Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores
Objective To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. Materials and methods The ADC values of liver parenchyma on diffusion-weighted magnetic r...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Onur, Mehmet Ruhi [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2013 |
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| Übergeordnetes Werk: |
Enthalten in: Insights into imaging - Berlin : Springer, 2010, 4(2013), 3 vom: 11. Mai, Seite 339-345 |
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| Übergeordnetes Werk: |
volume:4 ; year:2013 ; number:3 ; day:11 ; month:05 ; pages:339-345 |
| Links: |
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| DOI / URN: |
10.1007/s13244-013-0252-x |
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| 100 | 1 | |a Onur, Mehmet Ruhi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores |
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| 520 | |a Objective To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. Materials and methods The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained. Results Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05). Conclusion ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. Teaching Points • In chronic viral hepatitis apparent coefficient values are decreased in the liver • There is no correlation between ADC values and histopathologic severity of CVH • DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis | ||
| 650 | 4 | |a Chronic viral hepatitis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Fibrosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Diffusion-weighted MRI |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a ADC measurements |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Poyraz, Ahmet Kursad |4 aut | |
| 700 | 1 | |a Bozdag, Pinar Gundogan |4 aut | |
| 700 | 1 | |a Onder, Semen |4 aut | |
| 700 | 1 | |a Aygun, Cem |4 aut | |
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10.1007/s13244-013-0252-x doi (DE-627)SPR03100220X (SPR)s13244-013-0252-x-e DE-627 ger DE-627 rakwb eng Onur, Mehmet Ruhi verfasserin aut Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Objective To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. Materials and methods The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained. Results Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05). Conclusion ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. Teaching Points • In chronic viral hepatitis apparent coefficient values are decreased in the liver • There is no correlation between ADC values and histopathologic severity of CVH • DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis Chronic viral hepatitis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Diffusion-weighted MRI (dpeaa)DE-He213 ADC measurements (dpeaa)DE-He213 Poyraz, Ahmet Kursad aut Bozdag, Pinar Gundogan aut Onder, Semen aut Aygun, Cem aut Enthalten in Insights into imaging Berlin : Springer, 2010 4(2013), 3 vom: 11. Mai, Seite 339-345 (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:4 year:2013 number:3 day:11 month:05 pages:339-345 https://dx.doi.org/10.1007/s13244-013-0252-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 3 11 05 339-345 |
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10.1007/s13244-013-0252-x doi (DE-627)SPR03100220X (SPR)s13244-013-0252-x-e DE-627 ger DE-627 rakwb eng Onur, Mehmet Ruhi verfasserin aut Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Objective To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. Materials and methods The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained. Results Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05). Conclusion ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. Teaching Points • In chronic viral hepatitis apparent coefficient values are decreased in the liver • There is no correlation between ADC values and histopathologic severity of CVH • DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis Chronic viral hepatitis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Diffusion-weighted MRI (dpeaa)DE-He213 ADC measurements (dpeaa)DE-He213 Poyraz, Ahmet Kursad aut Bozdag, Pinar Gundogan aut Onder, Semen aut Aygun, Cem aut Enthalten in Insights into imaging Berlin : Springer, 2010 4(2013), 3 vom: 11. Mai, Seite 339-345 (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:4 year:2013 number:3 day:11 month:05 pages:339-345 https://dx.doi.org/10.1007/s13244-013-0252-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 3 11 05 339-345 |
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10.1007/s13244-013-0252-x doi (DE-627)SPR03100220X (SPR)s13244-013-0252-x-e DE-627 ger DE-627 rakwb eng Onur, Mehmet Ruhi verfasserin aut Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Objective To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. Materials and methods The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained. Results Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05). Conclusion ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. Teaching Points • In chronic viral hepatitis apparent coefficient values are decreased in the liver • There is no correlation between ADC values and histopathologic severity of CVH • DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis Chronic viral hepatitis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Diffusion-weighted MRI (dpeaa)DE-He213 ADC measurements (dpeaa)DE-He213 Poyraz, Ahmet Kursad aut Bozdag, Pinar Gundogan aut Onder, Semen aut Aygun, Cem aut Enthalten in Insights into imaging Berlin : Springer, 2010 4(2013), 3 vom: 11. Mai, Seite 339-345 (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:4 year:2013 number:3 day:11 month:05 pages:339-345 https://dx.doi.org/10.1007/s13244-013-0252-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 3 11 05 339-345 |
