Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts
Abstract Dedifferentiation of more mature cell types into multipotential cells is of interest since they have potential regenerative capacity. Reversine has the ability to induce the reversion of adult cells to a multipotent state from which they can re-differentiate into other cell types when induc...
Ausführliche Beschreibung
Autor*in: |
Mandal, Chanchal [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2013 |
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Schlagwörter: |
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Anmerkung: |
© The Korean BioChip Society and Springer-Verlag Berlin Heidelberg 2013 |
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Übergeordnetes Werk: |
Enthalten in: BioChip journal - Seoul : Soc., 2007, 7(2013), 3 vom: Sept., Seite 278-287 |
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Übergeordnetes Werk: |
volume:7 ; year:2013 ; number:3 ; month:09 ; pages:278-287 |
Links: |
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DOI / URN: |
10.1007/s13206-013-7311-8 |
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Katalog-ID: |
SPR030868807 |
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520 | |a Abstract Dedifferentiation of more mature cell types into multipotential cells is of interest since they have potential regenerative capacity. Reversine has the ability to induce the reversion of adult cells to a multipotent state from which they can re-differentiate into other cell types when induced by appropriate culture conditions. To evaluate the dedifferentiation caused by short-term treatment with reversine, NIH-3T3 fibroblast cells were cultured with reversine and then transferred to induction media for osteogenic and adipogenic differentiation. Furthermore, genome wide transcriptomic analysis was performed to observe the trends in gene expression associated with short-term reversine treatment. We found that reversine-treated fibroblast cells transdifferentiated into osteoblasts and that treatment induced some important genes including Ids, Cp, Btg2, Nrg1, Npas4, and Has2. These genes are involved in the growth and development of different organs, protein binding, transcriptional regulation, and other major functions. Our findings suggest that reversine-mediated induction of some genes or transcription factors may alter the status of differentiated cells and cause dedifferentiation. These data will provide a platform to investigate the key epigenetic factors that increase cellular plasticity and facilitate further differentiation to other cell types. | ||
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650 | 4 | |a Transdifferentiation |7 (dpeaa)DE-He213 | |
650 | 4 | |a Reversine |7 (dpeaa)DE-He213 | |
650 | 4 | |a Microarray analysis |7 (dpeaa)DE-He213 | |
700 | 1 | |a Baek, Mi Na |4 aut | |
700 | 1 | |a Jung, Kyoung Hwa |4 aut | |
700 | 1 | |a Chai, Jin Cheol |4 aut | |
700 | 1 | |a Lee, Young Seek |4 aut | |
700 | 1 | |a Chai, Young Gyu |4 aut | |
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10.1007/s13206-013-7311-8 doi (DE-627)SPR030868807 (SPR)s13206-013-7311-8-e DE-627 ger DE-627 rakwb eng Mandal, Chanchal verfasserin aut Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean BioChip Society and Springer-Verlag Berlin Heidelberg 2013 Abstract Dedifferentiation of more mature cell types into multipotential cells is of interest since they have potential regenerative capacity. Reversine has the ability to induce the reversion of adult cells to a multipotent state from which they can re-differentiate into other cell types when induced by appropriate culture conditions. To evaluate the dedifferentiation caused by short-term treatment with reversine, NIH-3T3 fibroblast cells were cultured with reversine and then transferred to induction media for osteogenic and adipogenic differentiation. Furthermore, genome wide transcriptomic analysis was performed to observe the trends in gene expression associated with short-term reversine treatment. We found that reversine-treated fibroblast cells transdifferentiated into osteoblasts and that treatment induced some important genes including Ids, Cp, Btg2, Nrg1, Npas4, and Has2. These genes are involved in the growth and development of different organs, protein binding, transcriptional regulation, and other major functions. Our findings suggest that reversine-mediated induction of some genes or transcription factors may alter the status of differentiated cells and cause dedifferentiation. These data will provide a platform to investigate the key epigenetic factors that increase cellular plasticity and facilitate further differentiation to other cell types. Dedifferentiation (dpeaa)DE-He213 Transdifferentiation (dpeaa)DE-He213 Reversine (dpeaa)DE-He213 Microarray analysis (dpeaa)DE-He213 Baek, Mi Na aut Jung, Kyoung Hwa aut Chai, Jin Cheol aut Lee, Young Seek aut Chai, Young Gyu aut Enthalten in BioChip journal Seoul : Soc., 2007 7(2013), 3 vom: Sept., Seite 278-287 (DE-627)608497258 (DE-600)2513796-7 2092-7843 nnns volume:7 year:2013 number:3 month:09 pages:278-287 https://dx.doi.org/10.1007/s13206-013-7311-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 7 2013 3 09 278-287 |
