Long-standing insulinoma: two case reports and review of the literature

Background Insulinomas are rare pancreatic endocrine tumors. Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both...
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Autor*in:	Tarchouli, Mohamed [verfasserIn] Ait Ali, Abdelmounaim Ratbi, Moulay Brahim Belhamidi, Mohamed said Essarghini, Mohamed Aboulfeth, El Mehdi Bouzroud, Mohamed Sbitti, Yassir Oukabli, Mohamed Elfahssi, Mohammed Sair, Khalid

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Insulinoma Pancreas Diagnosis Management Surgery

Anmerkung:	© Tarchouli et al. 2015

Übergeordnetes Werk:	Enthalten in: BMC Research Notes - London, 2008, 8(2015), 1 vom: 15. Sept.
Übergeordnetes Werk:	volume:8 ; year:2015 ; number:1 ; day:15 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s13104-015-1424-1

Katalog-ID:	SPR030308836

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520			\|a Background Insulinomas are rare pancreatic endocrine tumors. Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both patients presented episodic hypoglycemic symptoms respectively during 10 and 2 years. Biochemical and morphological workup detected localized pancreatic insulinoma. Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. Conclusion Insulinoma remains a diagnostic challenge to practitioners. Diagnosis of suspected cases is easily confirmed by standard endocrine tests, especially the supervised fasting test. Accurate preoperative localization is essential for more effective and safest surgery.
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allfields	10.1186/s13104-015-1424-1 doi (DE-627)SPR030308836 (SPR)s13104-015-1424-1-e DE-627 ger DE-627 rakwb eng Tarchouli, Mohamed verfasserin aut Long-standing insulinoma: two case reports and review of the literature 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tarchouli et al. 2015 Background Insulinomas are rare pancreatic endocrine tumors. Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both patients presented episodic hypoglycemic symptoms respectively during 10 and 2 years. Biochemical and morphological workup detected localized pancreatic insulinoma. Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. Conclusion Insulinoma remains a diagnostic challenge to practitioners. Diagnosis of suspected cases is easily confirmed by standard endocrine tests, especially the supervised fasting test. Accurate preoperative localization is essential for more effective and safest surgery. Insulinoma (dpeaa)DE-He213 Pancreas (dpeaa)DE-He213 Diagnosis (dpeaa)DE-He213 Management (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Ait Ali, Abdelmounaim aut Ratbi, Moulay Brahim aut Belhamidi, Mohamed said aut Essarghini, Mohamed aut Aboulfeth, El Mehdi aut Bouzroud, Mohamed aut Sbitti, Yassir aut Oukabli, Mohamed aut Elfahssi, Mohammed aut Sair, Khalid aut Enthalten in BMC Research Notes London, 2008 8(2015), 1 vom: 15. Sept. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:8 year:2015 number:1 day:15 month:09 https://dx.doi.org/10.1186/s13104-015-1424-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 1 15 09
spelling	10.1186/s13104-015-1424-1 doi (DE-627)SPR030308836 (SPR)s13104-015-1424-1-e DE-627 ger DE-627 rakwb eng Tarchouli, Mohamed verfasserin aut Long-standing insulinoma: two case reports and review of the literature 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tarchouli et al. 2015 Background Insulinomas are rare pancreatic endocrine tumors. Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both patients presented episodic hypoglycemic symptoms respectively during 10 and 2 years. Biochemical and morphological workup detected localized pancreatic insulinoma. Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. Conclusion Insulinoma remains a diagnostic challenge to practitioners. Diagnosis of suspected cases is easily confirmed by standard endocrine tests, especially the supervised fasting test. Accurate preoperative localization is essential for more effective and safest surgery. Insulinoma (dpeaa)DE-He213 Pancreas (dpeaa)DE-He213 Diagnosis (dpeaa)DE-He213 Management (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Ait Ali, Abdelmounaim aut Ratbi, Moulay Brahim aut Belhamidi, Mohamed said aut Essarghini, Mohamed aut Aboulfeth, El Mehdi aut Bouzroud, Mohamed aut Sbitti, Yassir aut Oukabli, Mohamed aut Elfahssi, Mohammed aut Sair, Khalid aut Enthalten in BMC Research Notes London, 2008 8(2015), 1 vom: 15. Sept. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:8 year:2015 number:1 day:15 month:09 https://dx.doi.org/10.1186/s13104-015-1424-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 1 15 09