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10.1007/s13244-013-0252-x doi (DE-627)SPR03100220X (SPR)s13244-013-0252-x-e DE-627 ger DE-627 rakwb eng Onur, Mehmet Ruhi verfasserin aut Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Objective To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. Materials and methods The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained. Results Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05). Conclusion ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. Teaching Points • In chronic viral hepatitis apparent coefficient values are decreased in the liver • There is no correlation between ADC values and histopathologic severity of CVH • DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis Chronic viral hepatitis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Diffusion-weighted MRI (dpeaa)DE-He213 ADC measurements (dpeaa)DE-He213 Poyraz, Ahmet Kursad aut Bozdag, Pinar Gundogan aut Onder, Semen aut Aygun, Cem aut Enthalten in Insights into imaging Berlin : Springer, 2010 4(2013), 3 vom: 11. Mai, Seite 339-345 (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:4 year:2013 number:3 day:11 month:05 pages:339-345 https://dx.doi.org/10.1007/s13244-013-0252-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 3 11 05 339-345 |
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10.1007/s13244-013-0252-x doi (DE-627)SPR03100220X (SPR)s13244-013-0252-x-e DE-627 ger DE-627 rakwb eng Onur, Mehmet Ruhi verfasserin aut Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2013 Objective To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. Materials and methods The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained. Results Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05). Conclusion ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. Teaching Points • In chronic viral hepatitis apparent coefficient values are decreased in the liver • There is no correlation between ADC values and histopathologic severity of CVH • DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis Chronic viral hepatitis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Diffusion-weighted MRI (dpeaa)DE-He213 ADC measurements (dpeaa)DE-He213 Poyraz, Ahmet Kursad aut Bozdag, Pinar Gundogan aut Onder, Semen aut Aygun, Cem aut Enthalten in Insights into imaging Berlin : Springer, 2010 4(2013), 3 vom: 11. Mai, Seite 339-345 (DE-627)621547425 (DE-600)2543323-4 1869-4101 nnns volume:4 year:2013 number:3 day:11 month:05 pages:339-345 https://dx.doi.org/10.1007/s13244-013-0252-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2013 3 11 05 339-345 |
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ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. 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Onur, Mehmet Ruhi |
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Onur, Mehmet Ruhi misc Chronic viral hepatitis misc Fibrosis misc Diffusion-weighted MRI misc ADC measurements Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores |
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Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores Chronic viral hepatitis (dpeaa)DE-He213 Fibrosis (dpeaa)DE-He213 Diffusion-weighted MRI (dpeaa)DE-He213 ADC measurements (dpeaa)DE-He213 |
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diffusion weighted mri in chronic viral hepatitis: correlation between adc values and histopathological scores |
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Diffusion weighted MRI in chronic viral hepatitis: correlation between ADC values and histopathological scores |
| abstract |
Objective To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. Materials and methods The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained. Results Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05). Conclusion ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. Teaching Points • In chronic viral hepatitis apparent coefficient values are decreased in the liver • There is no correlation between ADC values and histopathologic severity of CVH • DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis © The Author(s) 2013 |
| abstractGer |
Objective To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. Materials and methods The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained. Results Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05). Conclusion ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. Teaching Points • In chronic viral hepatitis apparent coefficient values are decreased in the liver • There is no correlation between ADC values and histopathologic severity of CVH • DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis © The Author(s) 2013 |
| abstract_unstemmed |
Objective To investigate the utility of apparent diffusion coefficient (ADC) measurement in the diagnosis of chronic viral hepatitis (CVH) and correlation between ADC values and histopathologic severity of CVH. Materials and methods The ADC values of liver parenchyma on diffusion-weighted magnetic resonance imaging (DWMRI) were measured in 50 patients with a history of CVH and 51 healthy subjects at b 100, b 600 and b 1,000 gradients. Comparison between mean ADC values of the CVH and control groups and correlation results between ADC values and necroinflammation and fibrosis scores in CVH were obtained. Results Mean ADC values of CVH patients were significantly lower than mean ADC values of the control group at b 100 and b 600 gradients (P < 0.05). There was no significant difference between the CVH and control groups at the b 1,000 gradient (P > 0.05). No significant correlation was found between ADC values and histopathologic scores of CVH (P > 0.05). Conclusion ADC values obtained at the b 100 and b 600 gradients can be used to distinguish between the liver parenchyma of CVH and healthy subjects. ADC measurement was not found to be useful for estimation of the degree of necroinflammation and fibrosis in CVH. Teaching Points • In chronic viral hepatitis apparent coefficient values are decreased in the liver • There is no correlation between ADC values and histopathologic severity of CVH • DW images obtained at low b values have more ability to demonstrate an ADC decrease in viral hepatitis © The Author(s) 2013 |
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