AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth

Abstract Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain unclear. Here we report that AMP-activated protein kinase (AMPK) interacts with DSCA...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zhu, Kun [verfasserIn] Chen, Xiaoping Liu, Jianghong Ye, Haihong Zhu, Li Wu, Jane Y.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Schlagwörter:	AMP-activated protein kinase (AMPK) neurite outgrowth Down syndrome cell adhesion molecule (DSCAM) netrin

Anmerkung:	© Higher Education Press and Springer-Verlag Berlin Heidelberg 2013

Übergeordnetes Werk:	Enthalten in: Protein & cell - Beijing : Higher Education Press, 2010, 4(2013), 2 vom: Feb., Seite 155-161
Übergeordnetes Werk:	volume:4 ; year:2013 ; number:2 ; month:02 ; pages:155-161

Links:	Volltext

DOI / URN:	10.1007/s13238-012-2126-2

Katalog-ID:	SPR030985595

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520			\|a Abstract Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain unclear. Here we report that AMP-activated protein kinase (AMPK) interacts with DSCAM through its γ subunit, but does not interact with DCC (deleted in colorectal cancer), another major receptor for netrin-1. Netrin-treatment of cultured cortical neurons leads to increased phosphorylation of AMPK. Both AMPK mutant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite outgrowth. Together, these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth. Our study uncovers a previously unknown component, AMPK, in netrin-DSCAM signaling pathway.
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allfields	10.1007/s13238-012-2126-2 doi (DE-627)SPR030985595 (SPR)s13238-012-2126-2-e DE-627 ger DE-627 rakwb eng Zhu, Kun verfasserin aut AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press and Springer-Verlag Berlin Heidelberg 2013 Abstract Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain unclear. Here we report that AMP-activated protein kinase (AMPK) interacts with DSCAM through its γ subunit, but does not interact with DCC (deleted in colorectal cancer), another major receptor for netrin-1. Netrin-treatment of cultured cortical neurons leads to increased phosphorylation of AMPK. Both AMPK mutant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite outgrowth. Together, these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth. Our study uncovers a previously unknown component, AMPK, in netrin-DSCAM signaling pathway. AMP-activated protein kinase (AMPK) (dpeaa)DE-He213 neurite outgrowth (dpeaa)DE-He213 Down syndrome cell adhesion molecule (DSCAM) (dpeaa)DE-He213 netrin (dpeaa)DE-He213 Chen, Xiaoping aut Liu, Jianghong aut Ye, Haihong aut Zhu, Li aut Wu, Jane Y. aut Enthalten in Protein & cell Beijing : Higher Education Press, 2010 4(2013), 2 vom: Feb., Seite 155-161 (DE-627)621548308 (DE-600)2543451-2 1674-8018 nnns volume:4 year:2013 number:2 month:02 pages:155-161 https://dx.doi.org/10.1007/s13238-012-2126-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 2 02 155-161
spelling	10.1007/s13238-012-2126-2 doi (DE-627)SPR030985595 (SPR)s13238-012-2126-2-e DE-627 ger DE-627 rakwb eng Zhu, Kun verfasserin aut AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press and Springer-Verlag Berlin Heidelberg 2013 Abstract Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain unclear. Here we report that AMP-activated protein kinase (AMPK) interacts with DSCAM through its γ subunit, but does not interact with DCC (deleted in colorectal cancer), another major receptor for netrin-1. Netrin-treatment of cultured cortical neurons leads to increased phosphorylation of AMPK. Both AMPK mutant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite outgrowth. Together, these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth. Our study uncovers a previously unknown component, AMPK, in netrin-DSCAM signaling pathway. AMP-activated protein kinase (AMPK) (dpeaa)DE-He213 neurite outgrowth (dpeaa)DE-He213 Down syndrome cell adhesion molecule (DSCAM) (dpeaa)DE-He213 netrin (dpeaa)DE-He213 Chen, Xiaoping aut Liu, Jianghong aut Ye, Haihong aut Zhu, Li aut Wu, Jane Y. aut Enthalten in Protein & cell Beijing : Higher Education Press, 2010 4(2013), 2 vom: Feb., Seite 155-161 (DE-627)621548308 (DE-600)2543451-2 1674-8018 nnns volume:4 year:2013 number:2 month:02 pages:155-161 https://dx.doi.org/10.1007/s13238-012-2126-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 2 02 155-161
