Novel insights into the differential functions of Notch ligands in vascular formation

Abstract The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of endothelial tip and...
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Gespeichert in:

Autor*in:	Kume, Tsutomu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Schlagwörter:	Vascular Endothelial Growth Factor Notch Signaling Notch Pathway Notch Receptor Notch Ligand

Anmerkung:	© Kume; licensee BioMed Central Ltd. 2009

Übergeordnetes Werk:	Enthalten in: Journal of angiogenesis research - London : BioMed Central, 2009, 1(2009), 1 vom: 16. Nov.
Übergeordnetes Werk:	volume:1 ; year:2009 ; number:1 ; day:16 ; month:11

Links:	Volltext

DOI / URN:	10.1186/2040-2384-1-8

Katalog-ID:	SPR030900735

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allfields	10.1186/2040-2384-1-8 doi (DE-627)SPR030900735 (SPR)2040-2384-1-8-e DE-627 ger DE-627 rakwb eng Kume, Tsutomu verfasserin aut Novel insights into the differential functions of Notch ligands in vascular formation 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kume; licensee BioMed Central Ltd. 2009 Abstract The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of endothelial tip and stalk cells during sprouting angiogenesis. In mammals, two of the four Notch receptors (Notch1 and Notch4) and three of the five Notch ligands (Jagged1, Dll1, and Dll4) are predominantly expressed in vascular endothelial cells and are important for many aspects of vascular biology. During arterial cell-fate selection and angiogenesis, the roles of Notch1 and Notch4 are thought to be similar, and the function of Dll4 is well-characterized. However, the molecular mechanisms that determine the functional similarities and differences of Notch ligands in vascular endothelial cells remain largely unknown; consequently, additional research is needed to elucidate the ligand-specific functions and mechanisms associated with Notch activation in the vascular endothelium. Results from recent studies indicate that Dll1 and Dll4 have distinct roles in the specification and maintenance of arterial cell identity, while Dll4 and Jagged1 have opposing functions in tip- and stalk-cell selection during sprouting angiogenesis. This review will focus on the newly discovered, distinct functions of several Notch ligands in the regulation of blood vessel formation and will provide perspectives for future research in the field. Vascular Endothelial Growth Factor (dpeaa)DE-He213 Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Enthalten in Journal of angiogenesis research London : BioMed Central, 2009 1(2009), 1 vom: 16. Nov. (DE-627)609775553 (DE-600)2516062-X 2040-2384 nnns volume:1 year:2009 number:1 day:16 month:11 https://dx.doi.org/10.1186/2040-2384-1-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 16 11
spelling	10.1186/2040-2384-1-8 doi (DE-627)SPR030900735 (SPR)2040-2384-1-8-e DE-627 ger DE-627 rakwb eng Kume, Tsutomu verfasserin aut Novel insights into the differential functions of Notch ligands in vascular formation 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kume; licensee BioMed Central Ltd. 2009 Abstract The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of endothelial tip and stalk cells during sprouting angiogenesis. In mammals, two of the four Notch receptors (Notch1 and Notch4) and three of the five Notch ligands (Jagged1, Dll1, and Dll4) are predominantly expressed in vascular endothelial cells and are important for many aspects of vascular biology. During arterial cell-fate selection and angiogenesis, the roles of Notch1 and Notch4 are thought to be similar, and the function of Dll4 is well-characterized. However, the molecular mechanisms that determine the functional similarities and differences of Notch ligands in vascular endothelial cells remain largely unknown; consequently, additional research is needed to elucidate the ligand-specific functions and mechanisms associated with Notch activation in the vascular endothelium. Results from recent studies indicate that Dll1 and Dll4 have distinct roles in the specification and maintenance of arterial cell identity, while Dll4 and Jagged1 have opposing functions in tip- and stalk-cell selection during sprouting angiogenesis. This review will focus on the newly discovered, distinct functions of several Notch ligands in the regulation of blood vessel formation and will provide perspectives for future research in the field. Vascular Endothelial Growth Factor (dpeaa)DE-He213 Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Enthalten in Journal of angiogenesis research London : BioMed Central, 2009 1(2009), 1 vom: 16. Nov. (DE-627)609775553 (DE-600)2516062-X 2040-2384 nnns volume:1 year:2009 number:1 day:16 month:11 https://dx.doi.org/10.1186/2040-2384-1-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 16 11
allfields_unstemmed	10.1186/2040-2384-1-8 doi (DE-627)SPR030900735 (SPR)2040-2384-1-8-e DE-627 ger DE-627 rakwb eng Kume, Tsutomu verfasserin aut Novel insights into the differential functions of Notch ligands in vascular formation 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kume; licensee BioMed Central Ltd. 2009 Abstract The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of endothelial tip and stalk cells during sprouting angiogenesis. In mammals, two of the four Notch receptors (Notch1 and Notch4) and three of the five Notch ligands (Jagged1, Dll1, and Dll4) are predominantly expressed in vascular endothelial cells and are important for many aspects of vascular biology. During arterial cell-fate selection and angiogenesis, the roles of Notch1 and Notch4 are thought to be similar, and the function of Dll4 is well-characterized. However, the molecular mechanisms that determine the functional similarities and differences of Notch ligands in vascular endothelial cells remain largely unknown; consequently, additional