Lack of association of HLA-DRA polymorphisms with aspirin exacerbated respiratory disease in a Korean population
Abstract The human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence suscepti...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lee, Jin Sol [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2011 |
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| Schlagwörter: |
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| Anmerkung: |
© The Genetics Society of Korea and Springer Netherlands 2011 |
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| Übergeordnetes Werk: |
Enthalten in: Genes & Genomics - The Genetics Society of Korea, 2010, 33(2011), 6 vom: Dez., Seite 613-620 |
|---|---|
| Übergeordnetes Werk: |
volume:33 ; year:2011 ; number:6 ; month:12 ; pages:613-620 |
| Links: |
|---|
| DOI / URN: |
10.1007/s13258-011-0077-2 |
|---|
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SPR031098320 |
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| 520 | |a Abstract The human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence susceptibility for aspirin exacerbated respiratory disease (AERD). To carry out the investigation, 22 single nucleotide polymorphisms (SNPs) in HLA-DRA were genotyped in 592 Korean asthma patients. Logistic and regression analyseis wereas used to evaluate the P-values for associations of HLA-DRA polymorphisms with AERD and a relevant phenotype, the fall rate of forced expiratory volume in the $ 1^{st} $ second ($ FEV_{1} $). Logistic analyses revealed that two variants, rs6911777 and HLA_DRA_BL1_ht3 were initially associated with AERD via dominant and recessive models (P = 0.05 and 0.01, respectively), however, the signals did not reach the threshold of significance after multiple corrections. Furthermore, we observed that fall rate of FEV1 by aspirin provocation was marginally different between AERD cases and aspirin-tolerant asthma (ATA) controls (mean = 24.63 vs 3.54, respectively). This study provides result of first association analysis between the variants of HLA-DRA and the risk of AERD, and conclusions derived from the study do not support significant roles of polymorphisms in HLA-DRA with AERD. | ||
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10.1007/s13258-011-0077-2 doi (DE-627)SPR031098320 (SPR)s13258-011-0077-2-e DE-627 ger DE-627 rakwb eng Lee, Jin Sol verfasserin aut Lack of association of HLA-DRA polymorphisms with aspirin exacerbated respiratory disease in a Korean population 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer Netherlands 2011 Abstract The human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence susceptibility for aspirin exacerbated respiratory disease (AERD). To carry out the investigation, 22 single nucleotide polymorphisms (SNPs) in HLA-DRA were genotyped in 592 Korean asthma patients. Logistic and regression analyseis wereas used to evaluate the P-values for associations of HLA-DRA polymorphisms with AERD and a relevant phenotype, the fall rate of forced expiratory volume in the $ 1^{st} $ second ($ FEV_{1} $). Logistic analyses revealed that two variants, rs6911777 and HLA_DRA_BL1_ht3 were initially associated with AERD via dominant and recessive models (P = 0.05 and 0.01, respectively), however, the signals did not reach the threshold of significance after multiple corrections. Furthermore, we observed that fall rate of FEV1 by aspirin provocation was marginally different between AERD cases and aspirin-tolerant asthma (ATA) controls (mean = 24.63 vs 3.54, respectively). This study provides result of first association analysis between the variants of HLA-DRA and the risk of AERD, and conclusions derived from the study do not support significant roles of polymorphisms in HLA-DRA with AERD. Aspirin exacerbated respiratory disease (AERD) (dpeaa)DE-He213 Aspirin tolerant asthma (ATA) (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Bae, Joon Seol aut Park, Byung-Lae aut Cheong, Hyun Sub aut Kim, Jeong-Hyun aut Pasaje, Charisse Flerida A. aut Kim, Jason Yongha aut Park, Tae Joon aut Uh, Soo-Taek aut Park, Choon-Sik aut Shin, Hyoung Doo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 33(2011), 6 vom: Dez., Seite 613-620 (DE-627)SPR031096425 nnns volume:33 year:2011 number:6 month:12 pages:613-620 https://dx.doi.org/10.1007/s13258-011-0077-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 33 2011 6 12 613-620 |