spelling |
10.1007/s13206-013-7311-8 doi (DE-627)SPR030868807 (SPR)s13206-013-7311-8-e DE-627 ger DE-627 rakwb eng Mandal, Chanchal verfasserin aut Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean BioChip Society and Springer-Verlag Berlin Heidelberg 2013 Abstract Dedifferentiation of more mature cell types into multipotential cells is of interest since they have potential regenerative capacity. Reversine has the ability to induce the reversion of adult cells to a multipotent state from which they can re-differentiate into other cell types when induced by appropriate culture conditions. To evaluate the dedifferentiation caused by short-term treatment with reversine, NIH-3T3 fibroblast cells were cultured with reversine and then transferred to induction media for osteogenic and adipogenic differentiation. Furthermore, genome wide transcriptomic analysis was performed to observe the trends in gene expression associated with short-term reversine treatment. We found that reversine-treated fibroblast cells transdifferentiated into osteoblasts and that treatment induced some important genes including Ids, Cp, Btg2, Nrg1, Npas4, and Has2. These genes are involved in the growth and development of different organs, protein binding, transcriptional regulation, and other major functions. Our findings suggest that reversine-mediated induction of some genes or transcription factors may alter the status of differentiated cells and cause dedifferentiation. These data will provide a platform to investigate the key epigenetic factors that increase cellular plasticity and facilitate further differentiation to other cell types. Dedifferentiation (dpeaa)DE-He213 Transdifferentiation (dpeaa)DE-He213 Reversine (dpeaa)DE-He213 Microarray analysis (dpeaa)DE-He213 Baek, Mi Na aut Jung, Kyoung Hwa aut Chai, Jin Cheol aut Lee, Young Seek aut Chai, Young Gyu aut Enthalten in BioChip journal Seoul : Soc., 2007 7(2013), 3 vom: Sept., Seite 278-287 (DE-627)608497258 (DE-600)2513796-7 2092-7843 nnns volume:7 year:2013 number:3 month:09 pages:278-287 https://dx.doi.org/10.1007/s13206-013-7311-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 7 2013 3 09 278-287 |
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10.1007/s13206-013-7311-8 doi (DE-627)SPR030868807 (SPR)s13206-013-7311-8-e DE-627 ger DE-627 rakwb eng Mandal, Chanchal verfasserin aut Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean BioChip Society and Springer-Verlag Berlin Heidelberg 2013 Abstract Dedifferentiation of more mature cell types into multipotential cells is of interest since they have potential regenerative capacity. Reversine has the ability to induce the reversion of adult cells to a multipotent state from which they can re-differentiate into other cell types when induced by appropriate culture conditions. To evaluate the dedifferentiation caused by short-term treatment with reversine, NIH-3T3 fibroblast cells were cultured with reversine and then transferred to induction media for osteogenic and adipogenic differentiation. Furthermore, genome wide transcriptomic analysis was performed to observe the trends in gene expression associated with short-term reversine treatment. We found that reversine-treated fibroblast cells transdifferentiated into osteoblasts and that treatment induced some important genes including Ids, Cp, Btg2, Nrg1, Npas4, and Has2. These genes are involved in the growth and development of different organs, protein binding, transcriptional regulation, and other major functions. Our findings suggest that reversine-mediated induction of some genes or transcription factors may alter the status of differentiated cells and cause dedifferentiation. These data will provide a platform to investigate the key epigenetic factors that increase cellular plasticity and facilitate further differentiation to other cell types. Dedifferentiation (dpeaa)DE-He213 Transdifferentiation (dpeaa)DE-He213 Reversine (dpeaa)DE-He213 Microarray analysis (dpeaa)DE-He213 Baek, Mi Na aut Jung, Kyoung Hwa aut Chai, Jin Cheol aut Lee, Young Seek aut Chai, Young Gyu aut Enthalten in BioChip journal Seoul : Soc., 2007 7(2013), 3 vom: Sept., Seite 278-287 (DE-627)608497258 (DE-600)2513796-7 2092-7843 nnns volume:7 year:2013 number:3 month:09 pages:278-287 https://dx.doi.org/10.1007/s13206-013-7311-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 7 2013 3 09 278-287 |