research is needed to elucidate the ligand-specific functions and mechanisms associated with Notch activation in the vascular endothelium. Results from recent studies indicate that Dll1 and Dll4 have distinct roles in the specification and maintenance of arterial cell identity, while Dll4 and Jagged1 have opposing functions in tip- and stalk-cell selection during sprouting angiogenesis. This review will focus on the newly discovered, distinct functions of several Notch ligands in the regulation of blood vessel formation and will provide perspectives for future research in the field. Vascular Endothelial Growth Factor (dpeaa)DE-He213 Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Enthalten in Journal of angiogenesis research London : BioMed Central, 2009 1(2009), 1 vom: 16. Nov. (DE-627)609775553 (DE-600)2516062-X 2040-2384 nnns volume:1 year:2009 number:1 day:16 month:11 https://dx.doi.org/10.1186/2040-2384-1-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 16 11
allfieldsGer	10.1186/2040-2384-1-8 doi (DE-627)SPR030900735 (SPR)2040-2384-1-8-e DE-627 ger DE-627 rakwb eng Kume, Tsutomu verfasserin aut Novel insights into the differential functions of Notch ligands in vascular formation 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kume; licensee BioMed Central Ltd. 2009 Abstract The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of endothelial tip and stalk cells during sprouting angiogenesis. In mammals, two of the four Notch receptors (Notch1 and Notch4) and three of the five Notch ligands (Jagged1, Dll1, and Dll4) are predominantly expressed in vascular endothelial cells and are important for many aspects of vascular biology. During arterial cell-fate selection and angiogenesis, the roles of Notch1 and Notch4 are thought to be similar, and the function of Dll4 is well-characterized. However, the molecular mechanisms that determine the functional similarities and differences of Notch ligands in vascular endothelial cells remain largely unknown; consequently, additional research is needed to elucidate the ligand-specific functions and mechanisms associated with Notch activation in the vascular endothelium. Results from recent studies indicate that Dll1 and Dll4 have distinct roles in the specification and maintenance of arterial cell identity, while Dll4 and Jagged1 have opposing functions in tip- and stalk-cell selection during sprouting angiogenesis. This review will focus on the newly discovered, distinct functions of several Notch ligands in the regulation of blood vessel formation and will provide perspectives for future research in the field. Vascular Endothelial Growth Factor (dpeaa)DE-He213 Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Enthalten in Journal of angiogenesis research London : BioMed Central, 2009 1(2009), 1 vom: 16. Nov. (DE-627)609775553 (DE-600)2516062-X 2040-2384 nnns volume:1 year:2009 number:1 day:16 month:11 https://dx.doi.org/10.1186/2040-2384-1-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 16 11
allfieldsSound	10.1186/2040-2384-1-8 doi (DE-627)SPR030900735 (SPR)2040-2384-1-8-e DE-627 ger DE-627 rakwb eng Kume, Tsutomu verfasserin aut Novel insights into the differential functions of Notch ligands in vascular formation 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Kume; licensee BioMed Central Ltd. 2009 Abstract The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of endothelial tip and stalk cells during sprouting angiogenesis. In mammals, two of the four Notch receptors (Notch1 and Notch4) and three of the five Notch ligands (Jagged1, Dll1, and Dll4) are predominantly expressed in vascular endothelial cells and are important for many aspects of vascular biology. During arterial cell-fate selection and angiogenesis, the roles of Notch1 and Notch4 are thought to be similar, and the function of Dll4 is well-characterized. However, the molecular mechanisms that determine the functional similarities and differences of Notch ligands in vascular endothelial cells remain largely unknown; consequently, additional research is needed to elucidate the ligand-specific functions and mechanisms associated with Notch activation in the vascular endothelium. Results from recent studies indicate that Dll1 and Dll4 have distinct roles in the specification and maintenance of arterial cell identity, while Dll4 and Jagged1 have opposing functions in tip- and stalk-cell selection during sprouting angiogenesis. This review will focus on the newly discovered, distinct functions of several Notch ligands in the regulation of blood vessel formation and will provide perspectives for future research in the field. Vascular Endothelial Growth Factor (dpeaa)DE-He213 Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213 Enthalten in Journal of angiogenesis research London : BioMed Central, 2009 1(2009), 1 vom: 16. Nov. (DE-627)609775553 (DE-600)2516062-X 2040-2384 nnns volume:1 year:2009 number:1 day:16 month:11 https://dx.doi.org/10.1186/2040-2384-1-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2009 1 16 11
language	English
source	Enthalten in Journal of angiogenesis research 1(2009), 1 vom: 16. Nov. volume:1 year:2009 number:1 day:16 month:11
sourceStr	Enthalten in Journal of angiogenesis research 1(2009), 1 vom: 16. Nov. volume:1 year:2009 number:1 day:16 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Vascular Endothelial Growth Factor Notch Signaling Notch Pathway Notch Receptor Notch Ligand
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container_title	Journal of angiogenesis research
authorswithroles_txt_mv	Kume, Tsutomu @@aut@@
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author	Kume, Tsutomu
spellingShingle	Kume, Tsutomu misc Vascular Endothelial Growth Factor misc Notch Signaling misc Notch Pathway misc Notch Receptor misc Notch Ligand Novel insights into the differential functions of Notch ligands in vascular formation
