Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles

Abstract In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with p...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Ku, Eun Bi [verfasserIn] Oh, Kyung Taek Youn, Yu Seok Lee, Eun Seong

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Schlagwörter:	globular poly(ethylene glycol) mitochondria-selective photodynamic tumor therapy water-soluble nanoparticle iodomethyltriphenylphosphonium (IMTP)

Anmerkung:	© The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2016

Übergeordnetes Werk:	Enthalten in: Macromolecular research - Heidelberg : Springer, 2010, 24(2016), 7 vom: 22. Juni, Seite 634-639
Übergeordnetes Werk:	volume:24 ; year:2016 ; number:7 ; day:22 ; month:06 ; pages:634-639

Links:	Volltext

DOI / URN:	10.1007/s13233-016-4090-9

Katalog-ID:	SPR03096797X

Internformat


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520			\|a Abstract In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery.
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912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
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912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
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912			\|a GBV_ILN_2009
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912			\|a GBV_ILN_2015
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912			\|a GBV_ILN_2021
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912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
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912			\|a GBV_ILN_2038
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912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
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912			\|a GBV_ILN_2055
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912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2070
912			\|a GBV_ILN_2086
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
912			\|a GBV_ILN_2116
912			\|a GBV_ILN_2118
912			\|a GBV_ILN_2119
912			\|a GBV_ILN_2122
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2144
912			\|a GBV_ILN_2147
912			\|a GBV_ILN_2148
912			\|a GBV_ILN_2152
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2188
912			\|a GBV_ILN_2190
912			\|a GBV_ILN_2232
912			\|a GBV_ILN_2336
912			\|a GBV_ILN_2446
912			\|a GBV_ILN_2470
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912			\|a GBV_ILN_2507
912			\|a GBV_ILN_2522
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Indexfelder

