Obesity and the brain: a possible genetic link

Abstract Structural brain deficits have been repeatedly linked to body mass index and obesity, which itself is controlled by the effects of a number of independent genetic loci. One of the most consistently replicated of these putative obesity genes is fat mass and obesity-associated protein (FTO)....
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Bertram, Lars [verfasserIn] Heekeren, Hauke

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	Brain Volume Occipital Lobe Elevated Body Mass Index Normal Brain Function Body Mass Index Effect

Anmerkung:	© BioMed Central Ltd 2010

Übergeordnetes Werk:	Enthalten in: Alzheimer's research & therapy - London : BioMed Central, 2009, 2(2010), 5 vom: 27. Sept.
Übergeordnetes Werk:	volume:2 ; year:2010 ; number:5 ; day:27 ; month:09

Links:	Volltext

DOI / URN:	10.1186/alzrt51

Katalog-ID:	SPR030811104

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spelling	10.1186/alzrt51 doi (DE-627)SPR030811104 (SPR)alzrt51-e DE-627 ger DE-627 rakwb eng Bertram, Lars verfasserin aut Obesity and the brain: a possible genetic link 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2010 Abstract Structural brain deficits have been repeatedly linked to body mass index and obesity, which itself is controlled by the effects of a number of independent genetic loci. One of the most consistently replicated of these putative obesity genes is fat mass and obesity-associated protein (FTO). A recent study by investigators from the Alzheimer's Disease Neuroimaging Initiative set out to assess whether polymorphisms in FTO are directly correlated with brain volume in a collection of over 200 healthy older individuals. The authors found a modest but significant reduction in brain volume in the frontal and occipital lobes exerted by the same FTO alleles that also predispose to obesity. Although potentially providing a novel genetic link between obesity and brain structure, the relevance of these findings for normal brain function and disease remains to be determined. Brain Volume (dpeaa)DE-He213 Occipital Lobe (dpeaa)DE-He213 Elevated Body Mass Index (dpeaa)DE-He213 Normal Brain Function (dpeaa)DE-He213 Body Mass Index Effect (dpeaa)DE-He213 Heekeren, Hauke aut Enthalten in Alzheimer's research & therapy London : BioMed Central, 2009 2(2010), 5 vom: 27. Sept. (DE-627)605683557 (DE-600)2506521-X 1758-9193 nnns volume:2 year:2010 number:5 day:27 month:09 https://dx.doi.org/10.1186/alzrt51 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2010 5 27 09
allfields_unstemmed	10.1186/alzrt51 doi (DE-627)SPR030811104 (SPR)alzrt51-e DE-627 ger DE-627 rakwb eng Bertram, Lars verfasserin aut Obesity and the brain: a possible genetic link 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2010 Abstract Structural brain deficits have been repeatedly linked to body mass index and obesity, which itself is controlled by the effects of a number of independent genetic loci. One of the most consistently replicated of these putative obesity genes is fat mass and obesity-associated protein (FTO). A recent study by investigators from the Alzheimer's Disease Neuroimaging Initiative set out to assess whether polymorphisms in FTO are directly correlated with brain volume in a collection of over 200 healthy older individuals. The authors found a modest but significant reduction in brain volume in the frontal and occipital lobes exerted by the same FTO alleles that also predispose to obesity. Although potentially providing a novel genetic link between obesity and brain structure, the relevance of these findings for normal brain function and disease remains to be determined. Brain Volume (dpeaa)DE-He213 Occipital Lobe (dpeaa)DE-He213 Elevated Body Mass Index (dpeaa)DE-He213 Normal Brain Function (dpeaa)DE-He213 Body Mass Index Effect (dpeaa)DE-He213 Heekeren, Hauke aut Enthalten in Alzheimer's research & therapy London : BioMed Central, 2009 2(2010), 5 vom: 27. Sept. (DE-627)605683557 (DE-600)2506521-X 1758-9193 nnns volume:2 year:2010 number:5 day:27 month:09 https://dx.doi.org/10.1186/alzrt51 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2010 5 27 09
allfieldsGer	10.1186/alzrt51 doi (DE-627)SPR030811104 (SPR)alzrt51-e DE-627 ger DE-627 rakwb eng Bertram, Lars verfasserin aut Obesity and the brain: a possible genetic link 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2010 Abstract Structural brain deficits have been repeatedly linked to body mass index and obesity, which itself is controlled by the effects of a number of independent genetic loci. One of the most consistently replicated of these putative obesity genes is fat mass and obesity-associated protein (FTO). A recent study by investigators from the Alzheimer's Disease Neuroimaging Initiative set out to assess whether polymorphisms in FTO are directly correlated with brain volume in a collection of over 200 healthy older individuals. The authors found a modest but significant reduction in brain volume in the frontal and occipital lobes exerted by the same FTO alleles that also predispose to obesity. Although potentially providing a novel genetic link between obesity and brain structure, the relevance of these findings for normal brain function and disease remains to be determined. Brain Volume (dpeaa)DE-He213 Occipital Lobe (dpeaa)DE-He213 Elevated Body Mass Index (dpeaa)DE-He213 Normal Brain Function (dpeaa)DE-He213 Body Mass Index Effect (dpeaa)DE-He213 Heekeren, Hauke aut Enthalten in Alzheimer's research & therapy London : BioMed Central, 2009 2(2010), 5 vom: 27. Sept. (DE-627)605683557 (DE-600)2506521-X 1758-9193 nnns volume:2 year:2010 number:5 day:27 month:09 https://dx.doi.org/10.1186/alzrt51 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2010 5 27 09