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topic_title	Novel insights into the differential functions of Notch ligands in vascular formation Vascular Endothelial Growth Factor (dpeaa)DE-He213 Notch Signaling (dpeaa)DE-He213 Notch Pathway (dpeaa)DE-He213 Notch Receptor (dpeaa)DE-He213 Notch Ligand (dpeaa)DE-He213
topic	misc Vascular Endothelial Growth Factor misc Notch Signaling misc Notch Pathway misc Notch Receptor misc Notch Ligand
topic_unstemmed	misc Vascular Endothelial Growth Factor misc Notch Signaling misc Notch Pathway misc Notch Receptor misc Notch Ligand
topic_browse	misc Vascular Endothelial Growth Factor misc Notch Signaling misc Notch Pathway misc Notch Receptor misc Notch Ligand
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title	Novel insights into the differential functions of Notch ligands in vascular formation
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title_full	Novel insights into the differential functions of Notch ligands in vascular formation
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title_sort	novel insights into the differential functions of notch ligands in vascular formation
title_auth	Novel insights into the differential functions of Notch ligands in vascular formation
abstract	Abstract The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of endothelial tip and stalk cells during sprouting angiogenesis. In mammals, two of the four Notch receptors (Notch1 and Notch4) and three of the five Notch ligands (Jagged1, Dll1, and Dll4) are predominantly expressed in vascular endothelial cells and are important for many aspects of vascular biology. During arterial cell-fate selection and angiogenesis, the roles of Notch1 and Notch4 are thought to be similar, and the function of Dll4 is well-characterized. However, the molecular mechanisms that determine the functional similarities and differences of Notch ligands in vascular endothelial cells remain largely unknown; consequently, additional research is needed to elucidate the ligand-specific functions and mechanisms associated with Notch activation in the vascular endothelium. Results from recent studies indicate that Dll1 and Dll4 have distinct roles in the specification and maintenance of arterial cell identity, while Dll4 and Jagged1 have opposing functions in tip- and stalk-cell selection during sprouting angiogenesis. This review will focus on the newly discovered, distinct functions of several Notch ligands in the regulation of blood vessel formation and will provide perspectives for future research in the field. © Kume; licensee BioMed Central Ltd. 2009
abstractGer	Abstract The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of endothelial tip and stalk cells during sprouting angiogenesis. In mammals, two of the four Notch receptors (Notch1 and Notch4) and three of the five Notch ligands (Jagged1, Dll1, and Dll4) are predominantly expressed in vascular endothelial cells and are important for many aspects of vascular biology. During arterial cell-fate selection and angiogenesis, the roles of Notch1 and Notch4 are thought to be similar, and the function of Dll4 is well-characterized. However, the molecular mechanisms that determine the functional similarities and differences of Notch ligands in vascular endothelial cells remain largely unknown; consequently, additional research is needed to elucidate the ligand-specific functions and mechanisms associated with Notch activation in the vascular endothelium. Results from recent studies indicate that Dll1 and Dll4 have distinct roles in the specification and maintenance of arterial cell identity, while Dll4 and Jagged1 have opposing functions in tip- and stalk-cell selection during sprouting angiogenesis. This review will focus on the newly discovered, distinct functions of several Notch ligands in the regulation of blood vessel formation and will provide perspectives for future research in the field. © Kume; licensee BioMed Central Ltd. 2009
abstract_unstemmed	Abstract The Notch signaling pathway is a critical component of vascular formation and morphogenesis in both development and disease. Compelling evidence indicates that Notch signaling is required for the induction of arterial-cell fate during development and for the selection of endothelial tip and stalk cells during sprouting angiogenesis. In mammals, two of the four Notch receptors (Notch1 and Notch4) and three of the five Notch ligands (Jagged1, Dll1, and Dll4) are predominantly expressed in vascular endothelial cells and are important for many aspects of vascular biology. During arterial cell-fate selection and angiogenesis, the roles of Notch1 and Notch4 are thought to be similar, and the function of Dll4 is well-characterized. However, the molecular mechanisms that determine the functional similarities and differences of Notch ligands in vascular endothelial cells remain largely unknown; consequently, additional research is needed to elucidate the ligand-specific functions and mechanisms associated with Notch activation in the vascular endothelium. Results from recent studies indicate that Dll1 and Dll4 have distinct roles in the specification and maintenance of arterial cell identity, while Dll4 and Jagged1 have opposing functions in tip- and stalk-cell selection during sprouting angiogenesis. This review will focus on the newly discovered, distinct functions of several Notch ligands in the regulation of blood vessel formation and will provide perspectives for future research in the field. © Kume; licensee BioMed Central Ltd. 2009
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title_short	Novel insights into the differential functions of Notch ligands in vascular formation
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Novel insights into the differential functions of Notch ligands in vascular formation

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