Genes and epigenetic processes as prospective pain targets

Abstract Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecu...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Crow, Megan [verfasserIn] Denk, Franziska McMahon, Stephen B

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	Chronic Pain HDAC Inhibitor Chronic Constriction Injury Spinal Dorsal Horn Chronic Pain Condition

Anmerkung:	© BioMed Central Ltd 2013

Übergeordnetes Werk:	Enthalten in: Genome medicine - London : BioMed Central, 2009, 5(2013), 2 vom: 15. Feb.
Übergeordnetes Werk:	volume:5 ; year:2013 ; number:2 ; day:15 ; month:02

Links:	Volltext

DOI / URN:	10.1186/gm416

Katalog-ID:	SPR030598249

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spelling	10.1186/gm416 doi (DE-627)SPR030598249 (SPR)gm416-e DE-627 ger DE-627 rakwb eng Crow, Megan verfasserin aut Genes and epigenetic processes as prospective pain targets 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecular mechanisms underlying chronic pain states we can discover new and improved therapies. Although genetic research has flourished over the past decade and has identified many key genes in pain processing, the budding field of epigenetics promises to provide new insights and a more dynamic view of pain regulation. This review gives an overview of basic mechanisms and current therapies to treat pain, and discusses the clinical and preclinical evidence for the contribution of genetic and epigenetic factors, with a focus on how this knowledge can affect drug development. Chronic Pain (dpeaa)DE-He213 HDAC Inhibitor (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Spinal Dorsal Horn (dpeaa)DE-He213 Chronic Pain Condition (dpeaa)DE-He213 Denk, Franziska aut McMahon, Stephen B aut Enthalten in Genome medicine London : BioMed Central, 2009 5(2013), 2 vom: 15. Feb. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:5 year:2013 number:2 day:15 month:02 https://dx.doi.org/10.1186/gm416 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2013 2 15 02
allfields_unstemmed	10.1186/gm416 doi (DE-627)SPR030598249 (SPR)gm416-e DE-627 ger DE-627 rakwb eng Crow, Megan verfasserin aut Genes and epigenetic processes as prospective pain targets 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecular mechanisms underlying chronic pain states we can discover new and improved therapies. Although genetic research has flourished over the past decade and has identified many key genes in pain processing, the budding field of epigenetics promises to provide new insights and a more dynamic view of pain regulation. This review gives an overview of basic mechanisms and current therapies to treat pain, and discusses the clinical and preclinical evidence for the contribution of genetic and epigenetic factors, with a focus on how this knowledge can affect drug development. Chronic Pain (dpeaa)DE-He213 HDAC Inhibitor (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Spinal Dorsal Horn (dpeaa)DE-He213 Chronic Pain Condition (dpeaa)DE-He213 Denk, Franziska aut McMahon, Stephen B aut Enthalten in Genome medicine London : BioMed Central, 2009 5(2013), 2 vom: 15. Feb. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:5 year:2013 number:2 day:15 month:02 https://dx.doi.org/10.1186/gm416 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2013 2 15 02
allfieldsGer	10.1186/gm416 doi (DE-627)SPR030598249 (SPR)gm416-e DE-627 ger DE-627 rakwb eng Crow, Megan verfasserin aut Genes and epigenetic processes as prospective pain targets 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecular mechanisms underlying chronic pain states we can discover new and improved therapies. Although genetic research has flourished over the past decade and has identified many key genes in pain processing, the budding field of epigenetics promises to provide new insights and a more dynamic view of pain regulation. This review gives an overview of basic mechanisms and current therapies to treat pain, and discusses the clinical and preclinical evidence for the contribution of genetic and epigenetic factors, with a focus on how this knowledge can affect drug development. Chronic Pain (dpeaa)DE-He213 HDAC Inhibitor (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Spinal Dorsal Horn (dpeaa)DE-He213 Chronic Pain Condition (dpeaa)DE-He213 Denk, Franziska aut McMahon, Stephen B aut Enthalten in Genome medicine London : BioMed Central, 2009 5(2013), 2 vom: 15. Feb. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:5 year:2013 number:2 day:15 month:02 https://dx.doi.org/10.1186/gm416 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2013 2 15 02
