The spliceosome, a potential Achilles heel of MYC-driven tumors

Abstract Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC. These findings pro...
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Gespeichert in:

Autor*in:	Anczuków, Olga [verfasserIn] Krainer, Adrian R.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2015

Schlagwörter:	Chronic Lymphocytic Leukemia Human Breast Cancer Cell Line Splice Event Intron Retention Splice Machinery

Anmerkung:	© Anczuków and Krainer. 2015

Übergeordnetes Werk:	Enthalten in: Genome medicine - London : BioMed Central, 2009, 7(2015), 1 vom: 22. Okt.
Übergeordnetes Werk:	volume:7 ; year:2015 ; number:1 ; day:22 ; month:10

Links:	Volltext

DOI / URN:	10.1186/s13073-015-0234-3

Katalog-ID:	SPR030632838

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allfields	10.1186/s13073-015-0234-3 doi (DE-627)SPR030632838 (SPR)s13073-015-0234-3-e DE-627 ger DE-627 rakwb eng Anczuków, Olga verfasserin aut The spliceosome, a potential Achilles heel of MYC-driven tumors 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Anczuków and Krainer. 2015 Abstract Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors. Chronic Lymphocytic Leukemia (dpeaa)DE-He213 Human Breast Cancer Cell Line (dpeaa)DE-He213 Splice Event (dpeaa)DE-He213 Intron Retention (dpeaa)DE-He213 Splice Machinery (dpeaa)DE-He213 Krainer, Adrian R. aut Enthalten in Genome medicine London : BioMed Central, 2009 7(2015), 1 vom: 22. Okt. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:7 year:2015 number:1 day:22 month:10 https://dx.doi.org/10.1186/s13073-015-0234-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2015 1 22 10
spelling	10.1186/s13073-015-0234-3 doi (DE-627)SPR030632838 (SPR)s13073-015-0234-3-e DE-627 ger DE-627 rakwb eng Anczuków, Olga verfasserin aut The spliceosome, a potential Achilles heel of MYC-driven tumors 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Anczuków and Krainer. 2015 Abstract Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors. Chronic Lymphocytic Leukemia (dpeaa)DE-He213 Human Breast Cancer Cell Line (dpeaa)DE-He213 Splice Event (dpeaa)DE-He213 Intron Retention (dpeaa)DE-He213 Splice Machinery (dpeaa)DE-He213 Krainer, Adrian R. aut Enthalten in Genome medicine London : BioMed Central, 2009 7(2015), 1 vom: 22. Okt. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:7 year:2015 number:1 day:22 month:10 https://dx.doi.org/10.1186/s13073-015-0234-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2015 1 22 10
allfields_unstemmed	10.1186/s13073-015-0234-3 doi (DE-627)SPR030632838 (SPR)s13073-015-0234-3-e DE-627 ger DE-627 rakwb eng Anczuków, Olga verfasserin aut The spliceosome, a potential Achilles heel of MYC-driven tumors 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Anczuków and Krainer. 2015 Abstract Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors. Chronic Lymphocytic Leukemia (dpeaa)DE-He213 Human Breast Cancer Cell Line (dpeaa)DE-He213 Splice Event (dpeaa)DE-He213 Intron Retention (dpeaa)DE-He213 Splice Machinery (dpeaa)DE-He213 Krainer, Adrian R. aut Enthalten in Genome medicine London : BioMed Central, 2009 7(2015), 1 vom: 22. Okt. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:7 year:2015 number:1 day:22 month:10 https://dx.doi.org/10.1186/s13073-015-0234-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2015 1 22 10
allfieldsGer	10.1186/s13073-015-0234-3 doi (DE-627)SPR030632838 (SPR)s13073-015-0234-3-e DE-627 ger DE-627 rakwb eng Anczuków, Olga verfasserin aut The spliceosome, a potential Achilles heel of MYC-driven tumors 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Anczuków and Krainer. 2015 Abstract Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors. Chronic Lymphocytic Leukemia (dpeaa)DE-He213 Human Breast Cancer Cell Line (dpeaa)DE-He213 Splice Event (dpeaa)DE-He213 Intron Retention (dpeaa)DE-He213 Splice Machinery (dpeaa)DE-He213 Krainer, Adrian R. aut Enthalten in Genome medicine London : BioMed Central, 2009 7(2015), 1 vom: 22. Okt. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:7 year:2015 number:1 day:22 month:10 https://dx.doi.org/10.1186/s13073-015-0234-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2015 1 22 10
