Epigenetic features of FoxP3 in children with cow’s milk allergy

Background DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether toleranc...
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Autor*in:	Paparo, Lorella [verfasserIn] Nocerino, Rita Cosenza, Linda Aitoro, Rosita D’Argenio, Valeria Del Monaco, Valentina Di Scala, Carmen Amoroso, Antonio Di Costanzo, Margherita Salvatore, Francesco Berni Canani, Roberto

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	Food allergy Extensively hydrolyzed casein formula Oral tolerance GG

Anmerkung:	© The Author(s). 2016

Übergeordnetes Werk:	Enthalten in: Clinical epigenetics - [S.l.] : BioMed Central, 2010, 8(2016), 1 vom: 12. Aug.
Übergeordnetes Werk:	volume:8 ; year:2016 ; number:1 ; day:12 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s13148-016-0252-z

Katalog-ID:	SPR030673798

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520			\|a Background DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. This feature could be a new target for preventive and therapeutic strategies against CMA.
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allfields	10.1186/s13148-016-0252-z doi (DE-627)SPR030673798 (SPR)s13148-016-0252-z-e DE-627 ger DE-627 rakwb eng Paparo, Lorella verfasserin aut Epigenetic features of FoxP3 in children with cow’s milk allergy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. This feature could be a new target for preventive and therapeutic strategies against CMA. Food allergy (dpeaa)DE-He213 Extensively hydrolyzed casein formula (dpeaa)DE-He213 Oral tolerance (dpeaa)DE-He213 GG (dpeaa)DE-He213 Nocerino, Rita aut Cosenza, Linda aut Aitoro, Rosita aut D’Argenio, Valeria aut Del Monaco, Valentina aut Di Scala, Carmen aut Amoroso, Antonio aut Di Costanzo, Margherita aut Salvatore, Francesco aut Berni Canani, Roberto aut Enthalten in Clinical epigenetics [S.l.] : BioMed Central, 2010 8(2016), 1 vom: 12. Aug. (DE-627)626459028 (DE-600)2553921-8 1868-7083 nnns volume:8 year:2016 number:1 day:12 month:08 https://dx.doi.org/10.1186/s13148-016-0252-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 1 12 08
spelling	10.1186/s13148-016-0252-z doi (DE-627)SPR030673798 (SPR)s13148-016-0252-z-e DE-627 ger DE-627 rakwb eng Paparo, Lorella verfasserin aut Epigenetic features of FoxP3 in children with cow’s milk allergy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. This feature could be a new target for preventive and therapeutic strategies against CMA. Food allergy (dpeaa)DE-He213 Extensively hydrolyzed casein formula (dpeaa)DE-He213 Oral tolerance (dpeaa)DE-He213 GG (dpeaa)DE-He213 Nocerino, Rita aut Cosenza, Linda aut Aitoro, Rosita aut D’Argenio, Valeria aut Del Monaco, Valentina aut Di Scala, Carmen aut Amoroso, Antonio aut Di Costanzo, Margherita aut Salvatore, Francesco aut Berni Canani, Roberto aut Enthalten in Clinical epigenetics [S.l.] : BioMed Central, 2010 8(2016), 1 vom: 12. Aug. (DE-627)626459028 (DE-600)2553921-8 1868-7083 nnns volume:8 year:2016 number:1 day:12 month:08 https://dx.doi.org/10.1186/s13148-016-0252-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 1 12 08
allfields_unstemmed	10.1186/s13148-016-0252-z doi (DE-627)SPR030673798 (SPR)s13148-016-0252-z-e DE-627 ger DE-627 rakwb eng Paparo, Lorella verfasserin aut Epigenetic features of FoxP3 in children with cow’s milk allergy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. This feature could be a new target for preventive and therapeutic strategies against CMA. Food allergy (dpeaa)DE-He213 Extensively hydrolyzed casein formula (dpeaa)DE-He213 Oral tolerance (dpeaa)DE-He213 GG (dpeaa)DE-He213 Nocerino, Rita aut Cosenza, Linda aut Aitoro, Rosita aut D’Argenio, Valeria aut Del Monaco, Valentina aut Di Scala, Carmen aut Amoroso, Antonio aut Di Costanzo, Margherita aut Salvatore, Francesco aut Berni Canani, Roberto aut Enthalten in Clinical epigenetics [S.l.] : BioMed Central, 2010 8(2016), 1 vom: 12. Aug. (DE-627)626459028 (DE-600)2553921-8 1868-7083 nnns volume:8 year:2016 number:1 day:12 month:08 https://dx.doi.org/10.1186/s13148-016-0252-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 1 12 08
allfieldsGer	10.1186/s13148-016-0252-z doi (DE-627)SPR030673798 (SPR)s13148-016-0252-z-e DE-627 ger DE-627 rakwb eng Paparo, Lorella verfasserin aut Epigenetic features of FoxP3 in children with cow’s milk allergy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. This feature could be a new target for preventive and therapeutic strategies against CMA. Food allergy (dpeaa)DE-He213 Extensively hydrolyzed casein formula (dpeaa)DE-He213 Oral tolerance (dpeaa)DE-He213 GG (dpeaa)DE-He213 Nocerino, Rita aut Cosenza, Linda aut Aitoro, Rosita aut D’Argenio, Valeria aut Del Monaco, Valentina aut Di Scala, Carmen aut Amoroso, Antonio aut Di Costanzo, Margherita aut Salvatore, Francesco aut Berni Canani, Roberto aut Enthalten in Clinical epigenetics [S.l.] : BioMed Central, 2010 8(2016), 1 vom: 12. Aug. (DE-627)626459028 (DE-600)2553921-8 1868-7083 nnns volume:8 year:2016 number:1 day:12 month:08 https://dx.doi.org/10.1186/s13148-016-0252-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 1 12 08