allfields_unstemmed	10.1007/s13238-012-2126-2 doi (DE-627)SPR030985595 (SPR)s13238-012-2126-2-e DE-627 ger DE-627 rakwb eng Zhu, Kun verfasserin aut AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press and Springer-Verlag Berlin Heidelberg 2013 Abstract Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain unclear. Here we report that AMP-activated protein kinase (AMPK) interacts with DSCAM through its γ subunit, but does not interact with DCC (deleted in colorectal cancer), another major receptor for netrin-1. Netrin-treatment of cultured cortical neurons leads to increased phosphorylation of AMPK. Both AMPK mutant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite outgrowth. Together, these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth. Our study uncovers a previously unknown component, AMPK, in netrin-DSCAM signaling pathway. AMP-activated protein kinase (AMPK) (dpeaa)DE-He213 neurite outgrowth (dpeaa)DE-He213 Down syndrome cell adhesion molecule (DSCAM) (dpeaa)DE-He213 netrin (dpeaa)DE-He213 Chen, Xiaoping aut Liu, Jianghong aut Ye, Haihong aut Zhu, Li aut Wu, Jane Y. aut Enthalten in Protein & cell Beijing : Higher Education Press, 2010 4(2013), 2 vom: Feb., Seite 155-161 (DE-627)621548308 (DE-600)2543451-2 1674-8018 nnns volume:4 year:2013 number:2 month:02 pages:155-161 https://dx.doi.org/10.1007/s13238-012-2126-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 2 02 155-161
allfieldsGer	10.1007/s13238-012-2126-2 doi (DE-627)SPR030985595 (SPR)s13238-012-2126-2-e DE-627 ger DE-627 rakwb eng Zhu, Kun verfasserin aut AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press and Springer-Verlag Berlin Heidelberg 2013 Abstract Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain unclear. Here we report that AMP-activated protein kinase (AMPK) interacts with DSCAM through its γ subunit, but does not interact with DCC (deleted in colorectal cancer), another major receptor for netrin-1. Netrin-treatment of cultured cortical neurons leads to increased phosphorylation of AMPK. Both AMPK mutant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite outgrowth. Together, these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth. Our study uncovers a previously unknown component, AMPK, in netrin-DSCAM signaling pathway. AMP-activated protein kinase (AMPK) (dpeaa)DE-He213 neurite outgrowth (dpeaa)DE-He213 Down syndrome cell adhesion molecule (DSCAM) (dpeaa)DE-He213 netrin (dpeaa)DE-He213 Chen, Xiaoping aut Liu, Jianghong aut Ye, Haihong aut Zhu, Li aut Wu, Jane Y. aut Enthalten in Protein & cell Beijing : Higher Education Press, 2010 4(2013), 2 vom: Feb., Seite 155-161 (DE-627)621548308 (DE-600)2543451-2 1674-8018 nnns volume:4 year:2013 number:2 month:02 pages:155-161 https://dx.doi.org/10.1007/s13238-012-2126-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 2 02 155-161
allfieldsSound	10.1007/s13238-012-2126-2 doi (DE-627)SPR030985595 (SPR)s13238-012-2126-2-e DE-627 ger DE-627 rakwb eng Zhu, Kun verfasserin aut AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Higher Education Press and Springer-Verlag Berlin Heidelberg 2013 Abstract Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain unclear. Here we report that AMP-activated protein kinase (AMPK) interacts with DSCAM through its γ subunit, but does not interact with DCC (deleted in colorectal cancer), another major receptor for netrin-1. Netrin-treatment of cultured cortical neurons leads to increased phosphorylation of AMPK. Both AMPK mutant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite outgrowth. Together, these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth. Our study uncovers a previously unknown component, AMPK, in netrin-DSCAM signaling pathway. AMP-activated protein kinase (AMPK) (dpeaa)DE-He213 neurite outgrowth (dpeaa)DE-He213 Down syndrome cell adhesion molecule (DSCAM) (dpeaa)DE-He213 netrin (dpeaa)DE-He213 Chen, Xiaoping aut Liu, Jianghong aut Ye, Haihong aut Zhu, Li aut Wu, Jane Y. aut Enthalten in Protein & cell Beijing : Higher Education Press, 2010 4(2013), 2 vom: Feb., Seite 155-161 (DE-627)621548308 (DE-600)2543451-2 1674-8018 nnns volume:4 year:2013 number:2 month:02 pages:155-161 https://dx.doi.org/10.1007/s13238-012-2126-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2014 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 2 02 155-161
language	English
source	Enthalten in Protein & cell 4(2013), 2 vom: Feb., Seite 155-161 volume:4 year:2013 number:2 month:02 pages:155-161
sourceStr	Enthalten in Protein & cell 4(2013), 2 vom: Feb., Seite 155-161 volume:4 year:2013 number:2 month:02 pages:155-161