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10.1007/s13258-011-0077-2 doi (DE-627)SPR031098320 (SPR)s13258-011-0077-2-e DE-627 ger DE-627 rakwb eng Lee, Jin Sol verfasserin aut Lack of association of HLA-DRA polymorphisms with aspirin exacerbated respiratory disease in a Korean population 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer Netherlands 2011 Abstract The human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence susceptibility for aspirin exacerbated respiratory disease (AERD). To carry out the investigation, 22 single nucleotide polymorphisms (SNPs) in HLA-DRA were genotyped in 592 Korean asthma patients. Logistic and regression analyseis wereas used to evaluate the P-values for associations of HLA-DRA polymorphisms with AERD and a relevant phenotype, the fall rate of forced expiratory volume in the $ 1^{st} $ second ($ FEV_{1} $). Logistic analyses revealed that two variants, rs6911777 and HLA_DRA_BL1_ht3 were initially associated with AERD via dominant and recessive models (P = 0.05 and 0.01, respectively), however, the signals did not reach the threshold of significance after multiple corrections. Furthermore, we observed that fall rate of FEV1 by aspirin provocation was marginally different between AERD cases and aspirin-tolerant asthma (ATA) controls (mean = 24.63 vs 3.54, respectively). This study provides result of first association analysis between the variants of HLA-DRA and the risk of AERD, and conclusions derived from the study do not support significant roles of polymorphisms in HLA-DRA with AERD. Aspirin exacerbated respiratory disease (AERD) (dpeaa)DE-He213 Aspirin tolerant asthma (ATA) (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Bae, Joon Seol aut Park, Byung-Lae aut Cheong, Hyun Sub aut Kim, Jeong-Hyun aut Pasaje, Charisse Flerida A. aut Kim, Jason Yongha aut Park, Tae Joon aut Uh, Soo-Taek aut Park, Choon-Sik aut Shin, Hyoung Doo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 33(2011), 6 vom: Dez., Seite 613-620 (DE-627)SPR031096425 nnns volume:33 year:2011 number:6 month:12 pages:613-620 https://dx.doi.org/10.1007/s13258-011-0077-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 33 2011 6 12 613-620 |
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10.1007/s13258-011-0077-2 doi (DE-627)SPR031098320 (SPR)s13258-011-0077-2-e DE-627 ger DE-627 rakwb eng Lee, Jin Sol verfasserin aut Lack of association of HLA-DRA polymorphisms with aspirin exacerbated respiratory disease in a Korean population 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer Netherlands 2011 Abstract The human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence susceptibility for aspirin exacerbated respiratory disease (AERD). To carry out the investigation, 22 single nucleotide polymorphisms (SNPs) in HLA-DRA were genotyped in 592 Korean asthma patients. Logistic and regression analyseis wereas used to evaluate the P-values for associations of HLA-DRA polymorphisms with AERD and a relevant phenotype, the fall rate of forced expiratory volume in the $ 1^{st} $ second ($ FEV_{1} $). Logistic analyses revealed that two variants, rs6911777 and HLA_DRA_BL1_ht3 were initially associated with AERD via dominant and recessive models (P = 0.05 and 0.01, respectively), however, the signals did not reach the threshold of significance after multiple corrections. Furthermore, we observed that fall rate of FEV1 by aspirin provocation was marginally different between AERD cases and aspirin-tolerant asthma (ATA) controls (mean = 24.63 vs 3.54, respectively). This study provides result of first association analysis between the variants of HLA-DRA and the risk of AERD, and conclusions derived from the study do not support significant roles of polymorphisms in HLA-DRA with AERD. Aspirin exacerbated respiratory disease (AERD) (dpeaa)DE-He213 Aspirin tolerant asthma (ATA) (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Bae, Joon Seol aut Park, Byung-Lae aut Cheong, Hyun Sub aut Kim, Jeong-Hyun aut Pasaje, Charisse Flerida A. aut Kim, Jason Yongha aut Park, Tae Joon aut Uh, Soo-Taek aut Park, Choon-Sik aut Shin, Hyoung Doo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 33(2011), 6 vom: Dez., Seite 613-620 (DE-627)SPR031096425 nnns volume:33 year:2011 number:6 month:12 pages:613-620 https://dx.doi.org/10.1007/s13258-011-0077-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 33 2011 6 12 613-620 |
