Studying chromosome-wide transcriptional networks: new insights into disease?

Abstract A large amount of experimental data collected over the last decade has shown that genomic organization is very complex and has highlighted the fact that the current set of gene annotations does not fully capture this complexity. Much of the RNA detected in a cell is found to originate from...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kapranov, Philipp [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Nucleotide Change Genomic Distance Chimeric Transcript Annotate Exon Chimeric RNAs

Anmerkung:	© BioMed Central Ltd 2009

Übergeordnetes Werk:	Enthalten in: Genome medicine - London : BioMed Central, 2009, 1(2009), 5 vom: 11. Mai
Übergeordnetes Werk:	volume:1 ; year:2009 ; number:5 ; day:11 ; month:05

Links:	Volltext

DOI / URN:	10.1186/gm50

Katalog-ID:	SPR03055912X

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allfields	10.1186/gm50 doi (DE-627)SPR03055912X (SPR)gm50-e DE-627 ger DE-627 rakwb eng Kapranov, Philipp verfasserin aut Studying chromosome-wide transcriptional networks: new insights into disease? 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2009 Abstract A large amount of experimental data collected over the last decade has shown that genomic organization is very complex and has highlighted the fact that the current set of gene annotations does not fully capture this complexity. Much of the RNA detected in a cell is found to originate from outside the exons of annotated genes. Exons of annotated and unannotated transcripts separated by large genomic distances can be joined together in chimeric transcripts. Any given base-pair in a genome could be traversed by many protein-coding and non-coding RNAs. We discuss the implications of these effects for our understanding of disease. Nucleotide Change (dpeaa)DE-He213 Genomic Distance (dpeaa)DE-He213 Chimeric Transcript (dpeaa)DE-He213 Annotate Exon (dpeaa)DE-He213 Chimeric RNAs (dpeaa)DE-He213 Enthalten in Genome medicine London : BioMed Central, 2009 1(2009), 5 vom: 11. Mai (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:1 year:2009 number:5 day:11 month:05 https://dx.doi.org/10.1186/gm50 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 5 11 05
spelling	10.1186/gm50 doi (DE-627)SPR03055912X (SPR)gm50-e DE-627 ger DE-627 rakwb eng Kapranov, Philipp verfasserin aut Studying chromosome-wide transcriptional networks: new insights into disease? 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2009 Abstract A large amount of experimental data collected over the last decade has shown that genomic organization is very complex and has highlighted the fact that the current set of gene annotations does not fully capture this complexity. Much of the RNA detected in a cell is found to originate from outside the exons of annotated genes. Exons of annotated and unannotated transcripts separated by large genomic distances can be joined together in chimeric transcripts. Any given base-pair in a genome could be traversed by many protein-coding and non-coding RNAs. We discuss the implications of these effects for our understanding of disease. Nucleotide Change (dpeaa)DE-He213 Genomic Distance (dpeaa)DE-He213 Chimeric Transcript (dpeaa)DE-He213 Annotate Exon (dpeaa)DE-He213 Chimeric RNAs (dpeaa)DE-He213 Enthalten in Genome medicine London : BioMed Central, 2009 1(2009), 5 vom: 11. Mai (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:1 year:2009 number:5 day:11 month:05 https://dx.doi.org/10.1186/gm50 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 5 11 05
allfields_unstemmed	10.1186/gm50 doi (DE-627)SPR03055912X (SPR)gm50-e DE-627 ger DE-627 rakwb eng Kapranov, Philipp verfasserin aut Studying chromosome-wide transcriptional networks: new insights into disease? 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2009 Abstract A large amount of experimental data collected over the last decade has shown that genomic organization is very complex and has highlighted the fact that the current set of gene annotations does not fully capture this complexity. Much of the RNA detected in a cell is found to originate from outside the exons of annotated genes. Exons of annotated and unannotated transcripts separated by large genomic distances can be joined together in chimeric transcripts. Any given base-pair in a genome could be traversed by many protein-coding and non-coding RNAs. We discuss the implications of these effects for our understanding of disease. Nucleotide Change (dpeaa)DE-He213 Genomic Distance (dpeaa)DE-He213 Chimeric Transcript (dpeaa)DE-He213 Annotate Exon (dpeaa)DE-He213 Chimeric RNAs (dpeaa)DE-He213 Enthalten in Genome medicine London : BioMed Central, 2009 1(2009), 5 vom: 11. Mai (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:1 year:2009 number:5 day:11 month:05 https://dx.doi.org/10.1186/gm50 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 5 11 05
allfieldsGer	10.1186/gm50 doi (DE-627)SPR03055912X (SPR)gm50-e DE-627 ger DE-627 rakwb eng Kapranov, Philipp verfasserin aut Studying chromosome-wide transcriptional networks: new insights into disease? 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2009 Abstract A large amount of experimental data collected over the last decade has shown that genomic organization is very complex and has highlighted the fact that the current set of gene annotations does not fully capture this complexity. Much of the RNA detected in a cell is found to originate from outside the exons of annotated genes. Exons of annotated and unannotated transcripts separated by large genomic distances can be joined together in chimeric transcripts. Any given base-pair in a genome could be traversed by many protein-coding and non-coding RNAs. We discuss the implications of these effects for our understanding of disease. Nucleotide Change (dpeaa)DE-He213 Genomic Distance (dpeaa)DE-He213 Chimeric Transcript (dpeaa)DE-He213 Annotate Exon (dpeaa)DE-He213 Chimeric RNAs (dpeaa)DE-He213 Enthalten in Genome medicine London : BioMed Central, 2009 1(2009), 5 vom: 11. Mai (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:1 year:2009 number:5 day:11 month:05 https://dx.doi.org/10.1186/gm50 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 5 11 05
