Texture analysis of cartilage $ T_{2} $ maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR $ T_{2} $ compared to normal controls - data from the osteoarthritis initiative
Introduction The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage $ T_{2} $ relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) $ T_{2} $ relaxation times between subjects with and without risk factors for Osteoarth...
Ausführliche Beschreibung
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Joseph, Gabby B [verfasserIn] |
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2011 |
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© Joseph et al.; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( |
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Enthalten in: Arthritis Research & Therapy - London : BioMed Central, 1999, 13(2011), 5 vom: 20. Sept. |
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volume:13 ; year:2011 ; number:5 ; day:20 ; month:09 |
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DOI / URN: |
10.1186/ar3469 |
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SPR030839246 |
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245 | 1 | 0 | |a Texture analysis of cartilage $ T_{2} $ maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR $ T_{2} $ compared to normal controls - data from the osteoarthritis initiative |
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520 | |a Introduction The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage $ T_{2} $ relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) $ T_{2} $ relaxation times between subjects with and without risk factors for Osteoarthritis (OA), (ii) to determine the relationship between MR cartilage $ T_{2} $ parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and $ T_{2} $ relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the Osteoarthritis Initiative (OAI) incidence and control cohorts, respectively. The specific inclusion criteria for this study were (1) age range 45-55 years, (2) body mass index (BMI) of 19-27 kg/$ m^{2} $, (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage $ T_{2} $ mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, bone marrow lesions, meniscus lesions) between controls and subjects at risk for OA, $ T_{2} $ parameters (mean $ T_{2} $, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage $ T_{2} $ parameters was evident. Conclusions Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous cartilage $ T_{2} $ values than controls, and that $ T_{2} $ parameters are associated with morphologic degeneration. | ||
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10.1186/ar3469 doi (DE-627)SPR030839246 (SPR)ar3469-e DE-627 ger DE-627 rakwb eng Joseph, Gabby B verfasserin aut Texture analysis of cartilage $ T_{2} $ maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR $ T_{2} $ compared to normal controls - data from the osteoarthritis initiative 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Joseph et al.; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Introduction The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage $ T_{2} $ relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) $ T_{2} $ relaxation times between subjects with and without risk factors for Osteoarthritis (OA), (ii) to determine the relationship between MR cartilage $ T_{2} $ parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and $ T_{2} $ relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the Osteoarthritis Initiative (OAI) incidence and control cohorts, respectively. The specific inclusion criteria for this study were (1) age range 45-55 years, (2) body mass index (BMI) of 19-27 kg/$ m^{2} $, (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage $ T_{2} $ mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, bone marrow lesions, meniscus lesions) between controls and subjects at risk for OA, $ T_{2} $ parameters (mean $ T_{2} $, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage $ T_{2} $ parameters was evident. Conclusions Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous cartilage $ T_{2} $ values than controls, and that $ T_{2} $ parameters are associated with morphologic degeneration. Cartilage Lesion (dpeaa)DE-He213 Bone Marrow Lesion (dpeaa)DE-He213 Incidence Group (dpeaa)DE-He213 Medial Tibia (dpeaa)DE-He213 Kellgren Lawrence (dpeaa)DE-He213 Baum, Thomas aut Carballido-Gamio, Julio aut Nardo, Lorenzo aut Virayavanich, Warapat aut Alizai, Hamza aut Lynch, John A aut McCulloch, Charles E aut Majumdar, Sharmila aut Link, Thomas M aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 13(2011), 5 vom: 20. Sept. (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:13 year:2011 number:5 day:20 month:09 https://dx.doi.org/10.1186/ar3469 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2011 5 20 09 |