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10.1007/s13258-011-0077-2 doi (DE-627)SPR031098320 (SPR)s13258-011-0077-2-e DE-627 ger DE-627 rakwb eng Lee, Jin Sol verfasserin aut Lack of association of HLA-DRA polymorphisms with aspirin exacerbated respiratory disease in a Korean population 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer Netherlands 2011 Abstract The human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence susceptibility for aspirin exacerbated respiratory disease (AERD). To carry out the investigation, 22 single nucleotide polymorphisms (SNPs) in HLA-DRA were genotyped in 592 Korean asthma patients. Logistic and regression analyseis wereas used to evaluate the P-values for associations of HLA-DRA polymorphisms with AERD and a relevant phenotype, the fall rate of forced expiratory volume in the $ 1^{st} $ second ($ FEV_{1} $). Logistic analyses revealed that two variants, rs6911777 and HLA_DRA_BL1_ht3 were initially associated with AERD via dominant and recessive models (P = 0.05 and 0.01, respectively), however, the signals did not reach the threshold of significance after multiple corrections. Furthermore, we observed that fall rate of FEV1 by aspirin provocation was marginally different between AERD cases and aspirin-tolerant asthma (ATA) controls (mean = 24.63 vs 3.54, respectively). This study provides result of first association analysis between the variants of HLA-DRA and the risk of AERD, and conclusions derived from the study do not support significant roles of polymorphisms in HLA-DRA with AERD. Aspirin exacerbated respiratory disease (AERD) (dpeaa)DE-He213 Aspirin tolerant asthma (ATA) (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Bae, Joon Seol aut Park, Byung-Lae aut Cheong, Hyun Sub aut Kim, Jeong-Hyun aut Pasaje, Charisse Flerida A. aut Kim, Jason Yongha aut Park, Tae Joon aut Uh, Soo-Taek aut Park, Choon-Sik aut Shin, Hyoung Doo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 33(2011), 6 vom: Dez., Seite 613-620 (DE-627)SPR031096425 nnns volume:33 year:2011 number:6 month:12 pages:613-620 https://dx.doi.org/10.1007/s13258-011-0077-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 33 2011 6 12 613-620 |
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10.1007/s13258-011-0077-2 doi (DE-627)SPR031098320 (SPR)s13258-011-0077-2-e DE-627 ger DE-627 rakwb eng Lee, Jin Sol verfasserin aut Lack of association of HLA-DRA polymorphisms with aspirin exacerbated respiratory disease in a Korean population 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Genetics Society of Korea and Springer Netherlands 2011 Abstract The human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence susceptibility for aspirin exacerbated respiratory disease (AERD). To carry out the investigation, 22 single nucleotide polymorphisms (SNPs) in HLA-DRA were genotyped in 592 Korean asthma patients. Logistic and regression analyseis wereas used to evaluate the P-values for associations of HLA-DRA polymorphisms with AERD and a relevant phenotype, the fall rate of forced expiratory volume in the $ 1^{st} $ second ($ FEV_{1} $). Logistic analyses revealed that two variants, rs6911777 and HLA_DRA_BL1_ht3 were initially associated with AERD via dominant and recessive models (P = 0.05 and 0.01, respectively), however, the signals did not reach the threshold of significance after multiple corrections. Furthermore, we observed that fall rate of FEV1 by aspirin provocation was marginally different between AERD cases and aspirin-tolerant asthma (ATA) controls (mean = 24.63 vs 3.54, respectively). This study provides result of first association analysis between the variants of HLA-DRA and the risk of AERD, and conclusions derived from the study do not support significant roles of polymorphisms in HLA-DRA with AERD. Aspirin exacerbated respiratory disease (AERD) (dpeaa)DE-He213 Aspirin tolerant asthma (ATA) (dpeaa)DE-He213 Polymorphism (dpeaa)DE-He213 Bae, Joon Seol aut Park, Byung-Lae aut Cheong, Hyun Sub aut Kim, Jeong-Hyun aut Pasaje, Charisse Flerida A. aut Kim, Jason Yongha aut Park, Tae Joon aut Uh, Soo-Taek aut Park, Choon-Sik aut Shin, Hyoung Doo aut Enthalten in Genes & Genomics The Genetics Society of Korea, 2010 33(2011), 6 vom: Dez., Seite 613-620 (DE-627)SPR031096425 nnns volume:33 year:2011 number:6 month:12 pages:613-620 https://dx.doi.org/10.1007/s13258-011-0077-2 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER SSG-OLC-PHA AR 33 2011 6 12 613-620 |
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Lack of association of HLA-DRA polymorphisms with aspirin exacerbated respiratory disease in a Korean population |
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Lack of association of HLA-DRA polymorphisms with aspirin exacerbated respiratory disease in a Korean population |
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Lee, Jin Sol |
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Lee, Jin Sol Bae, Joon Seol Park, Byung-Lae Cheong, Hyun Sub Kim, Jeong-Hyun Pasaje, Charisse Flerida A. Kim, Jason Yongha Park, Tae Joon Uh, Soo-Taek Park, Choon-Sik Shin, Hyoung Doo |
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lack of association of hla-dra polymorphisms with aspirin exacerbated respiratory disease in a korean population |
