The clinical utility of testicular cancer risk loci

Abstract Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kratz, Christian P [verfasserIn] Bratslavsky, Gennady Shi, Jianxin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	Testicular Cancer Clinical Risk Factor Cryptorchidism Testicular Germ Cell Tumor High Relative Risk

Anmerkung:	© BioMed Central Ltd. 2011

Übergeordnetes Werk:	Enthalten in: Genome medicine - London : BioMed Central, 2009, 3(2011), 1 vom: 21. Jan.
Übergeordnetes Werk:	volume:3 ; year:2011 ; number:1 ; day:21 ; month:01

Links:	Volltext

DOI / URN:	10.1186/gm215

Katalog-ID:	SPR030574110

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allfields	10.1186/gm215 doi (DE-627)SPR030574110 (SPR)gm215-e DE-627 ger DE-627 rakwb eng Kratz, Christian P verfasserin aut The clinical utility of testicular cancer risk loci 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd. 2011 Abstract Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care. Testicular Cancer (dpeaa)DE-He213 Clinical Risk Factor (dpeaa)DE-He213 Cryptorchidism (dpeaa)DE-He213 Testicular Germ Cell Tumor (dpeaa)DE-He213 High Relative Risk (dpeaa)DE-He213 Bratslavsky, Gennady aut Shi, Jianxin aut Enthalten in Genome medicine London : BioMed Central, 2009 3(2011), 1 vom: 21. Jan. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:3 year:2011 number:1 day:21 month:01 https://dx.doi.org/10.1186/gm215 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 1 21 01
spelling	10.1186/gm215 doi (DE-627)SPR030574110 (SPR)gm215-e DE-627 ger DE-627 rakwb eng Kratz, Christian P verfasserin aut The clinical utility of testicular cancer risk loci 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd. 2011 Abstract Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care. Testicular Cancer (dpeaa)DE-He213 Clinical Risk Factor (dpeaa)DE-He213 Cryptorchidism (dpeaa)DE-He213 Testicular Germ Cell Tumor (dpeaa)DE-He213 High Relative Risk (dpeaa)DE-He213 Bratslavsky, Gennady aut Shi, Jianxin aut Enthalten in Genome medicine London : BioMed Central, 2009 3(2011), 1 vom: 21. Jan. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:3 year:2011 number:1 day:21 month:01 https://dx.doi.org/10.1186/gm215 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 1 21 01
allfields_unstemmed	10.1186/gm215 doi (DE-627)SPR030574110 (SPR)gm215-e DE-627 ger DE-627 rakwb eng Kratz, Christian P verfasserin aut The clinical utility of testicular cancer risk loci 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd. 2011 Abstract Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care. Testicular Cancer (dpeaa)DE-He213 Clinical Risk Factor (dpeaa)DE-He213 Cryptorchidism (dpeaa)DE-He213 Testicular Germ Cell Tumor (dpeaa)DE-He213 High Relative Risk (dpeaa)DE-He213 Bratslavsky, Gennady aut Shi, Jianxin aut Enthalten in Genome medicine London : BioMed Central, 2009 3(2011), 1 vom: 21. Jan. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:3 year:2011 number:1 day:21 month:01 https://dx.doi.org/10.1186/gm215 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 1 21 01
allfieldsGer	10.1186/gm215 doi (DE-627)SPR030574110 (SPR)gm215-e DE-627 ger DE-627 rakwb eng Kratz, Christian P verfasserin aut The clinical utility of testicular cancer risk loci 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd. 2011 Abstract Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care. Testicular Cancer (dpeaa)DE-He213 Clinical Risk Factor (dpeaa)DE-He213 Cryptorchidism (dpeaa)DE-He213 Testicular Germ Cell Tumor (dpeaa)DE-He213 High Relative Risk (dpeaa)DE-He213 Bratslavsky, Gennady aut Shi, Jianxin aut Enthalten in Genome medicine London : BioMed Central, 2009 3(2011), 1 vom: 21. Jan. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:3 year:2011 number:1 day:21 month:01 https://dx.doi.org/10.1186/gm215 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 1 21 01
allfieldsSound	10.1186/gm215 doi (DE-627)SPR030574110 (SPR)gm215-e DE-627 ger DE-627 rakwb eng Kratz, Christian P verfasserin aut The clinical utility of testicular cancer risk loci 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd. 2011 Abstract Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care. Testicular Cancer (dpeaa)DE-He213 Clinical Risk Factor (dpeaa)DE-He213 Cryptorchidism (dpeaa)DE-He213 Testicular Germ Cell Tumor (dpeaa)DE-He213 High Relative Risk (dpeaa)DE-He213 Bratslavsky, Gennady aut Shi, Jianxin aut Enthalten in Genome medicine London : BioMed Central, 2009 3(2011), 1 vom: 21. Jan. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:3 year:2011 number:1 day:21 month:01 https://dx.doi.org/10.1186/gm215 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2011 1 21 01
language	English
source	Enthalten in Genome medicine 3(2011), 1 vom: 21. Jan. volume:3 year:2011 number:1 day:21 month:01
sourceStr	Enthalten in Genome medicine 3(2011), 1 vom: 21. Jan. volume:3 year:2011 number:1 day:21 month:01
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institution	findex.gbv.de
topic_facet	Testicular Cancer Clinical Risk Factor Cryptorchidism Testicular Germ Cell Tumor High Relative Risk
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author	Kratz, Christian P
spellingShingle	Kratz, Christian P misc Testicular Cancer misc Clinical Risk Factor misc Cryptorchidism misc Testicular Germ Cell Tumor misc High Relative Risk The clinical utility of testicular cancer risk loci
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topic_title	The clinical utility of testicular cancer risk loci Testicular Cancer (dpeaa)DE-He213 Clinical Risk Factor (dpeaa)DE-He213 Cryptorchidism (dpeaa)DE-He213 Testicular Germ Cell Tumor (dpeaa)DE-He213 High Relative Risk (dpeaa)DE-He213
topic	misc Testicular Cancer misc Clinical Risk Factor misc Cryptorchidism misc Testicular Germ Cell Tumor misc High Relative Risk
topic_unstemmed	misc Testicular Cancer misc Clinical Risk Factor misc Cryptorchidism misc Testicular Germ Cell Tumor misc High Relative Risk
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title	The clinical utility of testicular cancer risk loci
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title_full	The clinical utility of testicular cancer risk loci
author_sort	Kratz, Christian P
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title_sort	clinical utility of testicular cancer risk loci
title_auth	The clinical utility of testicular cancer risk loci
abstract	Abstract Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care. © BioMed Central Ltd. 2011
abstractGer	Abstract Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care. © BioMed Central Ltd. 2011
abstract_unstemmed	Abstract Three recent genome-wide association studies of testicular germ cell tumors have uncovered predisposition alleles in or near several genes, including KITLG, BAK1, SPRY4, TERT, ATF7IP, and DMRT1. The calculated per-allele odds ratio for variants in the region of KITLG is the highest reported for any malignancy so far. These findings are in agreement with epidemiological data indicating that testicular cancer has a higher heritability than most other cancers. Here, we discuss the question of whether the newly identified risk polymorphisms can be used to guide patient care. © BioMed Central Ltd. 2011
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title_short	The clinical utility of testicular cancer risk loci
url	https://dx.doi.org/10.1186/gm215
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up_date	2024-07-03T18:41:11.038Z
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