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10.1186/ar3469 doi (DE-627)SPR030839246 (SPR)ar3469-e DE-627 ger DE-627 rakwb eng Joseph, Gabby B verfasserin aut Texture analysis of cartilage $ T_{2} $ maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR $ T_{2} $ compared to normal controls - data from the osteoarthritis initiative 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Joseph et al.; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Introduction The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage $ T_{2} $ relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) $ T_{2} $ relaxation times between subjects with and without risk factors for Osteoarthritis (OA), (ii) to determine the relationship between MR cartilage $ T_{2} $ parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and $ T_{2} $ relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the Osteoarthritis Initiative (OAI) incidence and control cohorts, respectively. The specific inclusion criteria for this study were (1) age range 45-55 years, (2) body mass index (BMI) of 19-27 kg/$ m^{2} $, (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage $ T_{2} $ mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, bone marrow lesions, meniscus lesions) between controls and subjects at risk for OA, $ T_{2} $ parameters (mean $ T_{2} $, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage $ T_{2} $ parameters was evident. Conclusions Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous cartilage $ T_{2} $ values than controls, and that $ T_{2} $ parameters are associated with morphologic degeneration. Cartilage Lesion (dpeaa)DE-He213 Bone Marrow Lesion (dpeaa)DE-He213 Incidence Group (dpeaa)DE-He213 Medial Tibia (dpeaa)DE-He213 Kellgren Lawrence (dpeaa)DE-He213 Baum, Thomas aut Carballido-Gamio, Julio aut Nardo, Lorenzo aut Virayavanich, Warapat aut Alizai, Hamza aut Lynch, John A aut McCulloch, Charles E aut Majumdar, Sharmila aut Link, Thomas M aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 13(2011), 5 vom: 20. Sept. (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:13 year:2011 number:5 day:20 month:09 https://dx.doi.org/10.1186/ar3469 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2011 5 20 09 |
allfields_unstemmed |
10.1186/ar3469 doi (DE-627)SPR030839246 (SPR)ar3469-e DE-627 ger DE-627 rakwb eng Joseph, Gabby B verfasserin aut Texture analysis of cartilage $ T_{2} $ maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR $ T_{2} $ compared to normal controls - data from the osteoarthritis initiative 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Joseph et al.; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Introduction The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage $ T_{2} $ relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) $ T_{2} $ relaxation times between subjects with and without risk factors for Osteoarthritis (OA), (ii) to determine the relationship between MR cartilage $ T_{2} $ parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and $ T_{2} $ relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the Osteoarthritis Initiative (OAI) incidence and control cohorts, respectively. The specific inclusion criteria for this study were (1) age range 45-55 years, (2) body mass index (BMI) of 19-27 kg/$ m^{2} $, (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage $ T_{2} $ mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, bone marrow lesions, meniscus lesions) between controls and subjects at risk for OA, $ T_{2} $ parameters (mean $ T_{2} $, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage $ T_{2} $ parameters was evident. Conclusions Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous cartilage $ T_{2} $ values than controls, and that $ T_{2} $ parameters are associated with morphologic degeneration. Cartilage Lesion (dpeaa)DE-He213 Bone Marrow Lesion (dpeaa)DE-He213 Incidence Group (dpeaa)DE-He213 Medial Tibia (dpeaa)DE-He213 Kellgren Lawrence (dpeaa)DE-He213 Baum, Thomas aut Carballido-Gamio, Julio aut Nardo, Lorenzo aut Virayavanich, Warapat aut Alizai, Hamza aut Lynch, John A aut McCulloch, Charles E aut Majumdar, Sharmila aut Link, Thomas M aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 13(2011), 5 vom: 20. Sept. (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:13 year:2011 number:5 day:20 month:09 https://dx.doi.org/10.1186/ar3469 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2011 5 20 09 |
allfieldsGer |