allfields_unstemmed	10.1186/s13104-015-1424-1 doi (DE-627)SPR030308836 (SPR)s13104-015-1424-1-e DE-627 ger DE-627 rakwb eng Tarchouli, Mohamed verfasserin aut Long-standing insulinoma: two case reports and review of the literature 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tarchouli et al. 2015 Background Insulinomas are rare pancreatic endocrine tumors. Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both patients presented episodic hypoglycemic symptoms respectively during 10 and 2 years. Biochemical and morphological workup detected localized pancreatic insulinoma. Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. Conclusion Insulinoma remains a diagnostic challenge to practitioners. Diagnosis of suspected cases is easily confirmed by standard endocrine tests, especially the supervised fasting test. Accurate preoperative localization is essential for more effective and safest surgery. Insulinoma (dpeaa)DE-He213 Pancreas (dpeaa)DE-He213 Diagnosis (dpeaa)DE-He213 Management (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Ait Ali, Abdelmounaim aut Ratbi, Moulay Brahim aut Belhamidi, Mohamed said aut Essarghini, Mohamed aut Aboulfeth, El Mehdi aut Bouzroud, Mohamed aut Sbitti, Yassir aut Oukabli, Mohamed aut Elfahssi, Mohammed aut Sair, Khalid aut Enthalten in BMC Research Notes London, 2008 8(2015), 1 vom: 15. Sept. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:8 year:2015 number:1 day:15 month:09 https://dx.doi.org/10.1186/s13104-015-1424-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 1 15 09
allfieldsGer	10.1186/s13104-015-1424-1 doi (DE-627)SPR030308836 (SPR)s13104-015-1424-1-e DE-627 ger DE-627 rakwb eng Tarchouli, Mohamed verfasserin aut Long-standing insulinoma: two case reports and review of the literature 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tarchouli et al. 2015 Background Insulinomas are rare pancreatic endocrine tumors. Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both patients presented episodic hypoglycemic symptoms respectively during 10 and 2 years. Biochemical and morphological workup detected localized pancreatic insulinoma. Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. Conclusion Insulinoma remains a diagnostic challenge to practitioners. Diagnosis of suspected cases is easily confirmed by standard endocrine tests, especially the supervised fasting test. Accurate preoperative localization is essential for more effective and safest surgery. Insulinoma (dpeaa)DE-He213 Pancreas (dpeaa)DE-He213 Diagnosis (dpeaa)DE-He213 Management (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Ait Ali, Abdelmounaim aut Ratbi, Moulay Brahim aut Belhamidi, Mohamed said aut Essarghini, Mohamed aut Aboulfeth, El Mehdi aut Bouzroud, Mohamed aut Sbitti, Yassir aut Oukabli, Mohamed aut Elfahssi, Mohammed aut Sair, Khalid aut Enthalten in BMC Research Notes London, 2008 8(2015), 1 vom: 15. Sept. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:8 year:2015 number:1 day:15 month:09 https://dx.doi.org/10.1186/s13104-015-1424-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 1 15 09
allfieldsSound	10.1186/s13104-015-1424-1 doi (DE-627)SPR030308836 (SPR)s13104-015-1424-1-e DE-627 ger DE-627 rakwb eng Tarchouli, Mohamed verfasserin aut Long-standing insulinoma: two case reports and review of the literature 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tarchouli et al. 2015 Background Insulinomas are rare pancreatic endocrine tumors. Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both patients presented episodic hypoglycemic symptoms respectively during 10 and 2 years. Biochemical and morphological workup detected localized pancreatic insulinoma. Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. Conclusion Insulinoma remains a diagnostic challenge to practitioners. Diagnosis of suspected cases is easily confirmed by standard endocrine tests, especially the supervised fasting test. Accurate preoperative localization is essential for more effective and safest surgery. Insulinoma (dpeaa)DE-He213 Pancreas (dpeaa)DE-He213 Diagnosis (dpeaa)DE-He213 Management (dpeaa)DE-He213 Surgery (dpeaa)DE-He213 Ait Ali, Abdelmounaim aut Ratbi, Moulay Brahim aut Belhamidi, Mohamed said aut Essarghini, Mohamed aut Aboulfeth, El Mehdi aut Bouzroud, Mohamed aut Sbitti, Yassir aut Oukabli, Mohamed aut Elfahssi, Mohammed aut Sair, Khalid aut Enthalten in BMC Research Notes London, 2008 8(2015), 1 vom: 15. Sept. (DE-627)559431805 (DE-600)2413336-X 1756-0500 nnns volume:8 year:2015 number:1 day:15 month:09 https://dx.doi.org/10.1186/s13104-015-1424-1 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2015 1 15 09
language	English
source	Enthalten in BMC Research Notes 8(2015), 1 vom: 15. Sept. volume:8 year:2015 number:1 day:15 month:09
sourceStr	Enthalten in BMC Research Notes 8(2015), 1 vom: 15. Sept. volume:8 year:2015 number:1 day:15 month:09
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Insulinoma Pancreas Diagnosis Management Surgery
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container_title	BMC Research Notes
authorswithroles_txt_mv	Tarchouli, Mohamed @@aut@@ Ait Ali, Abdelmounaim @@aut@@ Ratbi, Moulay Brahim @@aut@@ Belhamidi, Mohamed said @@aut@@ Essarghini, Mohamed @@aut@@ Aboulfeth, El Mehdi @@aut@@ Bouzroud, Mohamed @@aut@@ Sbitti, Yassir @@aut@@ Oukabli, Mohamed @@aut@@ Elfahssi, Mohammed @@aut@@ Sair, Khalid @@aut@@