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Lack of association of HLA-DRA polymorphisms with aspirin exacerbated respiratory disease in a Korean population |
| abstract |
Abstract The human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence susceptibility for aspirin exacerbated respiratory disease (AERD). To carry out the investigation, 22 single nucleotide polymorphisms (SNPs) in HLA-DRA were genotyped in 592 Korean asthma patients. Logistic and regression analyseis wereas used to evaluate the P-values for associations of HLA-DRA polymorphisms with AERD and a relevant phenotype, the fall rate of forced expiratory volume in the $ 1^{st} $ second ($ FEV_{1} $). Logistic analyses revealed that two variants, rs6911777 and HLA_DRA_BL1_ht3 were initially associated with AERD via dominant and recessive models (P = 0.05 and 0.01, respectively), however, the signals did not reach the threshold of significance after multiple corrections. Furthermore, we observed that fall rate of FEV1 by aspirin provocation was marginally different between AERD cases and aspirin-tolerant asthma (ATA) controls (mean = 24.63 vs 3.54, respectively). This study provides result of first association analysis between the variants of HLA-DRA and the risk of AERD, and conclusions derived from the study do not support significant roles of polymorphisms in HLA-DRA with AERD. © The Genetics Society of Korea and Springer Netherlands 2011 |
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Abstract The human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence susceptibility for aspirin exacerbated respiratory disease (AERD). To carry out the investigation, 22 single nucleotide polymorphisms (SNPs) in HLA-DRA were genotyped in 592 Korean asthma patients. Logistic and regression analyseis wereas used to evaluate the P-values for associations of HLA-DRA polymorphisms with AERD and a relevant phenotype, the fall rate of forced expiratory volume in the $ 1^{st} $ second ($ FEV_{1} $). Logistic analyses revealed that two variants, rs6911777 and HLA_DRA_BL1_ht3 were initially associated with AERD via dominant and recessive models (P = 0.05 and 0.01, respectively), however, the signals did not reach the threshold of significance after multiple corrections. Furthermore, we observed that fall rate of FEV1 by aspirin provocation was marginally different between AERD cases and aspirin-tolerant asthma (ATA) controls (mean = 24.63 vs 3.54, respectively). This study provides result of first association analysis between the variants of HLA-DRA and the risk of AERD, and conclusions derived from the study do not support significant roles of polymorphisms in HLA-DRA with AERD. © The Genetics Society of Korea and Springer Netherlands 2011 |
| abstract_unstemmed |
Abstract The human HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) is a member of the MHC class II gene family that activates T cells allowing secretion in various cytokines to immune responses. Thus, we explored whether the genetic variations in HLA-DRA gene can influence susceptibility for aspirin exacerbated respiratory disease (AERD). To carry out the investigation, 22 single nucleotide polymorphisms (SNPs) in HLA-DRA were genotyped in 592 Korean asthma patients. Logistic and regression analyseis wereas used to evaluate the P-values for associations of HLA-DRA polymorphisms with AERD and a relevant phenotype, the fall rate of forced expiratory volume in the $ 1^{st} $ second ($ FEV_{1} $). Logistic analyses revealed that two variants, rs6911777 and HLA_DRA_BL1_ht3 were initially associated with AERD via dominant and recessive models (P = 0.05 and 0.01, respectively), however, the signals did not reach the threshold of significance after multiple corrections. Furthermore, we observed that fall rate of FEV1 by aspirin provocation was marginally different between AERD cases and aspirin-tolerant asthma (ATA) controls (mean = 24.63 vs 3.54, respectively). This study provides result of first association analysis between the variants of HLA-DRA and the risk of AERD, and conclusions derived from the study do not support significant roles of polymorphisms in HLA-DRA with AERD. © The Genetics Society of Korea and Springer Netherlands 2011 |
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Lack of association of HLA-DRA polymorphisms with aspirin exacerbated respiratory disease in a Korean population |
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Bae, Joon Seol Park, Byung-Lae Cheong, Hyun Sub Kim, Jeong-Hyun Pasaje, Charisse Flerida A. Kim, Jason Yongha Park, Tae Joon Uh, Soo-Taek Park, Choon-Sik Shin, Hyoung Doo |
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