Cells of the synovium in rheumatoid arthritis. Dendritic cells

Abstract Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals tha...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Lutzky, Viviana [verfasserIn] Hannawi, Suad Thomas, Ranjeny

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Schlagwörter:	Dendritic Cell Synovial Tissue Plasmacytoid Dendritic Cell Dendritic Cell Maturation Immature Dendritic Cell

Anmerkung:	© BioMed Central Ltd 2007

Übergeordnetes Werk:	Enthalten in: Arthritis Research & Therapy - London : BioMed Central, 1999, 9(2007), 4 vom: 07. Sept.
Übergeordnetes Werk:	volume:9 ; year:2007 ; number:4 ; day:07 ; month:09

Links:	Volltext

DOI / URN:	10.1186/ar2200

Katalog-ID:	SPR030825520

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allfields	10.1186/ar2200 doi (DE-627)SPR030825520 (SPR)ar2200-e DE-627 ger DE-627 rakwb eng Lutzky, Viviana verfasserin aut Cells of the synovium in rheumatoid arthritis. Dendritic cells 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2007 Abstract Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB. Dendritic Cell (dpeaa)DE-He213 Synovial Tissue (dpeaa)DE-He213 Plasmacytoid Dendritic Cell (dpeaa)DE-He213 Dendritic Cell Maturation (dpeaa)DE-He213 Immature Dendritic Cell (dpeaa)DE-He213 Hannawi, Suad aut Thomas, Ranjeny aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 9(2007), 4 vom: 07. Sept. (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:9 year:2007 number:4 day:07 month:09 https://dx.doi.org/10.1186/ar2200 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2007 4 07 09
spelling	10.1186/ar2200 doi (DE-627)SPR030825520 (SPR)ar2200-e DE-627 ger DE-627 rakwb eng Lutzky, Viviana verfasserin aut Cells of the synovium in rheumatoid arthritis. Dendritic cells 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2007 Abstract Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB. Dendritic Cell (dpeaa)DE-He213 Synovial Tissue (dpeaa)DE-He213 Plasmacytoid Dendritic Cell (dpeaa)DE-He213 Dendritic Cell Maturation (dpeaa)DE-He213 Immature Dendritic Cell (dpeaa)DE-He213 Hannawi, Suad aut Thomas, Ranjeny aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 9(2007), 4 vom: 07. Sept. (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:9 year:2007 number:4 day:07 month:09 https://dx.doi.org/10.1186/ar2200 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2007 4 07 09
allfields_unstemmed	10.1186/ar2200 doi (DE-627)SPR030825520 (SPR)ar2200-e DE-627 ger DE-627 rakwb eng Lutzky, Viviana verfasserin aut Cells of the synovium in rheumatoid arthritis. Dendritic cells 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2007 Abstract Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB. Dendritic Cell (dpeaa)DE-He213 Synovial Tissue (dpeaa)DE-He213 Plasmacytoid Dendritic Cell (dpeaa)DE-He213 Dendritic Cell Maturation (dpeaa)DE-He213 Immature Dendritic Cell (dpeaa)DE-He213 Hannawi, Suad aut Thomas, Ranjeny aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 9(2007), 4 vom: 07. Sept. (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:9 year:2007 number:4 day:07 month:09 https://dx.doi.org/10.1186/ar2200 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2007 4 07 09
allfieldsGer	10.1186/ar2200 doi (DE-627)SPR030825520 (SPR)ar2200-e DE-627 ger DE-627 rakwb eng Lutzky, Viviana verfasserin aut Cells of the synovium in rheumatoid arthritis. Dendritic cells 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2007 Abstract Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB. Dendritic Cell (dpeaa)DE-He213 Synovial Tissue (dpeaa)DE-He213 Plasmacytoid Dendritic Cell (dpeaa)DE-He213 Dendritic Cell Maturation (dpeaa)DE-He213 Immature Dendritic Cell (dpeaa)DE-He213 Hannawi, Suad aut Thomas, Ranjeny aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 9(2007), 4 vom: 07. Sept. (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:9 year:2007 number:4 day:07 month:09 https://dx.doi.org/10.1186/ar2200 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2007 4 07 09