allfieldsSound	10.1186/gm416 doi (DE-627)SPR030598249 (SPR)gm416-e DE-627 ger DE-627 rakwb eng Crow, Megan verfasserin aut Genes and epigenetic processes as prospective pain targets 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2013 Abstract Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecular mechanisms underlying chronic pain states we can discover new and improved therapies. Although genetic research has flourished over the past decade and has identified many key genes in pain processing, the budding field of epigenetics promises to provide new insights and a more dynamic view of pain regulation. This review gives an overview of basic mechanisms and current therapies to treat pain, and discusses the clinical and preclinical evidence for the contribution of genetic and epigenetic factors, with a focus on how this knowledge can affect drug development. Chronic Pain (dpeaa)DE-He213 HDAC Inhibitor (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Spinal Dorsal Horn (dpeaa)DE-He213 Chronic Pain Condition (dpeaa)DE-He213 Denk, Franziska aut McMahon, Stephen B aut Enthalten in Genome medicine London : BioMed Central, 2009 5(2013), 2 vom: 15. Feb. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:5 year:2013 number:2 day:15 month:02 https://dx.doi.org/10.1186/gm416 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2013 2 15 02
language	English
source	Enthalten in Genome medicine 5(2013), 2 vom: 15. Feb. volume:5 year:2013 number:2 day:15 month:02
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format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chronic Pain HDAC Inhibitor Chronic Constriction Injury Spinal Dorsal Horn Chronic Pain Condition
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container_title	Genome medicine
authorswithroles_txt_mv	Crow, Megan @@aut@@ Denk, Franziska @@aut@@ McMahon, Stephen B @@aut@@
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author	Crow, Megan
spellingShingle	Crow, Megan misc Chronic Pain misc HDAC Inhibitor misc Chronic Constriction Injury misc Spinal Dorsal Horn misc Chronic Pain Condition Genes and epigenetic processes as prospective pain targets
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topic_title	Genes and epigenetic processes as prospective pain targets Chronic Pain (dpeaa)DE-He213 HDAC Inhibitor (dpeaa)DE-He213 Chronic Constriction Injury (dpeaa)DE-He213 Spinal Dorsal Horn (dpeaa)DE-He213 Chronic Pain Condition (dpeaa)DE-He213
topic	misc Chronic Pain misc HDAC Inhibitor misc Chronic Constriction Injury misc Spinal Dorsal Horn misc Chronic Pain Condition
topic_unstemmed	misc Chronic Pain misc HDAC Inhibitor misc Chronic Constriction Injury misc Spinal Dorsal Horn misc Chronic Pain Condition
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title	Genes and epigenetic processes as prospective pain targets
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title_full	Genes and epigenetic processes as prospective pain targets
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title_sort	genes and epigenetic processes as prospective pain targets
title_auth	Genes and epigenetic processes as prospective pain targets
abstract	Abstract Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecular mechanisms underlying chronic pain states we can discover new and improved therapies. Although genetic research has flourished over the past decade and has identified many key genes in pain processing, the budding field of epigenetics promises to provide new insights and a more dynamic view of pain regulation. This review gives an overview of basic mechanisms and current therapies to treat pain, and discusses the clinical and preclinical evidence for the contribution of genetic and epigenetic factors, with a focus on how this knowledge can affect drug development. © BioMed Central Ltd 2013
abstractGer	Abstract Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecular mechanisms underlying chronic pain states we can discover new and improved therapies. Although genetic research has flourished over the past decade and has identified many key genes in pain processing, the budding field of epigenetics promises to provide new insights and a more dynamic view of pain regulation. This review gives an overview of basic mechanisms and current therapies to treat pain, and discusses the clinical and preclinical evidence for the contribution of genetic and epigenetic factors, with a focus on how this knowledge can affect drug development. © BioMed Central Ltd 2013
abstract_unstemmed	Abstract Chronic pain affects approximately one in five adults, resulting in a greatly reduced quality of life and a higher risk of developing co-morbidities such as depression. Available treatments often provide inadequate pain relief, but it is hoped that through deeper understanding of the molecular mechanisms underlying chronic pain states we can discover new and improved therapies. Although genetic research has flourished over the past decade and has identified many key genes in pain processing, the budding field of epigenetics promises to provide new insights and a more dynamic view of pain regulation. This review gives an overview of basic mechanisms and current therapies to treat pain, and discusses the clinical and preclinical evidence for the contribution of genetic and epigenetic factors, with a focus on how this knowledge can affect drug development. © BioMed Central Ltd 2013
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title_short	Genes and epigenetic processes as prospective pain targets
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