allfieldsSound	10.1186/gm50 doi (DE-627)SPR03055912X (SPR)gm50-e DE-627 ger DE-627 rakwb eng Kapranov, Philipp verfasserin aut Studying chromosome-wide transcriptional networks: new insights into disease? 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2009 Abstract A large amount of experimental data collected over the last decade has shown that genomic organization is very complex and has highlighted the fact that the current set of gene annotations does not fully capture this complexity. Much of the RNA detected in a cell is found to originate from outside the exons of annotated genes. Exons of annotated and unannotated transcripts separated by large genomic distances can be joined together in chimeric transcripts. Any given base-pair in a genome could be traversed by many protein-coding and non-coding RNAs. We discuss the implications of these effects for our understanding of disease. Nucleotide Change (dpeaa)DE-He213 Genomic Distance (dpeaa)DE-He213 Chimeric Transcript (dpeaa)DE-He213 Annotate Exon (dpeaa)DE-He213 Chimeric RNAs (dpeaa)DE-He213 Enthalten in Genome medicine London : BioMed Central, 2009 1(2009), 5 vom: 11. Mai (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:1 year:2009 number:5 day:11 month:05 https://dx.doi.org/10.1186/gm50 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 5 11 05
language	English
source	Enthalten in Genome medicine 1(2009), 5 vom: 11. Mai volume:1 year:2009 number:5 day:11 month:05
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topic_facet	Nucleotide Change Genomic Distance Chimeric Transcript Annotate Exon Chimeric RNAs
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author	Kapranov, Philipp
spellingShingle	Kapranov, Philipp misc Nucleotide Change misc Genomic Distance misc Chimeric Transcript misc Annotate Exon misc Chimeric RNAs Studying chromosome-wide transcriptional networks: new insights into disease?
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topic_title	Studying chromosome-wide transcriptional networks: new insights into disease? Nucleotide Change (dpeaa)DE-He213 Genomic Distance (dpeaa)DE-He213 Chimeric Transcript (dpeaa)DE-He213 Annotate Exon (dpeaa)DE-He213 Chimeric RNAs (dpeaa)DE-He213
topic	misc Nucleotide Change misc Genomic Distance misc Chimeric Transcript misc Annotate Exon misc Chimeric RNAs
topic_unstemmed	misc Nucleotide Change misc Genomic Distance misc Chimeric Transcript misc Annotate Exon misc Chimeric RNAs
topic_browse	misc Nucleotide Change misc Genomic Distance misc Chimeric Transcript misc Annotate Exon misc Chimeric RNAs
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
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title	Studying chromosome-wide transcriptional networks: new insights into disease?
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title_full	Studying chromosome-wide transcriptional networks: new insights into disease?
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title_sort	studying chromosome-wide transcriptional networks: new insights into disease?
title_auth	Studying chromosome-wide transcriptional networks: new insights into disease?
abstract	Abstract A large amount of experimental data collected over the last decade has shown that genomic organization is very complex and has highlighted the fact that the current set of gene annotations does not fully capture this complexity. Much of the RNA detected in a cell is found to originate from outside the exons of annotated genes. Exons of annotated and unannotated transcripts separated by large genomic distances can be joined together in chimeric transcripts. Any given base-pair in a genome could be traversed by many protein-coding and non-coding RNAs. We discuss the implications of these effects for our understanding of disease. © BioMed Central Ltd 2009
abstractGer	Abstract A large amount of experimental data collected over the last decade has shown that genomic organization is very complex and has highlighted the fact that the current set of gene annotations does not fully capture this complexity. Much of the RNA detected in a cell is found to originate from outside the exons of annotated genes. Exons of annotated and unannotated transcripts separated by large genomic distances can be joined together in chimeric transcripts. Any given base-pair in a genome could be traversed by many protein-coding and non-coding RNAs. We discuss the implications of these effects for our understanding of disease. © BioMed Central Ltd 2009
abstract_unstemmed	Abstract A large amount of experimental data collected over the last decade has shown that genomic organization is very complex and has highlighted the fact that the current set of gene annotations does not fully capture this complexity. Much of the RNA detected in a cell is found to originate from outside the exons of annotated genes. Exons of annotated and unannotated transcripts separated by large genomic distances can be joined together in chimeric transcripts. Any given base-pair in a genome could be traversed by many protein-coding and non-coding RNAs. We discuss the implications of these effects for our understanding of disease. © BioMed Central Ltd 2009
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title_short	Studying chromosome-wide transcriptional networks: new insights into disease?
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