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	AMP-activated protein kinase (AMPK) neurite outgrowth Down syndrome cell adhesion molecule (DSCAM) netrin
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container_title	Protein & cell
authorswithroles_txt_mv	Zhu, Kun @@aut@@ Chen, Xiaoping @@aut@@ Liu, Jianghong @@aut@@ Ye, Haihong @@aut@@ Zhu, Li @@aut@@ Wu, Jane Y. @@aut@@
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author	Zhu, Kun
spellingShingle	Zhu, Kun misc AMP-activated protein kinase (AMPK) misc neurite outgrowth misc Down syndrome cell adhesion molecule (DSCAM) misc netrin AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth
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topic_title	AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth AMP-activated protein kinase (AMPK) (dpeaa)DE-He213 neurite outgrowth (dpeaa)DE-He213 Down syndrome cell adhesion molecule (DSCAM) (dpeaa)DE-He213 netrin (dpeaa)DE-He213
topic	misc AMP-activated protein kinase (AMPK) misc neurite outgrowth misc Down syndrome cell adhesion molecule (DSCAM) misc netrin
topic_unstemmed	misc AMP-activated protein kinase (AMPK) misc neurite outgrowth misc Down syndrome cell adhesion molecule (DSCAM) misc netrin
topic_browse	misc AMP-activated protein kinase (AMPK) misc neurite outgrowth misc Down syndrome cell adhesion molecule (DSCAM) misc netrin
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title	AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth
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title_full	AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth
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title_sort	ampk interacts with dscam and plays an important role in netrin-1 induced neurite outgrowth
title_auth	AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth
abstract	Abstract Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain unclear. Here we report that AMP-activated protein kinase (AMPK) interacts with DSCAM through its γ subunit, but does not interact with DCC (deleted in colorectal cancer), another major receptor for netrin-1. Netrin-treatment of cultured cortical neurons leads to increased phosphorylation of AMPK. Both AMPK mutant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite outgrowth. Together, these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth. Our study uncovers a previously unknown component, AMPK, in netrin-DSCAM signaling pathway. © Higher Education Press and Springer-Verlag Berlin Heidelberg 2013
abstractGer	Abstract Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain unclear. Here we report that AMP-activated protein kinase (AMPK) interacts with DSCAM through its γ subunit, but does not interact with DCC (deleted in colorectal cancer), another major receptor for netrin-1. Netrin-treatment of cultured cortical neurons leads to increased phosphorylation of AMPK. Both AMPK mutant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite outgrowth. Together, these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth. Our study uncovers a previously unknown component, AMPK, in netrin-DSCAM signaling pathway. © Higher Education Press and Springer-Verlag Berlin Heidelberg 2013
abstract_unstemmed	Abstract Down syndrome cell adhesion molecule (DSCAM) acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development. However, the signaling mechanisms of netrin-DSCAM remain unclear. Here we report that AMP-activated protein kinase (AMPK) interacts with DSCAM through its γ subunit, but does not interact with DCC (deleted in colorectal cancer), another major receptor for netrin-1. Netrin-treatment of cultured cortical neurons leads to increased phosphorylation of AMPK. Both AMPK mutant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite outgrowth. Together, these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth. Our study uncovers a previously unknown component, AMPK, in netrin-DSCAM signaling pathway. © Higher Education Press and Springer-Verlag Berlin Heidelberg 2013
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title_short	AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth
url	https://dx.doi.org/10.1007/s13238-012-2126-2
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author2	Chen, Xiaoping Liu, Jianghong Ye, Haihong Zhu, Li Wu, Jane Y.
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up_date	2024-07-03T21:19:16.766Z
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