Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentia...
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Gespeichert in:

Autor*in:	Fox, Edward J. [verfasserIn] Salk, Jesse J. Loeb, Lawrence A.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Cancer Genome Driver Mutation Mutational Signature Mutation Accumulation International Cancer Genome Consortium

Anmerkung:	© Fox et al. 2016

Übergeordnetes Werk:	Enthalten in: Genome medicine - London : BioMed Central, 2009, 8(2016), 1 vom: 17. März
Übergeordnetes Werk:	volume:8 ; year:2016 ; number:1 ; day:17 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s13073-016-0286-z

Katalog-ID:	SPR030638615

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allfields	10.1186/s13073-016-0286-z doi (DE-627)SPR030638615 (SPR)s13073-016-0286-z-e DE-627 ger DE-627 rakwb eng Fox, Edward J. verfasserin (orcid)0000-0002-3740-651X aut Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Fox et al. 2016 Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications. Cancer Genome (dpeaa)DE-He213 Driver Mutation (dpeaa)DE-He213 Mutational Signature (dpeaa)DE-He213 Mutation Accumulation (dpeaa)DE-He213 International Cancer Genome Consortium (dpeaa)DE-He213 Salk, Jesse J. aut Loeb, Lawrence A. aut Enthalten in Genome medicine London : BioMed Central, 2009 8(2016), 1 vom: 17. März (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:8 year:2016 number:1 day:17 month:03 https://dx.doi.org/10.1186/s13073-016-0286-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 1 17 03
spelling	10.1186/s13073-016-0286-z doi (DE-627)SPR030638615 (SPR)s13073-016-0286-z-e DE-627 ger DE-627 rakwb eng Fox, Edward J. verfasserin (orcid)0000-0002-3740-651X aut Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Fox et al. 2016 Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications. Cancer Genome (dpeaa)DE-He213 Driver Mutation (dpeaa)DE-He213 Mutational Signature (dpeaa)DE-He213 Mutation Accumulation (dpeaa)DE-He213 International Cancer Genome Consortium (dpeaa)DE-He213 Salk, Jesse J. aut Loeb, Lawrence A. aut Enthalten in Genome medicine London : BioMed Central, 2009 8(2016), 1 vom: 17. März (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:8 year:2016 number:1 day:17 month:03 https://dx.doi.org/10.1186/s13073-016-0286-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 1 17 03
allfields_unstemmed	10.1186/s13073-016-0286-z doi (DE-627)SPR030638615 (SPR)s13073-016-0286-z-e DE-627 ger DE-627 rakwb eng Fox, Edward J. verfasserin (orcid)0000-0002-3740-651X aut Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Fox et al. 2016 Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications. Cancer Genome (dpeaa)DE-He213 Driver Mutation (dpeaa)DE-He213 Mutational Signature (dpeaa)DE-He213 Mutation Accumulation (dpeaa)DE-He213 International Cancer Genome Consortium (dpeaa)DE-He213 Salk, Jesse J. aut Loeb, Lawrence A. aut Enthalten in Genome medicine London : BioMed Central, 2009 8(2016), 1 vom: 17. März (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:8 year:2016 number:1 day:17 month:03 https://dx.doi.org/10.1186/s13073-016-0286-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 1 17 03
allfieldsGer	10.1186/s13073-016-0286-z doi (DE-627)SPR030638615 (SPR)s13073-016-0286-z-e DE-627 ger DE-627 rakwb eng Fox, Edward J. verfasserin (orcid)0000-0002-3740-651X aut Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Fox et al. 2016 Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications. Cancer Genome (dpeaa)DE-He213 Driver Mutation (dpeaa)DE-He213 Mutational Signature (dpeaa)DE-He213 Mutation Accumulation (dpeaa)DE-He213 International Cancer Genome Consortium (dpeaa)DE-He213 Salk, Jesse J. aut Loeb, Lawrence A. aut Enthalten in Genome medicine London : BioMed Central, 2009 8(2016), 1 vom: 17. März (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:8 year:2016 number:1 day:17 month:03 https://dx.doi.org/10.1186/s13073-016-0286-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 1 17 03
allfieldsSound	10.1186/s13073-016-0286-z doi (DE-627)SPR030638615 (SPR)s13073-016-0286-z-e DE-627 ger DE-627 rakwb eng Fox, Edward J. verfasserin (orcid)0000-0002-3740-651X aut Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Fox et al. 2016 Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications. Cancer Genome (dpeaa)DE-He213 Driver Mutation (dpeaa)DE-He213 Mutational Signature (dpeaa)DE-He213 Mutation Accumulation (dpeaa)DE-He213 International Cancer Genome Consortium (dpeaa)DE-He213 Salk, Jesse J. aut Loeb, Lawrence A. aut Enthalten in Genome medicine London : BioMed Central, 2009 8(2016), 1 vom: 17. März (DE-627)594424275 (DE-600)2484394-5 1756-994X nnns volume:8 year:2016 number:1 day:17 month:03 https://dx.doi.org/10.1186/s13073-016-0286-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 1 17 03
language	English
source	Enthalten in Genome medicine 8(2016), 1 vom: 17. März volume:8 year:2016 number:1 day:17 month:03
sourceStr	Enthalten in Genome medicine 8(2016), 1 vom: 17. März volume:8 year:2016 number:1 day:17 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Cancer Genome Driver Mutation Mutational Signature Mutation Accumulation International Cancer Genome Consortium
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spellingShingle	Fox, Edward J. misc Cancer Genome misc Driver Mutation misc Mutational Signature misc Mutation Accumulation misc International Cancer Genome Consortium Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer
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topic_title	Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer Cancer Genome (dpeaa)DE-He213 Driver Mutation (dpeaa)DE-He213 Mutational Signature (dpeaa)DE-He213 Mutation Accumulation (dpeaa)DE-He213 International Cancer Genome Consortium (dpeaa)DE-He213
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title	Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer
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title_full	Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer
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title_sort	exploring the implications of distinct mutational signatures and mutation rates in aging and cancer
title_auth	Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer
abstract	Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications. © Fox et al. 2016
abstractGer	Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications. © Fox et al. 2016
abstract_unstemmed	Editorial summary Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications. © Fox et al. 2016
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title_short	Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer
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