10.1186/ar3469 doi (DE-627)SPR030839246 (SPR)ar3469-e DE-627 ger DE-627 rakwb eng Joseph, Gabby B verfasserin aut Texture analysis of cartilage $ T_{2} $ maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR $ T_{2} $ compared to normal controls - data from the osteoarthritis initiative 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Joseph et al.; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Introduction The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage $ T_{2} $ relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) $ T_{2} $ relaxation times between subjects with and without risk factors for Osteoarthritis (OA), (ii) to determine the relationship between MR cartilage $ T_{2} $ parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and $ T_{2} $ relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the Osteoarthritis Initiative (OAI) incidence and control cohorts, respectively. The specific inclusion criteria for this study were (1) age range 45-55 years, (2) body mass index (BMI) of 19-27 kg/$ m^{2} $, (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage $ T_{2} $ mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, bone marrow lesions, meniscus lesions) between controls and subjects at risk for OA, $ T_{2} $ parameters (mean $ T_{2} $, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage $ T_{2} $ parameters was evident. Conclusions Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous cartilage $ T_{2} $ values than controls, and that $ T_{2} $ parameters are associated with morphologic degeneration. Cartilage Lesion (dpeaa)DE-He213 Bone Marrow Lesion (dpeaa)DE-He213 Incidence Group (dpeaa)DE-He213 Medial Tibia (dpeaa)DE-He213 Kellgren Lawrence (dpeaa)DE-He213 Baum, Thomas aut Carballido-Gamio, Julio aut Nardo, Lorenzo aut Virayavanich, Warapat aut Alizai, Hamza aut Lynch, John A aut McCulloch, Charles E aut Majumdar, Sharmila aut Link, Thomas M aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 13(2011), 5 vom: 20. Sept. (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:13 year:2011 number:5 day:20 month:09 https://dx.doi.org/10.1186/ar3469 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2011 5 20 09 |
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10.1186/ar3469 doi (DE-627)SPR030839246 (SPR)ar3469-e DE-627 ger DE-627 rakwb eng Joseph, Gabby B verfasserin aut Texture analysis of cartilage $ T_{2} $ maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR $ T_{2} $ compared to normal controls - data from the osteoarthritis initiative 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Joseph et al.; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( Introduction The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage $ T_{2} $ relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) $ T_{2} $ relaxation times between subjects with and without risk factors for Osteoarthritis (OA), (ii) to determine the relationship between MR cartilage $ T_{2} $ parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and $ T_{2} $ relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the Osteoarthritis Initiative (OAI) incidence and control cohorts, respectively. The specific inclusion criteria for this study were (1) age range 45-55 years, (2) body mass index (BMI) of 19-27 kg/$ m^{2} $, (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage $ T_{2} $ mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, bone marrow lesions, meniscus lesions) between controls and subjects at risk for OA, $ T_{2} $ parameters (mean $ T_{2} $, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage $ T_{2} $ parameters was evident. Conclusions Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous cartilage $ T_{2} $ values than controls, and that $ T_{2} $ parameters are associated with morphologic degeneration. Cartilage Lesion (dpeaa)DE-He213 Bone Marrow Lesion (dpeaa)DE-He213 Incidence Group (dpeaa)DE-He213 Medial Tibia (dpeaa)DE-He213 Kellgren Lawrence (dpeaa)DE-He213 Baum, Thomas aut Carballido-Gamio, Julio aut Nardo, Lorenzo aut Virayavanich, Warapat aut Alizai, Hamza aut Lynch, John A aut McCulloch, Charles E aut Majumdar, Sharmila aut Link, Thomas M aut Enthalten in Arthritis Research & Therapy London : BioMed Central, 1999 13(2011), 5 vom: 20. Sept. (DE-627)326646418 (DE-600)2041668-4 1478-6354 nnns volume:13 year:2011 number:5 day:20 month:09 https://dx.doi.org/10.1186/ar3469 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2011 5 20 09 |
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Texture analysis of cartilage $ T_{2} $ maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR $ T_{2} $ compared to normal controls - data from the osteoarthritis initiative |
abstract |
Introduction The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage $ T_{2} $ relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) $ T_{2} $ relaxation times between subjects with and without risk factors for Osteoarthritis (OA), (ii) to determine the relationship between MR cartilage $ T_{2} $ parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and $ T_{2} $ relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the Osteoarthritis Initiative (OAI) incidence and control cohorts, respectively. The specific inclusion criteria for this study were (1) age range 45-55 years, (2) body mass index (BMI) of 19-27 kg/$ m^{2} $, (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage $ T_{2} $ mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, bone marrow lesions, meniscus lesions) between controls and subjects at risk for OA, $ T_{2} $ parameters (mean $ T_{2} $, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage $ T_{2} $ parameters was evident. Conclusions Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous cartilage $ T_{2} $ values than controls, and that $ T_{2} $ parameters are associated with morphologic degeneration. © Joseph et al.; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( |