allfieldsSound	10.1186/ar2200 doi (DE-627)SPR030825520 (SPR)ar2200-e DE-627 ger DE-627 rakwb eng Lutzky, Viviana verfasserin aut Cells of the synovium in rheumatoid arthritis. Dendritic cells 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © BioMed Central Ltd 2007 Abstract Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB. Dendritic Cell (dpeaa)DE-He213 Synovial Tissue (dpeaa)DE-He213 Plasmacytoid Dendritic Cell (dpeaa)DE-He213 Dendritic Cell Maturation (dpeaa)DE-He213 Immature Dendritic Cell (dpeaa)DE-He213 Hannawi, Suad aut Thomas, Ranjeny aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 9(2007), 4 vom: 07. Sept. (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:9 year:2007 number:4 day:07 month:09 https://dx.doi.org/10.1186/ar2200 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2007 4 07 09
language	English
source	Enthalten in Arthritis Research & Therapy 9(2007), 4 vom: 07. Sept. volume:9 year:2007 number:4 day:07 month:09
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topic_facet	Dendritic Cell Synovial Tissue Plasmacytoid Dendritic Cell Dendritic Cell Maturation Immature Dendritic Cell
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author	Lutzky, Viviana
spellingShingle	Lutzky, Viviana misc Dendritic Cell misc Synovial Tissue misc Plasmacytoid Dendritic Cell misc Dendritic Cell Maturation misc Immature Dendritic Cell Cells of the synovium in rheumatoid arthritis. Dendritic cells
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topic_title	Cells of the synovium in rheumatoid arthritis. Dendritic cells Dendritic Cell (dpeaa)DE-He213 Synovial Tissue (dpeaa)DE-He213 Plasmacytoid Dendritic Cell (dpeaa)DE-He213 Dendritic Cell Maturation (dpeaa)DE-He213 Immature Dendritic Cell (dpeaa)DE-He213
topic	misc Dendritic Cell misc Synovial Tissue misc Plasmacytoid Dendritic Cell misc Dendritic Cell Maturation misc Immature Dendritic Cell
topic_unstemmed	misc Dendritic Cell misc Synovial Tissue misc Plasmacytoid Dendritic Cell misc Dendritic Cell Maturation misc Immature Dendritic Cell
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title	Cells of the synovium in rheumatoid arthritis. Dendritic cells
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title_full	Cells of the synovium in rheumatoid arthritis. Dendritic cells
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author_browse	Lutzky, Viviana Hannawi, Suad Thomas, Ranjeny
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title_sort	cells of the synovium in rheumatoid arthritis. dendritic cells
title_auth	Cells of the synovium in rheumatoid arthritis. Dendritic cells
abstract	Abstract Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB. © BioMed Central Ltd 2007
abstractGer	Abstract Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB. © BioMed Central Ltd 2007
abstract_unstemmed	Abstract Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-κB and the secretion of TNF and IL-1 drive the maturation of dendritic cells to prime self-specific responses, and drive the perpetuation of synovial inflammation. These signals may include genetic factors, infection, cigarette smoking, immunostimulatory DNA and oxidized low-density lipoprotein, with major involvement of autoantibodies. We propose that the pathogenesis of RA and atherosclerosis is intimately linked, with the vascular disease of RA driven by similar and simultaneous triggers to NF-κB. © BioMed Central Ltd 2007
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title_short	Cells of the synovium in rheumatoid arthritis. Dendritic cells
url	https://dx.doi.org/10.1186/ar2200
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author2	Hannawi, Suad Thomas, Ranjeny
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up_date	2024-07-03T20:20:14.262Z
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