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10.1007/s13206-013-7311-8 doi (DE-627)SPR030868807 (SPR)s13206-013-7311-8-e DE-627 ger DE-627 rakwb eng Mandal, Chanchal verfasserin aut Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean BioChip Society and Springer-Verlag Berlin Heidelberg 2013 Abstract Dedifferentiation of more mature cell types into multipotential cells is of interest since they have potential regenerative capacity. Reversine has the ability to induce the reversion of adult cells to a multipotent state from which they can re-differentiate into other cell types when induced by appropriate culture conditions. To evaluate the dedifferentiation caused by short-term treatment with reversine, NIH-3T3 fibroblast cells were cultured with reversine and then transferred to induction media for osteogenic and adipogenic differentiation. Furthermore, genome wide transcriptomic analysis was performed to observe the trends in gene expression associated with short-term reversine treatment. We found that reversine-treated fibroblast cells transdifferentiated into osteoblasts and that treatment induced some important genes including Ids, Cp, Btg2, Nrg1, Npas4, and Has2. These genes are involved in the growth and development of different organs, protein binding, transcriptional regulation, and other major functions. Our findings suggest that reversine-mediated induction of some genes or transcription factors may alter the status of differentiated cells and cause dedifferentiation. These data will provide a platform to investigate the key epigenetic factors that increase cellular plasticity and facilitate further differentiation to other cell types. Dedifferentiation (dpeaa)DE-He213 Transdifferentiation (dpeaa)DE-He213 Reversine (dpeaa)DE-He213 Microarray analysis (dpeaa)DE-He213 Baek, Mi Na aut Jung, Kyoung Hwa aut Chai, Jin Cheol aut Lee, Young Seek aut Chai, Young Gyu aut Enthalten in BioChip journal Seoul : Soc., 2007 7(2013), 3 vom: Sept., Seite 278-287 (DE-627)608497258 (DE-600)2513796-7 2092-7843 nnns volume:7 year:2013 number:3 month:09 pages:278-287 https://dx.doi.org/10.1007/s13206-013-7311-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 7 2013 3 09 278-287 |
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10.1007/s13206-013-7311-8 doi (DE-627)SPR030868807 (SPR)s13206-013-7311-8-e DE-627 ger DE-627 rakwb eng Mandal, Chanchal verfasserin aut Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Korean BioChip Society and Springer-Verlag Berlin Heidelberg 2013 Abstract Dedifferentiation of more mature cell types into multipotential cells is of interest since they have potential regenerative capacity. Reversine has the ability to induce the reversion of adult cells to a multipotent state from which they can re-differentiate into other cell types when induced by appropriate culture conditions. To evaluate the dedifferentiation caused by short-term treatment with reversine, NIH-3T3 fibroblast cells were cultured with reversine and then transferred to induction media for osteogenic and adipogenic differentiation. Furthermore, genome wide transcriptomic analysis was performed to observe the trends in gene expression associated with short-term reversine treatment. We found that reversine-treated fibroblast cells transdifferentiated into osteoblasts and that treatment induced some important genes including Ids, Cp, Btg2, Nrg1, Npas4, and Has2. These genes are involved in the growth and development of different organs, protein binding, transcriptional regulation, and other major functions. Our findings suggest that reversine-mediated induction of some genes or transcription factors may alter the status of differentiated cells and cause dedifferentiation. These data will provide a platform to investigate the key epigenetic factors that increase cellular plasticity and facilitate further differentiation to other cell types. Dedifferentiation (dpeaa)DE-He213 Transdifferentiation (dpeaa)DE-He213 Reversine (dpeaa)DE-He213 Microarray analysis (dpeaa)DE-He213 Baek, Mi Na aut Jung, Kyoung Hwa aut Chai, Jin Cheol aut Lee, Young Seek aut Chai, Young Gyu aut Enthalten in BioChip journal Seoul : Soc., 2007 7(2013), 3 vom: Sept., Seite 278-287 (DE-627)608497258 (DE-600)2513796-7 2092-7843 nnns volume:7 year:2013 number:3 month:09 pages:278-287 https://dx.doi.org/10.1007/s13206-013-7311-8 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 7 2013 3 09 278-287 |
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Enthalten in BioChip journal 7(2013), 3 vom: Sept., Seite 278-287 volume:7 year:2013 number:3 month:09 pages:278-287 |
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Mandal, Chanchal @@aut@@ Baek, Mi Na @@aut@@ Jung, Kyoung Hwa @@aut@@ Chai, Jin Cheol @@aut@@ Lee, Young Seek @@aut@@ Chai, Young Gyu @@aut@@ |
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Mandal, Chanchal |
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Mandal, Chanchal misc Dedifferentiation misc Transdifferentiation misc Reversine misc Microarray analysis Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts |
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Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts Dedifferentiation (dpeaa)DE-He213 Transdifferentiation (dpeaa)DE-He213 Reversine (dpeaa)DE-He213 Microarray analysis (dpeaa)DE-He213 |
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Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts |
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Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts |
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Mandal, Chanchal Baek, Mi Na Jung, Kyoung Hwa Chai, Jin Cheol Lee, Young Seek Chai, Young Gyu |
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10.1007/s13206-013-7311-8 |
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gene expression profile associated with the reversine-mediated transdifferentiation of nih-3t3 fibroblast cells into osteoblasts |