author_variant	e b k eb ebk k t o kt kto y s y ys ysy e s l es esl
matchkey_str	article:20927673:2016----::iohnraeetvpooyaitmrhrpuiglb
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publishDate	2016
allfields	10.1007/s13233-016-4090-9 doi (DE-627)SPR03096797X (SPR)s13233-016-4090-9-e DE-627 ger DE-627 rakwb eng Ku, Eun Bi verfasserin aut Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2016 Abstract In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery. globular poly(ethylene glycol) (dpeaa)DE-He213 mitochondria-selective (dpeaa)DE-He213 photodynamic tumor therapy (dpeaa)DE-He213 water-soluble nanoparticle (dpeaa)DE-He213 iodomethyltriphenylphosphonium (IMTP) (dpeaa)DE-He213 Oh, Kyung Taek aut Youn, Yu Seok aut Lee, Eun Seong aut Enthalten in Macromolecular research Heidelberg : Springer, 2010 24(2016), 7 vom: 22. Juni, Seite 634-639 (DE-627)618327576 (DE-600)2537708-5 2092-7673 nnns volume:24 year:2016 number:7 day:22 month:06 pages:634-639 https://dx.doi.org/10.1007/s13233-016-4090-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2016 7 22 06 634-639
spelling	10.1007/s13233-016-4090-9 doi (DE-627)SPR03096797X (SPR)s13233-016-4090-9-e DE-627 ger DE-627 rakwb eng Ku, Eun Bi verfasserin aut Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2016 Abstract In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery. globular poly(ethylene glycol) (dpeaa)DE-He213 mitochondria-selective (dpeaa)DE-He213 photodynamic tumor therapy (dpeaa)DE-He213 water-soluble nanoparticle (dpeaa)DE-He213 iodomethyltriphenylphosphonium (IMTP) (dpeaa)DE-He213 Oh, Kyung Taek aut Youn, Yu Seok aut Lee, Eun Seong aut Enthalten in Macromolecular research Heidelberg : Springer, 2010 24(2016), 7 vom: 22. Juni, Seite 634-639 (DE-627)618327576 (DE-600)2537708-5 2092-7673 nnns volume:24 year:2016 number:7 day:22 month:06 pages:634-639 https://dx.doi.org/10.1007/s13233-016-4090-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2016 7 22 06 634-639
allfields_unstemmed	10.1007/s13233-016-4090-9 doi (DE-627)SPR03096797X (SPR)s13233-016-4090-9-e DE-627 ger DE-627 rakwb eng Ku, Eun Bi verfasserin aut Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2016 Abstract In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery. globular poly(ethylene glycol) (dpeaa)DE-He213 mitochondria-selective (dpeaa)DE-He213 photodynamic tumor therapy (dpeaa)DE-He213 water-soluble nanoparticle (dpeaa)DE-He213 iodomethyltriphenylphosphonium (IMTP) (dpeaa)DE-He213 Oh, Kyung Taek aut Youn, Yu Seok aut Lee, Eun Seong aut Enthalten in Macromolecular research Heidelberg : Springer, 2010 24(2016), 7 vom: 22. Juni, Seite 634-639 (DE-627)618327576 (DE-600)2537708-5 2092-7673 nnns volume:24 year:2016 number:7 day:22 month:06 pages:634-639 https://dx.doi.org/10.1007/s13233-016-4090-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2016 7 22 06 634-639
allfieldsGer	10.1007/s13233-016-4090-9 doi (DE-627)SPR03096797X (SPR)s13233-016-4090-9-e DE-627 ger DE-627 rakwb eng Ku, Eun Bi verfasserin aut Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2016 Abstract In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery. globular poly(ethylene glycol) (dpeaa)DE-He213 mitochondria-selective (dpeaa)DE-He213 photodynamic tumor therapy (dpeaa)DE-He213 water-soluble nanoparticle (dpeaa)DE-He213 iodomethyltriphenylphosphonium (IMTP) (dpeaa)DE-He213 Oh, Kyung Taek aut Youn, Yu Seok aut Lee, Eun Seong aut Enthalten in Macromolecular research Heidelberg : Springer, 2010 24(2016), 7 vom: 22. Juni, Seite 634-639 (DE-627)618327576 (DE-600)2537708-5 2092-7673 nnns volume:24 year:2016 number:7 day:22 month:06 pages:634-639 https://dx.doi.org/10.1007/s13233-016-4090-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2016 7 22 06 634-639
allfieldsSound	10.1007/s13233-016-4090-9 doi (DE-627)SPR03096797X (SPR)s13233-016-4090-9-e DE-627 ger DE-627 rakwb eng Ku, Eun Bi verfasserin aut Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2016 Abstract In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery. globular poly(ethylene glycol) (dpeaa)DE-He213 mitochondria-selective (dpeaa)DE-He213 photodynamic tumor therapy (dpeaa)DE-He213 water-soluble nanoparticle (dpeaa)DE-He213 iodomethyltriphenylphosphonium (IMTP) (dpeaa)DE-He213 Oh, Kyung Taek aut Youn, Yu Seok aut Lee, Eun Seong aut Enthalten in Macromolecular research Heidelberg : Springer, 2010 24(2016), 7 vom: 22. Juni, Seite 634-639 (DE-627)618327576 (DE-600)2537708-5 2092-7673 nnns volume:24 year:2016 number:7 day:22 month:06 pages:634-639 https://dx.doi.org/10.1007/s13233-016-4090-9 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2070 GBV_ILN_2086 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 24 2016 7 22 06 634-639