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Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both patients presented episodic hypoglycemic symptoms respectively during 10 and 2 years. Biochemical and morphological workup detected localized pancreatic insulinoma. Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. Conclusion Insulinoma remains a diagnostic challenge to practitioners. Diagnosis of suspected cases is easily confirmed by standard endocrine tests, especially the supervised fasting test. 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author	Tarchouli, Mohamed
spellingShingle	Tarchouli, Mohamed misc Insulinoma misc Pancreas misc Diagnosis misc Management misc Surgery Long-standing insulinoma: two case reports and review of the literature
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topic_title	Long-standing insulinoma: two case reports and review of the literature Insulinoma (dpeaa)DE-He213 Pancreas (dpeaa)DE-He213 Diagnosis (dpeaa)DE-He213 Management (dpeaa)DE-He213 Surgery (dpeaa)DE-He213
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title	Long-standing insulinoma: two case reports and review of the literature
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title_full	Long-standing insulinoma: two case reports and review of the literature
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author_browse	Tarchouli, Mohamed Ait Ali, Abdelmounaim Ratbi, Moulay Brahim Belhamidi, Mohamed said Essarghini, Mohamed Aboulfeth, El Mehdi Bouzroud, Mohamed Sbitti, Yassir Oukabli, Mohamed Elfahssi, Mohammed Sair, Khalid
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title_sort	long-standing insulinoma: two case reports and review of the literature
title_auth	Long-standing insulinoma: two case reports and review of the literature
abstract	Background Insulinomas are rare pancreatic endocrine tumors. Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both patients presented episodic hypoglycemic symptoms respectively during 10 and 2 years. Biochemical and morphological workup detected localized pancreatic insulinoma. Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. Conclusion Insulinoma remains a diagnostic challenge to practitioners. Diagnosis of suspected cases is easily confirmed by standard endocrine tests, especially the supervised fasting test. Accurate preoperative localization is essential for more effective and safest surgery. © Tarchouli et al. 2015
abstractGer	Background Insulinomas are rare pancreatic endocrine tumors. Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both patients presented episodic hypoglycemic symptoms respectively during 10 and 2 years. Biochemical and morphological workup detected localized pancreatic insulinoma. Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. Conclusion Insulinoma remains a diagnostic challenge to practitioners. Diagnosis of suspected cases is easily confirmed by standard endocrine tests, especially the supervised fasting test. Accurate preoperative localization is essential for more effective and safest surgery. © Tarchouli et al. 2015
abstract_unstemmed	Background Insulinomas are rare pancreatic endocrine tumors. Most are benign and solitary. However, the nonspecific symptoms and small size of these tumors led to difficulties of diagnosis and localization. Case presentation We present two Arab patients with pancreatic long-standing insulinoma. Both patients presented episodic hypoglycemic symptoms respectively during 10 and 2 years. Biochemical and morphological workup detected localized pancreatic insulinoma. Open procedure surgery was done for the two patients and insulinomas were successfully removed by enucleation. Conclusion Insulinoma remains a diagnostic challenge to practitioners. Diagnosis of suspected cases is easily confirmed by standard endocrine tests, especially the supervised fasting test. Accurate preoperative localization is essential for more effective and safest surgery. © Tarchouli et al. 2015
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title_short	Long-standing insulinoma: two case reports and review of the literature
url	https://dx.doi.org/10.1186/s13104-015-1424-1
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author2	Ait Ali, Abdelmounaim Ratbi, Moulay Brahim Belhamidi, Mohamed said Essarghini, Mohamed Aboulfeth, El Mehdi Bouzroud, Mohamed Sbitti, Yassir Oukabli, Mohamed Elfahssi, Mohammed Sair, Khalid
author2Str	Ait Ali, Abdelmounaim Ratbi, Moulay Brahim Belhamidi, Mohamed said Essarghini, Mohamed Aboulfeth, El Mehdi Bouzroud, Mohamed Sbitti, Yassir Oukabli, Mohamed Elfahssi, Mohammed Sair, Khalid
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Long-standing insulinoma: two case reports and review of the literature

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