume	8
format_se	Elektronische Aufsätze
author-letter	Celotto, Andrea Carla
doi_str_mv	10.1186/s13104-015-1422-3
title_sort	high conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent
title_auth	High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent
abstract	Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent. © Celotto et al. 2015
abstractGer	Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent. © Celotto et al. 2015
abstract_unstemmed	Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent. © Celotto et al. 2015
collection_details	GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700
container_issue	1
title_short	High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent
url	https://dx.doi.org/10.1186/s13104-015-1422-3
remote_bool	true
author2	Capellini, Verena Kise Albuquerque, Agnes Afrodite Sumarelli Ferreira, Luciana Garros Silveira, Ana Paula Cassiano de Nadai, Tales Rubens Evora, Paulo Roberto Barbosa
author2Str	Capellini, Verena Kise Albuquerque, Agnes Afrodite Sumarelli Ferreira, Luciana Garros Silveira, Ana Paula Cassiano de Nadai, Tales Rubens Evora, Paulo Roberto Barbosa
ppnlink	559431805
mediatype_str_mv	c
isOA_txt	true
hochschulschrift_bool	false
doi_str	10.1186/s13104-015-1422-3
up_date	2024-07-03T15:20:35.054Z
_version_	1803571728283074560
fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR03030881X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230519190953.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">201007s2015 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s13104-015-1422-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR03030881X</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s13104-015-1422-3-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Celotto, Andrea Carla</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Celotto et al. 2015</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background We investigated, previously, the mechanism by which extracellular acidification promotes relaxation in rat thoracic aorta. These studies suggested that extracellular acidosis promotes vasodilation mediated by NO, $ K_{ATP} $ and $ SK_{Ca} $, and maybe other $ K^{+} $ channels in isolated rat thoracic aorta. This study was carried out to investigate the paxilline-mediated hyperpolarization induced by acid exposure. Results The relaxation response to HCl-induced extracellular acidification (7.4–6.5) was measured in rat aortic rings pre-contracted with phenylephrine (PE, $ 10^{−6} $ M). The vascular reactivity experiments were performed in endothelium-intact and denuded rings, in the presence of paxilline ($ 10^{−6} $ M), which is an inhibitor of high calcium conductance potassium $ BK_{Ca} $ channels. In rings with endothelium, paxilline inhibits relaxation, triggered by acidification at all pH values lower than 7.2 and had no effect on rings without endothelium, showing that the activation of $ BK_{Ca} $ is endothelium-dependent. Conclusion High conductance potassium channel activation induced by acid exposure is endothelium-dependent.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Potassium channels</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Endothelium</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Paxilline</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Rat aortic rings</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Capellini, Verena Kise</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Albuquerque, Agnes Afrodite Sumarelli</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ferreira, Luciana Garros</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Silveira, Ana Paula Cassiano</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">de Nadai, Tales Rubens</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Evora, Paulo Roberto Barbosa</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">BMC Research Notes</subfield><subfield code="d">London, 2008</subfield><subfield code="g">8(2015), 1 vom: 19. Sept.</subfield><subfield code="w">(DE-627)559431805</subfield><subfield code="w">(DE-600)2413336-X</subfield><subfield code="x">1756-0500</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:8</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:1</subfield><subfield code="g">day:19</subfield><subfield code="g">month:09</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s13104-015-1422-3</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">8</subfield><subfield code="j">2015</subfield><subfield code="e">1</subfield><subfield code="b">19</subfield><subfield code="c">09</subfield></datafield></record></collection>
score	7.403097

Nicht das Richtige dabei?

Schreiben Sie uns!

High conductance potassium channels activation by acid exposure in rat aorta is endothelium-dependent

Nicht das Richtige dabei?

Zugang & Verfügbarkeit

Vorhandene Bände

Nicht das Richtige dabei?