language	English
source	Enthalten in Macromolecular research 24(2016), 7 vom: 22. Juni, Seite 634-639 volume:24 year:2016 number:7 day:22 month:06 pages:634-639
sourceStr	Enthalten in Macromolecular research 24(2016), 7 vom: 22. Juni, Seite 634-639 volume:24 year:2016 number:7 day:22 month:06 pages:634-639
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	globular poly(ethylene glycol) mitochondria-selective photodynamic tumor therapy water-soluble nanoparticle iodomethyltriphenylphosphonium (IMTP)
isfreeaccess_bool	false
container_title	Macromolecular research
authorswithroles_txt_mv	Ku, Eun Bi @@aut@@ Oh, Kyung Taek @@aut@@ Youn, Yu Seok @@aut@@ Lee, Eun Seong @@aut@@
publishDateDaySort_date	2016-06-22T00:00:00Z
hierarchy_top_id	618327576
id	SPR03096797X
language_de	englisch
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author	Ku, Eun Bi
spellingShingle	Ku, Eun Bi misc globular poly(ethylene glycol) misc mitochondria-selective misc photodynamic tumor therapy misc water-soluble nanoparticle misc iodomethyltriphenylphosphonium (IMTP) Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles
authorStr	Ku, Eun Bi
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topic_title	Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles globular poly(ethylene glycol) (dpeaa)DE-He213 mitochondria-selective (dpeaa)DE-He213 photodynamic tumor therapy (dpeaa)DE-He213 water-soluble nanoparticle (dpeaa)DE-He213 iodomethyltriphenylphosphonium (IMTP) (dpeaa)DE-He213
topic	misc globular poly(ethylene glycol) misc mitochondria-selective misc photodynamic tumor therapy misc water-soluble nanoparticle misc iodomethyltriphenylphosphonium (IMTP)
topic_unstemmed	misc globular poly(ethylene glycol) misc mitochondria-selective misc photodynamic tumor therapy misc water-soluble nanoparticle misc iodomethyltriphenylphosphonium (IMTP)
topic_browse	misc globular poly(ethylene glycol) misc mitochondria-selective misc photodynamic tumor therapy misc water-soluble nanoparticle misc iodomethyltriphenylphosphonium (IMTP)
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title	Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles
ctrlnum	(DE-627)SPR03096797X (SPR)s13233-016-4090-9-e
title_full	Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles
author_sort	Ku, Eun Bi
journal	Macromolecular research
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container_start_page	634
author_browse	Ku, Eun Bi Oh, Kyung Taek Youn, Yu Seok Lee, Eun Seong
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author-letter	Ku, Eun Bi
doi_str_mv	10.1007/s13233-016-4090-9
title_sort	mitochondria-selective photodynamic tumor therapy using globular peg nanoparticles
title_auth	Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles
abstract	Abstract In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery. © The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2016
abstractGer	Abstract In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery. © The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2016
abstract_unstemmed	Abstract In this study, we report water-soluble globular poly(ethylene glycol) (gPEG) nanoparticles for targeting mitochondria and for improved photodynamic tumor therapy. Here, gPEG (prepared after all of the π-π carbon bonds in fullerene (as a hollow core structure) were chemically combined with poly(ethylene glycol) (PEG)) was chemically linked with chlorin e6 (Ce6, as a photosensitizing anticancer drug) and iodomethyltriphenylphosphonium (IMTP). In particular, IMTP acted as a mitochondria-targeting molecule, accelerating the localization of nanoparticles into the mitochondria of tumor cells. From an in vitro evaluation, these nanoparticles exhibited improved singlet oxygen generation and significantly increased photodynamic tumor ablation. We believe that this nanoparticle provides a promising pathway for photodynamic drug delivery. © The Polymer Society of Korea and Springer Sciene+Business Media Dordrecht 2016
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container_issue	7
title_short	Mitochondria-selective photodynamic tumor therapy using globular PEG nanoparticles
url	https://dx.doi.org/10.1007/s13233-016-4090-9
remote_bool	true
author2	Oh, Kyung Taek Youn, Yu Seok Lee, Eun Seong
author2Str	Oh, Kyung Taek Youn, Yu Seok Lee, Eun Seong
ppnlink	618327576
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isOA_txt	false
hochschulschrift_bool	false
doi_str	10.1007/s13233-016-4090-9
up_date	2024-07-03T21:12:58.822Z
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