allfieldsSound	10.1186/s13073-015-0234-3 doi (DE-627)SPR030632838 (SPR)s13073-015-0234-3-e DE-627 ger DE-627 rakwb eng Anczuków, Olga verfasserin aut The spliceosome, a potential Achilles heel of MYC-driven tumors 2015 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Anczuków and Krainer. 2015 Abstract Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors. Chronic Lymphocytic Leukemia (dpeaa)DE-He213 Human Breast Cancer Cell Line (dpeaa)DE-He213 Splice Event (dpeaa)DE-He213 Intron Retention (dpeaa)DE-He213 Splice Machinery (dpeaa)DE-He213 Krainer, Adrian R. aut Enthalten in Genome medicine London : BioMed Central, 2009 7(2015), 1 vom: 22. Okt. (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:7 year:2015 number:1 day:22 month:10 https://dx.doi.org/10.1186/s13073-015-0234-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2015 1 22 10
language	English
source	Enthalten in Genome medicine 7(2015), 1 vom: 22. Okt. volume:7 year:2015 number:1 day:22 month:10
sourceStr	Enthalten in Genome medicine 7(2015), 1 vom: 22. Okt. volume:7 year:2015 number:1 day:22 month:10
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Chronic Lymphocytic Leukemia Human Breast Cancer Cell Line Splice Event Intron Retention Splice Machinery
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author	Anczuków, Olga
spellingShingle	Anczuków, Olga misc Chronic Lymphocytic Leukemia misc Human Breast Cancer Cell Line misc Splice Event misc Intron Retention misc Splice Machinery The spliceosome, a potential Achilles heel of MYC-driven tumors
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topic_title	The spliceosome, a potential Achilles heel of MYC-driven tumors Chronic Lymphocytic Leukemia (dpeaa)DE-He213 Human Breast Cancer Cell Line (dpeaa)DE-He213 Splice Event (dpeaa)DE-He213 Intron Retention (dpeaa)DE-He213 Splice Machinery (dpeaa)DE-He213
topic	misc Chronic Lymphocytic Leukemia misc Human Breast Cancer Cell Line misc Splice Event misc Intron Retention misc Splice Machinery
topic_unstemmed	misc Chronic Lymphocytic Leukemia misc Human Breast Cancer Cell Line misc Splice Event misc Intron Retention misc Splice Machinery
topic_browse	misc Chronic Lymphocytic Leukemia misc Human Breast Cancer Cell Line misc Splice Event misc Intron Retention misc Splice Machinery
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title	The spliceosome, a potential Achilles heel of MYC-driven tumors
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title_full	The spliceosome, a potential Achilles heel of MYC-driven tumors
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author_browse	Anczuków, Olga Krainer, Adrian R.
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title_sort	spliceosome, a potential achilles heel of myc-driven tumors
title_auth	The spliceosome, a potential Achilles heel of MYC-driven tumors
abstract	Abstract Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors. © Anczuków and Krainer. 2015
abstractGer	Abstract Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors. © Anczuków and Krainer. 2015
abstract_unstemmed	Abstract Alterations in RNA splicing are frequent in human tumors. Two recent studies of lymphoma and breast cancer have identified components of the spliceosome — the core splicing machinery — that are essential for malignant transformation driven by the transcription factor MYC. These findings provide a direct link between MYC and RNA splicing deregulation, and raise the exciting possibility of targeting spliceosome components in MYC-driven tumors. © Anczuków and Krainer. 2015
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title_short	The spliceosome, a potential Achilles heel of MYC-driven tumors
url	https://dx.doi.org/10.1186/s13073-015-0234-3
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doi_str	10.1186/s13073-015-0234-3
up_date	2024-07-03T19:13:52.616Z
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