allfieldsSound	10.1186/alzrt51 doi (DE-627)SPR030811104 (SPR)alzrt51-e DE-627 ger DE-627 rakwb eng Bertram, Lars verfasserin aut Obesity and the brain: a possible genetic link 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2010 Abstract Structural brain deficits have been repeatedly linked to body mass index and obesity, which itself is controlled by the effects of a number of independent genetic loci. One of the most consistently replicated of these putative obesity genes is fat mass and obesity-associated protein (FTO). A recent study by investigators from the Alzheimer's Disease Neuroimaging Initiative set out to assess whether polymorphisms in FTO are directly correlated with brain volume in a collection of over 200 healthy older individuals. The authors found a modest but significant reduction in brain volume in the frontal and occipital lobes exerted by the same FTO alleles that also predispose to obesity. Although potentially providing a novel genetic link between obesity and brain structure, the relevance of these findings for normal brain function and disease remains to be determined. Brain Volume (dpeaa)DE-He213 Occipital Lobe (dpeaa)DE-He213 Elevated Body Mass Index (dpeaa)DE-He213 Normal Brain Function (dpeaa)DE-He213 Body Mass Index Effect (dpeaa)DE-He213 Heekeren, Hauke aut Enthalten in Alzheimer's research & therapy London : BioMed Central, 2009 2(2010), 5 vom: 27. Sept. (DE-627)605683557 (DE-600)2506521-X 1758-9193 nnns volume:2 year:2010 number:5 day:27 month:09 https://dx.doi.org/10.1186/alzrt51 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2010 5 27 09
language	English
source	Enthalten in Alzheimer's research & therapy 2(2010), 5 vom: 27. Sept. volume:2 year:2010 number:5 day:27 month:09
sourceStr	Enthalten in Alzheimer's research & therapy 2(2010), 5 vom: 27. Sept. volume:2 year:2010 number:5 day:27 month:09
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topic_facet	Brain Volume Occipital Lobe Elevated Body Mass Index Normal Brain Function Body Mass Index Effect
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container_title	Alzheimer's research & therapy
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author	Bertram, Lars
spellingShingle	Bertram, Lars misc Brain Volume misc Occipital Lobe misc Elevated Body Mass Index misc Normal Brain Function misc Body Mass Index Effect Obesity and the brain: a possible genetic link
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topic_title	Obesity and the brain: a possible genetic link Brain Volume (dpeaa)DE-He213 Occipital Lobe (dpeaa)DE-He213 Elevated Body Mass Index (dpeaa)DE-He213 Normal Brain Function (dpeaa)DE-He213 Body Mass Index Effect (dpeaa)DE-He213
topic	misc Brain Volume misc Occipital Lobe misc Elevated Body Mass Index misc Normal Brain Function misc Body Mass Index Effect
topic_unstemmed	misc Brain Volume misc Occipital Lobe misc Elevated Body Mass Index misc Normal Brain Function misc Body Mass Index Effect
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title	Obesity and the brain: a possible genetic link
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title_full	Obesity and the brain: a possible genetic link
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title_sort	obesity and the brain: a possible genetic link
title_auth	Obesity and the brain: a possible genetic link
abstract	Abstract Structural brain deficits have been repeatedly linked to body mass index and obesity, which itself is controlled by the effects of a number of independent genetic loci. One of the most consistently replicated of these putative obesity genes is fat mass and obesity-associated protein (FTO). A recent study by investigators from the Alzheimer's Disease Neuroimaging Initiative set out to assess whether polymorphisms in FTO are directly correlated with brain volume in a collection of over 200 healthy older individuals. The authors found a modest but significant reduction in brain volume in the frontal and occipital lobes exerted by the same FTO alleles that also predispose to obesity. Although potentially providing a novel genetic link between obesity and brain structure, the relevance of these findings for normal brain function and disease remains to be determined. © BioMed Central Ltd 2010
abstractGer	Abstract Structural brain deficits have been repeatedly linked to body mass index and obesity, which itself is controlled by the effects of a number of independent genetic loci. One of the most consistently replicated of these putative obesity genes is fat mass and obesity-associated protein (FTO). A recent study by investigators from the Alzheimer's Disease Neuroimaging Initiative set out to assess whether polymorphisms in FTO are directly correlated with brain volume in a collection of over 200 healthy older individuals. The authors found a modest but significant reduction in brain volume in the frontal and occipital lobes exerted by the same FTO alleles that also predispose to obesity. Although potentially providing a novel genetic link between obesity and brain structure, the relevance of these findings for normal brain function and disease remains to be determined. © BioMed Central Ltd 2010
abstract_unstemmed	Abstract Structural brain deficits have been repeatedly linked to body mass index and obesity, which itself is controlled by the effects of a number of independent genetic loci. One of the most consistently replicated of these putative obesity genes is fat mass and obesity-associated protein (FTO). A recent study by investigators from the Alzheimer's Disease Neuroimaging Initiative set out to assess whether polymorphisms in FTO are directly correlated with brain volume in a collection of over 200 healthy older individuals. The authors found a modest but significant reduction in brain volume in the frontal and occipital lobes exerted by the same FTO alleles that also predispose to obesity. Although potentially providing a novel genetic link between obesity and brain structure, the relevance of these findings for normal brain function and disease remains to be determined. © BioMed Central Ltd 2010
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title_short	Obesity and the brain: a possible genetic link
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