title_auth |
Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts |
abstract |
Abstract Dedifferentiation of more mature cell types into multipotential cells is of interest since they have potential regenerative capacity. Reversine has the ability to induce the reversion of adult cells to a multipotent state from which they can re-differentiate into other cell types when induced by appropriate culture conditions. To evaluate the dedifferentiation caused by short-term treatment with reversine, NIH-3T3 fibroblast cells were cultured with reversine and then transferred to induction media for osteogenic and adipogenic differentiation. Furthermore, genome wide transcriptomic analysis was performed to observe the trends in gene expression associated with short-term reversine treatment. We found that reversine-treated fibroblast cells transdifferentiated into osteoblasts and that treatment induced some important genes including Ids, Cp, Btg2, Nrg1, Npas4, and Has2. These genes are involved in the growth and development of different organs, protein binding, transcriptional regulation, and other major functions. Our findings suggest that reversine-mediated induction of some genes or transcription factors may alter the status of differentiated cells and cause dedifferentiation. These data will provide a platform to investigate the key epigenetic factors that increase cellular plasticity and facilitate further differentiation to other cell types. © The Korean BioChip Society and Springer-Verlag Berlin Heidelberg 2013 |
abstractGer |
Abstract Dedifferentiation of more mature cell types into multipotential cells is of interest since they have potential regenerative capacity. Reversine has the ability to induce the reversion of adult cells to a multipotent state from which they can re-differentiate into other cell types when induced by appropriate culture conditions. To evaluate the dedifferentiation caused by short-term treatment with reversine, NIH-3T3 fibroblast cells were cultured with reversine and then transferred to induction media for osteogenic and adipogenic differentiation. Furthermore, genome wide transcriptomic analysis was performed to observe the trends in gene expression associated with short-term reversine treatment. We found that reversine-treated fibroblast cells transdifferentiated into osteoblasts and that treatment induced some important genes including Ids, Cp, Btg2, Nrg1, Npas4, and Has2. These genes are involved in the growth and development of different organs, protein binding, transcriptional regulation, and other major functions. Our findings suggest that reversine-mediated induction of some genes or transcription factors may alter the status of differentiated cells and cause dedifferentiation. These data will provide a platform to investigate the key epigenetic factors that increase cellular plasticity and facilitate further differentiation to other cell types. © The Korean BioChip Society and Springer-Verlag Berlin Heidelberg 2013 |
abstract_unstemmed |
Abstract Dedifferentiation of more mature cell types into multipotential cells is of interest since they have potential regenerative capacity. Reversine has the ability to induce the reversion of adult cells to a multipotent state from which they can re-differentiate into other cell types when induced by appropriate culture conditions. To evaluate the dedifferentiation caused by short-term treatment with reversine, NIH-3T3 fibroblast cells were cultured with reversine and then transferred to induction media for osteogenic and adipogenic differentiation. Furthermore, genome wide transcriptomic analysis was performed to observe the trends in gene expression associated with short-term reversine treatment. We found that reversine-treated fibroblast cells transdifferentiated into osteoblasts and that treatment induced some important genes including Ids, Cp, Btg2, Nrg1, Npas4, and Has2. These genes are involved in the growth and development of different organs, protein binding, transcriptional regulation, and other major functions. Our findings suggest that reversine-mediated induction of some genes or transcription factors may alter the status of differentiated cells and cause dedifferentiation. These data will provide a platform to investigate the key epigenetic factors that increase cellular plasticity and facilitate further differentiation to other cell types. © The Korean BioChip Society and Springer-Verlag Berlin Heidelberg 2013 |
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container_issue |
3 |
title_short |
Gene expression profile associated with the reversine-mediated transdifferentiation of NIH-3T3 fibroblast cells into osteoblasts |
url |
https://dx.doi.org/10.1007/s13206-013-7311-8 |
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Baek, Mi Na Jung, Kyoung Hwa Chai, Jin Cheol Lee, Young Seek Chai, Young Gyu |
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Baek, Mi Na Jung, Kyoung Hwa Chai, Jin Cheol Lee, Young Seek Chai, Young Gyu |
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doi_str |
10.1007/s13206-013-7311-8 |
up_date |
2024-07-03T20:36:38.868Z |
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score |
7.398798 |