abstractGer |
Introduction The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage $ T_{2} $ relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) $ T_{2} $ relaxation times between subjects with and without risk factors for Osteoarthritis (OA), (ii) to determine the relationship between MR cartilage $ T_{2} $ parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and $ T_{2} $ relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the Osteoarthritis Initiative (OAI) incidence and control cohorts, respectively. The specific inclusion criteria for this study were (1) age range 45-55 years, (2) body mass index (BMI) of 19-27 kg/$ m^{2} $, (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage $ T_{2} $ mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, bone marrow lesions, meniscus lesions) between controls and subjects at risk for OA, $ T_{2} $ parameters (mean $ T_{2} $, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage $ T_{2} $ parameters was evident. Conclusions Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous cartilage $ T_{2} $ values than controls, and that $ T_{2} $ parameters are associated with morphologic degeneration. © Joseph et al.; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( |
abstract_unstemmed |
Introduction The goals of this study were (i) to compare the prevalence of focal knee abnormalities, the mean cartilage $ T_{2} $ relaxation time, and the spatial distribution of cartilage magnetic resonance (MR) $ T_{2} $ relaxation times between subjects with and without risk factors for Osteoarthritis (OA), (ii) to determine the relationship between MR cartilage $ T_{2} $ parameters, age and cartilage morphology as determined with whole-organ magnetic resonance imaging scores (WORMS) and (iii) to assess the reproducibility of WORMS scoring and $ T_{2} $ relaxation time measurements including the mean and grey level co-occurrence matrix (GLCM) texture parameters. Methods Subjects with risk factors for OA (n = 92) and healthy controls (n = 53) were randomly selected from the Osteoarthritis Initiative (OAI) incidence and control cohorts, respectively. The specific inclusion criteria for this study were (1) age range 45-55 years, (2) body mass index (BMI) of 19-27 kg/$ m^{2} $, (3) Western Ontario and McMaster University (WOMAC) pain score of zero and (4) Kellgren Lawrence (KL) score of zero at baseline. 3.0 Tesla MR images of the right knee were analyzed using morphological gradings of cartilage, bone marrow and menisci (WORMS) as well as compartment specific cartilage $ T_{2} $ mean and heterogeneity. Regression models adjusted for age, gender, and BMI were used to determine the difference in cartilage parameters between groups. Results While there was no significant difference in the prevalence of knee abnormalities (cartilage lesions, bone marrow lesions, meniscus lesions) between controls and subjects at risk for OA, $ T_{2} $ parameters (mean $ T_{2} $, GLCM contrast, and GLCM variance) were significantly elevated in those at risk for OA. Additionally, a positive significant association between cartilage WORMS score and cartilage $ T_{2} $ parameters was evident. Conclusions Overall, this study demonstrated that subjects at risk for OA have both higher and more heterogeneous cartilage $ T_{2} $ values than controls, and that $ T_{2} $ parameters are associated with morphologic degeneration. © Joseph et al.; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License ( |
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title_short |
Texture analysis of cartilage $ T_{2} $ maps: individuals with risk factors for OA have higher and more heterogeneous knee cartilage MR $ T_{2} $ compared to normal controls - data from the osteoarthritis initiative |
url |
https://dx.doi.org/10.1186/ar3469 |
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Baum, Thomas Carballido-Gamio, Julio Nardo, Lorenzo Virayavanich, Warapat Alizai, Hamza Lynch, John A McCulloch, Charles E Majumdar, Sharmila Link, Thomas M |
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Baum, Thomas Carballido-Gamio, Julio Nardo, Lorenzo Virayavanich, Warapat Alizai, Hamza Lynch, John A McCulloch, Charles E Majumdar, Sharmila Link, Thomas M |
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