allfieldsSound	10.1186/s13148-016-0252-z doi (DE-627)SPR030673798 (SPR)s13148-016-0252-z-e DE-627 ger DE-627 rakwb eng Paparo, Lorella verfasserin aut Epigenetic features of FoxP3 in children with cow’s milk allergy 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s). 2016 Background DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. This feature could be a new target for preventive and therapeutic strategies against CMA. Food allergy (dpeaa)DE-He213 Extensively hydrolyzed casein formula (dpeaa)DE-He213 Oral tolerance (dpeaa)DE-He213 GG (dpeaa)DE-He213 Nocerino, Rita aut Cosenza, Linda aut Aitoro, Rosita aut D’Argenio, Valeria aut Del Monaco, Valentina aut Di Scala, Carmen aut Amoroso, Antonio aut Di Costanzo, Margherita aut Salvatore, Francesco aut Berni Canani, Roberto aut Enthalten in Clinical epigenetics [S.l.] : BioMed Central, 2010 8(2016), 1 vom: 12. Aug. (DE-627)626459028 (DE-600)2553921-8 1868-7083 nnns volume:8 year:2016 number:1 day:12 month:08 https://dx.doi.org/10.1186/s13148-016-0252-z kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2016 1 12 08
language	English
source	Enthalten in Clinical epigenetics 8(2016), 1 vom: 12. Aug. volume:8 year:2016 number:1 day:12 month:08
sourceStr	Enthalten in Clinical epigenetics 8(2016), 1 vom: 12. Aug. volume:8 year:2016 number:1 day:12 month:08
format_phy_str_mv	Article
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topic_facet	Food allergy Extensively hydrolyzed casein formula Oral tolerance GG
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container_title	Clinical epigenetics
authorswithroles_txt_mv	Paparo, Lorella @@aut@@ Nocerino, Rita @@aut@@ Cosenza, Linda @@aut@@ Aitoro, Rosita @@aut@@ D’Argenio, Valeria @@aut@@ Del Monaco, Valentina @@aut@@ Di Scala, Carmen @@aut@@ Amoroso, Antonio @@aut@@ Di Costanzo, Margherita @@aut@@ Salvatore, Francesco @@aut@@ Berni Canani, Roberto @@aut@@
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Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. 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author	Paparo, Lorella
spellingShingle	Paparo, Lorella misc Food allergy misc Extensively hydrolyzed casein formula misc Oral tolerance misc GG Epigenetic features of FoxP3 in children with cow’s milk allergy
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topic_title	Epigenetic features of FoxP3 in children with cow’s milk allergy Food allergy (dpeaa)DE-He213 Extensively hydrolyzed casein formula (dpeaa)DE-He213 Oral tolerance (dpeaa)DE-He213 GG (dpeaa)DE-He213
topic	misc Food allergy misc Extensively hydrolyzed casein formula misc Oral tolerance misc GG
topic_unstemmed	misc Food allergy misc Extensively hydrolyzed casein formula misc Oral tolerance misc GG
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title	Epigenetic features of FoxP3 in children with cow’s milk allergy
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title_full	Epigenetic features of FoxP3 in children with cow’s milk allergy
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author_browse	Paparo, Lorella Nocerino, Rita Cosenza, Linda Aitoro, Rosita D’Argenio, Valeria Del Monaco, Valentina Di Scala, Carmen Amoroso, Antonio Di Costanzo, Margherita Salvatore, Francesco Berni Canani, Roberto
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title_sort	epigenetic features of foxp3 in children with cow’s milk allergy
title_auth	Epigenetic features of FoxP3 in children with cow’s milk allergy
abstract	Background DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. This feature could be a new target for preventive and therapeutic strategies against CMA. © The Author(s). 2016
abstractGer	Background DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. This feature could be a new target for preventive and therapeutic strategies against CMA. © The Author(s). 2016
abstract_unstemmed	Background DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. This feature could be a new target for preventive and therapeutic strategies against CMA. © The Author(s). 2016
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title_short	Epigenetic features of FoxP3 in children with cow’s milk allergy
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author2	Nocerino, Rita Cosenza, Linda Aitoro, Rosita D’Argenio, Valeria Del Monaco, Valentina Di Scala, Carmen Amoroso, Antonio Di Costanzo, Margherita Salvatore, Francesco Berni Canani, Roberto
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up_date	2024-07-03T19:28:35.840Z
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Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3. Results Forty children (aged 3–18 months) were enrolled: 10 children with active IgE-mediated CMA (group 1), 10 children who outgrew CMA after dietary treatment with an extensively hydrolyzed casein formula containing the probiotic Lactobacillus rhamnosus GG (group 2), 10 children who outgrew CMA after treatment with other formulas (group 3), and 10 healthy controls (group 4). FoxP3 TSDR demethylation and expression were measured in mononuclear cells purified from peripheral blood of the four groups of children. FoxP3 TSDR demethylation was significantly lower in children with active IgE-mediated CMA than in either children who outgrew CMA or in healthy children. Formula selection influenced the FoxP3 TSDR demethylation profile. The FoxP3 TSDR demethylation rate and expression level were correlated. Conclusions Tolerance acquisition in children with IgE-mediated CMA involves epigenetic regulation of the FoxP3 gene. 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Epigenetic features of FoxP3 in children with cow’s milk allergy

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